Lluis Fajas Coll

Publications | Mémoires et thèses

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113 publications

En préparation
 
CDK4 deletion in mice prevents fat accumulation and increases endurance capacity through activation of estrogen-related receptor (ERR)-driven oxidative metabolism in skeletal muscle
Barquissau Valentin, Zanou Nadège, Geller Sarah, Castillo-Armengol Judit, Marzetta Flavia, Huber Katharina, Ziegler Dorian, Lopez-Mejia Isabel, Fernandez Joan Blanco, Roger Catherine et al..
[DOI][serval:BIB_2CA3F1A4A423]
Sous presse
 
E2F transcription factor-1 modulates expression of glutamine metabolic genes in mouse embryonic fibroblasts and uterine sarcoma cells.
Huber K., Giralt A., Dreos R., Michenthaler H., Geller S., Barquissau V., Ziegler D.V., Tavernari D., Gallart-Ayala H., Krajina K. et al. Biochimica et biophysica acta. Molecular cell research. Peer-reviewed.
[DOI][Pmid][serval:BIB_5EAE29F4CAA9]
2024
Beyond cell cycle regulation: The pleiotropic function of CDK4 in cancer.
Ziegler D.V., Parashar K., Fajas L., 2024/01. Seminars in cancer biology, 98 pp. 51-63. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_6A45AB8377C2]
2023
 
β-Cell-Specific E2f1 Deficiency Impairs Glucose Homeostasis, β-Cell Identity, and Insulin Secretion.
Oger F., Bourouh C., Friano M.E., Courty E., Rolland L., Gromada X., Moreno M., Carney C., Rabhi N., Durand E. et al., 2023/08/01. Diabetes, 72 (8) pp. 1112-1126. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_2F2100785D5D]
 
Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs.
Yildiz E., El Alam G., Perino A., Jalil A., Denechaud P.D., Huber K., Fajas L., Auwerx J., Sorrentino G., Schoonjans K., 2023/03/06. eLife, 12 pp. e81926. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8530865240EA]
Oxidative stress-induced FAK activation contributes to uterine serous carcinoma aggressiveness.
Lopez-Mejia I.C., Pijuan J., Navaridas R., Santacana M., Gatius S., Velasco A., Castellà G., Panosa A., Cabiscol E., Pinyol M. et al., 2023/01. Molecular oncology, 17 (1) pp. 98-118. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_549BE66DECEF]
2022
Adipocyte-specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction.
Chen Y., Fernandez E.A., Roger C., Lopez-Mejia I.C., Fajas Coll L., Ji H., 2022/06. FEBS letters, 596 (11) pp. 1434-1444. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_C1D722D17E1D]
Glucose Starvation or Pyruvate Dehydrogenase Activation Induce a Broad, ERK5-Mediated, Metabolic Remodeling Leading to Fatty Acid Oxidation.
Khan AUH, Salehi H., Alexia C., Valdivielso J.M., Bozic M., Lopez-Mejia I.C., Fajas L., Gerbal-Chaloin S., Daujat-Chavanieu M., Gitenay D. et al., 2022/04/20. Cells, 11 (9) p. 1392. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_0CB7B6A1E909]
Sex-Biased Control of Inflammation and Metabolism by a Mitochondrial Nod-Like Receptor.
Snäkä T., Bekkar A., Desponds C., Prével F., Claudinot S., Isorce N., Teixeira F., Grasset C., Xenarios I., Lopez-Mejia I.C. et al., 2022. Frontiers in immunology, 13 p. 882867. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_6C22CA5A408C]
2021
 
The Intricate Interplay between Cell Cycle Regulators and Autophagy in Cancer.
Ziegler D.V., Huber K., Fajas L., 2021/12/29. Cancers, 14 (1) p. 153. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F80CD35B4D7C]
 
The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes.
Lacroix M., Linares L.K., Rueda-Rincon N., Bloch K., Di Michele M., De Blasio C., Fau C., Gayte L., Blanchet E., Mairal A. et al., 2021/12/02. Nature communications, 12 (1) p. 7037. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_9A257A1F04A8]
Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity.
Dumauthioz N., Tschumi B., Wenes M., Marti B., Wang H., Franco F., Li W., Lopez-Mejia I.C., Fajas L., Ho P.C. et al., 2021/07. Cellular & molecular immunology, 18 (7) pp. 1761-1771. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_D554C59D6F3C]
The multifaceted role of cell cycle regulators in the coordination of growth and metabolism.
Huber K., Mestres-Arenas A., Fajas L., Leal-Esteban L.C., 2021/06. The FEBS journal, 288 (12) pp. 3813-3833. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_71F450E7C4FC]
2020
 
PamgeneAnalyzeR: open and reproducible pipeline for kinase profiling.
Bekkar A., Nasrallah A., Guex N., Fajas L., Xenarios I., Lopez-Mejia I.C., 2020/12/22. Bioinformatics, 36 (20) pp. 5117-5119. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F6B4F7EFAFFB]
 
Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas.
Esteban-Burgos L., Wang H., Nieto P., Zheng J., Blanco-Aparicio C., Varela C., Gómez-López G., Fernández-García F., Sanclemente M., Guerra C. et al., 2020/09/29. Proceedings of the National Academy of Sciences of the United States of America, 117 (39) pp. 24415-24426. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_05519E55AA11]
 
Hypothalamic CDK4 regulates thermogenesis by modulating sympathetic innervation of adipose tissues.
Castillo-Armengol J., Barquissau V., Geller S., Ji H., Severi I., Venema W., Fenandez E.A., Moret C., Huber K., Leal-Esteban L.C. et al., 2020/09/03. EMBO reports, 21 (9) pp. e49807. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_BA842E7BA291]
 
CDK7 Mediates the Beta-Adrenergic Signaling in Thermogenic Brown and White Adipose Tissues.
Ji H., Chen Y., Castillo-Armengol J., Dreos R., Moret C., Niederhäuser G., Delacuisine B., Lopez-Mejia I.C., Denechaud P.D., Fajas L., 2020/06/26. iScience, 23 (6) p. 101163. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_EBF3BB5349A2]
 
Cell cycle regulators in cancer cell metabolism.
Leal-Esteban L.C., Fajas L., 2020/05/01. Biochimica et biophysica acta. Molecular basis of disease, 1866 (5) p. 165715. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_DADB4F066621]
2019
 
CDK4 Regulates Lysosomal Function and mTORC1 Activation to Promote Cancer Cell Survival.
Martínez-Carreres L., Puyal J., Leal-Esteban L.C., Orpinell M., Castillo-Armengol J., Giralt A., Dergai O., Moret C., Barquissau V., Nasrallah A. et al., 2019/10/15. Cancer research, 79 (20) pp. 5245-5259. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_A55F9416C381]
 
Inter-organ communication: a gatekeeper for metabolic health.
Castillo-Armengol J., Fajas L., Lopez-Mejia I.C., 2019/09. EMBO reports, 20 (9) pp. e47903. Peer-reviewed.
[DOI][Pmid][serval:BIB_3D85056E88C8]
Human adipose tissue H3K4me3 histone mark in adipogenic, lipid metabolism and inflammatory genes is positively associated with BMI and HOMA-IR.
Castellano-Castillo D., Denechaud P.D., Fajas L., Moreno-Indias I., Oliva-Olivera W., Tinahones F., Queipo-Ortuño M.I., Cardona F., 2019. PloS one, 14 (4) pp. e0215083. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_C928AE0660CB]
2018
 
β-Klotho deficiency shifts the gut-liver bile acid axis and induces hepatic alterations in mice.
Somm E., Henry H., Bruce S.J., Bonnet N., Montandon S.A., Niederländer N.J., Messina A., Aeby S., Rosikiewicz M., Fajas L. et al., 2018/11/01. American journal of physiology. Endocrinology and metabolism, 315 (5) pp. E833-E847. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_4784D51A916B]
 
Dietary Fiber Confers Protection against Flu by Shaping Ly6c<sup>-</sup> Patrolling Monocyte Hematopoiesis and CD8<sup>+</sup> T Cell Metabolism.
Trompette A., Gollwitzer E.S., Pattaroni C., Lopez-Mejia I.C., Riva E., Pernot J., Ubags N., Fajas L., Nicod L.P., Marsland B.J., 2018/05/15. Immunity, 48 (5) pp. 992-1005.e8. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_0721FE87A408]
E2F1 promotes hepatic gluconeogenesis and contributes to hyperglycemia during diabetes.
Giralt A., Denechaud P.D., Lopez-Mejia I.C., Delacuisine B., Blanchet E., Bonner C., Pattou F., Annicotte J.S., Fajas L., 2018/05. Molecular metabolism, 11 pp. 104-112. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_ED95377F8A23]
 
Role of cell cycle regulators in adipose tissue and whole body energy homeostasis.
Lopez-Mejia I.C., Castillo-Armengol J., Lagarrigue S., Fajas L., 2018/03. Cellular and molecular life sciences, 75 (6) pp. 975-987. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D70173D2EEC9]
Cdkn2a deficiency promotes adipose tissue browning.
Rabhi N., Hannou S.A., Gromada X., Salas E., Yao X., Oger F., Carney C., Lopez-Mejia I.C., Durand E., Rabearivelo I. et al., 2018/02. Molecular metabolism, 8 pp. 65-76. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_2CA9563F93C5]
CDK4, a new metabolic sensor that antagonizes AMPK.
Fajas L., Lopez-Mejia I.C., 2018. Molecular & cellular oncology, 5 (5) pp. e1409862. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_31B3469F93CE]
Chromatin immunoprecipitation improvements for the processing of small frozen pieces of adipose tissue.
Castellano-Castillo D., Denechaud P.D., Moreno-Indias I., Tinahones F., Fajas L., Queipo-Ortuño M.I., Cardona F., 2018. PloS one, 13 (2) pp. e0192314. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_5E840542134A]
2017
The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway.
Khan AUH, Allende-Vega N., Gitenay D., Gerbal-Chaloin S., Gondeau C., Vo D.N., Belkahla S., Orecchioni S., Talarico G., Bertolini F. et al., 2017/09/06. Scientific reports, 7 (1) p. 10654. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_067DA1C10A2D]
β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue.
Somm E., Henry H., Bruce S.J., Aeby S., Rosikiewicz M., Sykiotis G.P., Asrih M., Jornayvaz F.R., Denechaud P.D., Albrecht U. et al., 2017/04/20. JCI insight, 2 (8). Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_94A6C8A6A9EA]
Cancer: Linking Powerhouses to Suicidal Bags.
Martinez-Carreres L., Nasrallah A., Fajas L., 2017. Frontiers in Oncology, 7 p. 204. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_030409EABA61]
 
CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation.
Lopez-Mejia I.C., Lagarrigue S., Giralt A., Martinez-Carreres L., Zanou N., Denechaud P.D., Castillo-Armengol J., Chavey C., Orpinell M., Delacuisine B. et al., 2017. Molecular Cell, 68 (2) pp. 336-349.e6. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F02666506F7E]
E2F1, a Novel Regulator of Metabolism.
Denechaud P.D., Fajas L., Giralt A., 2017. Frontiers in endocrinology, 8 p. 311. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_1D63D7156464]
Editorial: Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions.
Giralt A., Fajas L., 2017. Frontiers in Endocrinology, 8 p. 362. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_947817CD03B7]
 
Growth factor receptor binding protein 14 inhibition triggers insulin-induced mouse hepatocyte proliferation and is associated with hepatocellular carcinoma.
Morzyglod L., Caüzac M., Popineau L., Denechaud P.D., Fajas L., Ragazzon B., Fauveau V., Planchais J., Vasseur-Cognet M., Fartoux L. et al., 2017. Hepatology, 65 (4) pp. 1352-1368. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_1877D16828C8]
2016
 
Contrôle de l’homéostasie glucido-lipidique par les facteurs du cycle cellulaire CDK4 et E2F1 [Cell cycle regulators CDK4 and E2F1 control glucose and lipid homeostasis]
Denechaud P.D., Lopez-Mejia I.C., Fajas L., 2016/10. Medecine sciences : M/S, 32 (10) pp. 815-818.
[DOI][WoS][Pmid][serval:BIB_C6B5E0F7A130]
 
CDK4 is an essential insulin effector in adipocytes.
Lagarrigue S., Lopez-Mejia I.C., Denechaud P.D., Escoté X., Castillo-Armengol J., Jimenez V., Chavey C., Giralt A., Lai Q., Zhang L. et al., 2016. Journal of Clinical Investigation, 126 (1) pp. 335-348. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E56CC40E7CB9]
 
E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis.
Denechaud P.D., Lopez-Mejia I.C., Giralt A., Lai Q., Blanchet E., Delacuisine B., Nicolay B.N., Dyson N.J., Bonner C., Pattou F. et al., 2016. Journal of Clinical Investigation, 126 (1) pp. 137-150.
[DOI][WoS][Pmid][serval:BIB_D4C8969D5304]
KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response.
Rabhi N., Denechaud P.D., Gromada X., Hannou S.A., Zhang H., Rashid T., Salas E., Durand E., Sand O., Bonnefond A. et al., 2016. Cell reports, 15 (5) pp. 1051-1061. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_43901D6BF91E]
Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner.
Zhang L., Tschumi B.O., Lopez-Mejia I.C., Oberle S.G., Meyer M., Samson G., Rüegg M.A., Hall M.N., Fajas L., Zehn D. et al., 2016. Cell Reports, 14 (5) pp. 1206-1217. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_CB0706D22A19]
Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells.
Scholz G., Jandus C., Zhang L., Grandclément C., Lopez-Mejia I.C., Soneson C., Delorenzi M., Fajas L., Held W., Dormond O. et al., 2016. Ebiomedicine, 4 pp. 50-61. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_5D18A226530B]
 
Retinoblastoma Protein Knockdown Favors Oxidative Metabolism and Glucose and Fatty Acid Disposal in Muscle Cells.
Petrov P.D., Ribot J., López-Mejía I.C., Fajas L., Palou A., Bonet M.L., 2016. Journal of Cellular Physiology, 231 (3) pp. 708-718. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8B67B071031B]
2015
 
Cell cycle regulation of mitochondrial function.
Lopez-Mejia I.C., Fajas L., 2015. Current Opinion in Cell Biology, 33 pp. 19-25. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D9F84F046F43]
 
Metabolic adaptation to cancer growth: from the cell to the organism.
Escoté X., Fajas L., 2015. Cancer Letters, 356 (2 Pt A) pp. 171-175. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C6220C95B513]
2014
 
Antagonistic functions of LMNA isoforms in energy expenditure and lifespan.
Lopez-Mejia I.C., de Toledo M., Chavey C., Lapasset L., Cavelier P., Lopez-Herrera C., Chebli K., Fort P., Beranger G., Fajas L. et al., 2014. Embo Reports, 15 (5) pp. 529-539. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F93AC620BB91]
 
Extracellular-signal-regulated kinase 5 modulates the antioxidant response by transcriptionally controlling Sirtuin 1 expression in leukemic cells.
Lopez-Royuela N., Rathore M.G., Allende-Vega N., Annicotte J.S., Fajas L., Ramachandran B., Gulick T., Villalba M., 2014. International Journal of Biochemistry and Cell Biology, 53 pp. 253-261. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F41926E1FDD8]
2013
 
Metabolic control in cancer cells.
Fajas L., 2013. Annales d'endocrinologie, 74 (2) pp. 71-73.
[DOI][WoS][Pmid][serval:BIB_93D3D2F9CC0B]
Metabolic intervention on lipid synthesis converging pathways abrogates prostate cancer growth.
Fritz V., Benfodda Z., Henriquet C., Hure S., Cristol J.P., Michel F., Carbonneau M.A., Casas F., Fajas L., 2013. Oncogene, 32 (42) pp. 5101-5110.
[URN][DOI][WoS][Pmid][serval:BIB_6008DD9E3699]
Re-thinking cell cycle regulators: the cross-talk with metabolism.
Fajas L., 2013. Frontiers In Oncology, 3 p. 4.
[URN][DOI][Pmid][serval:BIB_921481056DE6]
2012
 
E2F transcription factor-1 deficiency reduces pathophysiology in the mouse model of Duchenne muscular dystrophy through increased muscle oxidative metabolism.
Blanchet E., Annicotte J.S., Pradelli L.A., Hugon G., Matecki S., Mornet D., Rivier F., Fajas L., 2012. Human Molecular Genetics, 21 (17) pp. 3910-3917.
[DOI][WoS][Pmid][serval:BIB_D908648F0201]
 
Mitochondrial T3 receptor p43 regulates insulin secretion and glucose homeostasis.
Blanchet E., Bertrand C., Annicotte J.S., Schlernitzauer A., Pessemesse L., Levin J., Fouret G., Feillet-Coudray C., Bonafos B., Fajas L. et al., 2012. Faseb Journal, 26 (1) pp. 40-50.
[DOI][WoS][Pmid][serval:BIB_C8B0CC971FB3]
 
PPARγ contributes to PKM2 and HK2 expression in fatty liver.
Panasyuk G., Espeillac C., Chauvin C., Pradelli L.A., Horie Y., Suzuki A., Annicotte J.S., Fajas L., Foretz M., Verdeguer F. et al., 2012. Nature Communications, 3 p. 672. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_4352B7A28491]
 
The RIP140 gene is a transcriptional target of E2F1.
Docquier A., Augereau P., Lapierre M., Harmand P.O., Badia E., Annicotte J.S., Fajas L., Cavaillès V., 2012. PLoS One, 7 (5) pp. e35839.
[DOI][WoS][Pmid][serval:BIB_5F85EBBE4579]
2011
 
Ciglitazone negatively regulates CXCL1 signaling through MITF to suppress melanoma growth.
Botton T., Puissant A., Cheli Y., Tomic T., Giuliano S., Fajas L., Deckert M., Ortonne J.P., Bertolotto C., Tartare-Deckert S. et al., 2011. Cell Death and Differentiation, 18 (1) pp. 109-121. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8E9D6C762ECB]
 
E2F transcription factor-1 regulates oxidative metabolism.
Blanchet E., Annicotte J.S., Lagarrigue S., Aguilar V., Clapé C., Chavey C., Fritz V., Casas F., Apparailly F., Auwerx J. et al., 2011. Nature Cell Biology, 13 (9) pp. 1146-1152.
[DOI][WoS][Pmid][serval:BIB_6C660BAC5236]
 
E2F1 at the crossroad of proliferation and oxidative metabolism.
Fajas L., Annicotte J.S., 2011. Cell Cycle, 10 (24) pp. 4193-4194.
[DOI][WoS][Pmid][serval:BIB_238D4FD11027]
 
Le double jeu des régulateurs du cycle cellulaire: contrôle de la prolifération et du métabolisme [Emerging key role of cell cycle regulators in cell metabolism].
Lagarrigue S., Blanchet É., Annicotte J.S., Fajas L., 2011. Médecine Sciences, 27 (5) pp. 508-513.
[DOI][WoS][Pmid][serval:BIB_4B38881E83FC]
2010
 
Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice.
Fritz V., Benfodda Z., Rodier G., Henriquet C., Iborra F., Avancès C., Allory Y., de la Taille A., Culine S., Blancou H. et al., 2010. Molecular Cancer Therapeutics, 9 (6) pp. 1740-1754. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E009BD17241D]
 
CDK4, pRB and E2F1: connected to insulin.
Fajas L., Blanchet E., Annicotte J.S., 2010. Cell Division, 5 (1) p. 6.
[DOI][WoS][Pmid][serval:BIB_0EAB3B53A694]
 
Cyclin G2 regulates adipogenesis through PPAR gamma coactivation.
Aguilar V., Annicotte J.S., Escote X., Vendrell J., Langin D., Fajas L., 2010. Endocrinology, 151 (11) pp. 5247-5254.
[DOI][WoS][Pmid][serval:BIB_E281836CA2D0]
 
Cycling through metabolism.
Aguilar V., Fajas L., 2010. EMBO Molecular Medicine, 2 (9) pp. 338-348.
[DOI][WoS][Pmid][serval:BIB_66F53146DC4A]
 
Metabolism and proliferation share common regulatory pathways in cancer cells.
Fritz V., Fajas L., 2010. Oncogene, 29 (31) pp. 4369-4377.
[DOI][WoS][Pmid][serval:BIB_4687DB122CA9]
 
Persistent organic pollutant exposure leads to insulin resistance syndrome.
Ruzzin J., Petersen R., Meugnier E., Madsen L., Lock E.J., Lillefosse H., Ma T., Pesenti S., Sonne S.B., Marstrand T.T. et al., 2010. Environmental Health Perspectives, 118 (4) pp. 465-471.
[DOI][WoS][Pmid][serval:BIB_16619B1D658F]
 
The CDK4-pRB-E2F1 pathway : A new modulator of insulin secretion.
Fajas L., Blanchet E., Annicotte J.S., 2010. Islets, 2 (1) pp. 51-53.
[DOI][WoS][Pmid][serval:BIB_E3D3C89896D8]
2009
 
Cell cycle regulators in the control of metabolism.
Blanchet E., Annicotte J.S., Fajas L., 2009. Cell Cycle, 8 (24) pp. 4029-4031.
[DOI][WoS][Pmid][serval:BIB_893BF44C6F6E]
 
CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance.
Chavey C., Lazennec G., Lagarrigue S., Clapé C., Iankova I., Teyssier J., Annicotte J.S., Schmidt J., Mataki C., Yamamoto H. et al., 2009. Cell Metabolism, 9 (4) pp. 339-349.
[DOI][WoS][Pmid][serval:BIB_E419E14D5D24]
 
CXCL5 drives obesity to diabetes, and further.
Chavey C., Fajas L., 2009. Aging, 1 (7) pp. 674-677.
[WoS][Pmid][serval:BIB_DC2254A43F64]
 
Downregulation of protein tyrosine phosphatase PTP-BL represses adipogenesis.
Glondu-Lassis M., Dromard M., Chavey C., Puech C., Fajas L., Hendriks W., Freiss G., 2009. International Journal of Biochemistry and Cell Biology, 41 (11) pp. 2173-2180.
[DOI][WoS][Pmid][serval:BIB_955F92E93F52]
 
In vitro and in vivo anti-melanoma effects of ciglitazone.
Botton T., Puissant A., Bahadoran P., Annicotte J.S., Fajas L., Ortonne J.P., Gozzerino G., Zamoum T., Tartare-Deckert S., Bertolotto C. et al., 2009. Journal of Investigative Dermatology, 129 (5) pp. 1208-1218.
[DOI][WoS][Pmid][serval:BIB_D97EEEF85638]
 
miR-143 interferes with ERK5 signaling, and abrogates prostate cancer progression in mice.
Clapé C., Fritz V., Henriquet C., Apparailly F., Fernandez P.L., Iborra F., Avancès C., Villalba M., Culine S., Fajas L., 2009. PLoS One, 4 (10) pp. e7542.
[DOI][WoS][Pmid][serval:BIB_89D589AB2E66]
 
The CDK4-pRB-E2F1 pathway controls insulin secretion.
Annicotte J.S., Blanchet E., Chavey C., Iankova I., Costes S., Assou S., Teyssier J., Dalle S., Sardet C., Fajas L., 2009. Nature Cell Biology, 11 (8) pp. 1017-1023.
[DOI][WoS][Pmid][serval:BIB_F95F6A64CCD2]
2008
 
Regulator of G protein signaling-4 controls fatty acid and glucose homeostasis.
Iankova I., Chavey C., Clapé C., Colomer C., Guérineau N.C., Grillet N., Brunet J.F., Annicotte J.S., Fajas L., 2008. Endocrinology, 149 (11) pp. 5706-5712.
[DOI][WoS][Pmid][serval:BIB_443682EB9268]
2007
 
Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure.
Dali-Youcef N., Mataki C., Coste A., Messaddeq N., Giroud S., Blanc S., Koehl C., Champy M.F., Chambon P., Fajas L. et al., 2007. Proceedings of the National Academy of Sciences of the United States of America, 104 (25) pp. 10703-10708.
[DOI][WoS][Pmid][serval:BIB_68C82A81AE43]
 
Rôle de PPARgamma dans la croissance du cancer de la prostate: de nouvelles pistes thérapeutiques .
Annicotte J.S., Culine S., Fajas L., 2007. Bulletin du Cancer, 94 (2) pp. 135-137.
[WoS][Pmid][serval:BIB_9BB03663C9E6]
 
The transcriptional coactivator peroxisome proliferator activated receptor (PPAR)gamma coactivator-1 alpha and the nuclear receptor PPAR alpha control the expression of glycerol kinase and metabolism genes independently of PPAR gamma activation in human white adipocytes.
Mazzucotelli A., Viguerie N., Tiraby C., Annicotte J.S., Mairal A., Klimcakova E., Lepin E., Delmar P., Dejean S., Tavernier G. et al., 2007. Diabetes, 56 (10) pp. 2467-2475.
[DOI][WoS][Pmid][serval:BIB_848732B2646F]
2006
 
Peroxisome proliferator-activated receptor gamma recruits the positive transcription elongation factor b complex to activate transcription and promote adipogenesis.
Iankova I., Petersen R.K., Annicotte J.S., Chavey C., Hansen J.B., Kratchmarova I., Sarruf D., Benkirane M., Kristiansen K., Fajas L., 2006. Molecular Endocrinology, 20 (7) pp. 1494-1505.
[DOI][WoS][Pmid][serval:BIB_B5554A508C70]
 
Peroxisome proliferator-activated receptor gamma regulates E-cadherin expression and inhibits growth and invasion of prostate cancer.
Annicotte J.S., Iankova I., Miard S., Fritz V., Sarruf D., Abella A., Berthe M.L., Noël D., Pillon A., Iborra F. et al., 2006. Molecular and Cellular Biology, 26 (20) pp. 7561-7574.
[DOI][WoS][Pmid][serval:BIB_87E70242B0CB]
2005
 
Anandamide induced PPARgamma transcriptional activation and 3T3-L1 preadipocyte differentiation.
Bouaboula M., Hilairet S., Marchand J., Fajas L., Le Fur G., Casellas P., 2005. European Journal of Pharmacology, 517 (3) pp. 174-181.
[DOI][WoS][Pmid][serval:BIB_8A1AFDB344C5]
 
Atypical transcriptional regulators and cofactors of PPARgamma.
Miard S., Fajas L., 2005. International Journal of Obesity, 29 Suppl 1 pp. S10-S12.
[DOI][WoS][Pmid][serval:BIB_5703C9AF8260]
 
Cdk4 promotes adipogenesis through PPARgamma activation.
Abella A., Dubus P., Malumbres M., Rane S.G., Kiyokawa H., Sicard A., Vignon F., Langin D., Barbacid M., Fajas L., 2005. Cell Metabolism, 2 (4) pp. 239-249.
[DOI][WoS][Pmid][serval:BIB_6881A35F3D69]
 
Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma.
Sarruf D.A., Iankova I., Abella A., Assou S., Miard S., Fajas L., 2005. Molecular and Cellular Biology, 25 (22) pp. 9985-9995.
[DOI][WoS][Pmid][serval:BIB_88191494A483]
 
Study of a new PPARgamma2 promoter polymorphism and haplotype analysis in a French population.
Meirhaeghe A., Tanck M.W., Fajas L., Janot C., Helbecque N., Cottel D., Auwerx J., Amouyel P., Dallongeville J., 2005. Molecular Genetics and Metabolism, 85 (2) pp. 140-148.
[DOI][WoS][Pmid][serval:BIB_BBE7578B951F]
 
The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene.
Annicotte J.S., Chavey C., Servant N., Teyssier J., Bardin A., Licznar A., Badia E., Pujol P., Vignon F., Maudelonde T. et al., 2005. Oncogene, 24 (55) pp. 8167-8175.
[DOI][WoS][Pmid][serval:BIB_2D2ECE6D726E]
2004
 
Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice.
Fajas L., Annicotte J.S., Miard S., Sarruf D., Watanabe M., Auwerx J., 2004. Journal of Clinical Investigation, 113 (9) pp. 1288-1295.
[DOI][WoS][Pmid][serval:BIB_FB03C7981490]
2003
 
A functional polymorphism in a STAT5B site of the human PPAR gamma 3 gene promoter affects height and lipid metabolism in a French population.
Meirhaeghe A., Fajas L., Gouilleux F., Cottel D., Helbecque N., Auwerx J., Amouyel P., 2003. Arteriosclerosis, Thrombosis, and Vascular Biology, 23 (2) pp. 289-294.
[DOI][WoS][Pmid][serval:BIB_9FDE44EAB77E]
 
Adipogenesis: a cross-talk between cell proliferation and cell differentiation.
Fajas L., 2003. Annals of Medicine, 35 (2) pp. 79-85.
[DOI][WoS][Pmid][serval:BIB_F318893025E0]
 
PPARgamma controls cell proliferation and apoptosis in an RB-dependent manner.
Fajas L., Egler V., Reiter R., Miard S., Lefebvre A.M., Auwerx J., 2003. Oncogene, 22 (27) pp. 4186-4193.
[DOI][WoS][Pmid][serval:BIB_1CAA0267627B]
 
Selective cyclo-oxygenase-2 inhibitors impair adipocyte differentiation through inhibition of the clonal expansion phase.
Fajas L., Miard S., Briggs M.R., Auwerx J., 2003. Journal of Lipid Research, 44 (9) pp. 1652-1659.
[DOI][WoS][Pmid][serval:BIB_BA978F91A7F3]
2002
 
The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation.
Fajas L., Egler V., Reiter R., Hansen J., Kristiansen K., Debril M.B., Miard S., Auwerx J., 2002. Developmental Cell, 3 (6) pp. 903-910.
[DOI][WoS][Pmid][serval:BIB_F0E2F1FD8DCE]
2001
 
Cyclin A is a mediator of p120E4F-dependent cell cycle arrest in G1.
Fajas L., Paul C., Vié A., Estrach S., Medema R., Blanchard J.M., Sardet C., Vignais M.L., 2001. Molecular and Cellular Biology, 21 (8) pp. 2956-2966.
[DOI][Pmid][serval:BIB_FB5186987042]
 
Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis.
Fajas L., Debril M.B., Auwerx J., 2001. Journal of Molecular Endocrinology, 27 (1) pp. 1-9.
[DOI][WoS][Pmid][serval:BIB_2C8FA1B4FD65]
 
PPAR gamma: an essential role in metabolic control.
Fajas L., Debril M.B., Auwerx J., 2001. Nutrition, Metabolism, and Cardiovascular Diseases, 11 (1) pp. 64-69.
[WoS][Pmid][serval:BIB_BBA12A0D8601]
 
The pleiotropic functions of peroxisome proliferator-activated receptor gamma.
Debril M.B., Renaud J.P., Fajas L., Auwerx J., 2001. Journal of Molecular Medicine, 79 (1) pp. 30-47.
[DOI][WoS][Pmid][serval:BIB_0E65A41522A4]
2000
 
A CDE/CHR-like element mediates repression of transcription of the mouse RB2 (p130) gene.
Fajas L., Le Cam L., Polanowska J., Fabbrizio E., Servant N., Philips A., Carnac G., Sardet C., 2000. FEBS Letters, 471 (1) pp. 29-33.
[DOI][WoS][Pmid][serval:BIB_191EA6A7CBC5]
 
Human E2F5 gene is oncogenic in primary rodent cells and is amplified in human breast tumors.
Polanowska J., Le Cam L., Orsetti B., Vallés H., Fabbrizio E., Fajas L., Taviaux S., Theillet C., Sardet C., 2000. Genes, Chromosomes and Cancer, 28 (1) pp. 126-130.
[DOI][WoS][Pmid][serval:BIB_F8B83C013480]
 
Impact of the Peroxisome Proliferator Activated Receptor gamma2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus.
Meirhaeghe A., Fajas L., Helbecque N., Cottel D., Auwerx J., Deeb S.S., Amouyel P., 2000. International Journal of Obesity and Related Metabolic Disorders, 24 (2) pp. 195-199.
[DOI][WoS][Pmid][serval:BIB_2A1EC14BF2AB]
 
pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F.
Fajas L., Paul C., Zugasti O., Le Cam L., Polanowska J., Fabbrizio E., Medema R., Vignais M.L., Sardet C., 2000. Proceedings of the National Academy of Sciences of the United States of America, 97 (14) pp. 7738-7743.
[DOI][WoS][Pmid][serval:BIB_52076D894A81]
 
The retinoblastoma-like protein p130 is involved in the determination of reserve cells in differentiating myoblasts.
Carnac G., Fajas L., L'honoré A., Sardet C., Lamb N.J., Fernandez A., 2000. Current Biology, 10 (9) pp. 543-546.
[DOI][WoS][Pmid][serval:BIB_3DC318EA9B62]
1999
 
Differential regulation of peroxisome proliferator activated receptor gamma1 (PPARgamma1) and PPARgamma2 messenger RNA expression in the early stages of adipogenesis.
Saladin R., Fajas L., Dana S., Halvorsen Y.D., Auwerx J., Briggs M., 1999. Cell Growth and Differentiation, 10 (1) pp. 43-48.
[WoS][Pmid][serval:BIB_AF31CF7A75EC]
 
Improved LM-PCR procedure for in vivo footprinting analysis of GC-rich promoters.
Le Cam L., Polanowska J., Fajas L., Fabbrizio E., Sardet C., 1999. Biotechniques, 26 (5) pp. 840-843.
[WoS][Pmid][serval:BIB_9E354763445E]
 
p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively.
Gelman L., Zhou G., Fajas L., Raspé E., Fruchart J.C., Auwerx J., 1999. Journal of Biological Chemistry, 274 (12) pp. 7681-7688.
[DOI][WoS][Pmid][serval:BIB_09AEDFD20902]
 
Peroxisome proliferator-activated receptor gamma is induced during differentiation of colon epithelium cells.
Lefebvre M., Paulweber B., Fajas L., Woods J., McCrary C., Colombel J.F., Najib J., Fruchart J.C., Datz C., Vidal H. et al., 1999. Journal of Endocrinology, 162 (3) pp. 331-340.
[WoS][Pmid][serval:BIB_63F02BB15DBB]
 
Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism.
Fajas L., Schoonjans K., Gelman L., Kim J.B., Najib J., Martin G., Fruchart J.C., Briggs M., Spiegelman B.M., Auwerx J., 1999. Molecular and Cellular Biology, 19 (8) pp. 5495-5503.
[WoS][Pmid][serval:BIB_06D5A6BEA7C9]
1998
 
A genetic polymorphism of the peroxisome proliferator-activated receptor gamma gene influences plasma leptin levels in obese humans.
Meirhaeghe A., Fajas L., Helbecque N., Cottel D., Lebel P., Dallongeville J., Deeb S., Auwerx J., Amouyel P., 1998. Human Molecular Genetics, 7 (3) pp. 435-440.
[DOI][WoS][Pmid][serval:BIB_D457E7B74F7B]
 
A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity.
Deeb S.S., Fajas L., Nemoto M., Pihlajamäki J., Mykkänen L., Kuusisto J., Laakso M., Fujimoto W., Auwerx J., 1998. Nature Genetics, 20 (3) pp. 284-287.
[DOI][WoS][Pmid][serval:BIB_02BF83E95440]
 
Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein.
Ricote M., Huang J., Fajas L., Li A., Welch J., Najib J., Witztum J.L., Auwerx J., Palinski W., Glass C.K., 1998. Proceedings of the National Academy of Sciences of the United States of America, 95 (13) pp. 7614-7619.
[DOI][WoS][Pmid][serval:BIB_1EFDA6B0CDCF]
 
Human peroxisome proliferator-activated receptor-gamma2: genetic mapping, identification of a variant in the coding sequence, and exclusion as the gene responsible for lipoatrophic diabetes.
Vigouroux C., Fajas L., Khallouf E., Meier M., Gyapay G., Lascols O., Auwerx J., Weissenbach J., Capeau J., Magré J., 1998. Diabetes, 47 (3) pp. 490-492.
[DOI][WoS][Pmid][serval:BIB_2A9FE3255C31]
 
PPARgamma3 mRNA: a distinct PPARgamma mRNA subtype transcribed from an independent promoter.
Fajas L., Fruchart J.C., Auwerx J., 1998. FEBS Letters, 438 (1-2) pp. 55-60.
[DOI][WoS][Pmid][serval:BIB_609731CAB2A7]
 
Transcriptional control of adipogenesis.
Fajas L., Fruchart J.C., Auwerx J., 1998. Current Opinion in Cell Biology, 10 (2) pp. 165-173.
[DOI][WoS][Pmid][serval:BIB_69571B557B25]
1997
 
Cycle sequencing on large DNA templates.
Fajas L., Staels B., Auwerx J., 1997. Biotechniques, 23 (6) pp. 1034-1036.
[WoS][Pmid][serval:BIB_49B97774002A]
 
The organization, promoter analysis, and expression of the human PPARgamma gene.
Fajas L., Auboeuf D., Raspé E., Schoonjans K., Lefebvre A.M., Saladin R., Najib J., Laville M., Fruchart J.C., Deeb S. et al., 1997. Journal of Biological Chemistry, 272 (30) pp. 18779-18789.
[DOI][WoS][Pmid][serval:BIB_DA274DBE1C5A]
 
Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients.
Auboeuf D., Rieusset J., Fajas L., Vallier P., Frering V., Riou J.P., Staels B., Auwerx J., Laville M., Vidal H., 1997. Diabetes, 46 (8) pp. 1319-1327.
[DOI][WoS][Pmid][serval:BIB_04E268818865]
1985
 
El test de liberación de histamina como parámetro diagnóstico y su posible modificación post inmunoterapia específica
Engel P., Malet A., Sanosa J., Fajas L., García-Calderón P.A., 1985. Allergologia et Immunopathologia, 13 (2) pp. 93-100.
[WoS][Pmid][serval:BIB_11B6AC2AF99D]
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