Nicolas Toni

Publications | Mémoires et thèses

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68 publications

2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1997 | 1996 |
 
GSK-3β orchestrates the inhibitory innervation of adult-born dentate granule cells in vivo.
Moreno-Jiménez E.P., Flor-García M., Hernández-Vivanco A., Terreros-Roncal J., Rodríguez-Moreno C.B., Toni N., Méndez P., Llorens-Martín M., 2023/07/23. Cellular and molecular life sciences, 80 (8) p. 225. Peer-reviewed.
Characterization of early psychosis patients carrying a genetic vulnerability to redox dysregulation: a computational analysis of mechanism-based gene expression profile in fibroblasts.
Giangreco B., Dwir D., Klauser P., Jenni R., Golay P., Cleusix M., Baumann P.S., Cuénod M., Conus P., Toni N. et al., 2023/05. Molecular psychiatry, 28 (5) pp. 1983-1994. Peer-reviewed.
Tau Transfer via Extracellular Vesicles Disturbs the Astrocytic Mitochondrial System.
Perbet R., Zufferey V., Leroux E., Parietti E., Espourteille J., Culebras L., Perriot S., Du Pasquier R., Bégard S., Deramecourt V. et al., 2023/03/23. Cells, 12 (7) p. 985. Peer-reviewed.
Extracellular vesicles: Major actors of heterogeneity in tau spreading among human tauopathies.
Leroux E., Perbet R., Caillierez R., Richetin K., Lieger S., Espourteille J., Bouillet T., Bégard S., Danis C., Loyens A. et al., 2022/02/02. Molecular Therapy, 30 (2) pp. 782-797. Peer-reviewed.
Role of adult hippocampal neurogenesis in the antidepressant actions of lactate.
Carrard A., Cassé F., Carron C., Burlet-Godinot S., Toni N., Magistretti P.J., Martin J.L., 2021/11. Molecular psychiatry, 26 (11) pp. 6723-6735. Peer-reviewed.
Gradient of electro-convulsive therapy's antidepressant effects along the longitudinal hippocampal axis.
Gyger L., Regen F., Ramponi C., Marquis R., Mall J.F., Swierkosz-Lenart K., von Gunten A., Toni N., Kherif F., Heuser I. et al., 2021/03/29. Translational psychiatry, 11 (1) p. 191. Peer-reviewed.
Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer's disease
Richetin Kevin, Steullet Pascal, Pachoud Mathieu, Perbet Romain, Parietti Enea, Maheswaran Mathischan, Eddarkaoui Sabiha, Bégard Séverine, Pythoud Catherine, Rey Maria et al., 2020/12. Nature Neuroscience, 23 (12) pp. 1567-1579. Peer-reviewed.
 
Limits to human neurogenesis-really?
Lucassen P.J., Toni N., Kempermann G., Frisen J., Gage F.H., Swaab D.F., 2020/10. Molecular psychiatry, 25 (10) pp. 2207-2209. Peer-reviewed.
Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunction.
Motori E., Atanassov I., Kochan SMV, Folz-Donahue K., Sakthivelu V., Giavalisco P., Toni N., Puyal J., Larsson N.G., 2020/08. Science advances, 6 (35) pp. eaba8271. Peer-reviewed.
Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain.
Schouten M., Bielefeld P., Garcia-Corzo L., Passchier EMJ, Gradari S., Jungenitz T., Pons-Espinal M., Gebara E., Martín-Suárez S., Lucassen P.J. et al., 2020/07. Molecular psychiatry, 25 (7) pp. 1382-1405. Peer-reviewed.
Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments.
Petrelli F., Dallérac G., Pucci L., Calì C., Zehnder T., Sultan S., Lecca S., Chicca A., Ivanov A., Asensio C.S. et al., 2020/04. Molecular psychiatry, 25 (4) pp. 732-749. Peer-reviewed.
Astrocyte function from information processing to cognition and cognitive impairment.
Santello M., Toni N., Volterra A., 2019/02. Nature neuroscience, 22 (2) pp. 154-166. Peer-reviewed.
Mossy Cells Control Adult Neural Stem Cell Quiescence and Maintenance through a Dynamic Balance between Direct and Indirect Pathways.
Yeh C.Y., Asrican B., Moss J., Quintanilla L.J., He T., Mao X., Cassé F., Gebara E., Bao H., Lu W. et al., 2018/08/08. Neuron, 99 (3) pp. 493-510.e4. Peer-reviewed.
 
Human Adult Neurogenesis: Evidence and Remaining Questions.
Kempermann G., Gage F.H., Aigner L., Song H., Curtis M.A., Thuret S., Kuhn H.G., Jessberger S., Frankland P.W., Cameron H.A. et al., 2018/07/05. Cell stem cell, 23 (1) pp. 25-30. Peer-reviewed.
Astrocytes' Contribution to Adult Neurogenesis in Physiology and Alzheimer's Disease.
Cassé F., Richetin K., Toni N., 2018. Frontiers in cellular neuroscience, 12 p. 432. Peer-reviewed.
Silent synapses generate sparse and orthogonal action potential firing in adult-born hippocampal granule cells.
Li L., Sultan S., Heigele S., Schmidt-Salzmann C., Toni N., Bischofberger J., 2017/08/08. eLife, 6 pp. e23612. Peer-reviewed.
Synaptic Adhesion Molecules Regulate the Integration of New Granule Neurons in the Postnatal Mouse Hippocampus and their Impact on Spatial Memory.
Krzisch M., Fülling C., Jabinet L., Armida J., Gebara E., Cassé F., Habbas S., Volterra A., Hornung J.P., Toni N., 2017/08/01. Cerebral cortex, 27 (8) pp. 4048-4059. Peer-reviewed.
 
Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis.
Beckervordersandforth R., Ebert B., Schäffner I., Moss J., Fiebig C., Shin J., Moore D.L., Ghosh L., Trinchero M.F., Stockburger C. et al., 2017/02/08. Neuron, 93 (3) pp. 560-573.e6. Peer-reviewed.
 
Development and characterization of a human embryonic stem cell-derived 3D neural tissue model for neurotoxicity testing.
Sandström J., Eggermann E., Charvet I., Roux A., Toni N., Greggio C., Broyer A., Monnet-Tschudi F., Stoppini L., 2017. Toxicology in vitro, 38 pp. 124-135. Peer-reviewed.
Forced neuronal interactions cause poor communication.
Krzisch M., Toni N., 2017. Neurogenesis (Austin, Tex.), 4 (1) pp. e1286424. Peer-reviewed.
 
Enhanced plasticity of mature granule cells reduces survival of newborn neurons in the adult mouse hippocampus.
Kleine Borgmann F.B., Gräff J., Mansuy I.M., Toni N., Jessberger S., 2016/12/29. Matters select, 2 (12) p. 201610000014. Peer-reviewed.
Shedding of neurexin 3β ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons.
Borcel E., Palczynska M., Krzisch M., Dimitrov M., Ulrich G., Toni N., Fraering P.C., 2016/12/19. Scientific reports, 6 p. 39310. Peer-reviewed.
Fine processes of Nestin-GFP-positive radial glia-like stem cells in the adult dentate gyrus ensheathe local synapses and vasculature.
Moss J., Gebara E., Bushong E.A., Sánchez-Pascual I., O'Laoi R., El M'Ghari I., Kocher-Braissant J., Ellisman M.H., Toni N., 2016/05/03. Proceedings of the National Academy of Sciences of the United States of America, 113 (18) pp. E2536-45. Peer-reviewed.
Heterogeneity of Radial Glia-Like Cells in the Adult Hippocampus.
Gebara E., Bonaguidi M.A., Beckervordersandforth R., Sultan S., Udry F., Gijs P.J., Lie D.C., Ming G.L., Song H., Toni N., 2016/04. Stem cells, 34 (4) pp. 997-1010. Peer-reviewed.
 
Bidirectional GABAergic control of action potential firing in newborn hippocampal granule cells.
Heigele S., Sultan S., Toni N., Bischofberger J., 2016. Nature Neuroscience, 19 (2) pp. 263-270. Peer-reviewed.
Distinct roles of NMDA receptors at different stages of granule cell development in the adult brain.
Mu Y., Zhao C., Toni N., Yao J., Gage F.H., 2015. Elife, 4 pp. e07871. Peer-reviewed.
Genetic manipulation of adult-born hippocampal neurons rescues memory in a mouse model of Alzheimer's disease.
Richetin K., Leclerc C., Toni N., Gallopin T., Pech S., Roybon L., Rampon C., 2015. Brain, 138 (Pt 2) pp. 440-455. Peer-reviewed.
Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus.
Toni N., Schinder A.F., 2015. Cold Spring Harbor Perspectives In Biology, 8 (1) pp. a018903.
Pre-existing astrocytes form functional perisynaptic processes on neurons generated in the adult hippocampus.
Krzisch M., Temprana S.G., Mongiat L.A., Armida J., Schmutz V., Virtanen M.A., Kocher-Braissant J., Kraftsik R., Vutskits L., Conzelmann K.K. et al., 2015. Brain Structure and Function, 220 (4) pp. 2027-2042. Peer-reviewed.
Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury.
Braun S.M., Pilz G.A., Machado R.A., Moss J., Becher B., Toni N., Jessberger S., 2015. Cell Reports, 11 (11) pp. 1679-1685. Peer-reviewed.
Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes.
Sultan S., Li L., Moss J., Petrelli F., Cassé F., Gebara E., Lopatar J., Pfrieger F.W., Bezzi P., Bischofberger J. et al., 2015. Neuron, 88 (5) pp. 957-972. Peer-reviewed.
 
Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain.
Sun G.J., Zhou Y., Stadel R.P., Moss J., Yong J.H., Ito S., Kawasaki N.K., Phan A.T., Oh J.H., Modak N. et al., 2015. Proceedings of the National Academy of Sciences of the United States of America, 112 (30) pp. 9484-9489. Peer-reviewed.
Taurine increases hippocampal neurogenesis in aging mice.
Gebara E., Udry F., Sultan S., Toni N., 2015. Stem Cell Research, 14 (3) pp. 369-379. Peer-reviewed.
 
Increased efflux of amyloid-β peptides through the blood-brain barrier by muscarinic acetylcholine receptor inhibition reduces pathological phenotypes in mouse models of brain amyloidosis.
Paganetti P., Antoniello K., Devraj K., Toni N., Kieran D., Madani R., Pihlgren M., Adolfsson O., Froestl W., Schrattenholz A. et al., 2014. Journal of Alzheimer's Disease, 38 (4) pp. 767-786. Peer-reviewed.
 
A circuit-based gatekeeper for adult neural stem cell proliferation: Parvalbumin-expressing interneurons of the dentate gyrus control the activation and proliferation of quiescent adult neural stem cells.
Moss J., Toni N., 2013. Bioessays, 35 (1) pp. 28-33. Peer-reviewed.
Adult hippocampal neurogenesis inversely correlates with microglia in conditions of voluntary running and aging.
Gebara E., Sultan S., Kocher-Braissant J., Toni N., 2013. Frontiers in Neuroscience, 7 (145) p. 145.
D-serine increases adult hippocampal neurogenesis.
Sultan S., Gebara E.G., Moullec K., Toni N., 2013. Frontiers in Neuroscience, 7 p. 155.
Doxycycline increases neurogenesis and reduces microglia in the adult hippocampus.
Sultan S., Gebara E., Toni N., 2013. Frontiers in Neuroscience, 7 (131) p. 131. Peer-reviewed.
 
In vivo reprogramming of circuit connectivity in postmitotic neocortical neurons.
De la Rossa A., Bellone C., Golding B., Vitali I., Moss J., Toni N., Lüscher C., Jabaudon D., 2013. Nature Neuroscience, 16 (2) pp. 193-200. Peer-reviewed.
 
Inflammation-induced alteration of astrocyte mitochondrial dynamics requires autophagy for mitochondrial network maintenance.
Motori E., Puyal J., Toni N., Ghanem A., Angeloni C., Malaguti M., Cantelli-Forti G., Berninger B., Conzelmann K.K., Götz M. et al., 2013. Cell Metabolism, 18 (6) pp. 844-859. Peer-reviewed.
Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus.
Song J., Sun J., Moss J., Wen Z., Sun G.J., Hsu D., Zhong C., Davoudi H., Christian K.M., Toni N. et al., 2013. Nature Neuroscience, 16 (12) pp. 1728-1730. Peer-reviewed.
Propofol anesthesia impairs the maturation and survival of adult-born hippocampal neurons.
Krzisch M., Sultan S., Sandell J., Demeter K., Vutskits L., Toni N., 2013. Anesthesiology, 118 (3) pp. 602-610. Peer-reviewed.
An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.
Adolfsson O., Pihlgren M., Toni N., Varisco Y., Buccarello A.L., Antoniello K., Lohmann S., Piorkowska K., Gafner V., Atwal J.K. et al., 2012. Journal of Neuroscience, 32 (28) pp. 9677-9689. Peer-reviewed.
Synapse formation on adult-born hippocampal neurons.
Toni N., Sultan S., 2011. European Journal of Neuroscience, 33 (6) pp. 1062-1068.
 
The long-term survival of in vitro engineered nervous tissue derived from the specific neural differentiation of mouse embryonic stem cells.
Dubois-Dauphin M.L., Toni N., Julien S.D., Charvet I., Sundstrom L.E., Stoppini L., 2010. Biomaterials, 31 (27) pp. 7032-7042. Peer-reviewed.
 
Hippocampus-dependent learning is associated with adult neurogenesis in MRL/MpJ mice.
Thuret S., Toni N., Aigner S., Yeo G.W., Gage F.H., 2009. Hippocampus, 19 (7) pp. 658-669. Peer-reviewed.
 
Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus.
Jessberger S., Aigner S., Clemenson G.D., Toni N., Lie D.C., Karalay O., Overall R., Kempermann G., Gage F.H., 2008. PLoS biology, 6 (11) pp. e272. Peer-reviewed.
 
Directed differentiation of hippocampal stem/progenitor cells in the adult brain.
Jessberger S., Toni N., Clemenson G.D., Ray J., Gage F.H., 2008. Nature neuroscience, 11 (8) pp. 888-893. Peer-reviewed.
 
Neurons born in the adult dentate gyrus form functional synapses with target cells.
Toni N., Laplagne D.A., Zhao C., Lombardi G., Ribak C.E., Gage F.H., Schinder A.F., 2008. Nature neuroscience, 11 (8) pp. 901-907. Peer-reviewed.
 
Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling.
Jessberger S., Zhao C., Toni N., Clemenson G.D., Li Y., Gage F.H., 2007. The Journal of neuroscience, 27 (35) pp. 9400-9407. Peer-reviewed.
 
Synapse formation on neurons born in the adult hippocampus.
Toni N., Teng E.M., Bushong E.A., Aimone J.B., Zhao C., Consiglio A., van Praag H., Martone M.E., Ellisman M.H., Gage F.H., 2007. Nature neuroscience, 10 (6) pp. 727-734. Peer-reviewed.
 
NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus.
Tashiro A., Sandler V.M., Toni N., Zhao C., Gage F.H., 2006. Nature, 442 (7105) pp. 929-933. Peer-reviewed.
 
Development of functional human embryonic stem cell-derived neurons in mouse brain.
Muotri A.R., Nakashima K., Toni N., Sandler V.M., Gage F.H., 2005. Proceedings of the National Academy of Sciences of the United States of America, 102 (51) pp. 18644-18648. Peer-reviewed.
 
Cell fusion-independent differentiation of neural stem cells to the endothelial lineage.
Wurmser A.E., Nakashima K., Summers R.G., Toni N., D'Amour K.A., Lie D.C., Gage F.H., 2004. Nature, 430 (6997) pp. 350-356. Peer-reviewed.
 
Polysialylated neural cell adhesion molecule promotes remodeling and formation of hippocampal synapses.
Dityatev A., Dityateva G., Sytnyk V., Delling M., Toni N., Nikonenko I., Muller D., Schachner M., 2004. The Journal of neuroscience, 24 (42) pp. 9372-9382. Peer-reviewed.
 
Integrins are involved in synaptogenesis, cell spreading, and adhesion in the postnatal brain.
Nikonenko I., Toni N., Moosmayer M., Shigeri Y., Muller D., Sargent Jones L., 2003. Brain research. Developmental brain research, 140 (2) pp. 185-194. Peer-reviewed.
 
Activity-induced changes of spine morphology.
Nikonenko I., Jourdain P., Alberi S., Toni N., Muller D., 2002. Hippocampus, 12 (5) pp. 585-591. Peer-reviewed.
 
Functional neurogenesis in the adult hippocampus.
van Praag H., Schinder A.F., Christie B.R., Toni N., Palmer T.D., Gage F.H., 2002. Nature, 415 (6875) pp. 1030-1034. Peer-reviewed.
 
Interface organotypic hippocampal slice cultures
Muller D., Toni N., Buchs P.A., Parisi L., Stoppini L., 2001. pp. 13-28 dans Fedoroff S., Richardson A. (eds.) Protocols for Neural Cell Culture chap. 2, Humana Press.
 
Remodeling of synaptic membranes after induction of long-term potentiation.
Toni N., Buchs P.A., Nikonenko I., Povilaitite P., Parisi L., Muller D., 2001. The Journal of neuroscience, 21 (16) pp. 6245-6251. Peer-reviewed.
 
An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motoneuron disease.
Sagot Y., Toni N., Perrelet D., Lurot S., King B., Rixner H., Mattenberger L., Waldmeier P.C., Kato A.C., 2000. British journal of pharmacology, 131 (4) pp. 721-728. Peer-reviewed.
 
Differential neurotoxic effects of propofol on dissociated cortical cells and organotypic hippocampal cultures.
Spahr-Schopfer I., Vutskits L., Toni N., Buchs P.A., Parisi L., Muller D., 2000. Anesthesiology, 92 (5) pp. 1408-1417. Peer-reviewed.
 
Long-Term Potentiation: from molecular mechanisms to structural changes
Muller D, Toni N, Buchs PA, 2000. pp. 87-101 dans Baudry M., Davis J.L., Thompson R.F. (eds.) Advances in synaptic plasticity chap. 4, MIT Press.
 
Spine changes associated with long-term potentiation.
Muller D., Toni N., Buchs P.A., 2000. Hippocampus, 10 (5) pp. 596-604. Peer-reviewed.
 
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite.
Toni N., Buchs P.A., Nikonenko I., Bron C.R., Muller D., 1999/11. Nature, 402 (6760) pp. 421-425. Peer-reviewed.
 
Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice.
Madani R., Hulo S., Toni N., Madani H., Steimer T., Muller D., Vassalli J.D., 1999. The EMBO journal, 18 (11) pp. 3007-3012. Peer-reviewed.
 
Staurosporine but not chelerythrine inhibits regeneration in hippocampal organotypic cultures.
Toni N., Stoppini L., Muller D., 1997. Synapse, 27 (3) pp. 199-207. Peer-reviewed.
 
PSA-NCAM is required for activity-induced synaptic plasticity.
Muller D., Wang C., Skibo G., Toni N., Cremer H., Calaora V., Rougon G., Kiss J.Z., 1996. Neuron, 17 (3) pp. 413-422. Peer-reviewed.
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