Pascal André

Publications | Phd and Masters theses

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42 publications

2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 |
2024
Real-world trough concentrations and effectiveness of long-acting cabotegravir and rilpivirine: a multicenter prospective observational study in Switzerland.
Thoueille P., Saldanha S.A., Schaller F., Choong E., Munting A., Cavassini M., Braun D., Günthard H.F., Kusejko K., Surial B. et al., 2024/01. The Lancet regional health. Europe, 36 p. 100793. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_EE4919775F0F]
2023
Population pharmacokinetic analysis of lopinavir in HIV negative individuals exposed to SARS-CoV-2: a COPEP (COronavirus Post-Exposure Prophylaxis) sub-study.
Thoueille P., Delfraysse M., Andre P., Buclin T., Decosterd L.A., Fedeli C., Ustero P., Calmy A., Guidi M., Swiss HIV Cohort Study, 2023/09/27. BMC pharmacology & toxicology, 24 (1) p. 47. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_0252DE874823]
 
A Highly Sensitive HPLC-MS/MS MethodFor Multiplex Analysis Of Janus KinaseInhibitors In Plasma
Tachet J., Mercier T., André P., Guidi M., Buclin T., Decosterd L., Choong E., Girardin F., 2023/07. dans 19th World Congress of Basic and Clinical Pharmacology (WCP), Glasgow, July 2023.
[serval:BIB_D39D174AB865]
Population pharmacokinetic modelling to characterize the effect of chronic kidney disease on tenofovir exposure after tenofovir alafenamide administration.
Thoueille P., Alves Saldanha S., Desfontaine V., Kusejko K., Courlet P., Andre P., Cavassini M., Decosterd L.A., Buclin T., Guidi M. et al., 2023/06/01. The Journal of antimicrobial chemotherapy, 78 (6) pp. 1433-1443. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_449BF24E5A20]
 
Interest of therapeutic drug monitoring: lumacaftor, ivacaftor, tezacaftor, and elexacaftor.
Choong Eva, Sauty A., Koutsokera A., Blanchon S., André Pascal, Decosterd L., 2023/03. dans Journée mucoviscidose romande March 2023 - Lausanne. Peer-reviewed.
[serval:BIB_27E71891505C]
An innovative ethosuximide granule formulation designed for pediatric use: Comparative pharmacokinetics, safety, tolerability, and palatability profile versus reference syrup.
Diezi L., Dao K., Jullien V., Roussel-Maupetit C., Burton I., André P., Bardinet C., Rothuizen L.E., Chtioui H., Manso-Silvan M.A. et al., 2023/02. Pharmacology research & perspectives, 11 (1) pp. e01032. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_8A3E445B0338]
Optimized LC-MS/MS quantification of tuberculosis drug candidate macozinone (PBTZ169), its dearomatized Meisenheimer Complex and other metabolites, in human plasma and urine.
Desfontaine V., Guinchard S., Marques S., Vocat A., Moulfi F., Versace F., Huser-Pitteloud J., Ivanyuk A., Bardinet C., Makarov V. et al., 2023/01/15. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1215 p. 123555. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_405A2D6AF487]
Estimating glomerular filtration rate from serum creatinine concentration in children with augmented renal clearance: all formulas are equivocal, but some are more equivocal than others.
André P., Chtioui H., Dao K., Rothuizen L.E., Di Paolo E.R., Diezi M., Crisinel P.A., Cachat F., Chehade H., Buclin T., 2023/01. Kidney international, 103 (1) pp. 225-226. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_E06602D511F4]
Precision oncology by point-of-care therapeutic drug monitoring and dosage adjustment of conventional cytotoxic chemotherapies: A perspective.
Briki M., André P., Thoma Y., Widmer N., Wagner A.D., Decosterd L.A., Buclin T., Guidi M., Carrara S., 2023. Pharmaceutics, 15 (4) p. 1283. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_A82A8DDE8796]
2022
Treatment-emergent adverse events and antiseizure medication actual drug load.
Prétat T., Aícua-Rapún I., André P., Lebon S., Rossetti A.O., Decosterd L.A., Buclin T., Novy J., 2022/12. Epilepsy & behavior, 137 (Pt A) p. 108980. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_7D05EB7BE2F8]
 
A battery of tandem mass spectrometry assays with stable isotope-dilution for the quantification of 15 anti-tuberculosis drugs and two metabolites in patients with susceptible-, multidrug-resistant- and extensively drug-resistant tuberculosis.
Mercier T., Desfontaine V., Cruchon S., Da Silva Pereira Clara J.A., Briki M., Mazza-Stalder J., Kajkus A., Burger R., Suttels V., Buclin T. et al., 2022/11/15. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1211 p. 123456. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8BD27ECE6B02]
Valproate in status epilepticus: Correlation between loading dose, serum levels, and clinical response.
Vijiala S., André P., Buclin T., Decosterd L.A., Rossetti A.O., Novy J., 2022/09. European journal of neurology, 29 (9) pp. 2607-2611. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_729D01C11191]
Métabolisme et suivi thérapeutique de l’azathioprine en gastroentérologie et hépatologie [Metabolism and therapeutic monitoring of azathioprine in gastroenterology and hepatology]
Bianchetti D., Salvador Nunes L., André P., Schoepfer A., Moradpour D., Chtioui H., 2022/08/31. Revue medicale suisse, 18 (793) pp. 1588-1593. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_8BF7916B0E8B]
Therapeutic Drug Monitoring of Ivacaftor, Lumacaftor, Tezacaftor, and Elexacaftor in Cystic Fibrosis: Where Are We Now?
Choong E., Sauty A., Koutsokera A., Blanchon S., André P., Decosterd L., 2022/08/11. Pharmaceutics, 14 (8) p. 1674. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_0CAC2AC96B31]
Real-Life Therapeutic Concentration Monitoring of Long-Acting Cabotegravir and Rilpivirine: Preliminary Results of an Ongoing Prospective Observational Study in Switzerland.
Thoueille P., Alves Saldanha S., Schaller F., Munting A., Cavassini M., Braun D., Günthard H.F., Kusejko K., Surial B., Furrer H. et al., 2022/07/29. Pharmaceutics, 14 (8) p. 1588. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_EA4A25E4F31E]
Development of an assay by liquid chromatography coupled to tandem mass spectrometry for thiopurines drugs in whole blood and application for their Therapeutic Drug Monitoring
Nguyen N., Da Silva Pereira Clara J. A., Mercier T., Desfontaines V., Ceppi F., Moradpour D., Chtioui H., André P., Buclin T., Decosterd L. A. et al., 2022/06/01. dans 6ème Congrès de printemps de la Société Suisse de Médecine Interne Générale du 1er juin 2022.
[URN][serval:BIB_144D7BE019DE]
Therapeutic drug monitoring of cefepime in a non-critically ill population: retrospective assessment and potential role for model-based dosing.
Suttels V., André P., Thoma Y., Veuve F., Decosterd L., Guery B., Buclin T., 2022/04. JAC-antimicrobial resistance, 4 (2) pp. dlac043. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_F7941F21C4D1]
Dosing strategies of imipenem in neonates based on pharmacometric modelling and simulation.
Dao K., Fuchs A., André P., Giannoni E., Decosterd L.A., Marchetti O., Asner S.A., Pfister M., Widmer N., Buclin T. et al., 2022/02/02. The Journal of antimicrobial chemotherapy, 77 (2) pp. 457-465. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_6EBEF14704F8]
 
Ensuring Sufficient Trough Plasma Concentrations for Broad-Spectrum Beta-Lactam Antibiotics in Children With Malignancies: Beware of Augmented Renal Clearance!
André P., Diezi L., Dao K., Crisinel P.A., Rothuizen L.E., Chtioui H., Decosterd L.A., Diezi M., Asner S., Buclin T., 2022. Frontiers in pediatrics, 9 p. 768438. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_B465A6064AF2]
 
Safety, tolerability and pharmacokinetic profile of Macozinone (PBTZ169) formulated as native crystal powder: multiple ascendingdoses, phase-Ib trial in healthy volunteers
Chtioui H., Prod'Hom S., Desfontaine V., André P., Moulfi F., Bardinet C., Abo-Loha C., Tessieras J., Rothuizen L.E., Diezi L. et al., 2022. dans 15th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT) - June 2022 Athens. European Journal of Clinical Pharmacology, 2022, 78: 1-163.
[serval:BIB_F1F116FD908F]
 
Safety, tolerability, pharmacokinetic profile and ex-vivo antitubercular acativity of macozinone formulated as spraydredi dispersion (SDD) versus native crystal powder (NCO?: single ascending doses, randomized, placebo-controlled, cross-ouver phase la trial in healthy volunteers
Rothuizen L.E., Ciullini L., Huser-Pitteloud J., Guidi M., Chtioui H., Ivanyuk A., André P., Bardinet C., Decosterd L.A., Spaggiari D. et al., 2022. dans SGAIM/SSMIG 6th Spring Congress Lausanne, June 2022. Primary and Hospital Care 2022: 22 (Suppl. 12), 173.
[serval:BIB_B502CD64B984]
Therapeutic drug monitoring of newer generation antiseizure medications at the point of treatment failure.
Fluckiger P., Aícua-Rapún I., André P., Rossetti A.O., Decosterd L.A., Buclin T., Novy J., 2022/01. Seizure, 94 pp. 66-69. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_3FCED610441B]
2021
 
Seizure freedom and plasma levels of newer generation antiseizure medications.
Aícua-Rapún I., André P., Rossetti A.O., Décosterd L.A., Buclin T., Novy J., 2021/08. Acta neurologica Scandinavica, 144 (2) pp. 202-208. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_1181D7D2379F]
Pharmacokinetics of anti-infective agents during CytoSorb hemoadsorption.
Schneider A.G., André P., Scheier J., Schmidt M., Ziervogel H., Buclin T., Kindgen-Milles D., 2021/05/18. Scientific reports, 11 (1) p. 10493. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_26E00ABAF022]
 
Saliva therapeutic drug monitoring of the newer anti-epileptic drugs
Choong E., Novy J., Decosterd L., Buclin T., Rossetti A., Stampfli C., Vassalo P., Andre P., Aícua-Rapún I., 2021/04/15., Spring Meeting of the Swiss Society of Pharmacology and Toxicology dans SSPT 2021 Spring Meeting: Abstract Book. Peer-reviewed, Swiss Society of Pharmacology and Toxicology.
[serval:BIB_95D3176315EC]
2020
Validation and clinical application of a multiplex high performance liquid chromatography - tandem mass spectrometry assay for the monitoring of plasma concentrations of 12 antibiotics in patients with severe bacterial infections.
Decosterd L.A., Mercier T., Ternon B., Cruchon S., Guignard N., Lahrichi S., Pesse B., Rochat B., Burger R., Lamoth F. et al., 2020/11/10. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1157 p. 122160. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_2ABB9B287690]
Development and validation of a multiplex UHPLC-MS/MS assay with stable isotopic internal standards for the monitoring of the plasma concentrations of the antiretroviral drugs bictegravir, cabotegravir, doravirine, and rilpivirine in people living with HIV.
Courlet P., Alves Saldanha S., Cavassini M., Marzolini C., Choong E., Csajka C., Günthard H.F., André P., Buclin T., Desfontaine V. et al., 2020/06. Journal of mass spectrometry, 55 (6) pp. e4506. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_1D794571C1B2]
Optimisation of vancomycin exposure in neonates based on the best level of evidence.
Dao K., Guidi M., André P., Giannoni E., Basterrechea S., Zhao W., Fuchs A., Pfister M., Buclin T., Csajka C., 2020/04. Pharmacological research, 154 p. 104278. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_E0DB9448258C]
 
Compassionate Use of Letermovir in a 2-Year-Old Immunocompromised Child With Resistant Cytomegalovirus Disease.
Pérez Marín M., Decosterd L.A., Andre P., Buclin T., Mercier T., Murray K., Rizzi M., Meylan P., Jaton-Ogay K., Opota O. et al., 2020/02/28. Journal of the Pediatric Infectious Diseases Society, 9 (1) pp. 96-99. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_34AA25DDD16D]
The steps to therapeutic drug monitoring: A structured approach illustrated with imatinib
Buclin T., Thoma Y., Widmer N., André P., Guidi M., Csajka C., Decosterd L..A., 2020. Frontiers in Pharmacology, 11 p. 177. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_9A25C1CC37D8]
Therapeutic Drug Monitoring of Newer Antiepileptic Drugs: A Randomized Trial for Dosage Adjustment.
Aícua-Rapún I., André P., Rossetti A.O., Ryvlin P., Hottinger A.F., Decosterd L.A., Buclin T., Novy J., 2020/01. Annals of neurology, 87 (1) pp. 22-29. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_7737AA14ABFD]
2019
 
Isavuconazole brain penetration in cerebral aspergillosis.
Lamoth F., Mercier T., André P., Pagani J.L., Pantet O., Maduri R., Guery B., Decosterd L.A., 2019/06/01. The Journal of antimicrobial chemotherapy, 74 (6) pp. 1751-1753. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_DBC07C267A48]
 
Clindamycin clearance during Cytosorb hemoadsorption: A case report and pharmacokinetic study.
Poli E.C., Simoni C., André P., Buclin T., Longchamp D., Perez M.H., Ferry T., Schneider A.G., 2019/05. The International journal of artificial organs, 42 (5) pp. 258-262. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C2601E538BC6]
Closed-loop Neuropharmacology for Epilepsy: Distant Dream or Future Reality?
Aicua-Rapun I., André P., Novy J., 2019. Current neuropharmacology, 17 (5) pp. 447-458. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_185B655D5EFA]
Intravenous brivaracetam in status epilepticus: Correlation between loading dose, plasma levels and clinical response.
Aicua-Rapun I., André P., Rossetti A.O., Decosterd L.A., Buclin T., Novy J., 2019/01. Epilepsy research, 149 pp. 88-91. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B534E0801A68]
 
Therapeutic drug monitoring (TDM)
Pascal A., Widmer N., Buclin T., 2019. pp. 1-9 dans Swiss recommendations for adult cystic fibrosis care chap. 4.2.3, RMS Editions/Médecine et Hygiène.
[serval:BIB_72DA940F4FA8]
2018
Levetiracetam circulating concentrations and response in status epilepticus.
Perrenoud M., André P., Buclin T., Decosterd L.A., Rossetti A.O., Novy J., 2018/11. Epilepsy & behavior, 88 pp. 61-65. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4F4192BBC5DD]
Efficacy and safety of continuous infusions with elastomeric pumps for outpatient parenteral antimicrobial therapy (OPAT): an observational study.
Voumard R., Gardiol C., André P., Arensdorff L., Cochet C., Boillat-Blanco N., Decosterd L., Buclin T., de Vallière S., 2018/09/01. The Journal of antimicrobial chemotherapy, 73 (9) pp. 2540-2545. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_A96B4B7DC3D0]
2017
Intravenous lacosamide in status epilepticus: Correlation between loading dose, serum levels, and clinical response.
Perrenoud M., André P., Alvarez V., Stähli C., Decosterd L.A., Rossetti A.O., Novy J., 2017. Epilepsy Research, 135 pp. 38-42. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4B7DEF70D1C9]
2016
 
The emerging role of multiplex tandem mass spectrometry analysis for therapeutic drug monitoring and personalized medicine
Decosterd L.A., Widmer N., André P., Aouri M., Buclin T., 2016/11. TrAC Trends in Analytical Chemistry, 84 pp. 5-13. Peer-reviewed.
[DOI][serval:BIB_61127FFB9A94]
2015
 
Multiplex Mass Spectrometry Analysis of Latest-Generation Antiepileptic Drugs: A Clinically Useful Laboratory Tool for Improved Real-Time Patients' Care.
Decosterd LA, Mercier T, André P, Bertholet S, Rothuizen LE, Rossetti AO, Buclin T, 2015/06. Epileptologie, 32 (2) pp. 85-89.
[serval:BIB_070F59406BE8]
 
Therapeutic Drug Monitoring of Antiepileptic Drugs in the 21st Century
André P., Novy J., Decosterd LA, Buclin T., Rothuizen LE, 2015/01/01. Epileptologie 32 pp. 78-84.
[serval:BIB_563351C391E5]
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