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Greta Guarda

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Ludigs K., Jandus C., Utzschneider D.T., Staehli F., Bessoles S., Dang A.T., Rota G., Castro W., Zehn D., Vivier E. et al., NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions. Nature Communications 7, p. 10554, 2016. [Document] [DOI] [Web of Science] [Pubmed] ok

Rota G., Ludigs K., Siegert S., Tardivel A., Morgado L., Reith W., De Gassart A., Guarda G., T Cell Priming by Activated Nlrc5-Deficient Dendritic Cells Is Unaffected despite Partially Reduced MHC Class I Levels. Journal of Immunology 196(7), pp. 2939-2946, 2016. [DOI] [Web of Science] [Pubmed]


Ludigs K., Seguín-Estévez Q., Lemeille S., Ferrero I., Rota G., Chelbi S., Mattmann C., MacDonald H.R., Reith W., Guarda G., NLRC5 exclusively transactivates MHC class I and related genes through a distinctive SXY module. Plos Genetics 11(3), p. e1005088, 2015. [Document] [DOI] [Web of Science] [Pubmed] ok


Dostert C., Ludigs K., Guarda G., Innate and adaptive effects of inflammasomes on T cell responses. Current Opinion in Immunology 25(3), pp. 359-365, 2013. [Document] [DOI] [Web of Science] [Pubmed]

Jankovic D., Ganesan J., Bscheider M., Stickel N., Weber F.C., Guarda G., Follo M., Pfeifer D., Tardivel A., Ludigs K. et al., The Nlrp3 inflammasome regulates acute graft-versus-host disease. Journal of Experimental Medicine 210(10), pp. 1899-1910, 2013. [Document] [DOI] [Web of Science] [Pubmed]

Kolly L., Busso N., von Scheven-Gete A., Bagnoud N., Moix I., Holzinger D., Simon G., Ives A., Guarda G., So A. et al., Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome is linked to dysregulated monocyte IL-1β production. Journal of Allergy and Clinical Immunology 131(6), pp. 1635-1643, 2013. [DOI] [Web of Science] [Pubmed] ok

Michallet M.C., Rota G., Maslowski K., Guarda G., Innate receptors for adaptive immunity. Current Opinion in Microbiology 16(3), pp. 296-302, 2013. [Document] [DOI] [Web of Science] [Pubmed]

Neerincx A., Castro W., Guarda G., Kufer T.A., NLRC5, at the Heart of Antigen Presentation. Frontiers in Immunology 4, p. 397, 2013. [Document] [DOI] [Web of Science] [Pubmed] ok

Yan Y., Jiang W., Spinetti T., Tardivel A., Castillo R., Bourquin C., Guarda G., Tian Z., Tschopp J., Zhou R., Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity 38(6), pp. 1154-1163, 2013. [DOI] [Web of Science] [Pubmed]


Gross O., Yazdi A.S., Thomas C.J., Masin M., Heinz L.X., Guarda G., Quadroni M., Drexler S.K., Tschopp J., Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity 36(3), pp. 388-400, 2012. [DOI] [Web of Science] [Pubmed]

Kupz A., Guarda G., Gebhardt T., Sander L.E., Short K.R., Diavatopoulos D.A., Wijburg O.L., Cao H., Waithman J.C., Chen W. et al., NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8⁺ T cells. Nature Immunology 13(2), pp. 162-169, 2012. [DOI] [Web of Science] [Pubmed]

Ludigs K., Parfenov V., Du Pasquier R.A., Guarda G., Type I IFN-mediated regulation of IL-1 production in inflammatory disorders. Cellular and Molecular Life Sciences 69(20), pp. 3395-3418, 2012. [DOI] [Web of Science] [Pubmed] ok

Staehli F., Ludigs K., Heinz L.X., Seguín-Estévez Q., Ferrero I., Braun M., Schroder K., Rebsamen M., Tardivel A., Mattmann C. et al., NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells. Journal of Immunology 188(8), pp. 3820-3828, 2012. [DOI] [Web of Science] [Pubmed]

Vince J.E., Wong W.W., Gentle I., Lawlor K.E., Allam R., O'Reilly L., Mason K., Gross O., Ma S., Guarda G. et al., Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. Immunity 36(2), pp. 215-227, 2012. [DOI] [Web of Science] [Pubmed]


Gross O., Thomas C.J., Guarda G., Tschopp J., The inflammasome: an integrated view. Immunological Reviews 243(1), pp. 136-151, 2011. [DOI] [Web of Science] [Pubmed]

Guarda G., Braun M., Staehli F., Tardivel A., Mattmann C., Förster I., Farlik M., Decker T., Du Pasquier R.A., Romero P. et al., Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 34(2), pp. 213-223, 2011. [DOI] [Web of Science] [Pubmed] ok

Guarda G., Yazdi A.S., D'Ombrain M.C., Drexler S.K., Acute gout: The inflammasome. Current Rheumatology Reviews 7(2), pp. 132-140, 2011.

Guarda G., Zenger M., Yazdi A.S., Schroder K., Ferrero I., Menu P., Tardivel A., Mattmann C., Tschopp J., Differential expression of NLRP3 among hematopoietic cells. Journal of Immunology 186(4), pp. 2529-2534, 2011. [DOI] [Web of Science] [Pubmed]

Rebsamen M., Vazquez J., Tardivel A., Guarda G., Curran J., Tschopp J., NLRX1/NOD5 deficiency does not affect MAVS signalling. Cell Death and Differentiation 18(8), p. 1387, 2011. [DOI] [Web of Science] [Pubmed]


Guarda G., So A., Regulation of inflammasome activity. Immunology 130(3), pp. 329-336, 2010. [DOI] [Web of Science] [Pubmed] ok

Yazdi A.S., Guarda G., D'Ombrain M.C., Drexler S.K., Inflammatory caspases in innate immunity and inflammation. Journal of Innate Immunity 2(3), pp. 228-237, 2010. [DOI] [Web of Science] [Pubmed] ok

Yazdi A.S., Guarda G., Riteau N., Drexler S.K., Tardivel A., Couillin I., Tschopp J., Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β. Proceedings of the National Academy of Sciences of the United States of America 107(45), pp. 19449-19454, 2010. [DOI] [Web of Science] [Pubmed] ok


Dostert C., Guarda G., Romero J.F., Menu P., Gross O., Tardivel A., Suva M.L., Stehle J.C., Kopf M., Stamenkovic I. et al., Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PloS one 4(8), p. e6510, 2009. [Document] [DOI] [Web of Science] [Pubmed] ok

Guarda G., Dostert C., Staehli F., Cabalzar K., Castillo R., Tardivel A., Schneider P., Tschopp J., T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature 460(7252), pp. 269-273, 2009. [DOI] [Web of Science] [Pubmed] ok


Lozza L., Rivino L., Guarda G., Jarrossay D., Rinaldi A., Bertoni F., Sallusto F., Lanzavecchia A., Geginat J., The strength of T cell stimulation determines IL-7 responsiveness, secondary expansion, and lineage commitment of primed human CD4+IL-7Rhi T cells. European Journal of Immunology 38(1), pp. 30-39, 2008. [DOI] [Web of Science] [Pubmed]

Martín-Fontecha A, Guarda G, Lanzavecchia A., Sallusto F., Activated lymph nodes recruit blood borne NK cells and effector T cells: implications for adaptive T cell responses. Current Immunology Reviews 4(1), pp. 20-27, 2008. [DOI]

Martín-Fontecha A., Baumjohann D., Guarda G., Reboldi A., Hons M., Lanzavecchia A., Sallusto F., CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming. Journal of Experimental Medicine 205(11), pp. 2561-2574, 2008. [DOI] [Web of Science] [Pubmed]


Guarda G., Hons M., Soriano S.F., Huang A.Y., Polley R., Martín-Fontecha A., Stein J.V., Germain R.N., Lanzavecchia A., Sallusto F., L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells. Nature Immunology 8(7), pp. 743-752, 2007. [DOI] [Web of Science] [Pubmed]


Melkko S., Sobek J., Guarda G., Scheuermann J., Dumelin C.E., Neri D., Encoded self-assembling chemical libraries. CHIMIA 59(11), pp. 798-802, 2005. [DOI] [Web of Science] ok

ok : Peer Reviewed

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