Silvano Gnesin

Publications | Phd and Masters theses

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45 publications

2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2012 |
2024
 
EANM guidance document: dosimetry for first-in-human studies and early phase clinical trials.
Stokke C., Gnesin S., Tran-Gia J., Cicone F., Holm S., Cremonesi M., Blakkisrud J., Wendler T., Gillings N., Herrmann K. et al., 2024/04. European journal of nuclear medicine and molecular imaging, 51 (5) pp. 1268-1286. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_4E53C3F0D378]
The contest between internal and external-beam dosimetry: The Zeno's paradox of Achilles and the tortoise.
Cicone F., Sjögreen Gleisner K., Sarnelli A., Indovina L., Gear J., Gnesin S., Kraeber-Bodéré F., Bischof Delaloye A., Valentini V., Cremonesi M., 2024/01. Physica medica, 117 p. 103188. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_43D0207A5F82]
2023
 
Monte Carlo Simulations Corroborate PET-Measured Discrepancies in Activity Assessments of Commercial <sup>90</sup>Y Vials.
Auditore L., Pistone D., Italiano A., Amato E., Gnesin S., 2023/09. Journal of nuclear medicine, 64 (9) pp. 1471-1477. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_061E7C064248]
99mTc-macroaggregated albumin SPECT/CT predictive dosimetry and dose-response relationship in uveal melanoma liver metastases treated with first-line selective internal radiation therapy.
Tabotta F., Gnesin S., Dunet V., Ponti A., Digklia A., Boughdad S., Schaefer N., Prior J.O., Villard N., Tsoumakidou G. et al., 2023/08/12. Scientific reports, 13 (1) p. 13118. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_21F17BF36DB0]
 
Correction to: EANM enabling guide: how to improve the accessibility of clinical dosimetry.
Gear J., Stokke C., Terwinghe C., Gnesin S., Sandström M., Tran-Gia J., Cremonesi M., Cicone F., Verburg F., Hustinx R. et al., 2023/08. European journal of nuclear medicine and molecular imaging, 50 (10) pp. 3157-3158. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_BFA0184E46CB]
 
Results from an EANM survey on time estimates and personnel responsible for main tasks in molecular radiotherapy dosimetry.
Gabiña P.M., Gleisner K.S., Cremonesi M., Stokke C., Flux G., Cicone F., Konijnenberg M., Aldridge M., Sandstrom M., Chiesa C. et al., 2023/07. European journal of nuclear medicine and molecular imaging, 50 (9) pp. 2595-2604. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_DD643D587E70]
From bench to bedside: 64Cu/177Lu 1C1m-Fc anti TEM-1: mice-to-human dosimetry extrapolations for future theranostic applications.
Gnesin S., Chouin N., Cherel M., Dunn S.M., Schaefer N., Faivre-Chauvet A., Prior J.O., Delage J.A., 2023/06/14. EJNMMI research, 13 (1) p. 59. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_91574209E2BB]
 
EANM enabling guide: how to improve the accessibility of clinical dosimetry.
Gear J., Stokke C., Terwinghe C., Gnesin S., Sandström M., Tran-Gia J., Cremonesi M., Cicone F., Verburg F., Hustinx R. et al., 2023/06. European journal of nuclear medicine and molecular imaging, 50 (7) pp. 1861-1868. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_CFE88D971A60]
 
A Multicenter Study on Observed Discrepancies Between Vendor-Stated and PET-Measured <sup>90</sup>Y Activities for Both Glass and Resin Microsphere Devices.
Gnesin S., Mikell J.K., Conti M., Prior J.O., Carlier T., Lima TVM, Dewaraja Y.K., 2023/05. Journal of nuclear medicine, 64 (5) pp. 825-828. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_FCF804BADDCE]
<sup>18</sup>F-PSMA-1007 salivary gland dosimetry: comparison between different methods for dose calculation and assessment of inter- and intra-patient variability.
Pistone D., Gnesin S., Auditore L., Italiano A., Cascini G.L., Amato E., Cicone F., 2023/04/07. Physics in medicine and biology, 68 (8). Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_C0193E521227]
2022
EANM dosimetry committee recommendations for dosimetry of 177Lu-labelled somatostatin-receptor- and PSMA-targeting ligands.
Sjögreen Gleisner K., Chouin N., Gabina P.M., Cicone F., Gnesin S., Stokke C., Konijnenberg M., Cremonesi M., Verburg F.A., Bernhardt P. et al., 2022/05. European journal of nuclear medicine and molecular imaging, 49 (6) pp. 1778-1809. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_EA14F99C4C05]
Comparison of absorbed dose extrapolation methods for mouse-to-human translation of radiolabelled macromolecules.
Cicone F., Viertl D., Denoël T., Stabin M.G., Prior J.O., Gnesin S., 2022/04/11. EJNMMI research, 12 (1) p. 21. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_0F49150CBF69]
EANM procedure guideline for the treatment of liver cancer and liver metastases with intra-arterial radioactive compounds.
Weber M., Lam M., Chiesa C., Konijnenberg M., Cremonesi M., Flamen P., Gnesin S., Bodei L., Kracmerova T., Luster M. et al., 2022/04. European journal of nuclear medicine and molecular imaging, 49 (5) pp. 1682-1699. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_5429972D1973]
2021
 
Simplified patient-specific renal dosimetry in 177Lu therapy: a proof of concept.
Ligonnet T., Pistone D., Auditore L., Italiano A., Amato E., Campennì A., Schaefer N., Boughdad S., Baldari S., Gnesin S., 2021/12/31. Physica medica, 92 pp. 75-85. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_2A1E7E7AB90C]
 
Dosimetry of nuclear medicine therapies: current controversies and impact on treatment optimization.
Cicone F., Gnesin S., Cremonesi M., 2021/12. The quarterly journal of nuclear medicine and molecular imaging, 65 (4) pp. 327-332. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_3ACF6B19FC06]
Copper-64-Labeled 1C1m-Fc, a New Tool for TEM-1 PET Imaging and Prediction of Lutetium-177-Labeled 1C1m-Fc Therapy Efficacy and Safety.
Delage J.A., Gnesin S., Prior J.O., Barbet J., Le Saëc P., Marionneau-Lambot S., Gouard S., Chérel M., Bourgeois M., Schaefer N. et al., 2021/11/25. Cancers, 13 (23) p. 5936. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_1AE49D79BF32]
 
Fifty Shades of Scandium: Comparative Study of PET Capabilities Using Sc-43 and Sc-44 with Respect to Conventional Clinical Radionuclides.
Lima TVM, Gnesin S., Strobel K., Pérez MDS, Roos J.E., Müller C., van der Meulen N.P., 2021/10/03. Diagnostics, 11 (10) p. 1826. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8A8C58AF63BB]
 
Relevance of Internal Bremsstrahlung photons from <sup>90</sup>Y decay: an experimental and Monte Carlo study.
Auditore L., Juget F., Italiano A., Pistone D., Nedjadi Y., Gnesin S., Amato E., 2021/10. Physica medica, 90 pp. 158-163. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_00C926EEA932]
 
International recommendations for personalised selective internal radiation therapy of primary and metastatic liver diseases with yttrium-90 resin microspheres.
Levillain H., Bagni O., Deroose C.M., Dieudonné A., Gnesin S., Grosser O.S., Kappadath S.C., Kennedy A., Kokabi N., Liu D.M. et al., 2021/05. European journal of nuclear medicine and molecular imaging, 48 (5) pp. 1570-1584. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_6C03E818DE0B]
 
Dose Optimization in Pediatric Studies: Why It Is Important and How It Can Benefit Every Nuclear Medicine Department.
Prior J.O., Mirzaei S., Gnesin S., Lalonde M.N., 2021/04. Journal of nuclear medicine, 62 (4) pp. 568-569. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D178257CFE28]
Impact of DOTA Conjugation on Pharmacokinetics and Immunoreactivity of [177Lu]Lu-1C1m-Fc, an Anti TEM-1 Fusion Protein Antibody in a TEM-1 Positive Tumor Mouse Model.
Delage J.A., Faivre-Chauvet A., Barbet J., Fierle J.K., Schaefer N., Coukos G., Viertl D., Dunn S.M., Gnesin S., Prior J.O., 2021/01/13. Pharmaceutics, 13 (1) p. 96. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_28C0A40301A0]
2020
 
Monte Carlo 90Y PET/CT dosimetry of unexpected focal radiation-induced lung damage after hepatic radioembolisation.
Auditore L., Amato E., Boughdad S., Meyer M., Testart N., Cicone F., Beigelman-Aubry C., Prior J.O., Schaefer N., Gnesin S., 2020/11/27. Physics in medicine and biology, 65 (23) p. 235014. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_912F2E9DF2C7]
 
<sup>177</sup>Lu radiolabeling and preclinical theranostic study of 1C1m-Fc: an anti-TEM-1 scFv-Fc fusion protein in soft tissue sarcoma.
Delage J.A., Faivre-Chauvet A., Fierle J.K., Gnesin S., Schaefer N., Coukos G., Dunn S.M., Viertl D., Prior J.O., 2020/08/17. EJNMMI research, 10 (1) p. 98. Peer-reviewed.
[DOI][Pmid][serval:BIB_4E04534CDA56]
 
Correction to: Preclinical Evaluation and Dosimetry of [111In] CHX-DTPA-scFv78-Fc Targeting Endosialin/Tumor Endothelial Marker 1 (TEM1)
Cicone Francesco, Denoël Thibaut, Gnesin Silvano, Riggi Nicolo, Irving Melita, Jakka Gopinadh, Schaefer Niklaus, Viertl David, Coukos George, Prior John O., 2020/08. 1.
[DOI][WoS][Pmid][serval:BIB_81A7D3CC3803]
Preclinical Evaluation and Dosimetry of [111In]CHX-DTPA-scFv78-Fc Targeting Endosialin/Tumor Endothelial Marker 1 (TEM1).
Cicone F., Denoël T., Gnesin S., Riggi N., Irving M., Jakka G., Schaefer N., Viertl D., Coukos G., Prior J.O., 2020/08. Molecular imaging and biology, 22 (4) pp. 979-991. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_813B48F40C5F]
Radiation dosimetry of 18F-AzaFol: A first in-human use of a folate receptor PET tracer
Gnesin S., Müller J., Burger I.A., Meisel A., Siano M., Früh M., Choschzick M., Müller C., Schibli R., Ametamey S.M. et al., 2020/04/08. EJNMMI research, 10 (1) p. 32. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_E6CC33686BEF]
Increased <sup>18</sup>F-FDG signal recovery from small physiological structures in digital PET/CT and application to the pituitary gland.
Meyer M., Allenbach G., Nicod Lalonde M., Schaefer N., Prior J.O., Gnesin S., 2020/01/15. Scientific reports, 10 (1) p. 368. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_070B4DB2E1EB]
Phantom-based image quality assessment of clinical <sup>18</sup>F-FDG protocols in digital PET/CT and comparison to conventional PMT-based PET/CT.
Gnesin S., Kieffer C., Zeimpekis K., Papazyan J.P., Guignard R., Prior J.O., Verdun F.R., Lima TVM, 2020/01/06. EJNMMI physics, 7 (1) p. 1. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_44D4CADAB6FE]
2019
Generalized SDNR analysis based on signal and noise power.
Monnin P., Gnesin S., Verdun F.R., Marshall N.W., 2019/08. Physica medica, 64 pp. 10-15. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_7F07EF29A034]
Internal radiation dosimetry of a <sup>152</sup>Tb-labeled antibody in tumor-bearing mice.
Cicone F., Gnesin S., Denoël T., Stora T., van der Meulen N.P., Müller C., Vermeulen C., Benešová M., Köster U., Johnston K. et al., 2019/06/11. EJNMMI research, 9 (1) p. 53. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_22C26DF26A4B]
2018
First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist (68)Ga-NODAGA-MJ9.
Gnesin S., Cicone F., Mitsakis P., Van der Gucht A., Baechler S., Miralbell R., Garibotto V., Zilli T., Prior J.O., 2018/12/12. EJNMMI research, 8 (1) p. 108. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_D3676E6FE53B]
 
Swiss survey on hybrid imaging CTs doses in Nuclear Medicine and proposed national dose reference levels.
Lima TVM, Gnesin S., Ryckx N., Strobel K., Stritt N., Linder R., Swiss Workgroup on Nuclear Medicine DRLs, 2018/12. Zeitschrift fur medizinische Physik, 28 (4) pp. 265-275. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C712E05C9E9C]
 
A Monte Carlo model for the internal dosimetry of choroid plexuses in nuclear medicine procedures.
Amato E., Cicone F., Auditore L., Baldari S., Prior J.O., Gnesin S., 2018/05. Physica medica, 49 pp. 52-57. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_2B4DBA3A6354]
2017
Cardiac PET/CT with Rb-82: optimization of image acquisition and reconstruction parameters.
Chilra P., Gnesin S., Allenbach G., Monteiro M., Prior J.O., Vieira L., Pires Jorge J.A., 2017/12. EJNMMI physics, 4 (1) p. 10. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_61E37EB0C15C]
First in-human radiation dosimetry of (68)Ga-NODAGA-RGDyK.
Gnesin S., Mitsakis P., Cicone F., Deshayes E., Dunet V., Gallino A.F., Kosinski M., Baechler S., Buchegger F., Viertl D. et al., 2017/12. EJNMMI research, 7 (1) p. 43. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B7AEC05B72D8]
 
Clinical evaluation of the radiolanthanide terbium-152: first-in-human PET/CT with (152)Tb-DOTATOC.
Baum R.P., Singh A., Benešová M., Vermeulen C., Gnesin S., Köster U., Johnston K., Müller D., Senftleben S., Kulkarni H.R. et al., 2017/10/31. Dalton transactions, 46 (42) pp. 14638-14646. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_9D479621E0AB]
 
Quantification and monitoring of PET/CT data in multicentre trials: The Swiss SAKK 56/07 trial experience. Quantification et surveillance de données PET/CT dans les études multicentriques : l’expérience de l’étude suisse SAKK 56/07
Gnesin S., Deshayes E., Camus F., Dunet V., Prior JO., Verdun F., 2017/08/07. Médecine Nucléaire, 41 (4) pp. 259-266. Peer-reviewed.
[serval:BIB_8A671BE0F8D4]
 
Resin Versus Glass Microspheres for (90)Y Transarterial Radioembolization: Comparing Survival in Unresectable Hepatocellular Carcinoma Using Pretreatment Partition Model Dosimetry.
Van Der Gucht A., Jreige M., Denys A., Blanc-Durand P., Boubaker A., Pomoni A., Mitsakis P., Silva-Monteiro M., Gnesin S., Lalonde M.N. et al., 2017/08. Journal of nuclear medicine, 58 (8) pp. 1334-1340. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8CA607532E3A]
 
(18)F-FDG PET/CT predicts survival after (90)Y transarterial radioembolization in unresectable hepatocellular carcinoma.
Jreige M., Mitsakis P., Van Der Gucht A., Pomoni A., Silva-Monteiro M., Gnesin S., Boubaker A., Nicod-Lalonde M., Duran R., Prior J.O. et al., 2017/07. European journal of nuclear medicine and molecular imaging, 44 (7) pp. 1215-1222. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E1E635AA8F47]
 
Quantification and monitoring of PET/CT data in multicentre trials: The Swiss SAKK 56/07 trial experience
Gnesin S., Deshayes E., Camus F., Dunet V., Prior J.O., Verdun F.R., 2017/07. Médecine Nucléaire, 41 (4) pp. 259-266.
[DOI][WoS][serval:BIB_AB946FBC707E]
 
18F-FDG PET/CT But Not Morphological Parameters Predict Survival after Yttrium-90 Transarterial Radioembolization in Unresectable Hepatocellular Carcinoma: an updated analysis
Jreige Mario, MITSAKIS PERIKLIS, Van Der Gucht Axel, Monteiro Marina, Gnesin Silvano, Nicod-Lalonde Marie, Duran Rafael, Prior John, Schaefer Niklaus, 2017. dans SNMMI 2021, Society of Nuclear Medicine.
[serval:BIB_342117826BA9]
Cardiac Radionuclide Imaging in Rodents: A Review of Methods, Results, and Factors at Play.
Cicone F., Viertl D., Quintela Pousa A.M., Denoël T., Gnesin S., Scopinaro F., Vozenin M.C., Prior J.O., 2017. Frontiers in medicine, 4 p. 35. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_791078E7C548]
2016
Phantom Validation of Tc-99m Absolute Quantification in a SPECT/CT Commercial Device.
Gnesin S., Leite Ferreira P., Malterre J., Laub P., Prior J.O., Verdun F.R., 2016. Computational and mathematical methods in medicine, 2016 p. 4360371. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_72FD3CCBBBFC]
2015
Medical physicists' implication in radiological diagnostic procedures: results after 1 y of experience.
Ryckx N., Gnesin S., Meuli R., Elandoy C., Verdun F.R., 2015/04. Radiation Protection Dosimetry, 164 (1-2) pp. 120-125.
[URN][DOI][WoS][Pmid][serval:BIB_950D01660012]
2012
 
Tc-99m-MAA SPECT-derived tumor-to-normal liver ratios for partition model dosimetry in selective internal radiation therapy (SIRT)
Gnesin S., Bertholet J., Boubaker A., Cherbuin N., Prior J., Verdun F., Baechler S., 2012. pp. S321 dans 25th Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), European Journal of Nuclear Medicine and Molecular Imaging.
[WoS][serval:BIB_9BBA153BE8BD]
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