Johanna Joyce

Publications | Phd and Masters theses

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56 publications

In press | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 |
In press
 
Trans-Atlantic twists and turns.
Joyce J.A. Nature cancer. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_2CF1DD3B86ED]
2024
 
Microenvironmental reorganization in brain tumors following radiotherapy and recurrence revealed by hyperplexed immunofluorescence imaging.
Watson S.S., Duc B., Kang Z., de Tonnac A., Eling N., Font L., Whitmarsh T., Massara M., iMAXT Consortium, Bodenmiller B. et al., 2024/04/15. Nature communications, 15 (1) p. 3226. Peer-reviewed.
[DOI][Pmid][serval:BIB_2A3F2605E502]
 
Embracing cancer complexity: Hallmarks of systemic disease.
Swanton C., Bernard E., Abbosh C., André F., Auwerx J., Balmain A., Bar-Sagi D., Bernards R., Bullman S., DeGregori J. et al., 2024/03/28. Cell, 187 (7) pp. 1589-1616. Peer-reviewed.
[DOI][Pmid][serval:BIB_9DD109A11BCF]
 
Closing the scissor-shaped curve: Strategies to promote gender equality in academia.
Joyce J.A., Masina S., Michalik L., Pot C., Sempoux C., Amati F., 2024/03/14. Cell, 187 (6) pp. 1335-1342. Peer-reviewed.
[DOI][Pmid][serval:BIB_FEEC014C3937]
Interrogation of endothelial and mural cells in brain metastasis reveals key immune-regulatory mechanisms.
Bejarano L., Kauzlaric A., Lamprou E., Lourenco J., Fournier N., Ballabio M., Colotti R., Maas R., Galland S., Massara M. et al., 2024/03/11. Cancer cell, 42 (3) pp. 378-395.e10. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_3AD4E56F8FEC]
2023
 
Compromised Blood-Brain Barrier Junctions Enhance Melanoma Cell Intercalation and Extravasation.
Saltarin F., Wegmüller A., Bejarano L., Ildiz E.S., Zwicky P., Vianin A., Spadin F., Soukup K., Wischnewski V., Engelhardt B. et al., 2023/10/20. Cancers, 15 (20). Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_CE5A6DC34AFB]
The local microenvironment drives activation of neutrophils in human brain tumors.
Maas R.R., Soukup K., Fournier N., Massara M., Galland S., Kornete M., Wischnewski V., Lourenco J., Croci D., Álvarez-Prado Á.F. et al., 2023/10/12. Cell, 186 (21) pp. 4546-4566.e27. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_698367BEBBF8]
 
Jeffrey W. Pollard (1950-2023).
Qian B.Z., Joyce J.A., 2023/06/13. Immunity, 56 (6) pp. 1153-1154. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_9083E4F60720]
Phenotypic diversity of T cells in human primary and metastatic brain tumors revealed by multiomic interrogation.
Wischnewski V., Maas R.R., Aruffo P.G., Soukup K., Galletti G., Kornete M., Galland S., Fournier N., Lilja J., Wirapati P. et al., 2023/06. Nature cancer, 4 (6) pp. 908-924. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_AF8A124C7797]
 
What do you most hope spatial molecular profiling will help us understand? Part 1
Theis Fabian J., Dar Daniel, Vento-Tormo Roser, Vicković Sanja, Wang Linghua, Kagohara Luciane T., Rendeiro André F., Joyce Johanna A., 2023/06. Cell Systems, 14 (6) pp. 423-427.
[DOI][Pmid][serval:BIB_36D9FC8EAE55]
 
The next big questions in cancer research.
Loi S., Settleman J., Joyce J.A., Pramesh C.S., Bernards R., Fan J., Merchant J.L., Moslehi J., Sellers W.R., 2023/04/13. Cell, 186 (8) pp. 1523-1527. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_0E706B90C176]
Cranial imaging window implantation technique for longitudinal multimodal imaging of the brain environment in live mice.
Croci D., Zomer A., Kowal J., Joyce J.A., 2023/03/24. STAR protocols, 4 (2) p. 102197. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_F28374E82AE6]
 
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth.
de Visser K.E., Joyce J.A., 2023/03/13. Cancer cell, 41 (3) pp. 374-403. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_65C7C1ECAE37]
Immunogenomic analysis of human brain metastases reveals diverse immune landscapes across genetically distinct tumors.
Álvarez-Prado Á.F., Maas R.R., Soukup K., Klemm F., Kornete M., Krebs F.S., Zoete V., Berezowska S., Brouland J.P., Hottinger A.F. et al., 2023/01/17. Cell reports. Medicine, 4 (1) p. 100900. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B718E4D7ABEC]
2022
Multispectral fluorine-19 MRI enables longitudinal and noninvasive monitoring of tumor-associated macrophages.
Croci D., Santalla Méndez R., Temme S., Soukup K., Fournier N., Zomer A., Colotti R., Wischnewski V., Flögel U., van Heeswijk R.B. et al., 2022/10/19. Science translational medicine, 14 (667) pp. eabo2952. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_5E24D876764F]
 
Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity.
Chryplewicz A., Scotton J., Tichet M., Zomer A., Shchors K., Joyce J.A., Homicsko K., Hanahan D., 2022/10/10. Cancer cell, 40 (10) pp. 1111-1127.e9. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D8C0A81E8E9D]
Multimodal imaging of the dynamic brain tumor microenvironment during glioblastoma progression and in response to treatment.
Zomer A., Croci D., Kowal J., van Gurp L., Joyce J.A., 2022/07/15. iScience, 25 (7) p. 104570. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4E776CBAF3C1]
Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies.
Wild S.A., Cannell I.G., Nicholls A., Kania K., Bressan D., CRUK IMAXT Grand Challenge Team, Hannon G.J., Sawicka K., 2022. eLife, 11 pp. e80981. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_A9C8C5466322]
2021
 
An integrated pipeline for comprehensive analysis of immune cells in human brain tumor clinical samples.
Maas R.R., Soukup K., Klemm F., Kornete M., Bowman R.L., Bedel R., Marie D.N., Álvarez-Prado Á.F., Labes D., Wilson A. et al., 2021/10. Nature protocols, 16 (10) pp. 4692-4721. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_56ABDAED12F3]
 
Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis.
Klemm F., Möckl A., Salamero-Boix A., Alekseeva T., Schäffer A., Schulz M., Niesel K., Maas R.R., Groth M., Elie B.T. et al., 2021/10. Nature cancer, 2 (10) pp. 1086-1101. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E98C80E092F1]
 
Clonal fitness inferred from time-series modelling of single-cell cancer genomes.
Salehi S., Kabeer F., Ceglia N., Andronescu M., Williams M.J., Campbell K.R., Masud T., Wang B., Biele J., Brimhall J. et al., 2021/07. Nature, 595 (7868) pp. 585-590. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C1DD3A50D86F]
 
Therapeutic Targeting of the Tumor Microenvironment.
Bejarano L., Jordāo MJC, Joyce J.A., 2021/04. Cancer discovery, 11 (4) pp. 933-959. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F799CD903FA0]
Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response.
Georgopoulou D., Callari M., Rueda O.M., Shea A., Martin A., Giovannetti A., Qosaj F., Dariush A., Chin S.F., Carnevalli L.S. et al., 2021/03/31. Nature communications, 12 (1) p. 1998. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_6CE9EEBF7E86]
 
Women in cancer research and oncology.
Joyce J., Wakelee H., Davis M.B., Teo S.H., Bell S., Rendo V., 2021/03/08. Cancer cell, 39 (3) pp. 285-287. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_5E120F0EF1E3]
 
Expansion sequencing: Spatially precise in situ transcriptomics in intact biological systems.
Alon S., Goodwin D.R., Sinha A., Wassie A.T., Chen F., Daugharthy E.R., Bando Y., Kajita A., Xue A.G., Marrett K. et al., 2021/01/29. Science, 371 (6528). Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F042AC6C0E34]
2020
Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation.
Pais Ferreira D., Silva J.G., Wyss T., Fuertes Marraco S.A., Scarpellino L., Charmoy M., Maas R., Siddiqui I., Tang L., Joyce J.A. et al., 2020/11/17. Immunity, 53 (5) pp. 985-1000.e11. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_A0FD9237651F]
 
Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines.
Valiente M., Van Swearingen AED, Anders C.K., Bairoch A., Boire A., Bos P.D., Cittelly D.M., Erez N., Ferraro G.B., Fukumura D. et al., 2020/10/15. Cancer Research, 80 (20) pp. 4314-4323. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_47CE3A073F78]
Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment.
Dumas A.A., Pomella N., Rosser G., Guglielmi L., Vinel C., Millner T.O., Rees J., Aley N., Sheer D., Wei J. et al., 2020/08/03. The EMBO journal, 39 (15) pp. e103790. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_FFF9B15DBC96]
 
Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance.
Akkari L., Bowman R.L., Tessier J., Klemm F., Handgraaf S.M., de Groot M., Quail D.F., Tillard L., Gadiot J., Huse J.T. et al., 2020/07/15. Science translational medicine, 12 (552) pp. eaaw7843. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_1B0920FD434E]
Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells
Klemm F., Maas R.R., Bowman R.L., Kornete M., Soukup K., Nassiri S., Brouland J.P., Iacobuzio-Donahue C.A., Brennan C., Tabar V. et al., 2020/06/25. Cell, 181 (7) pp. 1643-1660.e17. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B25384BE18E8]
Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation.
Hämälistö S., Stahl J.L., Favaro E., Yang Q., Liu B., Christoffersen L., Loos B., Guasch Boldú C., Joyce J.A., Reinheckel T. et al., 2020/01/13. Nature communications, 11 (1) p. 229. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_61F53FCBFD55]
 
A roadmap for the next decade in cancer research.
Bernards R., Jaffee E., Joyce J.A., Lowe S.W., Mardis E.R., Morrison S.J., Polyak K., Sears C.L., Vousden K.H., Zhang Z., 2020/01. Nature cancer, 1 (1) pp. 12-17. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_CC9E6CB7205D]
Charting the immune landscape in brain cancers
Soukup Klara, Joyce Johanna, 2020. TheScienceBreaker.
[URN][DOI][serval:BIB_BAB9056856AB]
2019
 
Evaluating Magnetic Resonance Spectroscopy as a Tool for Monitoring Therapeutic Response of Whole Brain Radiotherapy in a Mouse Model for Breast-to-Brain Metastasis.
Chae W.H., Niesel K., Schulz M., Klemm F., Joyce J.A., Prümmer M., Brill B., Bergs J., Rödel F., Pilatus U. et al., 2019/11/27. Frontiers in oncology, 9 p. 1324. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_22B16FC3657F]
 
Challenges to curing primary brain tumours.
Aldape K., Brindle K.M., Chesler L., Chopra R., Gajjar A., Gilbert M.R., Gottardo N., Gutmann D.H., Hargrave D., Holland E.C. et al., 2019/08. Nature reviews. Clinical oncology, 16 (8) pp. 509-520. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_BAF957625821]
 
Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'.
Aldape K., Brindle K.M., Chesler L., Chopra R., Gajjar A., Gilbert M.R., Gottardo N., Gutmann D.H., Hargrave D., Holland E.C. et al., 2019/08. Nature reviews. Clinical oncology, 16 (8) pp. 522-523. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_B957A30B68EB]
Re-education of macrophages as a therapeutic strategy in cancer.
Kowal J., Kornete M., Joyce J.A., 2019/06. Immunotherapy, 11 (8) pp. 677-689. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_7E2B9DDA760A]
Imaging endogenous macrophage iron deposits reveals a metabolic biomarker of polarized tumor macrophage infiltration and response to CSF1R breast cancer immunotherapy.
Leftin A., Ben-Chetrit N., Joyce J.A., Koutcher J.A., 2019/01/29. Scientific reports, 9 (1) p. 857. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_60BF21E76912]
2018
 
A Long-Distance Relay-tionship between Tumor and Bone.
Soukup K., Joyce J.A., 2018/01/16. Immunity, 48 (1) pp. 13-16. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8F1963FC24AF]
2017
 
Obesity and the tumor microenvironment.
Olson O.C., Quail D.F., Joyce J.A., 2017/12/01. Science, 358 (6367) pp. 1130-1131. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_99607CEF07CC]
 
A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux.
Jena P.V., Roxbury D., Galassi T.V., Akkari L., Horoszko C.P., Iaea D.B., Budhathoki-Uprety J., Pipalia N., Haka A.S., Harvey J.D. et al., 2017/11/28. ACS nano, 11 (11) pp. 10689-10703. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_1B6139F6FBC4]
 
Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression.
Bakst R.L., Xiong H., Chen C.H., Deborde S., Lyubchik A., Zhou Y., He S., McNamara W., Lee S.Y., Olson O.C. et al., 2017/11/15. Cancer research, 77 (22) pp. 6400-6414. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_1F176978670A]
Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas.
Yan D., Kowal J., Akkari L., Schuhmacher A.J., Huse J.T., West B.L., Joyce J.A., 2017/10/26. Oncogene, 36 (43) pp. 6049-6058. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_07614DBA0E81]
 
Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF.
Quail D.F., Olson O.C., Bhardwaj P., Walsh L.A., Akkari L., Quick M.L., Chen I.C., Wendel N., Ben-Chetrit N., Walker J. et al., 2017/08. Nature cell biology, 19 (8) pp. 974-987. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_FE7ACE5982F5]
Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents.
Olson O.C., Kim H., Quail D.F., Foley E.A., Joyce J.A., 2017/04/04. Cell reports, 19 (1) pp. 101-113. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_D85BBAB8A64B]
Metabolic origins of spatial organization in the tumor microenvironment.
Carmona-Fontaine C., Deforet M., Akkari L., Thompson C.B., Joyce J.A., Xavier J.B., 2017/03/14. Proceedings of the National Academy of Sciences of the United States of America, 114 (11) pp. 2934-2939. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4F0B877B8084]
 
The Microenvironmental Landscape of Brain Tumors.
Quail D.F., Joyce J.A., 2017/03/13. Cancer cell, 31 (3) pp. 326-341. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_66A33B0C2A3A]
 
Molecular Pathways: Deciphering Mechanisms of Resistance to Macrophage-Targeted Therapies.
Quail D.F., Joyce J.A., 2017/02/15. Clinical cancer research, 23 (4) pp. 876-884. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_A52BFAD7DA3C]
Iron imaging reveals tumor and metastasis macrophage hemosiderin deposits in breast cancer.
Leftin A., Ben-Chetrit N., Klemm F., Joyce J.A., Koutcher J.A., 2017. PloS one, 12 (9) pp. e0184765. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_5D3507371177]
2016
Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies.
Bowman R.L., Klemm F., Akkari L., Pyonteck S.M., Sevenich L., Quail D.F., Dhara S., Simpson K., Gardner E.E., Iacobuzio-Donahue C.A. et al., 2016/11/22. Cell reports, 17 (9) pp. 2445-2459. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_D0474EC65CDA]
STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation.
Yan D., Wang H.W., Bowman R.L., Joyce J.A., 2016/09/13. Cell reports, 16 (11) pp. 2914-2927. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_6B0AE4F9D236]
TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.
Prudova A., Gocheva V., Auf dem Keller U., Eckhard U., Olson O.C., Akkari L., Butler G.S., Fortelny N., Lange P.F., Mark J.C. et al., 2016/08/09. Cell reports, 16 (6) pp. 1762-1773. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_EFC4B030CCF3]
 
Microenvironmental InterFereNce of metabolism regulates chemosensitivity.
Akkari L., Joyce J.A., 2016/08. Cell research, 26 (8) pp. 867-868. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F79936FDD183]
Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer.
Akkari L., Gocheva V., Quick M.L., Kester J.C., Spencer A.K., Garfall A.L., Bowman R.L., Joyce J.A., 2016. Genes and Development, 30 (2) pp. 220-232. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_34BF0625B509]
 
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas.
Quail D.F., Bowman R.L., Akkari L., Quick M.L., Schuhmacher A.J., Huse J.T., Holland E.C., Sutton J.C., Joyce J.A., 2016. Science, 352 (6288) pp. aad3018. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F2EFF73DAC5C]
2015
 
Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response.
Olson O.C., Joyce J.A., 2015. Nature Reviews. Cancer, 15 (12) pp. 712-729. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_CED987E8D926]
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