Dirk Fasshauer

Publications | Mémoires et thèses

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62 publications

2020 | 2018 | 2017 | 2016 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1994 |
 
The diversification and lineage-specific expansion of nitric oxide signaling in Placozoa: insights in the evolution of gaseous transmission.
Moroz L.L., Romanova D.Y., Nikitin M.A., Sohn D., Kohn A.B., Neveu E., Varoqueaux F., Fasshauer D., 2020/08/03. Scientific reports, 10 (1) p. 13020. Peer-reviewed.
 
Prototypic SNARE Proteins Are Encoded in the Genomes of Heimdallarchaeota, Potentially Bridging the Gap between the Prokaryotes and Eukaryotes
Neveu Emilie, Khalifeh Dany, Salamin Nicolas, Fasshauer Dirk, 2020/07. Current Biology, 30 (13) pp. 2468-2480.e5.
 
PI(4,5)P<sub>2</sub>-dependent regulation of exocytosis by amisyn, the vertebrate-specific competitor of synaptobrevin 2.
Kondratiuk I., Jakhanwal S., Jin J., Sathyanarayanan U., Kroppen B., Pobbati A.V., Krisko A., Ashery U., Meinecke M., Jahn R. et al., 2020/06/16. Proceedings of the National Academy of Sciences of the United States of America, 117 (24) pp. 13468-13479. Peer-reviewed.
 
Glycine as a signaling molecule and chemoattractant in Trichoplax (Placozoa): insights into the early evolution of neurotransmitters.
Romanova D.Y., Heyland A., Sohn D., Kohn A.B., Fasshauer D., Varoqueaux F., Moroz L.L., 2020/04/08. Neuroreport, 31 (6) pp. 490-497. Peer-reviewed.
High Cell Diversity and Complex Peptidergic Signaling Underlie Placozoan Behavior.
Varoqueaux F., Williams E.A., Grandemange S., Truscello L., Kamm K., Schierwater B., Jékely G., Fasshauer D., 2018. Current Biology, 28 (21) pp. 3495-3501.e2. Peer-reviewed.
Functional assays for the assessment of the pathogenicity of variants of GOSR2, an ER-to-Golgi SNARE involved in progressive myoclonus epilepsies.
Völker J.M., Dergai M., Abriata L.A., Mingard Y., Ysselstein D., Krainc D., Dal Peraro M., Fischer von Mollard G., Fasshauer D., Koliwer J. et al., 2017/12/19. Disease models & mechanisms, 10 (12) pp. 1391-1398. Peer-reviewed.
 
Evidence for a conserved inhibitory binding mode between the membrane fusion assembly factors Munc18 and syntaxin in animals.
Morey C., Kienle C.N., Klöpper T.H., Burkhardt P., Fasshauer D., 2017/12/15. The Journal of biological chemistry, 292 (50) pp. 20449-20460. Peer-reviewed.
 
Getting Nervous: An Evolutionary Overhaul for Communication.
Varoqueaux F., Fasshauer D., 2017/11/27. Annual review of genetics, 51 pp. 455-476. Peer-reviewed.
Shedding light on the expansion and diversification of the Cdc48 protein family during the rise of the eukaryotic cell.
Kienle N., Kloepper T.H., Fasshauer D., 2016/10/18. BMC evolutionary biology, 16 (1) p. 215. Peer-reviewed.
Novel cell types, neurosecretory cells, and body plan of the early-diverging metazoan Trichoplax adhaerens.
Smith C.L., Varoqueaux F., Kittelmann M., Azzam R.N., Cooper B., Winters C.A., Eitel M., Fasshauer D., Reese T.S., 2014/07. Current Biology : Cb, 24 (14) pp. 1565-1572. Peer-reviewed.
The SM protein Sly1 accelerates assembly of the ER-Golgi SNARE complex.
Demircioglu F.E., Burkhardt P., Fasshauer D., 2014. Proceedings of the National Academy of Sciences of the United States of America, 111 (38) pp. 13828-13833. Peer-reviewed.
 
Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment.
Honigmann A., van den Bogaart G., Iraheta E., Risselada H.J., Milovanovic D., Mueller V., Müllar S., Diederichsen U., Fasshauer D., Grubmüller H. et al., 2013. Nature Structural and Molecular Biology, 20 (6) pp. 679-686. Peer-reviewed.
Syntaxin1a variants lacking an N-peptide or bearing the LE mutation bind to Munc18a in a closed conformation.
Colbert K.N., Hattendorf D.A., Weiss T.M., Burkhardt P., Fasshauer D., Weis W.I., 2013. Proceedings of the National Academy of Sciences of the United States of America, 110 (31) pp. 12637-12642. Peer-reviewed.
Molecular machines governing exocytosis of synaptic vesicles.
Jahn R., Fasshauer D., 2012. Nature, 490 (7419) pp. 201-207. Peer-reviewed.
 
Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission.
Meijer M., Burkhardt P., de Wit H., Toonen R.F., Fasshauer D., Verhage M., 2012. EMBO Journal, 31 (9) pp. 2156-2168. Peer-reviewed.
Untangling the evolution of Rab G proteins: implications of a comprehensive genomic analysis.
Klöpper T.H., Kienle N., Fasshauer D., Munro S., 2012. BMC Biology, 10 (1) p. 71.
Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis.
Burkhardt P., Stegmann C.M., Cooper B., Kloepper T.H., Imig C., Varoqueaux F., Wahl M.C., Fasshauer D., 2011. Proceedings of the National Academy of Sciences of the United States of America, 108 (37) pp. 15264-15269. Peer-reviewed.
A coiled coil trigger site is essential for rapid binding of synaptobrevin to the SNARE acceptor complex.
Wiederhold K., Kloepper T.H., Walter A.M., Stein A., Kienle N., Sørensen J.B., Fasshauer D., 2010. Journal of Biological Chemistry, 285 (28) pp. 21549-21559. Peer-reviewed.
Synaptobrevin N-terminally bound to syntaxin-SNAP-25 defines the primed vesicle state in regulated exocytosis.
Walter A.M., Wiederhold K., Bruns D., Fasshauer D., Sørensen J.B., 2010. Journal of Cell Biology, 188 (3) pp. 401-413.
A conserved membrane attachment site in alpha-SNAP facilitates N-ethylmaleimide-sensitive factor (NSF)-driven SNARE complex disassembly.
Winter U., Chen X., Fasshauer D., 2009. Journal of Biological Chemistry, 284 (46) pp. 31817-31826. Peer-reviewed.
Differences in the SNARE evolution of fungi and metazoa.
Kienle N., Kloepper T.H., Fasshauer D., 2009. Biochemical Society Transactions, 37 (Pt 4) pp. 787-791.
Is assembly of the SNARE complex enough to fuel membrane fusion?
Wiederhold K., Fasshauer D., 2009. Journal of Biological Chemistry, 284 (19) pp. 13143-13152. Peer-reviewed.
Phylogeny of the SNARE vesicle fusion machinery yields insights into the conservation of the secretory pathway in fungi.
Kienle N., Kloepper T.H., Fasshauer D., 2009. BMC Evolutionary Biology, 9 p. 19. Peer-reviewed.
Single vesicle millisecond fusion kinetics reveals number of SNARE complexes optimal for fast SNARE-mediated membrane fusion.
Domanska M.K., Kiessling V., Stein A., Fasshauer D., Tamm L.K., 2009. Journal of Biological Chemistry, 284 (46) pp. 32158-32166. Peer-reviewed.
The Ca2+ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate.
Radhakrishnan A., Stein A., Jahn R., Fasshauer D., 2009. Journal of Biological Chemistry, 284 (38) pp. 25749-25760. Peer-reviewed.
 
A novel site of action for alpha-SNAP in the SNARE conformational cycle controlling membrane fusion.
Barszczewski M., Chua J.J., Stein A., Winter U., Heintzmann R., Zilly F.E., Fasshauer D., Lang T., Jahn R., 2008. Molecular Biology of the Cell, 19 (3) pp. 776-784.
 
Imaging the assembly and disassembly kinetics of cis-SNARE complexes on native plasma membranes.
Bar-On D., Winter U., Nachliel E., Gutman M., Fasshauer D., Lang T., Ashery U., 2008. FEBS Letters, 582 (23-24) pp. 3563-3568. Peer-reviewed.
 
Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide.
Burkhardt P., Hattendorf D.A., Weis W.I., Fasshauer D., 2008. EMBO Journal, 27 (7) pp. 923-933. Peer-reviewed.
SNAREing the basis of multicellularity: consequences of protein family expansion during evolution.
Kloepper T.H., Kienle C.N., Fasshauer D., 2008. Molecular Biology and Evolution, 25 (9) pp. 2055-2068. Peer-reviewed.
 
An elaborate classification of SNARE proteins sheds light on the conservation of the eukaryotic endomembrane system.
Kloepper T.H., Kienle C.N., Fasshauer D., 2007. Molecular Biology of the Cell, 18 (9) pp. 3463-3471. Peer-reviewed.
Budding insights on cell polarity.
Fasshauer D., Jahn R., 2007. Nature Structural and Molecular Biology, 14 (5) pp. 360-362.
 
Determinants of synaptobrevin regulation in membranes.
Siddiqui T.J., Vites O., Stein A., Heintzmann R., Jahn R., Fasshauer D., 2007. Molecular Biology of the Cell, 18 (6) pp. 2037-2046. Peer-reviewed.
 
Early endosomal SNAREs form a structurally conserved SNARE complex and fuse liposomes with multiple topologies.
Zwilling D., Cypionka A., Pohl W.H., Fasshauer D., Walla P.J., Wahl M.C., Jahn R., 2007. EMBO Journal, 26 (1) pp. 9-18. Peer-reviewed.
 
Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids.
Stein A., Radhakrishnan A., Riedel D., Fasshauer D., Jahn R., 2007. Nature Structural and Molecular Biology, 14 (10) pp. 904-911. Peer-reviewed.
 
Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression.
Holt M., Varoqueaux F., Wiederhold K., Takamori S., Urlaub H., Fasshauer D., Jahn R., 2006. Journal of Biological Chemistry, 281 (25) pp. 17076-17083. Peer-reviewed.
 
N- to C-terminal SNARE complex assembly promotes rapid membrane fusion.
Pobbati A.V., Stein A., Fasshauer D., 2006. Science, 313 (5787) pp. 673-676. Peer-reviewed.
 
Sequential N- to C-terminal SNARE complex assembly drives priming and fusion of secretory vesicles.
Sørensen J.B., Wiederhold K., Müller E.M., Milosevic I., Nagy G., de Groot B.L., Grubmüller H., Fasshauer D., 2006. EMBO Journal, 25 (5) pp. 955-966. Peer-reviewed.
 
Alternative splicing of SNAP-25 regulates secretion through nonconservative substitutions in the SNARE domain.
Nagy G., Milosevic I., Fasshauer D., Müller E.M., de Groot B.L., Lang T., Wilson M.C., Sørensen J.B., 2005. Molecular Biology of the Cell, 16 (12) pp. 5675-5685. Peer-reviewed.
 
A transient N-terminal interaction of SNAP-25 and syntaxin nucleates SNARE assembly.
Fasshauer D., Margittai M., 2004. Journal of Biological Chemistry, 279 (9) pp. 7613-7621. Peer-reviewed.
 
Structural basis for the inhibitory role of tomosyn in exocytosis.
Pobbati A.V., Razeto A., Böddener M., Becker S., Fasshauer D., 2004. Journal of Biological Chemistry, 279 (45) pp. 47192-47200. Peer-reviewed.
 
Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide.
Reidt U., Wahl M.C., Fasshauer D., Horowitz D.S., Lührmann R., Ficner R., 2003. Journal of Molecular Biology, 331 (1) pp. 45-56. Peer-reviewed.
 
Single-molecule fluorescence resonance energy transfer reveals a dynamic equilibrium between closed and open conformations of syntaxin 1.
Margittai M., Widengren J., Schweinberger E., Schröder G.F., Felekyan S., Haustein E., König M., Fasshauer D., Grubmüller H., Jahn R. et al., 2003. Proceedings of the National Academy of Sciences of the United States of America, 100 (26) pp. 15516-15521. Peer-reviewed.
 
Structural insights into the SNARE mechanism.
Fasshauer D., 2003. Biochimica et Biophysica Acta-Molecular Cell Research, 1641 (2-3) pp. 87-97. Peer-reviewed.
 
The Habc domain and the SNARE core complex are connected by a highly flexible linker.
Margittai M., Fasshauer D., Jahn R., Langen R., 2003. Biochemistry, 42 (14) pp. 4009-4014. Peer-reviewed.
 
The R-SNARE motif of tomosyn forms SNARE core complexes with syntaxin 1 and SNAP-25 and down-regulates exocytosis.
Hatsuzawa K., Lang T., Fasshauer D., Bruns D., Jahn R., 2003. Journal of Biological Chemistry, 278 (33) pp. 31159-31166. Peer-reviewed.
 
Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs.
Antonin W., Fasshauer D., Becker S., Jahn R., Schneider T.R., 2002. Nature Structural Biology, 9 (2) pp. 107-111. Peer-reviewed.
 
Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis.
Pabst S., Margittai M., Vainius D., Langen R., Jahn R., Fasshauer D., 2002. Journal of Biological Chemistry, 277 (10) pp. 7838-7848. Peer-reviewed.
 
SNARE assembly and disassembly exhibit a pronounced hysteresis.
Fasshauer D., Antonin W., Subramaniam V., Jahn R., 2002. Nature Structural Biology, 9 (2) pp. 144-151. Peer-reviewed.
 
Homo- and heterooligomeric SNARE complexes studied by site-directed spin labeling.
Margittai M., Fasshauer D., Pabst S., Jahn R., Langen R., 2001. Journal of Biological Chemistry, 276 (16) pp. 13169-13177. Peer-reviewed.
 
Mechanisms of membrane fusion
Fasshauer D., Schütte C., Jahn R., 2001., 82nd International Titisee Conference held from October 25 to 29, 2000 pp. 13-23 dans Jahn R. (eds.) International Titisee Conferences, B.I.F.Futura.
 
A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function.
Antonin W., Holroyd C., Fasshauer D., Pabst S., Von Mollard G.F., Jahn R., 2000. EMBO Journal, 19 (23) pp. 6453-6464. Peer-reviewed.
 
Mechanismen intrazellulärer Membranfusion
Fasshauer D., Jahn R., 2000. BIOspektrum, 6 (1) pp. 27-31.
 
Selective interaction of complexin with the neuronal SNARE complex. Determination of the binding regions.
Pabst S., Hazzard J.W., Antonin W., Südhof T.C., Jahn R., Rizo J., Fasshauer D., 2000. Journal of Biological Chemistry, 275 (26) pp. 19808-19818. Peer-reviewed.
 
Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes.
Davis A.F., Bai J., Fasshauer D., Wolowick M.J., Lewis J.L., Chapman E.R., 1999. Neuron, 24 (2) pp. 363-376. Peer-reviewed.
 
Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties.
Fasshauer D., Antonin W., Margittai M., Pabst S., Jahn R., 1999. Journal of Biological Chemistry, 274 (22) pp. 15440-15446. Peer-reviewed.
 
Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs.
Fasshauer D., Sutton R.B., Brunger A.T., Jahn R., 1998. Proceedings of the National Academy of Sciences of the United States of America, 95 (26) pp. 15781-15786. Peer-reviewed.
 
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution.
Sutton R.B., Fasshauer D., Jahn R., Brunger A.T., 1998. Nature, 395 (6700) pp. 347-353. Peer-reviewed.
 
Identification of a minimal core of the synaptic SNARE complex sufficient for reversible assembly and disassembly.
Fasshauer D., Eliason W.K., Brünger A.T., Jahn R., 1998. Biochemistry, 37 (29) pp. 10354-10362. Peer-reviewed.
 
A structural change occurs upon binding of syntaxin to SNAP-25.
Fasshauer D., Bruns D., Shen B., Jahn R., Brünger A.T., 1997. Journal of Biological Chemistry, 272 (7) pp. 4582-4590. Peer-reviewed.
 
Structural changes are associated with soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor complex formation.
Fasshauer D., Otto H., Eliason W.K., Jahn R., Brünger A.T., 1997. Journal of Biological Chemistry, 272 (44) pp. 28036-28041. Peer-reviewed.
 
ADP ribosylation factor and a 14-kD polypeptide are associated with heparan sulfate-carrying post-trans-Golgi network secretory vesicles in rat hepatocytes.
Nickel W., Huber L.A., Kahn R.A., Kipper N., Barthel A., Fasshauer D., Söling H.D., 1994. Journal of Cell Biology, 125 (4) pp. 721-732. Peer-reviewed.
 
ARF and VAPP14: two proteins involved in the delivery of heparan sulfate proteoglycan from the trans-Golgi network to the plasma membrane.
Nickel W., Kipper N., Barthel A., Kahn R.A., Fasshauer D., Söling H.D., 1994. Annals of the New York Academy of Sciences, 733 pp. 344-356.
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