Michael Hebeisen

Publications | Mémoires et thèses

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14 publications

2019 | 2017 | 2015 | 2013 | 2012 | 2011 | 2010 |
NK cells specifically TCR-dressed to kill cancer cells.
Mensali N., Dillard P., Hebeisen M., Lorenz S., Theodossiou T., Myhre M.R., Fåne A., Gaudernack G., Kvalheim G., Myklebust J.H. et al., 2019/02. EBioMedicine, 40 pp. 106-117. Peer-reviewed.
TCR-ligand dissociation rate is a robust and stable biomarker of CD8+ T cell potency.
Allard M., Couturaud B., Carretero-Iglesia L., Duong M.N., Schmidt J., Monnot G.C., Romero P., Speiser D.E., Hebeisen M., Rufer N., 2017/07/20. JCI insight, 2 (14) pp. e92570. Peer-reviewed.
Heterogeneity assessment of functional T cell avidity.
Ioannidou K., Baumgaertner P., Gannon P.O., Speiser M.F., Allard M., Hebeisen M., Rufer N., Speiser D.E., 2017/03/13. Scientific reports, 7 p. 44320. Peer-reviewed.
Fine-Tuning of Optimal TCR Signaling in Tumor-Redirected CD8 T Cells by Distinct TCR Affinity-Mediated Mechanisms
Presotto D., Erdes E., Duong M.N., Allard M., Regamey P.O., Quadroni M., Doucey M.A., Rufer N., Hebeisen M., 2017. Frontiers in Immunology, 8 p. 1564. Peer-reviewed.
Fine-Tuning of Optimal TCR Signaling in Tumor-Redirected CD8 T Cells by Distinct TCR Affinity-Mediated Mechanisms.
Presotto D., Erdes E., Duong M.N., Allard M., Regamey P.O., Quadroni M., Doucey M.A., Rufer N., Hebeisen M., 2017. Frontiers in Immunology, 8 p. 1564. Peer-reviewed.
Identification of Rare High-Avidity, Tumor-Reactive CD8+ T Cells by Monomeric TCR-Ligand Off-Rates Measurements on Living Cells.
Hebeisen M., Schmidt J., Guillaume P., Baumgaertner P., Speiser D.E., Luescher I., Rufer N., 2015. Cancer Research, 75 (10) pp. 1983-1991. Peer-reviewed.
Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens.
Hebeisen M., Allard M., Gannon P.O., Schmidt J., Speiser D.E., Rufer N., 2015. Frontiers in Immunology, 6 p. 582. Peer-reviewed.
 
Quantitative TCR:pMHC Dissociation Rate Assessment by NTAmers Reveals Antimelanoma T Cell Repertoires Enriched for High Functional Competence.
Gannon P.O., Wieckowski S., Baumgaertner P., Hebeisen M., Allard M., Speiser D.E., Rufer N., 2015. Journal of Immunology, 195 (1) pp. 356-366. Peer-reviewed.
MicroRNA-155 Is Required for Effector CD8(+) T Cell Responses to Virus Infection and Cancer.
Dudda J.C., Salaun B., Ji Y., Palmer D.C., Monnot G.C., Merck E., Boudousquie C., Utzschneider D.T., Escobar T.M., Perret R. et al., 2013. Immunity, 38 (4) pp. 742-753. Peer-reviewed.
Molecular insights for optimizing T cell receptor specificity against cancer.
Hebeisen M., Oberle S.G., Presotto D., Speiser D.E., Zehn D., Rufer N., 2013. Frontiers In Immunology, 4 p. 154.
SHP-1 phosphatase activity counteracts increased T cell receptor affinity.
Hebeisen M., Baitsch L., Presotto D., Baumgaertner P., Romero P., Michielin O., Speiser D.E., Rufer N., 2013. Journal of Clinical Investigation, 123 (3) pp. 1044-1056.
 
Interplay between T cell receptor binding kinetics and the level of cognate peptide presented by major histocompatibility complexes governs CD8+ T cell responsiveness.
Irving M., Zoete V., Hebeisen M., Schmid D., Baumgartner P., Guillaume P., Romero P., Speiser D., Luescher I., Rufer N. et al., 2012. Journal of Biological Chemistry, 287 (27) pp. 23068-23078. Peer-reviewed.
 
Optimal CD8 T cell responsiveness is controlled within a defined TCR affinity window
Hebeisen M., Irving M., Schmid D., Zoete V., Romero P., Speiser D., Michielin O., Rufer N., 2011. p. 111 dans Annual Congress SGAI-SSAI, Advances in immunology and allergology: from research to diagnosis and therapy, Allergologie. Peer-reviewed.
 
Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function.
Schmid D.A., Irving M.B., Posevitz V., Hebeisen M., Posevitz-Fejfar A., Sarria J.C., Gomez-Eerland R., Thome M., Schumacher T.N., Romero P. et al., 2010. Journal of Immunology, 184 (9) pp. 4936-4946. Peer-reviewed.
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