Nicolas Place

Fields |

Research directions

Neuromuscular plasticity to exercise

We investigate neuromuscular adjustments during exercise and training using a translational approach (combining integrative and mechanistic experiments). Mechanistic experiments are performed at the DSB. Using human muscle biopsies, cell culture, qPCR, western blotting, fluorescence microscopy, high resolution respirometry, mouse muscle contractile properties, etc..., we assess the role of Ca2+ in cellular / molecular adaptations to exercise (e.g. sprint interval training) or disuse (e.g. myopathies). Experiments involving measurements in exercising humans are performed in our laboratory at the ISSUL and involve e.g. the quantification of neural vs. muscular adaptations to exercise using measures of voluntary and evoked forces (via electrical or magnetic stimulation) combined with surface electromyography recordings.

Examples of master projects recently conducted in our labs:
- Skeletal muscle adaptations to repeated sprints in normoxia vs. hypoxia
- Optimization of transcranial direct current stimulation to improve endurance performance
- Modulation of the force evoked via wide pulse, high frequency neuromuscular electrical stimulation

For more information:
https://www.unil.ch/physiologie/en/home/menuinst/groupes-de-recherche/bengt-kayser---nicolas-place.html

Bibliography
Schlittler M. et al. Three weeks of sprint interval training improved high-intensity cycling performance and limited ryanodine receptor modifications in recreationally active human subjects. Eur J Appl Physiol 119 (9) pp. 1951-1958, 2019
Neyroud D. et al. Neuromuscular adaptations to wide-pulse high-frequency neuromuscular electrical stimulation training. Eur J Appl Physiol 119 (5) pp. 1105-1116, 2019
Place N. et al. Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise. PNAS 112 (50) pp. 15492-15497, 2015

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Swiss University