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Fiche de cours

Reasoning and Logic in Experimental and Computational Biology - 63/QB/Série 1

Reasoning and logic in experimental and computational biology

Faculté de gestion: Ecole doctorale (FBM-DOCT)

Responsable(s): Paul Franken

Période de validité: 2019 ->

Horaires du cours (Apériodique)

Date Lieu Remarque Thématique Intervenant(s)
02.11.2020 de 16:00 à 18:00 ONLINE Preparation of publication(s) under 1 by students Federico Santoni
05.11.2020 de 16:00 à 18:00 ONLINE discussion of publication(s) with faculty Federico Santoni
16.11.2020 de 16:00 à 18:00 ONLINE preparation of publication(s) under 2 by students David Gatfield
18.11.2020 de 16:00 à 18:00 ONLINE discussion of publication(s) with faculty David Gatfield
30.11.2020 de 16:00 à 18:00 ONLINE preparation of publication(s) under 3 by students Alexandre Reymond
02.12.2020 de 16:00 à 18:00 ONLINE discussion of publication(s) with faculty Alexandre Reymond

Tutorial (optionnel)

Annuel
Apériodique
Langue(s) d'enseignement: anglais
Public: Oui
Crédits: 1.00

Objectif

: Tutorial in the thematic field "Quantitative Biology (QB)"

Modern, high throughput data generation methods allow the production of comprehensive data sets and thus a quantitatively unique analysis of many biological phenomena.
The tutorial "Reasoning and Logic in Experimental and Computational Biology" has the aim to illustrate the unique conceptual approaches to appropriate experimental design, data analysis and data interpretation required when using high throughput methods.

Contenu

Presentation and discussion of published examples of the application of high throughput DNA sequencing and other genomic methods, applied to a range of different biological questions.

Evaluation

Travail personnel de préparation: Oui
Présentation personnelle: Oui
Test final : Non
Evaluation de la participation par l'enseignant :Oui

Bibliographie

 

1)   "Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing" Maynard et al. Cell 2020 [PMID:32822576]

     

2)   "Non-optimal codon usage affects expression, structure and function of clock protein FRQ". Zhou et al. Nature 2013 [PMID: 23417067] AND "Non-optimal codon usage is a mechanism to achieve circadian clock conditionality" Xu et al. Nature 2013 [PMID: 23417065]

     

3)   "A de novo paradigm for mental retardation" Vissers et al. Nat Genetics 2010 [PMID: 21076407] AND "Genome sequencing identifies major causes of severe intellectual disability" Gilissen et al. Nature 2014 [PMID: 24896178]

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Exigences du cursus d'études

Aucun

Conditions d'octroi

Evaluation positive de la participation active par le tuteur.

Conditions d'accès

Inscription auprès de l'Ecole doctorale. Série 1.

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