Pascal Steullet

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65 publications

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Sex-specific interactions between stress axis and redox balance are associated with internalizing symptoms and brain white matter microstructure in adolescents.
Schilliger Z., Alemán-Gómez Y., Magnus Smith M., Celen Z., Meuleman B., Binz P.A., Steullet P., Do K.Q., Conus P., Merglen A. et al., 2024/01/17. Translational psychiatry, 14 (1) p. 30. Peer-reviewed.
 
Developmental changes in cerebral NAD and neuroenergetics of an antioxidant compromised mouse model of schizophrenia.
Skupienski R., Steullet P., Do K.Q., Xin L., 2023/08/05. Translational psychiatry, 13 (1) p. 275. Peer-reviewed.
 
Multimodal Magnetic Resonance Imaging Depicts Widespread and Subregion Specific Anomalies in the Thalamus of Early-Psychosis and Chronic Schizophrenia Patients.
Alemán-Gómez Y., Baumgartner T., Klauser P., Cleusix M., Jenni R., Hagmann P., Conus P., Do K.Q., Bach Cuadra M., Baumann P.S. et al., 2023/01/03. Schizophrenia bulletin, 49 (1) pp. 196-207. Peer-reviewed.
Alterations in TRN-anterodorsal thalamocortical circuits affect sleep architecture and homeostatic processes in oxidative stress vulnerable Gclm<sup>-/-</sup> mice.
Czekus C., Steullet P., Orero López A., Bozic I., Rusterholz T., Bandarabadi M., Do K.Q., Gutierrez Herrera C., 2022/11. Molecular psychiatry, 27 (11) pp. 4394-4406. Peer-reviewed.
Time of exposure to social defeat stress during childhood and adolescence and redox dysregulation on long-lasting behavioral changes, a translational study.
Schnider M., Jenni R., Ramain J., Camporesi S., Golay P., Alameda L., Conus P., Do K.Q., Steullet P., 2022/09/26. Translational psychiatry, 12 (1) p. 413. Peer-reviewed.
Caught in vicious circles: a perspective on dynamic feed-forward loops driving oxidative stress in schizophrenia; Response to "Adaptive changes to oxidative stress in schizophrenia by Lena Palaniyappan".
Cuenod M., Steullet P., Cabungcal J.H., Dwir D., Khadimallah I., Klauser P., Conus P., Do K.Q., 2022/09. Molecular psychiatry, 27 (9) pp. 3567-3568. Peer-reviewed.
 
Pleotropic Effects of 15q13.3 Microdeletion on Interneuron Development: Insight on Spatiotemporal Molecular Events Leading to Neurodevelopmental Disorders.
Steullet P., 2022/04/15. Biological psychiatry, 91 (8) pp. 694-696. Peer-reviewed.
Caught in vicious circles: a perspective on dynamic feed-forward loops driving oxidative stress in schizophrenia.
Cuenod M., Steullet P., Cabungcal J.H., Dwir D., Khadimallah I., Klauser P., Conus P., Do K.Q., 2022/04. Molecular psychiatry, 27 (4) pp. 1886-1897. Peer-reviewed.
Developmental oxidative stress leads to T-type Ca<sup>2+</sup> channel hypofunction in thalamic reticular nucleus of mouse models pertinent to schizophrenia.
El Khoueiry C., Cabungcal J.H., Rovó Z., Fournier M., Do K.Q., Steullet P., 2022/04. Molecular psychiatry, 27 (4) pp. 2042-2051. Peer-reviewed.
Mitochondrial, exosomal miR137-COX6A2 and gamma synchrony as biomarkers of parvalbumin interneurons, psychopathology, and neurocognition in schizophrenia.
Khadimallah I., Jenni R., Cabungcal J.H., Cleusix M., Fournier M., Beard E., Klauser P., Knebel J.F., Murray M.M., Retsa C. et al., 2022/02. Molecular psychiatry, 27 (2) pp. 1192-1204. Peer-reviewed.
Timely N-Acetyl-Cysteine and Environmental Enrichment Rescue Oxidative Stress-Induced Parvalbumin Interneuron Impairments via MMP9/RAGE Pathway: A Translational Approach for Early Intervention in Psychosis.
Dwir D., Cabungcal J.H., Xin L., Giangreco B., Parietti E., Cleusix M., Jenni R., Klauser P., Conus P., Cuénod M. et al., 2021/10/21. Schizophrenia bulletin, 47 (6) pp. 1782-1794. Peer-reviewed.
 
Redox Dysregulation, Myelination Deficit and Dysconnectivity in Schizophrenia: A Translational Study in First Episode Patients and Experimental Models
Do Kim Q., Cabungcal Jan-Harry, Cleusix Martine, Dwir Daniella, Fournier Margot, Griffa Alessandra, Gruetter Rolf, Hagmann Patric, Jenni Raoul, Klauser Paul et al., 2021/05. pp. S56 dans Biological Psychiatry.
 
Ch. 32. Neurobiologie et schizophrénie
Baumann Philipp Sebastian, Steullet Pascal, 2021/01/01. dans Conus Philipp, Söderström Dag (eds.) Approche psychothérapeutique des psychoses, RMS Editions.
White Matter Alterations Between Brain Network Hubs Underlie Processing Speed Impairment in Patients With Schizophrenia
Klauser Paul, Cropley Vanessa L, Baumann Philipp S, Lv Jinglei, Steullet Pascal, Dwir Daniella, Alemán-Gómez Yasser, Bach Cuadra Meritxell, Cuenod Michel, Do Kim Q et al., 2021/01/01. Schizophrenia Bulletin Open, 2 (1). Peer-reviewed.
Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer's disease
Richetin Kevin, Steullet Pascal, Pachoud Mathieu, Perbet Romain, Parietti Enea, Maheswaran Mathischan, Eddarkaoui Sabiha, Bégard Séverine, Pythoud Catherine, Rey Maria et al., 2020/12. Nature Neuroscience, 23 (12) pp. 1567-1579. Peer-reviewed.
Thalamus-related anomalies as candidate mechanism-based biomarkers for psychosis.
Steullet P., 2020/12. Schizophrenia research, 226 pp. 147-157. Peer-reviewed.
MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients.
Dwir D., Giangreco B., Xin L., Tenenbaum L., Cabungcal J.H., Steullet P., Goupil A., Cleusix M., Jenni R., Chtarto A. et al., 2020/11. Molecular psychiatry, 25 (11) pp. 2889-2904. Peer-reviewed.
Partial‐volume modeling reveals reduced gray matter in specific thalamic nuclei early in the time course of psychosis and chronic schizophrenia
Alemán-Gómez Yasser, Najdenovska Elena, Roine Timo, Fartaria Mário João, Canales-Rodríguez Erick J., Rovó Zita, Hagmann Patric, Conus Philippe, Do Kim Q., Klauser Paul et al., 2020/10. Human Brain Mapping, 41 (14) pp. 4041-4061. Peer-reviewed.
 
A developmental redox dysregulation leads to spatio-temporal deficit of parvalbumin neuron circuitry in a schizophrenia mouse model.
Cabungcal J.H., Steullet P., Kraftsik R., Cuenod M., Do K.Q., 2019/11. Schizophrenia research, 213 pp. 96-106. Peer-reviewed.
S.11.03 Similar anomalies in the thalamic reticular nucleus of a mice model of redox dysregulation and of schizophrenia patients
Steullet P., Cabungcal J.H., Bukhari S., Pantazopoulos H., Cuénod M., Berretta S., Do K.Q., 2019. European Neuropsychopharmacology, 29 pp. S16.
The thalamic reticular nucleus in schizophrenia and bipolar disorder: role of parvalbumin-expressing neuron networks and oxidative stress.
Steullet P., Cabungcal J.H., Bukhari S.A., Ardelt M.I., Pantazopoulos H., Hamati F., Salt T.E., Cuenod M., Do K.Q., Berretta S., 2018/10. Molecular psychiatry, 23 (10) pp. 2057-2065. Peer-reviewed.
A lack of GluN2A-containing NMDA receptors confers a vulnerability to redox dysregulation: Consequences on parvalbumin interneurons, and their perineuronal nets.
Cardis R., Cabungcal J.H., Dwir D., Do K.Q., Steullet P., 2018/01. Neurobiology of disease, 109 (Pt A) pp. 64-75. Peer-reviewed.
Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia.
Steullet P., Cabungcal J.H., Coyle J., Didriksen M., Gill K., Grace A.A., Hensch T.K., LaMantia A.S., Lindemann L., Maynard T.M. et al., 2017/07. Molecular psychiatry, 22 (7) pp. 936-943. Peer-reviewed.
Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A "central hub" in schizophrenia pathophysiology?
Steullet P., Cabungcal J.H., Monin A., Dwir D., O'Donnell P., Cuenod M., Do K.Q., 2016/09. Schizophrenia research, 176 (1) pp. 41-51. Peer-reviewed.
Glutamate Cysteine Ligase-Modulatory Subunit Knockout Mouse Shows Normal Insulin Sensitivity but Reduced Liver Glycogen Storage.
Lavoie S., Steullet P., Kulak A., Preitner F., Do K.Q., Magistretti P.J., 2016. Frontiers in Physiology, 7 p. 142. Peer-reviewed.
Glutathione Deficit Affects the Integrity and Function of the Fimbria/Fornix and Anterior Commissure in Mice: Relevance for Schizophrenia.
Corcoba A., Steullet P., Duarte J.M., Van de Looij Y., Monin A., Cuenod M., Gruetter R., Do K.Q., 2015/10/03. The international journal of neuropsychopharmacology, 19 (3) pp. pyv110. Peer-reviewed.
Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients.
Monin A., Baumann P.S., Griffa A., Xin L., Mekle R., Fournier M., Butticaz C., Klaey M., Cabungcal J.H., Steullet P. et al., 2015/07. Molecular psychiatry, 20 (7) pp. 827-838. Peer-reviewed.
 
Defect of the Perineuronal Nets Enwrapping Parvalbumin Interneurons in a Mouse Model of Schizophrenia can be Prevented by N-acetylcysteine
Cabungcal Jan-Harry, Steullet Pascal, Cottier Adeline, Cuenod Michel, Q. Do. Kim , 2014. pp. 176-177 dans Biological Psychiatry. Peer-reviewed.
 
Evaluation of Redox Dysregulation in the Pathology of Schizophrenia Using Induced Pluripotent Stem Cell Technology
Giangreco Basilio, Steullet Pascal, Cabungcal Jan-Harry, Bartesaghi Luca, Toni Nicolas, Chrast Roman, Q. Do. Kim , 2014. p. 186 dans Biological Psychiatry. Peer-reviewed.
Fast oscillatory activity in the anterior cingulate cortex: dopaminergic modulation and effect of perineuronal net loss.
Steullet P., Cabungcal J.H., Cuénod M., Do K.Q., 2014. Frontiers in Cellular Neuroscience, 8 p. 244. Peer-reviewed.
 
Impaired White Matter Integrity in Fornix and Anterior Commissure in a Schizophrenia Mouse Model of Redox Dysregulation
Corcoba Alberto, Steullet Pascal, Duarte João M.N., Van de Looij Yohan, Gruetter Rolf, Q. Do. Kim , 2014. p. 175 dans Biological Psychiatry. Peer-reviewed.
 
Involvement of the Receptor for Advanced Glycation End-product (RAGE) in Redox Dysregulation and Neuroinflammation in an Animal Model of Schizophrenia
Dwir Daniella, Cabungcal Jan-Harry, Steullet Pascal, Fournier Margot, Tirouvanziam Rabindra, Q. Do. Kim , 2014. pp. 185-186 dans Biological Psychiatry. Peer-reviewed.
 
Early-Life Insults Impair Parvalbumin Interneurons via Oxidative Stress: Reversal by N-Acetylcysteine.
Cabungcal J.H., Steullet P., Kraftsik R., Cuenod M., Do K.Q., 2013. Biological Psychiatry, 73 (6) pp. 574-582. Peer-reviewed.
 
Perineuronal nets protect fast-spiking interneurons against oxidative stress.
Cabungcal J.H., Steullet P., Morishita H., Kraftsik R., Cuenod M., Hensch T.K., Do K.Q., 2013. Proceedings of the National Academy of Sciences of the United States of America, 110 (22) pp. 9130-9135. Peer-reviewed.
 
Redox dysregulation in the pathophysiology of schizophrenia and bipolar disorder: insights from animal models.
Kulak A., Steullet P., Cabungcal J.H., Werge T., Ingason A., Cuenod M., Do K.Q., 2013. Antioxidants and Redox Signaling, 18 (12) pp. 1428-1443. Peer-reviewed.
 
Genetic dysregulation of glutathione synthesis predicts alteration of plasma thiol redox status in schizophrenia.
Gysin R., Kraftsik R., Boulat O., Bovet P., Conus P., Comte-Krieger E., Polari A., Steullet P., Preisig M., Teichmann T. et al., 2011. Antioxidants and Redox Signaling, 15 (7) pp. 2003-2010. Peer-reviewed.
Redox dysregulation affects the ventral but not dorsal hippocampus: impairment of parvalbumin neurons, gamma oscillations, and related behaviors.
Steullet P., Cabungcal J.H., Kulak A., Kraftsik R., Chen Y., Dalton T.P., Cuenod M., Do K.Q., 2010. Journal of Neuroscience, 30 (7) pp. 2547-2558. Peer-reviewed.
 
Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit.
Lavoie S., Chen Y., Dalton T.P., Gysin R., Cuénod M., Steullet P., Do K.Q., 2009. Journal of Neurochemistry, 108 (6) pp. 1410-1422. Peer-reviewed.
 
Redox dysregulation, neurodevelopment, and schizophrenia.
Do K.Q., Cabungcal J.H., Frank A., Steullet P., Cuenod M., 2009. Current opinion in neurobiology, 19 (2) pp. 220-30. Peer-reviewed.
 
A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons
Steullet Pascal, Lavoie Suzie, Kraftsik Rudolf, Guidi Raffaella, Gysin René, Cuénod Michel, Do Kim Q., 2008. Free Radical Biology & Medicine, 44 (6) pp. 1042-1054. Peer-reviewed.
 
An electric sense in crayfish?
Steullet P., Edwards D.H., Derby C.D., 2007/08. The Biological bulletin, 213 (1) pp. 16-20. Peer-reviewed.
 
Impaired glutathione synthesis in schizophrenia: convergent genetic and functional evidence
Gysin R., Kraftsik R., Sandell J., Bovet P., Chappuis C., Conus P., Deppen P., Preisig M., Ruiz V., Steullet P. et al., 2007. Proceedings of the National Academy of Sciences of the United States of America, 104 (42) pp. 16621-16626. Peer-reviewed.
 
TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity.
Kovács K.A., Steullet P., Steinmann M., Do K.Q., Magistretti P.J., Halfon O., Cardinaux J.R., 2007. Proceedings of the National Academy of Sciences of the United States of America, 104 (11) pp. 4700-5. Peer-reviewed.
 
Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: Relevance to schizophrenia
Steullet Pascal, Neijt H.C., Cuénod Michel, Do Kim Quang, 2006. Neuroscience, 137 (3) pp. 807-819. Peer-reviewed.
 
Role of glutathione deficit in the disconnectivity syndrome in schizophrenia: from pathogenetic mechanisms to therapeutic interventions
Do K.Q., Bovet P., Cabungcal J.H., Castagné V., Gheorghita F., Hornung J.P., Schenk F., Steullet P., Tosic M., Cuénod M., 2004. p. 13 dans 6. Drei-Länder-Symposium für Biologische Psychiatrie, European Archives of Psychiatry and Clinical Neuroscience. Peer-reviewed.
 
Amputation-induced activity of progenitor cells leads to rapid regeneration of olfactory tissue in lobsters.
Harrison P.J., Cate H.S., Steullet P., Derby C.D., 2003/04. Journal of neurobiology, 55 (1) pp. 97-114. Peer-reviewed.
 
Comparison of turnover in the olfactory organ of early juvenile stage and adult Caribbean spiny lobsters.
Derby C.D., Cate H.S., Steullet P., Harrison P.J., 2003/04. Arthropod structure & development, 31 (4) pp. 297-311. Peer-reviewed.
 
Dual antennular chemosensory pathways mediate odor-associative learning and odor discrimination in the Caribbean spiny lobster Panulirus argus.
Steullet P., Krützfeldt D.R., Hamidani G., Flavus T., Ngo V., Derby C.D., 2002/03. The Journal of experimental biology, 205 (Pt 6) pp. 851-867. Peer-reviewed.
 
A compound nose: functional organization and development of aesthetasc sensilla
Derby C.D., Steullet P., Cate H.S., Harrison P.J.H., 2002. pp. 346-358 dans Wiese Konrad (eds.) The crustacean nervous system, Springer.
 
Selective ablation of antennular sensilla on the Caribbean spiny lobster Panulirus argus suggests that dual antennular chemosensory pathways mediate odorant activation of searching and localization of food.
Steullet P., Dudar O., Flavus T., Zhou M., Derby C.D., 2001/12. The Journal of experimental biology, 204 (Pt 24) pp. 4259-4269. Peer-reviewed.
 
Structural plasticity in the olfactory system of adult spiny lobsters: Postembryonic development permits life-long growth, turnover, and regeneration
Harrison P.J.H., Cate H.S., Steullet P., Derby C.D., 2001., 6th International Conference and Workshop on Lobster Biology and Management pp. 1357-1365 dans Marine and Freshwater Research. Peer-reviewed.
 
The sensory basis of feeding behaviour in the Caribbean spiny lobster, Panulirus argus
Derby Charles D. , Steullet Pascal , Horner Amy J. , Cate Holly S., 2001., 6th International Conference and Workshop on Lobster Biology and Management pp. 1339-1350 dans Marine and Freshwater Research. Peer-reviewed.
 
Why do animals have so many receptors? The role of multiple chemosensors in animal perception.
Derby C.D., Steullet P., 2001., Workshop on Invertebrate Sensory Information Processing: Implications for Biologically Inspired Autonomous Systems pp. 211-215 dans Biological Bulletin. Peer-reviewed.
 
A spatiotemporal wave of turnover and functional maturation of olfactory receptor neurons in the spiny lobster Panulirus argus.
Steullet P., Cate H.S., Derby C.D., 2000/05/01. The Journal of neuroscience : the official journal of the Society for Neuroscience, 20 (9) pp. 3282-3294. Peer-reviewed.
 
Functional units of a compound nose: aesthetasc sensilla house similar populations of olfactory receptor neurons on the crustacean antennule.
Steullet P., Cate H.S., Michel W.C., Derby C.D., 2000/03/13. The Journal of comparative neurology, 418 (3) pp. 270-280. Peer-reviewed.
 
Chemosensory and Behavioural Adaptations of Ectoparasitic Arthropods
Guerin P.M., Kröber T., McMahon C.P., Guerenstein P., Grenacher S., Vlimant M., Diehl P.A., Steullet P., Syed Z., 2000. Nova acta Leopoldina: Abhandlungen der Kaiserlich Leopoldinisch-Carolinisch Deutschen Akademie der Naturforscher, 83 (316) pp. 213-229. Peer-reviewed.
 
High-resolution functional labeling of vertebrate and invertebrate olfactory receptor neurons using agmatine, a channel-permeant cation.
Michel W.C., Steullet P., Cate H.S., Burns C.J., Zhainazarov A.B., Derby C.D., 1999/08/15. Journal of neuroscience methods, 90 (2) pp. 143-156. Peer-reviewed.
 
Coding of blend ratios of binary mixtures by olfactory neurons in the Florida spiny lobster, Panulirus argus.
Steullet P., Derby C.D., 1997/02. Journal of comparative physiology. A, Sensory, neural, and behavioral physiology, 180 (2) pp. 123-135. Peer-reviewed.
 
Identification of vertebrate volatiles stimulating olfactory receptors on tarsus I of the tick Amblyomma vadegatum Fabricius (Ixodidae) II. Receptors outside the Haller's organ capsule
Steullet P., Guerin P.M., 1994. Journal of Comparative Physiology A-Sensory Neural and Behavioral Physiology, 174 (1) pp. 39-47. Peer-reviewed.
 
Identification of vertebrate volatiles stimulating olfactory receptors on tarsus I of the tick Amblyomma variegatum Fabricius (Ixodidae). I. Receptors within the Haller's organ capsule.
Steullet P., Guerin P.M., 1994/01. Journal of comparative physiology. A, Sensory, neural, and behavioral physiology, 174 (1) pp. 27-38. Peer-reviewed.
 
Perception of breath components by the tropical bont tick, Amblyomma variegatum Fabricius (Ixodidae). I. CO2-excited and CO2-inhibited receptors.
Steullet P., Guerin P.M., 1992/07. Journal of comparative physiology. A, Sensory, neural, and behavioral physiology, 170 (6) pp. 665-676. Peer-reviewed.
 
Perception of breath components by the tropical bont tick, Amblyomma variegatum Fabricius (Ixodidae). II. Sulfide-receptors.
Steullet P., Guerin P.M., 1992/07. Journal of comparative physiology. A, Sensory, neural, and behavioral physiology, 170 (6) pp. 677-685. Peer-reviewed.
 
The chemical ecology of ticks at the host-vector interface
Guerin P.M., Steullet P., Kröber T., Grenacher S., Diehl P.A., Vlimant M., de Bruyne M., Cordas T., Falk-Vairant J., Kuhnert F. et al., 1992. pp. 314–323 dans Munderloh Ulrike G. , Kurtti Timothy J. (eds.) First international conference on tick-borne pathogens at the host-vector interface : an agenda for research : proceedings and abstracts .
 
Biosynthesis, production site, and emission rates of aggregation-attachment pheromone in males of twoAmblyomma ticks.
Diehl P.A., Guerin P., Vlimant M., Steullet P., 1991/05. Journal of chemical ecology, 17 (5) pp. 833-847. Peer-reviewed.
 
Orientation of tsetse-flies to wind, within and outside host odor plumes in the field
Gibson G., Packer M.J., Steullet P., Brady J., 1991. Physiological Entomology, 16 (1) pp. 47-56. Peer-reviewed.
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