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Card-index course

Basis of Cell Biology

Bases de la biologie cellulaire

Responsible Faculty: School of Biology (FBM-BIO)

Teacher(s): Julia Santiago Cuellar

Validity: 2017 -> 2017

No timetable defined.

Course

Autumn semester
14 hours per semester

Teaching language(s): French
Public: Yes
Credits: 0

Objective

The objectives of this course are:

-Put cell biology into the context of evolution and development

-Provide a first overview of the fondamental structures and molecules within a cell

-Provide the necessary basis of molecular biology that allows and understanding of the cell as an assembly of complex molecular devices

Content

- The cells as the universal units of life
- Origin and definition of terms
- Origins of the Cell Theory
- The cells as molecular machines
- The four characteristics of a cellular system:
Energy, Selectivity, Complexity and Reproduction

- The chemical composition of cells
- The relevant elements in the periodic table
- The characteristics of water and lipid bilayers
- The major classes of polymers:
Polysaccharides, nucleic acids, proteins
- The negative entropie of cellular systems
- Where does the energy for the generation of order come from?
- Where do the building blocks for the cellular macromolecules come from?
- Proteins
- Amino acids and primary protein structure
- Secondary and tertiary structure
- What determines the specificit of interaction between proteins and other molecules/proteins?
- Examples of protein complexes

- DNA and Chromosomes
- Replication and Transmission of genetic information
- The composition and structure of DNA
- The challenges of precise replication
- Chromosomal structure in interphase and during mitosis
- Transcription of DNA into RNA
- The relationship between coding and non-coding DNA in a eukaryotic cell
- Differences between DNA and RNA
- The basic principles guiding initiation and termination of transcription
- Short overview of the modification during mRNA maturation

- Protein biosynthesis
- The computer code and the universal code of life
- The problem of translation and the role of the tRNA
- Ribosomal structures and basic principles of translation
- Ribosomal inhibitors

- Control of gene expression
- Different cell types are a result of differences in transcription
- Cloning of organisms as a demonstration of the unchanged DNA content of cells
- Regulation of transcription as a major control step for protein accumulation
- Sequence specific recognition of DNA by transcription factors
- Principles of transcriptional activation by transcription factors
- Signal transduction I:
- How are transcription factors regulated?
Presence/absence, ligands(nuclear receptors), direct/indirect modifications

- Signal transduction II:
- Example of a signal transduction pathway from the plasma membrane to the nucleus (GPCR)

- Structure and function of membranes
- Structure and composition of a eukaryotic membrane
- Lateral mobility of membrane proteins
- Different types of membrane proteins
- Different types of channels/transporters and their contribution to cellular homeostasis

- The cytoskeleton
- Role of the cytoskeleton in cellular homeostasis
- Dynamics of the cytoskeleton
- Actin microfilaments and Microtubules
- their structure and dynamics
- their regulation by associated proteins

Evaluation

1 hour exam (together with the course plant cell biology)

Bibliography

- Biologie moléculaire de la cellule
Auteur : ALBERTS | JOHNSON | LEWIS | RAFF | ROBERTS | WALTER |
Editeur : FLAMMARION
Année : 07/2004
N° ISBN : 2257162196

Programme requirements

none

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Swiss University
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