Petr Broz

Publications | Mémoires et thèses

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64 publications

Sous presse | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2008 | 2007 | 2005 | 2003 |
 
Pannexin-1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or Non-canonical inflammasome activation.
Chen K.W., Demarco B., Broz P. European journal of immunology. Peer-reviewed.
 
NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death.
Radulovic K., Ayata C.K., Mak'Anyengo R., Lechner K., Wuggenig P., Kaya B., Hruz P., Gomez de Agüero M., Broz P., Weigmann B. et al., 2019/07/15. Journal of immunology, 203 (2) pp. 544-556. Peer-reviewed.
 
Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly.
Chen K.W., Demarco B., Heilig R., Shkarina K., Boettcher A., Farady C.J., Pelczar P., Broz P., 2019/05/15. The EMBO Journal, 38 (10). Peer-reviewed.
 
Recognition of Intracellular Bacteria by Inflammasomes.
Broz P., 2019/03. Microbiology spectrum, 7 (2). Peer-reviewed.
 
A Surface-Induced Asymmetric Program Promotes Tissue Colonization by Pseudomonas aeruginosa.
Laventie B.J., Sangermani M., Estermann F., Manfredi P., Planes R., Hug I., Jaeger T., Meunier E., Broz P., Jenal U., 2019/01/09. Cell host & microbe, 25 (1) pp. 140-152.e6. Peer-reviewed.
 
Divide to conquer: NLRP3 is activated on dispersed trans-Golgi network.
Chen K.W., Boucher D., Broz P., 2019. Cell Research, 29 (3) pp. 181-182. Peer-reviewed.
 
Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation.
Demarco B., Chen K.W., Broz P., 2019. Molecular & cellular oncology, 6 (4) p. 1610324. Peer-reviewed.
Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection.
Cerqueira D.M., Gomes MTR, Silva ALN, Rungue M., Assis NRG, Guimarães E.S., Morais S.B., Broz P., Zamboni D.S., Oliveira S.C., 2018/12. PLoS pathogens, 14 (12) pp. e1007519. Peer-reviewed.
BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages.
Chauhan D., Bartok E., Gaidt M.M., Bock F.J., Herrmann J., Seeger J.M., Broz P., Beckmann R., Kashkar H., Tait SWG et al., 2018/11/27. Cell reports, 25 (9) pp. 2354-2368.e5. Peer-reviewed.
ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation.
Rühl S., Shkarina K., Demarco B., Heilig R., Santos J.C., Broz P., 2018/11/23. Science, 362 (6417) pp. 956-960. Peer-reviewed.
 
Sensing of invading pathogens by GBPs: At the crossroads between cell-autonomous and innate immunity.
Santos J.C., Broz P., 2018/10. Journal of leukocyte biology, 104 (4) pp. 729-735. Peer-reviewed.
 
Noncanonical inflammasome signaling elicits gasdermin D-dependent neutrophil extracellular traps.
Chen K.W., Monteleone M., Boucher D., Sollberger G., Ramnath D., Condon N.D., von Pein J.B., Broz P., Sweet M.J., Schroder K., 2018/08/24. Science immunology, 3 (26) pp. eaar6676. Peer-reviewed.
 
LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.
Santos J.C., Dick M.S., Lagrange B., Degrandi D., Pfeffer K., Yamamoto M., Meunier E., Pelczar P., Henry T., Broz P., 2018/03/15. The EMBO journal, 37 (6) pp. 1-19. Peer-reviewed.
 
Function and mechanism of the pyrin inflammasome.
Heilig R., Broz P., 2018/02. European journal of immunology, 48 (2) pp. 230-238. Peer-reviewed.
 
Mechanisms and Consequences of Inflammasome Activation.
Schroder K., Kanneganti T.D., Shao F., Broz P., 2018/01/19. Journal of molecular biology, 430 (2) pp. 131-132. Peer-reviewed.
 
Detecting Release of Bacterial dsDNA into the Host Cytosol Using Fluorescence Microscopy.
Dreier R.F., Santos J.C., Broz P., 2018. Methods in molecular biology, 1714 pp. 199-213. Peer-reviewed.
 
Global Ion Suppression Limits the Potential of Mass Spectrometry Based Phosphoproteomics.
Dreier R.F., Ahrné E., Broz P., Schmidt A., 2018. Journal of Proteome Research, 18 (1) pp. 493-507. Peer-reviewed.
Mobilizable Plasmids for Tunable Gene Expression in Francisella novicida.
Brodmann M., Heilig R., Broz P., Basler M., 2018. Frontiers in cellular and infection microbiology, 8 p. 284. Peer-reviewed.
 
The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice.
Heilig R., Dick M.S., Sborgi L., Meunier E., Hiller S., Broz P., 2018. European Journal of Immunology, 48 (4) pp. 584-592. Peer-reviewed.
The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity.
Schneider K.S., Groß C.J., Dreier R.F., Saller B.S., Mishra R., Gorka O., Heilig R., Meunier E., Dick M.S., Ćiković T. et al., 2017/12/26. Cell reports, 21 (13) pp. 3846-3859. Peer-reviewed.
 
Evolutionary Convergence and Divergence in NLR Function and Structure.
Meunier E., Broz P., 2017/10. Trends in immunology, 38 (10) pp. 744-757. Peer-reviewed.
Corrigendum: ASC filament formation serves as a signal amplification mechanism for inflammasomes.
Dick M.S., Sborgi L., Rühl S., Hiller S., Broz P., 2017. Nature Communications, 8 p. 15030. Peer-reviewed.
Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape.
Brodmann M., Dreier R.F., Broz P., Basler M., 2017. Nature Communications, 8 p. 15853. Peer-reviewed.
IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection.
Wallet P., Benaoudia S., Mosnier A., Lagrange B., Martin A., Lindgren H., Golovliov I., Michal F., Basso P., Djebali S. et al., 2017. PLoS Pathogens, 13 (10) pp. e1006630. Peer-reviewed.
 
Inflammasomes in Host Defense and Autoimmunity.
Broz P., 2016/12/21. Chimia, 70 (12) pp. 853-855. Peer-reviewed.
AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity.
Di Micco A., Frera G., Lugrin J., Jamilloux Y., Hsu E.T., Tardivel A., De Gassart A., Zaffalon L., Bujisic B., Siegert S. et al., 2016/08/09. Proceedings of the National Academy of Sciences of the United States of America, 113 (32) pp. E4671-80. Peer-reviewed.
Immune Response: Intracellular pathogens under attack.
Broz P., 2016/02/19. eLife, 5 pp. -. Peer-reviewed.
ASC filament formation serves as a signal amplification mechanism for inflammasomes.
Dick M.S., Sborgi L., Rühl S., Hiller S., Broz P., 2016. Nature Communications, 7 p. 11929. Peer-reviewed.
 
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death.
Sborgi L., Rühl S., Mulvihill E., Pipercevic J., Heilig R., Stahlberg H., Farady C.J., Müller D.J., Broz P., Hiller S., 2016. The EMBO Journal, 35 (16) pp. 1766-1778. Peer-reviewed.
 
Inflammasomes: Intracellular detection of extracellular bacteria.
Broz P., 2016. Cell Research, 26 (8) pp. 859-860. Peer-reviewed.
 
Inflammasomes: mechanism of assembly, regulation and signalling.
Broz P., Dixit V.M., 2016. Nature reviews. Immunology, 16 (7) pp. 407-420. Peer-reviewed.
 
Interferon-inducible GTPases in cell autonomous and innate immunity.
Meunier E., Broz P., 2016. Cellular Microbiology, 18 (2) pp. 168-180. Peer-reviewed.
 
K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria.
Groß C.J., Mishra R., Schneider K.S., Médard G., Wettmarshausen J., Dittlein D.C., Shi H., Gorka O., Koenig P.A., Fromm S. et al., 2016. Immunity, 45 (4) pp. 761-773. Peer-reviewed.
 
Sequence-specific solid-state NMR assignments of the mouse ASC PYRIN domain in its filament form.
Ravotti F., Sborgi L., Cadalbert R., Huber M., Mazur A., Broz P., Hiller S., Meier B.H., Böckmann A., 2016. Biomolecular NMR Assignments, 10 (1) pp. 107-115. Peer-reviewed.
The gasdermin-D pore: Executor of pyroptotic cell death.
Rühl S., Broz P., 2016. Oncotarget, 7 (36) pp. 57481-57482. Peer-reviewed.
 
Caspase-11 activates a canonical NLRP3 inflammasome by promoting K(+) efflux.
Rühl S., Broz P., 2015. European Journal of Immunology, 45 (10) pp. 2927-2936. Peer-reviewed.
 
Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.
Meunier E., Wallet P., Dreier R.F., Costanzo S., Anton L., Rühl S., Dussurgey S., Dick M.S., Kistner A., Rigard M. et al., 2015. Nature Immunology, 16 (5) pp. 476-484. Peer-reviewed.
 
Immunology: Caspase target drives pyroptosis.
Broz P., 2015. Nature, 526 (7575) pp. 642-643. Peer-reviewed.
 
Inflammasome assembly: The wheels are turning.
Broz P., 2015. Cell Research, 25 (12) pp. 1277-1278. Peer-reviewed.
 
Interferon-induced guanylate-binding proteins promote cytosolic lipopolysaccharide detection by caspase-11.
Meunier E., Broz P., 2015. DNA and Cell Biology, 34 (1) pp. 1-5. Peer-reviewed.
 
Quantification of Cytosolic vs. Vacuolar Salmonella in Primary Macrophages by Differential Permeabilization.
Meunier E., Broz P., 2015. Journal of Visualized Experiments 101 pp. e52960. Peer-reviewed.
 
Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy.
Sborgi L., Ravotti F., Dandey V.P., Dick M.S., Mazur A., Reckel S., Chami M., Scherer S., Huber M., Böckmann A. et al., 2015. Proceedings of the National Academy of Sciences of the United States of America, 112 (43) pp. 13237-13242. Peer-reviewed.
 
Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.
Meunier E., Dick M.S., Dreier R.F., Schürmann N., Kenzelmann Broz D., Warming S., Roose-Girma M., Bumann D., Kayagaki N., Takeda K. et al., 2014. Nature, 509 (7500) pp. 366-370. Peer-reviewed.
 
Getting rid of the bad apple: inflammasome-induced extrusion of Salmonella-infected enterocytes.
Broz P., 2014. Cell Host & Microbe, 16 (2) pp. 153-155. Peer-reviewed.
 
Toll-like receptor and inflammasome signals converge to amplify the innate bactericidal capacity of T helper 1 cells.
O'Donnell H., Pham O.H., Li L.X., Atif S.M., Lee S.J., Ravesloot M.M., Stolfi J.L., Nuccio S.P., Broz P., Monack D.M. et al., 2014. Immunity, 40 (2) pp. 213-224. Peer-reviewed.
 
A coupled protein and probe engineering approach for selective inhibition and activity-based probe labeling of the caspases.
Xiao J., Broz P., Puri A.W., Deu E., Morell M., Monack D.M., Bogyo M., 2013. Journal of the American Chemical Society, 135 (24) pp. 9130-9138. Peer-reviewed.
Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop.
Juruj C., Lelogeais V., Pierini R., Perret M., Py B.F., Jamilloux Y., Broz P., Ader F., Faure M., Henry T., 2013. Frontiers in Cellular and Infection Microbiology, 3 p. 14. Peer-reviewed.
 
Measuring inflammasome activation in response to bacterial infection.
Broz P., Monack D.M., 2013. Methods in Molecular Biology, 1040 pp. 65-84. Peer-reviewed.
 
Newly described pattern recognition receptors team up against intracellular pathogens.
Broz P., Monack D.M., 2013. Nature Reviews. Immunology, 13 (8) pp. 551-565. Peer-reviewed.
Noncanonical inflammasomes: caspase-11 activation and effector mechanisms.
Broz P., Monack D.M., 2013. PLoS Pathogens, 9 (2) pp. e1003144. Peer-reviewed.
 
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1.
Broz P., Ruby T., Belhocine K., Bouley D.M., Kayagaki N., Dixit V.M., Monack D.M., 2012. Nature, 490 (7419) pp. 288-291. Peer-reviewed.
 
Innate immune response to Salmonella typhimurium, a model enteric pathogen.
Broz P., Ohlson M.B., Monack D.M., 2012. Gut Microbes, 3 (2) pp. 62-70. Peer-reviewed.
 
Elevated AIM2-mediated pyroptosis triggered by hypercytotoxic Francisella mutant strains is attributed to increased intracellular bacteriolysis.
Peng K., Broz P., Jones J., Joubert L.M., Monack D., 2011. Cellular Microbiology, 13 (10) pp. 1586-1600. Peer-reviewed.
Innate immune recognition of francisella tularensis: activation of type-I interferons and the inflammasome.
Jones J.W., Broz P., Monack D.M., 2011. Frontiers in Microbiology, 2 p. 16. Peer-reviewed.
 
Molecular mechanisms of inflammasome activation during microbial infections.
Broz P., Monack D.M., 2011. Immunological Reviews, 243 (1) pp. 174-190. Peer-reviewed.
 
Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.
Jones J.W., Kayagaki N., Broz P., Henry T., Newton K., O'Rourke K., Chan S., Dong J., Qu Y., Roose-Girma M. et al., 2010. Proceedings of the National Academy of Sciences of the United States of America, 107 (21) pp. 9771-9776. Peer-reviewed.
 
Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing.
Broz P., von Moltke J., Jones J.W., Vance R.E., Monack D.M., 2010. Cell Host & Microbe, 8 (6) pp. 471-483. Peer-reviewed.
Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella.
Broz P., Newton K., Lamkanfi M., Mariathasan S., Dixit V.M., Monack D.M., 2010. Journal of Experimental Medicine, 207 (8) pp. 1745-1755. Peer-reviewed.
 
The type III secretion system tip complex and translocon.
Mueller C.A., Broz P., Cornelis G.R., 2008. Molecular Microbiology, 68 (5) pp. 1085-1095. Peer-reviewed.
 
Function and molecular architecture of the Yersinia injectisome tip complex.
Broz P., Mueller C.A., Müller S.A., Philippsen A., Sorg I., Engel A., Cornelis G.R., 2007. Molecular Microbiology, 65 (5) pp. 1311-1320. Peer-reviewed.
 
YscU recognizes translocators as export substrates of the Yersinia injectisome.
Sorg I., Wagner S., Amstutz M., Müller S.A., Broz P., Lussi Y., Engel A., Cornelis G.R., 2007. The EMBO Journal, 26 (12) pp. 3015-3024. Peer-reviewed.
 
Protective anti-V antibodies inhibit Pseudomonas and Yersinia translocon assembly within host membranes.
Goure J., Broz P., Attree O., Cornelis G.R., Attree I., 2005. Journal of Infectious Diseases, 192 (2) pp. 218-225. Peer-reviewed.
 
The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles.
Mueller C.A., Broz P., Müller S.A., Ringler P., Erne-Brand F., Sorg I., Kuhn M., Engel A., Cornelis G.R., 2005. Science, 310 (5748) pp. 674-676. Peer-reviewed.
 
The needle length of bacterial injectisomes is determined by a molecular ruler
Journet L., Agrain C., Broz P., Cornelis G. R., 2003. Science, 302 (5651) pp. 1757-60.
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