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Jean-Pierre Mach

Coordonnées Publications  
Publications | Mémoires et thèses

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Golay J., Choblet S., Iwaszkiewicz J., Cérutti P., Ozil A., Loisel S., Pugnière M., Ubiali G., Zoete V., Michielin O. et al., Design and Validation of a Novel Generic Platform for the Production of Tetravalent IgG1-like Bispecific Antibodies. Journal of Immunology 196(7), pp. 3199-3211, 2016. [DOI] [Web of Science] [Pubmed] ok

Ulmer A.J., Kaconis Y., Heinbockel L., Correa W., Alexander C., Rietschel E.T., Mach J.P., Gorczynski R.M., Heini A., Rössle M. et al., Enhancing actions of peptides derived from the γ-chain of fetal human hemoglobin on the immunostimulant activities of monophosphoryl lipid A. Innate Immunity 22(3), pp. 168-180, 2016. [DOI] [Web of Science] [Pubmed]

Zhang L., Tschumi B.O., Lopez-Mejia I.C., Oberle S.G., Meyer M., Samson G., Rüegg M.A., Hall M.N., Fajas L., Zehn D. et al., Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner. Cell Reports 14(5), pp. 1206-1217, 2016. [DOI] [Web of Science] [Pubmed]


Corgnac S., Perret R., Zhang L., Mach J.P., Romero P., Donda A., iNKT/CD1d-antitumor immunotherapy significantly increases the efficacy of therapeutic CpG/peptide-based cancer vaccine. Journal for Immunotherapy of Cancer 2(1), p. 39, 2014. [Document] [DOI] [Pubmed] ok

Engelhardt N., Mach J.P., In memory of Garry Abelev 1928-2013. Tumour Biology 35(7), pp. 6169-6173, 2014. [DOI] [Web of Science] [Pubmed]

Galluzzi L., Vacchelli E., Bravo-San Pedro J.M., Buqué A., Senovilla L., Baracco E.E., Bloy N., Castoldi F., Abastado J.P., Agostinis P. et al., Classification of current anticancer immunotherapies. Oncotarget 5(24), pp. 12472-12508, 2014. [Document] [Web of Science] [Pubmed]

Zhang L., Tschumi B.O., Corgnac S., Rüegg M.A., Hall M.N., Mach J.P., Romero P., Donda A., Mammalian target of rapamycin complex 1 orchestrates invariant NKT cell differentiation and effector function. Journal of Immunology 193(4), pp. 1759-1765, 2014. [DOI] [Web of Science] [Pubmed]


Buchegger F., Larson S.M., Mach J.P., Chalandon Y., Dietrich P.Y., Cairoli A., Prior J.O., Romero P., Speiser D.E., Radioimmunotherapy combined with maintenance anti-CD20 antibody may trigger long-term protective T cell immunity in follicular lymphoma patients. Clinical and Developmental Immunology 2013, p. 875343, 2013. [Document] [DOI] [Web of Science] [Pubmed]

Buchegger F., Mach J.P., Press O.W., Bischof Delaloye A., Larson S.M., Prior J.O., Ketterer N., Improving the chance of cure of follicular lymphoma by combining immunotherapy and radioimmunotherapy based on anti-CD20 antibodies? Annals of Oncology 24(7), pp. 1948-1949, 2013. [Document] [DOI] [Web of Science] [Pubmed]

Corgnac S., Perret R., Derré L., Zhang L., Stirnemann K., Zauderer M., Speiser D.E., Mach J.P., Romero P., Donda A., CD1d-antibody fusion proteins target iNKT cells to the tumor and trigger long-term therapeutic responses. Cancer Immunology, Immunotherapy 62(4), pp. 747-760, 2013. [Document] [DOI] [Web of Science] [Pubmed]


Larbouret C., Gaborit N., Chardès T., Coelho M., Campigna E., Bascoul-Mollevi C., Mach J.P., Azria D., Robert B., Pèlegrin A., In pancreatic carcinoma, dual EGFR/HER2 targeting with cetuximab/trastuzumab is more effective than treatment with trastuzumab/erlotinib or lapatinib alone: implication of receptors' down-regulation and dimers' disruption. Neoplasia 14(2), pp. 121-130, 2012. [Web of Science] [Pubmed] ok

Mach J.P., Introduction to monoclonal antibodies. Cancer Immunity 12, p. 11, 2012. [Document] [url site éditeur] [Pubmed]


Loisel S., André P.A., Golay J., Buchegger F., Kadouche J., Cérutti M., Bologna L., Kosinski M., Viertl D., Delaloye A.B. et al., Antitumour effects of single or combined monoclonal antibodies directed against membrane antigens expressed by human B cells leukaemia. Molecular Cancer 10, p. 42, 2011. [Document] [DOI] [Web of Science] [Pubmed]


Golay J., Bologna L., André P.A., Buchegger F., Mach J.P., Boumsell L., Introna M., Possible misinterpretation of the mode of action of therapeutic antibodies in vitro: homotypic adhesion and flow cytometry result in artefactual direct cell death. Blood 116(17), pp. 3372-3373, 2010. [DOI] [Web of Science] [Pubmed]

Larbouret C., Robert B., Bascoul-Mollevi C., Penault-Llorca F., Ho-Pun-Cheung A., Morisseau S., Navarro-Teulon I., Mach J.P., Pèlegrin A., Azria D., Combined cetuximab and trastuzumab are superior to gemcitabine in the treatment of human pancreatic carcinoma xenografts. Annals of Oncology 21(1), pp. 98-103, 2010. [DOI] [Web of Science] [Pubmed] ok


Kerth A., Garidel P., Howe J., Alexander C., Mach J.P., Waelli T., Blume A., Rietschel E.Th., Brandenburg K., An infrared reflection-absorption spectroscopic (IRRAS) study of the interaction of lipid A and lipopolysaccharide Re with endotoxin-binding proteins. Medicinal Chemistry 5(6), pp. 535-542, 2009. [DOI] [Web of Science] [Pubmed]

Khatri I., Alexander C., Brandenburg K., Fournier K., Mach J.P., Rietschel E.T., Ulmer A.J., Terzioglu E., Waelli T., Gorczynski R.M., Induction of tolerogenic vs immunogenic dendritic cells (DCs) in the presence of GM-CSF is regulated by the strength of signaling from monophosphoryl lipid A (MPLA) in association with glutathione and fetal hemoglobin gamma-chain. Immunology letters 124(1), pp. 44-49, 2009. [DOI] [Web of Science] [Pubmed] ok


Germain C., Campigna E., Salhi I., Morisseau S., Navarro-Teulon I., Mach J.P., Pèlegrin A., Robert B., Redirecting NK cells mediated tumor cell lysis by a new recombinant bifunctional protein. Protein engineering, design and selection 21(11), pp. 665-672, 2008. [Document] [DOI] [Web of Science] [Pubmed] ok

Howe J., Garidel P., Roessle M., Richter W., Alexander C., Fournier K., Mach J.P., Waelli T., Gorczynski R.M., Ulmer A.J. et al., Structural investigations into the interaction of hemoglobin and part structures with bacterial endotoxins. Innate immunity 14(1), pp. 39-49, 2008. [DOI] [Web of Science] [Pubmed] ok

Howe J., Richter W., Hawkins L., Rössle M., Alexander C., Fournier K., Mach J.P., Waelli T., Gorczynski R.M., Ulmer A.J. et al., Hemoglobin enhances the biological activity of synthetic and natural bacterial (endotoxic) virulence factors: a general principle. Medicinal chemistry 4(6), pp. 520-525, 2008. [DOI] [Web of Science] [Pubmed] ok

Khatri I., Alexander C., Brandenburg K., Fournier K., Lee L., Mach J.P., Rietschel E.T., Ulmer A.J., Waelli T., Gorczynski R.M., A role for altered TLR gene expression in association with increased expression of CD200R in the induction of mucosal tissue CD4(+) Treg in aged mice following gavage with a liver extract along with intramuscular monophosphoryl lipid A (MPLA) injection. Experimental gerontology 43(8), pp. 771-781, 2008. [DOI] [Web of Science] [Pubmed] ok

Stirnemann K., Romero J. F., Baldi L., Robert B., Cesson V., Besra G. S., Zauderer M., Wurm F., Corradin G., Mach J. P. et al., Sustained activation and tumor targeting of NKT cells using a CD1d-anti-HER2-scFv fusion protein induce antitumor effects in mice. Journal of Clinical Investigation 118(3), pp. 994-1005, 2008. [DOI] [Web of Science] [Pubmed] ok

Ychou M., Azria D., Menkarios C., Faurous P., Quenet F., Saint-Aubert B., Rouanet P., Pèlegrin M., Bascoul-Mollevi C., Guerreau D. et al., Adjuvant radioimmunotherapy trial with iodine-131-labeled anti-carcinoembryonic antigen monoclonal antibody F6 F(ab')2 after resection of liver metastases from colorectal cancer. Clinical cancer research 14(11), pp. 3487-3493, 2008. [DOI] [Web of Science] [Pubmed] ok


Gorczynski R.M., Alexander C., Bessler W., Brandenburg K., Fournier K., Mach J.P., Mueller S., Rietschel E.T., Ulmer A.J., Waelli T. et al., An alteration in the levels of populations of CD4+ Treg is in part responsible for altered cytokine production by cells of aged mice which follows injection with a fetal liver extract. Immunology letters 109(2), pp. 101-112, 2007. [DOI] [Web of Science] [Pubmed] ok

Howe J., Hammer M., Alexander C., Rössle M., Fournier K., Mach J.P., Waelli T., Gorczynski R.M., Ulmer A.J., Zähringer U. et al., Biophysical characterization of the interaction of endotoxins with hemoglobins. Medicinal chemistry 3(1), pp. 13-20, 2007. [DOI] [Web of Science] [Pubmed] ok

Larbouret C., Robert B., Navarro-Teulon I., Thèzenas S., Ladjemi M.Z., Morisseau S., Campigna E., Bibeau F., Mach J.P., Pèlegrin A. et al., In vivo therapeutic synergism of anti-epidermal growth factor receptor and anti-HER2 monoclonal antibodies against pancreatic carcinomas. Clinical Cancer Research 13(11), pp. 3356-3362, 2007. [DOI] [Web of Science] [Pubmed] ok


Buchegger F., Antonescu C., Delaloye A.B., Helg C., Kovacsovics T., Kosinski M., Mach J.P., Ketterer N., Long-term complete responses after 131I-tositumomab therapy for relapsed or refractory indolent non-Hodgkin's lymphoma. British journal of cancer 94(12), pp. 1770-1776, 2006. [Document] [DOI] [Web of Science] [Pubmed] ok

Cesson V., Stirnemann K., Robert B., Luescher I., Filleron T., Corradin G., Mach J.P., Donda A., Active antiviral T-lymphocyte response can be redirected against tumor cells by antitumor antibody x MHC/viral peptide conjugates. Clinical cancer research 12(24), pp. 7422-7430, 2006. [DOI] [Web of Science] [Pubmed] ok

Fattah O.M., Cloutier S.M., Kündig C., Felber L.M., Gygi C.M., Jichlinski P., Leisinger H.J., Gauthier E.R., Mach J.P., Deperthes D., Peptabody-EGF: a novel apoptosis inducer targeting ErbB1 receptor overexpressing cancer cells. International Journal of Cancer 119(10), pp. 2455-2463, 2006. [DOI] [Web of Science] [Pubmed] ok

Gorczynski R.M., Alexander C., Bessler W., Brandenburg K., Fournier K., Hoffmann P., Mach J.P., Mueller S., Rietschel E.T., Terzioglu E. et al., Role of MIF and glutathione, in association with fetal ovine globin chain (Hbgamma) and LPS, in induction of TNFalpha from cells of young and aged mice, and PBL from healthy human populations. Immunology Letters 105(2), pp. 140-149, 2006. [DOI] [Web of Science] [Pubmed] ok


Germain C., Larbouret C., Cesson V., Donda A., Held W., Mach J.P., Pèlegrin A., Robert B., MHC class I-related chain A conjugated to antitumor antibodies can sensitize tumor cells to specific lysis by natural killer cells. Clinical Cancer Research 11(20), pp. 7516-7522, 2005. [DOI] [Web of Science] [Pubmed] ok

Gorczynski R.M., Alexander C., Bessler W., Fournier K., Hoffmann P., Mach J.P., Rietschel E.T., Song L., Waelli T., Westphal O. et al., Analysis of interaction of cloned human and/or sheep fetal hemoglobin gamma-chain and LPS in augmenting induction of inflammatory cytokine production in vivo and in vitro. Immunology Letters 100(2), pp. 120-129, 2005. [DOI] [Web of Science] [Pubmed] ok

Müller S., Hoffmann P., Esche U.V., Mach J.P., Gorczynski R.M., Waelli T., Alexander C., Zähringer U., Rietschel E.T., Bessler W.G. et al., A fetal sheep liver extract containing immunostimulatory substances including LPS acts as leukocyte activator in cells of LPS responder and non responder mice. International Immunopharmacology 5(13-14), pp. 1809-1819, 2005. [DOI] [Web of Science] [Pubmed] ok


Buchegger F., Adamer F., Schaffland A.O., Kosinski M., Grannavel C., Dupertuis Y.M., de Tribolet N., Mach J.P., Delaloye A.B., Highly efficient DNA incorporation of intratumourally injected [125I]iododeoxyuridine under thymidine synthesis blocking in human glioblastoma xenografts. International Journal of Cancer 110(1), pp. 145-149, 2004. [DOI] [Web of Science] [Pubmed] ok

Gorczynski R.M., Alexander C., Bessler W., Fournier K., Hoffmann P., Mach J.P., Manuel J., Ramakrishna V., Rietschel E.T., Song L. et al., Characterization of an interaction between fetal hemoglobin and lipid A of LPS resulting in augmented induction of cytokine production in vivo and in vitro. International Immunopharmacology 4(14), pp. 1859-1872, 2004. [DOI] [Web of Science] [Pubmed] ok


Donda A., Cesson V., Mach J.P., Corradin G., Primus F.J., Robert B., In vivo targeting of an anti-tumor antibody coupled to antigenic MHC class I complexes induces specific growth inhibition and regression of established syngeneic tumor grafts. Cancer Immunity 3, p. 11, 2003. [Pubmed]


Cloutier S.M., Chagas J.R., Mach J.P., Gygi C.M., Leisinger H.J., Deperthes D., Substrate specificity of human kallikrein 2 (hK2) as determined by phage display technology. European journal of biochemistry / FEBS 269(11), pp. 2747-54, 2002. [DOI] [Web of Science] [Pubmed] ok


Dupertuis Y.M., Vazquez M., Mach J.P., De Tribolet N., Pichard C., Slosman D.O., Buchegger F., Fluorodeoxyuridine improves imaging of human glioblastoma xenografts with radiolabeled iododeoxyuridine. Cancer Research 61(21), pp. 7971-7977, 2001. [Web of Science] [Pubmed]

Houimel M., Schneider P., Terskikh A., Mach J.P., Selection of peptides and synthesis of pentameric peptabody molecules reacting specifically with ErbB-2 receptor. International Journal of Cancer 92(5), pp. 748-755, 2001. [DOI] [Web of Science] [Pubmed]

Robert B., Guillaume P., Luescher I., Doucey M.A., Cerottini J.C., Romero P., Mach J.P., Redirecting anti-viral CTL against cancer cells by surface targeting of monomeric MHC class I-viral peptide conjugated to antibody fragments. Cancer Immunity 1(2), pp. 1-13, 2001. [url site éditeur] [Pubmed]

Wong C., Waibel R., Sheets M., Mach J.P., Finnern R., Human scFv antibody fragments specific for the epithelial tumour marker MUC-1, selected by phage display on living cells. Cancer Immunology, Immunotherapy 50(2), pp. 93-101, 2001. [DOI] [Web of Science] [Pubmed] ok


Buchegger F., Allal A.S., Roth A., Papazyan J.P., Dupertuis Y., Mirimanoff R.O., Gillet M., Pelegrin A., Mach J.P., Slosman D.O., Combined radioimmunotherapy and radiotherapy of liver metastases from colorectal cancer: a feasibility study. Anticancer Research 20(3B), pp. 1889-1896, 2000. [Web of Science] [Pubmed]

Buchegger F., Roth A., Allal A., Dupertuis Y.M., Slosman D.O., Delaloye A.B., Mach J.P., Radioimmunotherapy of colorectal cancer liver metastases: combination with radiotherapy. Annals of the New York Academy of Sciences 910, pp. 263-9; discussion 269-70, 2000. [DOI] [Web of Science] [Pubmed] ok

Cloutier S.M., Couty S., Terskikh A., Marguerat L., Crivelli V., Pugnières M., Mani J.C., Leisinger H.J., Mach J.P., Deperthes D., Streptabody, a high avidity molecule made by tetramerization of in vivo biotinylated, phage display-selected scFv fragments on streptavidin. Molecular Immunology 37(17), pp. 1067-1077, 2000. [DOI] [Web of Science] [Pubmed] ok

Gervaz P., Blanchard A., Pampallona S., Mach J.P., Fontolliet C., Gillet M., Prognostic value of postoperative carcinoembryonic antigen concentration and extent of invasion of resection margins after hepatic resection for colorectal metastases. European Journal of Surgery 166(7), pp. 557-561, 2000. [DOI] [Web of Science] [Pubmed] ok

Pèlegrin A., Xavier F., Barbet J., Bartholeyns J., Baty D., Buchegger F., Chatal J.F., Dufief F., Gurreau D., Gruaz-Guyon A. et al., Immunociblage des tumeurs: situation et perspectives en 2000. Bulletin du Cancer 87(11), pp. 777-791, 2000. [Document] [Web of Science] [Pubmed] ok

Robert B., Guillaume P., Luescher I., Romero P., Mach J.P., Antibody-conjugated MHC class I tetramers can target tumor cells for specific lysis by T lymphocytes. European Journal of Immunology 30(11), pp. 3165-3170, 2000. [DOI] [Web of Science] [Pubmed] ok


Escobar P., Yu Z., Terskikh A., Holmes N., Corradin G., Mach J.P., Healy F., Induction in transgenic mice of HLA-A2.1-restricted cytotoxic T cells specific for a peptide sequence from a mutated p21ras protein. Clinical and Experimental Immunology 116(2), pp. 214-219, 1999. [Web of Science] [Pubmed]

Houimel M., Mach J.P., Corthésy-Theulaz I., Corthésy B., Fisch I., New inhibitors of Helicobacter pylori urease holoenzyme selected from phage-displayed peptide libraries. European Journal of Biochemistry 262(3), pp. 774-780, 1999. [DOI] [Web of Science] [Pubmed]

Leconte A., Garambois V., Ychou M., Robert B., Pourquier D., Terskikh A., Mach J.P., Pèlegrin A., Involvement of circulating CEA in liver metastases from colorectal cancers re-examined in a new experimental model. British Journal of Cancer 80(9), pp. 1373-1379, 1999. [Document] [DOI] [Web of Science] [Pubmed] ok

Robert B., Dorvillius M., Buchegger F., Garambois V., Mani J.C., Pugnières M., Mach J.P., Pèlegrin A., Tumor targeting with newly designed biparatopic antibodies directed against two different epitopes of the carcinoembryonic antigen (CEA). International Journal of Cancer 81(2), pp. 285-291, 1999. [DOI] [Web of Science] [Pubmed] ok

Waibel R., Alberto R., Willuda J., Finnern R., Schibli R., Stichelberger A., Egli A., Abram U., Mach J.P., Plückthun A. et al., Stable one-step technetium-99m labeling of His-tagged recombinant proteins with a novel Tc(I)-carbonyl complex. Nature biotechnology 17(9), pp. 897-901, 1999. [DOI] [Web of Science] [Pubmed] ok


Eberl G., Jiang S., Yu Z., Schneider P., Corradin G., Mach J.P., An anti-CD19 antibody coupled to a tetanus toxin peptide induces efficient Fas ligand (FasL)-mediated cytotoxicity of a transformed human B cell line by specific CD4+ T cells. Clinical and Experimental Immunology 114(2), pp. 173-178, 1998. [DOI] [Web of Science] [Pubmed] ok

Westerman P., Glanzmann T., Andrejevic S., Braichotte D.R., Forrer M., Wagnieres G.A., Monnier P., van den Bergh H., Mach J.P., Folli S., Long circulating half-life and high tumor selectivity of the photosensitizer meta-tetrahydroxyphenylchlorin conjugated to polyethylene glycol in nude mice grafted with a human colon carcinoma. International Journal of Cancer 76(6), pp. 842-850, 1998. [DOI] [Web of Science] [Pubmed] ok

Ychou M., Pelegrin A., Faurous P., Robert B., Saccavini J.C., Guerreau D., Rossi J.F., Fabbro M., Buchegger F., Mach J.P. et al., Phase-I/II radio-immunotherapy study with Iodine-131-labeled anti-CEA monoclonal antibody F6 F(ab')2 in patients with non-resectable liver metastases from colorectal cancer. International Journal of Cancer 75(4), pp. 615-619, 1998. [DOI] [Web of Science] [Pubmed]


Delaloye A.B., Delaloye B., Buchegger F., Vogel C.A., Gillet M., Mach J.P., Smith A., Schubiger P.A., Comparison of copper-67- and iodine-125-labeled anti-CEA monoclonal antibody biodistribution in patients with colorectal tumors. Journal of Nuclear Medicine 38(6), pp. 847-853, 1997. [Web of Science] [Pubmed] ok

Sun L.Q., Vogel C.A., Mirimanoff R.O., Coucke P., Slosman D.O., Mach J.P., Buchegger F., Timing effects of combined radioimmunotherapy and radiotherapy on a human solid tumor in nude mice. Cancer Research 57(7), pp. 1312-1319, 1997. [Web of Science] [Pubmed] ok

Terskikh A.V., Le Doussal J.M., Crameri R., Fisch I., Mach J.P., Kajava A.V., "Peptabody": a new type of high avidity binding protein. Proceedings of the National Academy of Sciences of the United States of America 94(5), pp. 1663-1668, 1997. [DOI] [Web of Science] [Pubmed] ok


Buchegger F., Gillet M., Doenz F., Vogel C.A., Achtari C., Mach J.P., Delaloye B., Delaloye A.B., Biodistribution of anti-CEA F(ab')2 fragments after intra-arterial and intravenous injection in patients with liver metastases due to colorectal carcinoma. Nuclear Medicine Communications 17(6), pp. 500-503, 1996. [DOI] [Web of Science] [Pubmed] ok

Buchegger F., Mach J.P., Folli S., Delaloye B., Bischof-Delaloye A., Pèlegrin A., Higher efficiency of 131I-labeled anti-carcinoembryonic antigen-monoclonal antibody F(ab')2 as compared to intact antibodies in radioimmunotherapy of established human colon carcinoma grafted in nude mice. Recent Results in Cancer Research 141, pp. 19-35, 1996. [Pubmed]

Galmiche M.C., Vogel C.A., Bischof Delaloye A., Schmidt P.M., Healy F., Mach J.P., Buchegger F., Combined effects of interleukin-3 and interleukin-11 on hematopoiesis in irradiated mice. Experimental Hematology 24(11), pp. 1298-306, 09-1996. [Web of Science] [Pubmed]

Robert B., Mach J.P., Mani J.C., Ychou M., Folli S., Artus J.C., Pèlegrin A., Cytokine targeting in tumors using a bispecific antibody directed against carcinoembryonic antigen and tumor necrosis factor alpha. Cancer research 56(20), pp. 4758-4765, 1996. [Web of Science] [Pubmed] ok

Vogel C.A., Galmiche M.C., Westermann P., Sun L.Q., Pèlegrin A., Folli S., Bischof Delaloye A., Slosman D.O., Mach J.P., Buchegger F., Carcinoembryonic antigen expression, antibody localisation and immunophotodetection of human colon cancer liver metastases in nude mice: a model for radioimmunotherapy. International Journal of Cancer 67(2), pp. 294-302, 1996. [DOI] [Web of Science] [Pubmed]


Buchegger F., Mach J.P., Pèlegrin A., Gillet M., Vogel C.A., Buclin T., Ryser J.E., Delaloye B., Delaloye A.B., Radiolabeled chimeric anti-CEA monoclonal antibody compared with the original mouse monoclonal antibody for surgically treated colorectal carcinoma. Journal of Nuclear Medicine 36(3), pp. 420-429, 1995. [Web of Science] [Pubmed]

Frikart L., Fournier K., Mach J.P., Givel J.C., Potential value of biliary CEA assay in early detection of colorectal adenocarcinoma liver metastases. European Journal of Surgical Oncology 21(3), pp. 276-279, 1995. [DOI] [Pubmed] ok


de Moraes J.Z., Gesztesi J.L., Westermann P., Le Doussal J.M., Lopes J.D., Mach J.P., Anti-idiotypic monoclonal antibody AB3, reacting with the primary antigen (CEA), can localize in human colon-carcinoma xenografts as efficiently as AB1. International Journal of Cancer 57(4), pp. 586-591, 1994. [DOI] [Web of Science] [Pubmed] ok

Folli S., Westermann P., Braichotte D., Pèlegrin A., Wagnières G., van den Bergh H., Mach J.P., Antibody-indocyanin conjugates for immunophotodetection of human squamous cell carcinoma in nude mice. Cancer Research 54(10), pp. 2643-2649, 1994. [Web of Science] [Pubmed] ok

Santoro L., Drouet C., Reboul A., Mach J.P., Colomb M.G., Covalent binding of C3b to monoclonal antibodies selectively up-regulates heavy chain epitope recognition by T cells. European Journal of Immunology 24(7), pp. 1620-1626, 1994. [DOI] [Web of Science] [Pubmed] ok

Terskikh A., Couty S., Pèlegrin A., Hardman N., Hunziker W., Mach J.P., Dimeric recombinant IgA directed against carcino-embryonic antigen, a novel tool for carcinoma localization. Molecular immunology 31(17), pp. 1313-1319, 1994. [DOI] [Web of Science] [Pubmed] ok

Yu Z., Healy F., Valmori D., Escobar P., Corradin G., Mach J.P., Peptide-antibody conjugates for tumour therapy: a MHC-class-II-restricted tetanus toxin peptide coupled to an anti-Ig light chain antibody can induce cytotoxic lysis of a human B-cell lymphoma by specific CD4 T cells. International Journal of Cancer 56(2), pp. 244-248, 1994. [DOI] [Web of Science] [Pubmed]


Folli S., Pèlegrin A., Chalandon Y., Yao X., Buchegger F., Lienard D., Lejeune F., Mach J.P., Tumor-necrosis factor can enhance radio-antibody uptake in human colon carcinoma xenografts by increasing vascular permeability. International Journal of Cancer 53(5), pp. 829-836, 1993. [DOI] [Web of Science] [Pubmed] ok

Kurth M., Pèlegrin A., Rose K., Offord R.E., Pochon S., Mach J.P., Buchegger F., Site-specific conjugation of a radioiodinated phenethylamine derivative to a monoclonal antibody results in increased radioactivity localization in tumor. Journal of Medicinal Chemistry 36(9), pp. 1255-1261, 1993. [DOI] [Web of Science] [Pubmed] ok

Terskikh A., Mach J.P., Pèlegrin A., Marked increase in the secretion of a fully antigenic recombinant carcinoembryonic antigen obtained by deletion of its hydrophobic tail. Molecular Immunology 30(10), pp. 921-927, 1993. [DOI] [Web of Science] [Pubmed] ok

Vogel C.A., Bischof-Delaloye A., Mach J.P., Pèlegrin A., Hardman N., Delaloye B., Buchegger F., Direct comparison of a radioiodinated intact chimeric anti-CEA MAb with its F(ab')2 fragment in nude mice bearing different human colon cancer xenografts. British Journal of Cancer 68(4), pp. 684-690, 1993. [DOI] [Web of Science] [Pubmed] ok

Ychou M., Ricard M., Lumbroso J., Rougier P., Mach J.P., Buchegger F., Saccavini J.C., Lasser P., Elias D., Eschwege F., Potential contribution of 131I-labelled monoclonal anti-CEA antibodies in the treatment of liver metastases from colorectal carcinomas: pretherapeutic study with dose recovery in resected tissues. European Journal of Cancer 29A(8), pp. 1105-1111, 1993. [DOI] [Web of Science] [Pubmed] ok


Buchegger F., Pèlegrin A., Hardman N., Heusser C., Lukas J., Dolci W., Mach J.P., Different behaviour of mouse-human chimeric antibody F(ab')2 fragments of IgG1, IgG2 and IgG4 sub-class in vivo. International Journal of Cancer 50(3), pp. 416-422, 1992. [DOI] [Web of Science] [Pubmed]

Chalandon Y., Mach J.P., Pèlegrin A., Folli S., Buchegger F., Combined radioimmunotherapy and chemotherapy of human colon carcinoma grafted in nude mice, advantages and limitations. Anticancer Research 12(4), pp. 1131-1139, 1992. [Web of Science] [Pubmed] ok

de Moraes J.Z., Carneiro C.R., Buchegger F., Mach J.P., Lopes J.D., Induction of an immune response through the idiotypic network with monoclonal anti-idiotype antibodies in the carcinoembryonic antigen system. Journal of Cellular Biochemistry 50(3), pp. 324-335, 1992. [DOI] [Web of Science] [Pubmed] ok

Mach J.P., Pèlegrin A., Folli S., Buchegger F., Les anticorps monoclonaux radiomarqués en tant que missiles anti-tumeurs, leurs succès diagnostiques, leur potentiel thérapeutique. Bulletin de l'Académie Nationale de Médecine 176(6), pp. 879-889, 1992. [Web of Science] [Pubmed] ok

Nap M., Hammarström M.L., Börmer O., Hammarström S., Wagener C., Handt S., Schreyer M., Mach J.P., Buchegger F., von Kleist S., Specificity and affinity of monoclonal antibodies against carcinoembryonic antigen. Cancer Research 52(8), pp. 2329-2339, 1992. [Web of Science] [Pubmed]


Buchegger F., Chalandon Y., Pèlegrin A., Hardman N., Mach J.P., Bone marrow dosimetry in rats using direct tissue counting after injection of radio-iodinated intact monoclonal antibodies or F(ab')2 fragments. Journal of Nuclear Medicine 32(7), pp. 1414-1421, 1991. [Web of Science] [Pubmed] ok

Gallay P., Mach J.P., Carrel S., Characterization and detection of naturally occurring antibodies against IL-1 alpha and IL-1 beta in normal human plasma. European Cytokine Network 2(5), pp. 329-338, 1991. [Pubmed] ok

Hayoz D., Rimoldi D., Kühn L., Mach J.P., Carrel S., Cloning of an interferon-gamma regulated human melanoma-associated antigen: identity to the intercellular adhesion molecule ICAM-1. Melanoma Research 1(4), pp. 251-259, 1991. [Pubmed] ok

Mach J.P., Pèlegrin A., Buchegger F., Imaging and therapy with monoclonal antibodies in non-hematopoietic tumors. Current Opinion in Immunology 3(5), pp. 685-693, 1991. [DOI] [Web of Science] [Pubmed] ok

Matzku S., Mach J.P., Buchegger F., Moldenhauer G., Stadler M., Kalthoff H., Detachment of cell surface-bound anticarcinoembryonic antigen immune complexes by phospholipase C. Tumour Biology 12(5), pp. 272-278, 1991. [DOI] [Web of Science] [Pubmed] ok

Pèlegrin A., Folli S., Buchegger F., Mach J.P., Wagnières G., van den Bergh H., Antibody-fluorescein conjugates for photoimmunodiagnosis of human colon carcinoma in nude mice. Cancer 67(10), pp. 2529-2537, 1991. [DOI] [Web of Science] [Pubmed] ok

Westera G., Reist H.W., Buchegger F., Heusser C.H., Hardman N., Pfeiffer A., Sharma H.L., von Schulthess G.K., Mach J.P., Radioimmuno positron emission tomography with monoclonal antibodies: a new approach to quantifying in vivo tumour concentration and biodistribution for radioimmunotherapy. Nuclear Medicine Communications 12(5), pp. 429-437, 1991. [DOI] [Web of Science] [Pubmed] ok


Buchegger F., Pèlegrin A., Delaloye B., Bischof-Delaloye A., Mach J.P., Iodine-131-labeled MAb F(ab')2 fragments are more efficient and less toxic than intact anti-CEA antibodies in radioimmunotherapy of large human colon carcinoma grafted in nude mice. Journal of Nuclear Medicine 31(6), pp. 1035-1044, 1990. [Web of Science] [Pubmed] ok

Mach J.P., Buchegger F., Pelegrin A., Ychou M., Ricard M., Lumbroso J., Rougier P., Lasser P., Elias D., Saccavini J.C., Radioimmunotherapy of colon carcinoma with I-131 labeled antibodies, successful experimental results and clinical dosimetry study. Pathologie-Biologie 38(8), p. 819, 1990. [Web of Science] [Pubmed] ok

Perey L., Hayes D.F., Tondini C., van Melle G., Bauer J., Lemarchand T., Reymond M., Mach J.P., Leyvraz S., Elevated CA125 levels in patients with metastatic breast carcinoma. British Journal of Cancer 62(4), pp. 668-670, 1990. [Document] [DOI] [Web of Science] [Pubmed] ok


Audette M., Carrel S., Hayoz D., Giuffrè L., Mach J.P., Kühn L.C., A novel interferon-gamma regulated human melanoma-associated antigen, gp33-38, defined by monoclonal antibody Me14-D12. II. Molecular cloning of a genomic probe. Molecular Immunology 26(6), pp. 515-522, 1989. [DOI] [Web of Science] [Pubmed] ok

Barr I.G., Miescher S., von Fliedner V., Buchegger F., Barras C., Lanzavecchia A., Mach J.P., Carrel S., In vivo localization of a bispecific antibody which targets human T lymphocytes to lyse human colon cancer cells. International Journal of Cancer 43(3), pp. 501-507, 1989. [DOI] [Web of Science] [Pubmed] ok

Bischof-Delaloye A., Delaloye B., Buchegger F., Gilgien W., Studer A., Curchod S., Givel J.C., Mosimann F., Pettavel J., Mach J.P., Clinical value of immunoscintigraphy in colorectal carcinoma patients: a prospective study. Journal of Nuclear Medicine 30(10), pp. 1646-1656, 1989. [Web of Science] [Pubmed] ok

Buchegger F., Pfister C., Fournier K., Prevel F., Schreyer M., Carrel S., Mach J.P., Ablation of human colon carcinoma in nude mice by 131I-labeled monoclonal anti-carcinoembryonic antigen antibody F(ab')2 fragments. Journal of Clinical Investigation 83(5), pp. 1449-1456, 1989. [Document] [DOI] [Web of Science] [Pubmed] ok

Hammarstrom S., Shively J.E., Paxton R.J., Beatty B.G., Larsson A., Ghosh R., Bormer O., Buchegger F., Mach J.P., Burtin P., Antigenic sites in carcinoembryonic antigen. Cancer Research 49(17), pp. 4852-4858, 1989. [Web of Science] [Pubmed] ok

Hardman N., Gill L.L., De Winter R.F., Wagner K., Hollis M., Businger F., Ammaturo D., Buchegger F., Mach J.P., Heusser C., Generation of a recombinant mouse-human chimaeric monoclonal antibody directed against human carcinoembryonic antigen. International Journal of Cancer 44(3), pp. 424-433, 1989. [DOI] [Web of Science] [Pubmed] ok

Pochon S., Buchegger F., Pélegrin A., Mach J.P., Offord R.E., Ryser J.E., Rose K., A novel derivative of the chelon desferrioxamine for site-specific conjugation to antibodies. International Journal of Cancer 43(6), pp. 1188-1194, 1989. [DOI] [Web of Science] [Pubmed] ok


Andres R.Y., Schubiger P.A., Tiefenauer L., Seybold K., Locher J.T., Mach J.P., Buchegger F., Immunoscintigraphic localization of inflammatory lesions: concept, radiolabelling and in vitro testing of a granulocyte specific antibody. European Journal of Nuclear Medicine 13(11), pp. 582-586, 1988. [DOI] [Web of Science] [Pubmed] ok

Behnke J., Mach J.P., Buchegger F., Carrel S., Delaloye B., De Tribolet N., In vivo localisation of radiolabelled monoclonal antibody in human gliomas. British Journal of Neurosurgery 2(2), pp. 193-197, 1988. [Pubmed] ok

Buchegger F., Vacca A., Carrel S., Schreyer M., Mach J.P., Radioimmunotherapy of human colon carcinoma by 131I-labelled monoclonal anti-CEA antibodies in a nude mouse model. International Journal of Cancer 41(1), pp. 127-134, 1988. [DOI] [Web of Science] [Pubmed] ok

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