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Fiche de cours

Genetic predispositions to obesity: is it all coded in our DNA?/Prédispositions génétiques à l'obésité: tous est codé dans notre ADN? - ED 20/Série 2

Faculté de gestion: Ecole doctorale (FBM-DOCT)

Responsable(s): Zoltan Kutalik

Période de validité: 2015 ->

Horaires du cours (Apériodique)

Date Lieu Remarque Thématique Intervenant(s)
12.02.2020 de 10:00 à 12:30 Salle Wirchow 01-170, IUMSP / Biopole 2, Rte de la Corniche 10, Lausanne 1010 General introduction to GWAS Zoltan Kutalik
19.02.2020 de 10:00 à 12:30 Salle Wirchow 01-170, IUMSP / Biopole 2, Rte de la Corniche 10, Lausanne 1010 Example studies + Article discussion Zoltan Kutalik
26.02.2020 de 10:00 à 12:30 Salle Wirchow 01-170, IUMSP / Biopole 2, Rte de la Corniche 10, Lausanne 1010 Gene-environment interactions +Article discussion Zoltan Kutalik
04.03.2020 de 10:00 à 12:30 Salle Wirchow 01-170, IUMSP / Biopole 2, Rte de la Corniche 10, Lausanne 1010 Total impact of common variants / Causation + Article discussion Zoltan Kutalik
11.03.2020 de 10:00 à 12:30 Salle Wirchow 01-170, IUMSP / Biopole 2, Rte de la Corniche 10, Lausanne 1010 Rare variants / region-based tests /pathway analysis + Article discussion Zoltan Kutalik

Tutorial (optionnel)

Annuel
Apériodique
Langue(s) d'enseignement: anglais
Public: Oui
Crédits: 1.00

Objectif

Very large genetic studies have been undertaken to study the effect of genetic variations on obesity. While Body Mass Index (BMI) is 40-70% heritable genome-wide association studies (GWAS) including over 300,000 individuals revealed only less than 6% of this heritability. During the course we will review many possible explanations where the remaining heritability is hiding.

Contenu

The tutorial will give a general overview on genetic association studies. Both computational methods and several clinical studies will be explained in details. Many open questions will then be discussed with the students: How to find rare genetic variants impacting obesity? How to detect many more hiding variants with very small effects? Do genetic effects change with age? How can genetic effects be modified? What are the major consequences of obesity?

Evaluation

Travail personnel de préparation : Oui
Présentation personnelle : Oui
Test final : Non
Evaluation de la participation par l'enseignant : Oui

Bibliographie

1) Bulik-Sullivan et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Gen 2015, 47, 291-295 (2015)

2) Visscher et al. 10 years of GWAS discovery: Biology, Function and Translation. AJHG 2017 Jul 6;101(1):5-22.

3) Locke et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015 Feb 12;518(7538):197-206.

Exigences du cursus d'études

Basic knowledge of genetics and statistics.

Conditions d'accès

Inscription auprès de l'Ecole doctorale. Série 2

Canton de Vaud
Swiss University
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