Annick Muhlethaler

Publications | Phd and Masters theses

Advanced search is available through Serval

Publications can be managed by accessing Serval via MyUnil


38 publications

2022 | 2021 | 2019 | 2016 | 2015 | 2014 | 2012 | 2011 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1994 |
2022
TWIST1 expression is associated with high-risk neuroblastoma and promotes primary and metastatic tumor growth.
Sepporta M.V., Praz V., Balmas Bourloud K., Joseph J.M., Jauquier N., Riggi N., Nardou-Auderset K., Petit A., Scoazec J.Y., Sartelet H. et al., 2022/01/12. Communications biology, 5 (1) p. 42. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_2625E45392D6]
Low number of neurosecretory vesicles in neuroblastoma impairs massive catecholamine release and prevents hypertension.
Mühlethaler-Mottet A., Uccella S., Marchiori D., La Rosa S., Daraspe J., Balmas Bourloud K., Beck Popovic M., Eugster P.J., Grouzmann E., Abid K., 2022. Frontiers in endocrinology, 13 p. 1027856. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_7CBCA91E69DA]
2021
Frequency and Prognostic Impact of ALK Amplifications and Mutations in the European Neuroblastoma Study Group (SIOPEN) High-Risk Neuroblastoma Trial (HR-NBL1).
Bellini A., Pötschger U., Bernard V., Lapouble E., Baulande S., Ambros P.F., Auger N., Beiske K., Bernkopf M., Betts D.R. et al., 2021/10/20. Journal of clinical oncology, 39 (30) pp. 3377-3390. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_69028FD04004]
The noradrenergic profile of plasma metanephrine in neuroblastoma patients is reproduced in xenograft mice models and arise from PNMT downregulation.
Abid K., Popovic M.B., Bourloud K.B., Schoumans J., Grand-Guillaume J., Grouzmann E., Mühlethaler-Mottet A., 2021/01/05. Oncotarget, 12 (1) pp. 49-60. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_F6E0642966A2]
2019
Expression of the Neuroblastoma-Associated ALK-F1174L Activating Mutation During Embryogenesis Impairs the Differentiation of Neural Crest Progenitors in Sympathetic Ganglia.
Vivancos Stalin L., Gualandi M., Schulte J.H., Renella R., Shakhova O., Mühlethaler-Mottet A., 2019. Frontiers in oncology, 9 p. 275. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_786ADE803D76]
2016
Aldehyde dehydrogenase activity plays a Key role in the aggressive phenotype of neuroblastoma.
Flahaut M., Jauquier N., Chevalier N., Nardou K., Balmas Bourloud K., Joseph J.M., Barras D., Widmann C., Gross N., Renella R. et al., 2016. Bmc Cancer, 16 (1) p. 781. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_8AFB2FAA16EB]
2015
The CXCR4/CXCR7/CXCL12 Axis Is Involved in a Secondary but Complex Control of Neuroblastoma Metastatic Cell Homing.
Mühlethaler-Mottet A., Liberman J., Ascenção K., Flahaut M., Balmas Bourloud K., Yan P., Jauquier N., Gross N., Joseph J.M., 2015/05. PloS one. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_0397AD69432B]
2014
Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells.
Montavon G., Jauquier N., Coulon A., Peuchmaur M., Flahaut M., Balmas Bourloud K., Yan P., Delattre O., Sommer L., Joseph J.M. et al., 2014. Oncotarget, 5 (12) pp. 4452-4466. Peer-reviewed.
[URN][WoS][Pmid][serval:BIB_9D95D6FECC81]
2012
Involvement of the CXCR7/CXCR4/CXCL12 Axis in the Malignant Progression of Human Neuroblastoma.
Liberman J., Sartelet H., Flahaut M., Mühlethaler-Mottet A., Coulon A., Nyalendo C., Vassal G., Joseph J.M., Gross N., 2012. Plos One, 7 (8) pp. e43665. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_841497C75C78]
2011
Functional sphere profiling reveals the complexity of neuroblastoma tumor-initiating cell model.
Coulon A, Flahaut M, Mühlethaler-Mottet A, Meier R, Liberman J, Balmas-Bourloud K, Nardou K, Yan P, Tercier S, Joseph JM et al., 2011/10. Neoplasia (New York, N.Y.) pp. 991-1004. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_3A2FE3C63C67]
Individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis.
Mühlethaler-Mottet A, Flahaut M, Bourloud KB, Nardou K, Coulon A, Liberman J, Thome M, Gross N, 2011/03. Cell death & disease. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_FAD3E0711522]
2009
 
The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/beta-catenin pathway.
Flahaut M., Meier R., Coulon A., Nardou K.A., Niggli F.K., Martinet D., Beckmann J.S., Joseph J.M., Mühlethaler-Mottet A., Gross N., 2009/05. Oncogene. Peer-reviewed.
[DOI][Pmid][serval:BIB_C9E64E50B2D3]
Fenretinide-induced caspase-8 activation and apoptosis in an established model of metastatic neuroblastoma.
Raguénez G, Mühlethaler-Mottet A, Meier R, Duros C, Bénard J, Gross N, 2009/03. BMC cancer, 9. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_19AF794B5C18]
2008
Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells.
Mühlethaler-Mottet A, Meier R, Flahaut M, Bourloud KB, Nardou K, Joseph JM, Gross N, 2008/06. Molecular cancer. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_D3898496EDEA]
2007
The chemokine receptor CXCR4 strongly promotes neuroblastoma primary tumour and metastatic growth, but not invasion.
Meier R., Mühlethaler-Mottet Annick, Flahaut M., Coulon A., Fusco C., Louache F., Auderset K., Balmas Bourloud K., Daudigeos E., Ruegg C. et al., 2007. PLoS ONE, 2 (10) pp. e1016. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_75476A10628B]
2006
 
Molecular cytogenetic characterization of doxorubicin-resistant neuroblastoma cell lines: evidence that acquired multidrug resistance results from a unique large amplification of the 7q21 region.
Flahaut M, Mühlethaler-Mottet A, Martinet D, Fattet S, Bourloud KB, Auderset K, Meier R, Schmutz NB, Delattre O, Joseph JM et al., 2006/05. Genes, chromosomes & cancer. Peer-reviewed.
[DOI][Pmid][serval:BIB_613AE9F0AC33]
Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio.
Mühlethaler-Mottet A., Flahaut M., Bourloud K.B., Auderset K., Meier R., Joseph J.M., Gross N., 2006. BMC Cancer, 6 p. 214. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_7FFF05EB8B58]
 
Persistent inhibition of FLIP(L) expression by lentiviral small hairpin RNA delivery restores death-receptor-induced apoptosis in neuroblastoma cells.
Flahaut M., Mühlethaler-Mottet A., Auderset K., Bourloud K.B., Meier R., Popovic M.B., Joseph J.M., Gross N., 2006. Apoptosis : an international journal on programmed cell death, 11 (2) pp. 255-63. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_18B97F558CD9]
2005
 
In vivo echographic evidence of tumoral vascularization and microenvironment interactions in metastatic orthotopic human neuroblastoma xenografts.
Joseph JM, Gross N, Lassau N, Rouffiac V, Opolon P, Laudani L, Auderset K, Geay JF, Mühlethaler-Mottet A, Vassal G, 2005/03. International journal of cancer. Peer-reviewed.
[DOI][Pmid][serval:BIB_02E6410C4371]
2004
 
Drug-mediated sensitization to TRAIL-induced apoptosis in caspase-8-complemented neuroblastoma cells proceeds via activation of intrinsic and extrinsic pathways and caspase-dependent cleavage of XIAP, Bcl-xL and RIP.
Mühlethaler-Mottet A, Bourloud KB, Auderset K, Joseph JM, Gross N, 2004/07. Oncogene. Peer-reviewed.
[DOI][Pmid][serval:BIB_7A9E6DD37E62]
 
The S box of major histocompatibility complex class II promoters is a key determinant for recruitment of the transcriptional co-activator CIITA.
Muhlethaler-Mottet A, Krawczyk M, Masternak K, Spilianakis C, Kretsovali A, Papamatheakis J, Reith W, 2004/07. The Journal of biological chemistry. Peer-reviewed.
[DOI][Pmid][serval:BIB_39A521193111]
2003
 
Restoration of TRAIL-induced apoptosis in a caspase-8-deficient neuroblastoma cell line by stable re-expression of caspase-8.
Mühlethaler-Mottet A, Balmas K, Auderset K, Joseph JM, Gross N, 2003/12. Annals of the New York Academy of Sciences. Peer-reviewed.
[DOI][Pmid][serval:BIB_6762CFD9B590]
 
CIITA and the MHCII Enhanceosome in the Regulation of MHCII Expression
Landmann S, Waldburger JM, Masternak K, Muhlethaler-Mottet A, Reith W, 2003/05/01. Current Genomics. Peer-reviewed.
[DOI][serval:BIB_2CF800D62920]
 
Hypermethylation-mediated regulation of CD44 gene expression in human neuroblastoma
Yan P., Muhlethaler A., Bourloud K. B., Beck M. N., Gross N., 2003/02. Genes Chromosomes and Cancer, 36 (2) pp. 129-38. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_CE090BB37B1C]
2002
 
Doxorubicin-induced death in neuroblastoma does not involve death receptors in S-type cells and is caspase-independent in N-type cells
Hopkins-Donaldson S., Yan P., Bourloud K. B., Muhlethaler A., Bodmer J. L., Gross N., 2002/09. Oncogene, 21 (39) pp. 6132-7. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_0CCC18BD9658]
2001
 
Maturation of dendritic cells is accompanied by rapid transcriptional silencing of class II transactivator (CIITA) expression.
Landmann S, Mühlethaler-Mottet A, Bernasconi L, Suter T, Waldburger JM, Masternak K, Arrighi JF, Hauser C, Fontana A, Reith W, 2001/08. The Journal of experimental medicine. Peer-reviewed.
[DOI][Pmid][serval:BIB_14EF7F226A0A]
 
Analysis of the sequence polymorphism within class II transactivator gene promoters.
Janitz M, Reiners-Schramm L, Muhlethaler-Mottet A, Rosowski M, Lauster R, 2001/01. Experimental and clinical immunogenetics. Peer-reviewed.
[DOI][Pmid][serval:BIB_B591430938B7]
2000
 
Lessons from the bare lymphocyte syndrome: molecular mechanisms regulating MHC class II expression.
Waldburger JM, Masternak K, Muhlethaler-Mottet A, Villard J, Peretti M, Landmann S, Reith W, 2000/12. Immunological reviews. Peer-reviewed.
[DOI][Pmid][serval:BIB_F6623469E613]
 
CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex.
Masternak K, Muhlethaler-Mottet A, Villard J, Zufferey M, Steimle V, Reith W, 2000/05. Genes & development. Peer-reviewed.
[Pmid][serval:BIB_2DA42E62A0B7]
 
Dendritic cells and differential usage of the MHC class II transactivator promoters in the central nervous system in experimental autoimmune encephalitis.
Suter T, Malipiero U, Otten L, Ludewig B, Muelethaler-Mottet A, Mach B, Reith W, Fontana A, 2000/03. European journal of immunology. Peer-reviewed.
[DOI][Pmid][serval:BIB_DF605CF81FB2]
 
Molecular genetics of the Bare lymphocyte syndrome.
Masternak K, Muhlethaler-Mottet A, Villard J, Peretti M, Reith W, 2000/01. Reviews in immunogenetics. Peer-reviewed.
[Pmid][serval:BIB_CD2205394BFA]
1999
 
The molecular basis of MHC class II deficiency and transcriptional control of MHC class II gene expression.
Reith W, Muhlethaler-Mottet A, Masternak K, Villard J, Mach B, 1999/09. Microbes and infection. Peer-reviewed.
[DOI][Pmid][serval:BIB_D75C18717796]
 
Escape of human cytomegalovirus from HLA-DR-restricted CD4(+) T-cell response is mediated by repression of gamma interferon-induced class II transactivator expression.
Le Roy E, Mühlethaler-Mottet A, Davrinche C, Mach B, Davignon JL, 1999/08. Journal of virology. Peer-reviewed.
[Pmid][serval:BIB_A0ED9092FC9F]
 
CIITA-induced occupation of MHC class II promoters is independent of the cooperative stabilization of the promoter-bound multi-protein complexes.
Villard J, Muhlethaler-Mottet A, Bontron S, Mach B, Reith W, 1999/03. International immunology. Peer-reviewed.
[DOI][Pmid][serval:BIB_67189AD831B0]
1998
 
Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1.
Muhlethaler-Mottet A, Di Berardino W, Otten LA, Mach B, 1998/02. Immunity. Peer-reviewed.
[DOI][Pmid][serval:BIB_3FDC97BD951B]
1997
 
Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA.
Muhlethaler-Mottet A, Otten LA, Steimle V, Mach B, 1997/05. The EMBO journal. Peer-reviewed.
[DOI][Pmid][serval:BIB_FFE9978DEEE9]
1994
 
Developmental extinction of major histocompatibility complex class II gene expression in plasmocytes is mediated by silencing of the transactivator gene CIITA.
Silacci P, Mottet A, Steimle V, Reith W, Mach B, 1994/10. The Journal of experimental medicine. Peer-reviewed.
[DOI][Pmid][serval:BIB_66AB85AAA3C7]
 
Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA.
Steimle V, Siegrist CA, Mottet A, Lisowska-Grospierre B, Mach B, 1994/07. Science (New York, N.Y.). Peer-reviewed.
[DOI][Pmid][serval:BIB_B8269BD8CA8B]
Partagez:
Unicentre - CH-1015 Lausanne
Suisse
Tél. +41 21 692 11 11
Canton de Vaud
Swiss University