Susanna Cotecchia

Publications | Mémoires et thèses

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119 publications

2017 | 2015 | 2013 | 2012 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 | 1990 | 1989 | 1988 | 1987 | 1986 | 1985 | 1984 | 1982 | 1981 |
 
Ezrin directly interacts with AQP2 and promotes its endocytosis.
Li W., Jin W.W., Tsuji K., Chen Y., Nomura N., Su L., Yui N., Arthur J., Cotecchia S., Paunescu T.G. et al., 2017/09/01. Journal of cell science, 130 (17) pp. 2914-2925. Peer-reviewed.
 
AKAP-Lbc mediates protection against doxorubicin-induced cardiomyocyte toxicity.
Caso S., Maric D., Arambasic M., Cotecchia S., Diviani D., 2017. Biochimica et Biophysica Acta. Molecular Cell Research, 1864 (12) pp. 2336-2346. Peer-reviewed.
 
The alpha1-adrenergic receptors in cardiac hypertrophy: Signaling mechanisms and functional implications.
Cotecchia S., Del Vescovo C.D., Colella M., Caso S., Diviani D., 2015. Cellular Signalling, 27 (10) pp. 1984-1993. Peer-reviewed.
 
A-kinase-anchoring protein-Lbc anchors IκB kinase β to support interleukin-6-mediated cardiomyocyte hypertrophy.
del Vescovo C.D., Cotecchia S., Diviani D., 2013. Molecular and Cellular Biology, 33 (1) pp. 14-27. Peer-reviewed.
Protein-protein interactions at the adrenergic receptors.
Cotecchia S., Stanasila L., Diviani D., 2012. Current Drug Targets, 13 (1) pp. 15-27.
 
Constitutive activity and inverse agonism at the α(₁a) and α(₁b) adrenergic receptor subtypes.
Cotecchia S., 2010. Methods in Enzymology, 485 pp. 123-138.
The α1-adrenergic receptors: diversity of signaling networks and regulation.
Cotecchia S., 2010. Journal of Receptor and Signal Transduction Research, 30 (6) pp. 410-419. Peer-reviewed.
 
Enhanced vascular contractility in alpha1-adrenergic receptor-deficient mice.
Sanbe A., Tanaka Y., Fujiwara Y., Miyauchi N., Mizutani R., Yamauchi J., Cotecchia S., Koike K., Tsujimoto G., Tanoue A., 2009. Life Sciences, 84 (21-22) pp. 713-718. Peer-reviewed.
 
Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50.
Stanasila L., Abuin L., Dey J., Cotecchia S., 2008. Molecular Pharmacology, 74 (3) pp. 562-573.
 
Neuroendocrine deregulation of food intake, adipose tissue and the gastrointestinal system in obesity and metabolic syndrome.
Garruti G., Cotecchia S., Giampetruzzi F., Giorgino F., Giorgino R., 2008. Journal of Gastrointestinal and Liver Diseases, 17 (2) pp. 193-198. Peer-reviewed.
 
Alpha1-adrenoceptor-dependent vascular hypertrophy and remodeling in murine hypoxic pulmonary hypertension.
Faber J.E., Szymeczek C.L., Cotecchia S., Thomas S.A., Tanoue A., Tsujimoto G., Zhang H., 2007. American Journal of Physiology. Heart and Circulatory Physiology, 292 (5) pp. H2316-H2323. Peer-reviewed.
 
Alpha1-adrenoceptors are required for normal male sexual function.
Sanbe A., Tanaka Y., Fujiwara Y., Tsumura H., Yamauchi J., Cotecchia S., Koike K., Tsujimoto G., Tanoue A., 2007. British Journal of Pharmacology, 152 (3) pp. 332-340.
 
Blockade of both alpha1A- and alpha1B-adrenergic receptor subtype signaling is required to inhibit neointimal formation in the mouse femoral artery.
Hosoda C., Hiroyama M., Sanbe A., Birumachi J., Kitamura T., Cotecchia S., Simpson P.C., Tsujimoto G., Tanoue A., 2007. American Journal of Physiology. Heart and Circulatory Physiology, 293 (1) pp. H514-H519. Peer-reviewed.
 
Constitutive activity and inverse agonism at the alpha1adrenoceptors.
Cotecchia S., 2007. Biochemical Pharmacology, 73 (8) pp. 1076-1083.
 
Expression and secretion of the atrial natriuretic peptide in human adipose tissue and preadipocytes.
Garruti G., Giusti V., Nussberger J., Darimont C., Verdumo C., Amstutz C., Puglisi F., Giorgino F., Giorgino R., Cotecchia S., 2007. Obesity, 15 (9) pp. 2181-2189. Peer-reviewed.
 
The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy.
Appert-Collin A., Cotecchia S., Nenniger-Tosato M., Pedrazzini T., Diviani D., 2007. Proceedings of the National Academy of Sciences of the United States of America, 104 (24) pp. 10140-10145.
 
Ezrin directly interacts with the alpha1b-adrenergic receptor and plays a role in receptor recycling.
Stanasila L., Abuin L., Diviani D., Cotecchia S., 2006. Journal of Biological Chemistry, 281 (7) pp. 4354-4363. Peer-reviewed.
 
Correlation between vasoconstrictor roles and mRNA expression of alpha1-adrenoceptor subtypes in blood vessels of genetically engineered mice.
Hosoda C., Tanoue A., Shibano M., Tanaka Y., Hiroyama M., Koshimizu T.A., Cotecchia S., Kitamura T., Tsujimoto G., Koike K., 2005. British Journal of Pharmacology, 146 (3) pp. 456-466.
 
Historical review: Negative efficacy and the constitutive activity of G-protein-coupled receptors.
Costa T., Cotecchia S., 2005. Trends in Pharmacological Sciences, 26 (12) pp. 618-624.
 
Paired activation of two components within muscarinic M3 receptor dimers is required for recruitment of beta-arrestin-1 to the plasma membrane.
Novi F., Stanasila L., Giorgi F., Corsini G.U., Cotecchia S., Maggio R., 2005. Journal of Biological Chemistry, 280 (20) pp. 19768-19776. Peer-reviewed.
 
Tissue transglutaminase (TG2) acting as G protein protects hepatocytes against Fas-mediated cell death in mice.
Sarang Z., Molnár P., Németh T., Gomba S., Kardon T., Melino G., Cotecchia S., Fésüs L., Szondy Z., 2005. Hepatology, 42 (3) pp. 578-587.
 
Two alpha1-adrenergic receptor subtypes regulating the vasopressor response have differential roles in blood pressure regulation.
Hosoda C., Koshimizu T.A., Tanoue A., Nasa Y., Oikawa R., Tomabechi T., Fukuda S., Shinoura H., Oshikawa S., Takeo S. et al., 2005. Molecular Pharmacology, 67 (3) pp. 912-922.
 
5-HT2A and alpha1b-adrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulants.
Auclair A., Drouin C., Cotecchia S., Glowinski J., Tassin J.P., 2004. European Journal of Neuroscience, 20 (11) pp. 3073-3084.
 
Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex.
Diviani D., Abuin L., Cotecchia S., Pansier L., 2004. EMBO Journal, 23 (14) pp. 2811-2820.
 
Critical role for the alpha-1B adrenergic receptor at the sympathetic neuroeffector junction.
Townsend S.A., Jung A.S., Hoe Y.S., Lefkowitz R.Y., Khan S.A., Lemmon C.A., Harrison R.W., Lee K., Barouch L.A., Cotecchia S. et al., 2004. Hypertension, 44 (5) pp. 776-782.
 
Gene deletion of dopamine beta-hydroxylase and alpha1-adrenoceptors demonstrates involvement of catecholamines in vascular remodeling.
Zhang H., Cotecchia S., Thomas S.A., Tanoue A., Tsujimoto G., Faber J.E., 2004. American Journal of Physiology. Heart and Circulatory Physiology, 287 (5) pp. H2106-H2114. Peer-reviewed.
 
Impaired glucose homeostasis in mice lacking the alpha1b-adrenergic receptor subtype.
Burcelin R., Uldry M., Foretz M., Perrin C., Dacosta A., Nenniger-Tosato M., Seydoux J., Cotecchia S., Thorens B., 2004. Journal of Biological Chemistry, 279 (2) pp. 1108-1115.
 
Structural determinants involved in the activation and regulation of G protein-coupled receptors: lessons from the alpha1-adrenegic receptor subtypes.
Cotecchia S., Stanasila L., Diviani D., Björklöf K., Rossier O., Fanelli F., 2004. Biology of the Cell, 96 (5) pp. 327-333.
 
Constitutively active G protein-coupled receptor mutants: implications on receptor function and drug action.
Cotecchia S., Fanelli F., Costa T., 2003. Assay and Drug Development Technologies, 1 (2) pp. 311-316.
 
Oligomerization of the alpha 1a- and alpha 1b-adrenergic receptor subtypes. Potential implications in receptor internalization.
Stanasila L., Perez J.B., Vogel H., Cotecchia S., 2003. Journal of Biological Chemistry, 278 (41) pp. 40239-40251. Peer-reviewed.
 
The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis.
Diviani D., Lattion A.L., Abuin L., Staub O., Cotecchia S., 2003. Journal of Biological Chemistry, 278 (21) pp. 19331-19340. Peer-reviewed.
 
The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse.
O'Connell T.D., Ishizaka S., Nakamura A., Swigart P.M., Rodrigo M.C., Simpson G.L., Cotecchia S., Rokosh D.G., Grossman W., Foster E. et al., 2003. Journal of Clinical Investigation, 111 (11) pp. 1783-1791.
 
Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates.
Drouin C., Darracq L., Trovero F., Blanc G., Glowinski J., Cotecchia S., Tassin J.P., 2002. Journal of Neuroscience, 22 (7) pp. 2873-2884.
 
Beta(1)-selective agonist (-)-1-(3,4-dimethoxyphenetylamino)-3-(3,4-dihydroxy)-2-propanol [(-)-RO363] differentially interacts with key amino acids responsible for beta(1)-selective binding in resting and active states.
Sugimoto Y., Fujisawa R., Tanimura R., Lattion A.L., Cotecchia S., Tsujimoto G., Nagao T., Kurose H., 2002. Journal of Pharmacology and Experimental Therapeutics, 301 (1) pp. 51-58. Peer-reviewed.
 
Cardiovascular influences of alpha1b-adrenergic receptor defect in mice.
Vecchione C., Fratta L., Rizzoni D., Notte A., Poulet R., Porteri E., Frati G., Guelfi D., Trimarco V., Mulvany M.J. et al., 2002. Circulation, 105 (14) pp. 1700-1707.
 
Co- and posttranslational modification of the alpha(1B)-adrenergic receptor: effects on receptor expression and function.
Björklöf K., Lundström K., Abuin L., Greasley P.J., Cotecchia S., 2002. Biochemistry, 41 (13) pp. 4281-4291.
 
D-amphetamine fails to increase extracellular dopamine levels in mice lacking alpha 1b-adrenergic receptors: relationship between functional and nonfunctional dopamine release.
Auclair A., Cotecchia S., Glowinski J., Tassin J.P., 2002. Journal of Neuroscience, 22 (21) pp. 9150-9154.
 
Mutagenesis and modelling of the alpha(1b)-adrenergic receptor highlight the role of the helix 3/helix 6 interface in receptor activation.
Greasley P.J., Fanelli F., Rossier O., Abuin L., Cotecchia S., 2002. Molecular Pharmacology, 61 (5) pp. 1025-1032.
 
Mutations inducing divergent shifts of constitutive activity reveal different modes of binding among catecholamine analogues to the beta(2)-adrenergic receptor.
Del Carmine R., Ambrosio C., Sbraccia M., Cotecchia S., Ijzerman A.P., Costa T., 2002. British Journal of Pharmacology, 135 (7) pp. 1715-1722.
 
Role of brain alpha 1B-adrenoceptors in modafinil-induced behavioral activity.
Stone E.A., Cotecchia S., Lin Y., Quartermain D., 2002. Synapse, 46 (4) pp. 269-270.
 
The alpha1b-adrenergic receptor subtype: molecular properties and physiological implications.
Cotecchia S., Björklöf K., Rossier O., Stanasila L., Greasley P., Fanelli F., 2002. Journal of Receptor and Signal Transduction Research, 22 (1-4) pp. 1-16.
 
A behavioral study of alpha-1b adrenergic receptor knockout mice: increased reaction to novelty and selectively reduced learning capacities.
Spreng M., Cotecchia S., Schenk F., 2001. Neurobiology of Learning and Memory, 75 (2) pp. 214-229. Peer-reviewed.
 
A quantitative analysis of antagonism and inverse agonism at wild-type and constitutively active hamster alpha1B-adrenoceptors.
Hein P., Goepel M., Cotecchia S., Michel M.C., 2001. Naunyn-schmiedeberg's Archives of Pharmacology, 363 (1) pp. 34-39.
 
Mutational and computational analysis of the alpha(1b)-adrenergic receptor. Involvement of basic and hydrophobic residues in receptor activation and G protein coupling.
Greasley P.J., Fanelli F., Scheer A., Abuin L., Nenniger-Tosato M., DeBenedetti P.G., Cotecchia S., 2001. Journal of Biological Chemistry, 276 (49) pp. 46485-46494. Peer-reviewed.
 
Catechol-binding serines of beta(2)-adrenergic receptors control the equilibrium between active and inactive receptor states.
Ambrosio C., Molinari P., Cotecchia S., Costa T., 2000. Molecular Pharmacology, 57 (1) pp. 198-210.
 
Comparison of [3H]tamsulosin and [3H]prazosin binding to wild-type and constitutively active alpha1B-adrenoceptors.
Hein P., Goepel M., Cotecchia S., Michel M.C., 2000. Life Sciences, 67 (5) pp. 503-508.
 
Mutational analysis of the highly conserved arginine within the Glu/Asp-Arg-Tyr motif of the alpha(1b)-adrenergic receptor: effects on receptor isomerization and activation.
Scheer A., Costa T., Fanelli F., De Benedetti P.G., Mhaouty-Kodja S., Abuin L., Nenniger-Tosato M., Cotecchia S., 2000. Molecular Pharmacology, 57 (2) pp. 219-231.
 
The alpha 1a and alpha 1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action.
Cotecchia S., Rossier O., Fanelli F., Leonardi A., De Benedetti P.G., 2000. Pharmaceutica Acta Helvetiae, 74 (2-3) pp. 173-179.
 
The effect of mutations in the DRY motif on the constitutive activity and structural instability of the histamine H(2) receptor.
Alewijnse A.E., Timmerman H., Jacobs E.H., Smit M.J., Roovers E., Cotecchia S., Leurs R., 2000. Molecular Pharmacology, 57 (5) pp. 890-898.
 
Complete hypogonadotropic hypogonadism associated with a novel inactivating mutation of the gonadotropin-releasing hormone receptor.
Pralong F.P., Gomez F., Castillo E., Cotecchia S., Abuin L., Aubert M.L., Portmann L., Gaillard R.C., 1999. Journal of Clinical Endocrinology and Metabolism, 84 (10) pp. 3811-3816.
 
Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features.
Mhaouty-Kodja S., Barak L.S., Scheer A., Abuin L., Diviani D., Caron M.G., Cotecchia S., 1999. Molecular Pharmacology, 55 (2) pp. 339-347.
 
Constitutively active mutants of the beta1-adrenergic receptor.
Lattion A., Abuin L., Nenniger-Tosato M., Cotecchia S., 1999. FEBS Letters, 457 (3) pp. 302-306.
 
Expression of the alpha 1b-adrenergic receptor and G protein subunits in mammalian cell lines using the Semliki Forest virus expression system.
Scheer A., Björklöf K., Cotecchia S., Lundstrom K., 1999. Journal of Receptor and Signal Transduction Research, 19 (1-4) pp. 369-378.
 
Inverse agonism and neutral antagonism at alpha(1a)- and alpha(1b)-adrenergic receptor subtypes.
Rossier O., Abuin L., Fanelli F., Leonardi A., Cotecchia S., 1999. Molecular Pharmacology, 56 (5) pp. 858-866.
 
Regulatory mechanisms of alpha 1B-adrenergic receptor function.
Cotecchia S., Mhaouty-Kodja S., 1999. Biochemical Society Transactions, 27 (2) pp. 154-157.
 
Structure-function relationships of the alpha1b-adrenergic receptor.
Scheer A., Fanelli F., Diviani D., de Benedetti P.G., Cotecchia S., 1999. European Urology, 36 Suppl 1 pp. 11-16.
 
Theoretical study of the electrostatically driven step of receptor-G protein recognition.
Fanelli F., Menziani C., Scheer A., Cotecchia S., De Benedetti P.G., 1999. Proteins, 37 (2) pp. 145-156.
 
Theoretical study on receptor-G protein recognition: new insights into the mechanisms of the alpha1b-adrenergic recptor activation
Fanelli F., Menziani C., Scheer A., Cotecchia S., De Benedetti P. G., 1999. International Journal of Quantum Chemistry, 73 (2) pp. 71-83.
 
Ab initio modeling and molecular dynamics simulation of the alpha 1b-adrenergic receptor activation.
Fanelli F., Menziani C., Scheer A., Cotecchia S., De Benedetti P.G., 1998. Methods, 14 (3) pp. 302-317.
 
Molecular mechanisms involved in the activation and regulation of the alpha 1-adrenergic receptor subtypes.
Cotecchia S., Scheer A., Diviani D., Fanelli F., De Benedetti P.G., 1998. Farmaco, 53 (4) pp. 273-277.
 
Murine alpha1-adrenoceptor subtypes. I. Radioligand binding studies.
Yang M., Reese J., Cotecchia S., Michel M.C., 1998. Journal of Pharmacology and Experimental Therapeutics, 286 (2) pp. 841-847.
 
Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor.
Diviani D., Lattion A.L., Cotecchia S., 1997. Journal of Biological Chemistry, 272 (45) pp. 28712-28719.
 
Constitutively active G protein-coupled receptors: potential mechanisms of receptor activation.
Scheer A., Cotecchia S., 1997. Journal of Receptor and Signal Transduction Research, 17 (1-3) pp. 57-73.
 
Costimulation of adenylyl cyclase and phospholipase C by a mutant alpha 1B-adrenergic receptor transgene promotes malignant transformation of thyroid follicular cells.
Ledent C., Denef J.F., Cottecchia S., Lefkowitz R., Dumont J., Vassart G., Parmentier M., 1997. Endocrinology, 138 (1) pp. 369-378.
 
Decreased blood pressure response in mice deficient of the alpha1b-adrenergic receptor.
Cavalli A., Lattion A.L., Hummler E., Nenniger M., Pedrazzini T., Aubert J.F., Michel M.C., Yang M., Lembo G., Vecchione C. et al., 1997. Proceedings of the National Academy of Sciences of the United States of America, 94 (21) pp. 11589-11594. Peer-reviewed.
 
The activation process of the alpha1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate.
Scheer A., Fanelli F., Costa T., De Benedetti P.G., Cotecchia S., 1997. Proceedings of the National Academy of Sciences of the United States of America, 94 (3) pp. 808-813.
 
Up-regulation of the levels of expression and function of a constitutively active mutant of the hamster alpha1B-adrenoceptor by ligands that act as inverse agonists.
Lee T.W., Cotecchia S., Milligan G., 1997. Biochemical Journal, 325 (3) pp. 733-739.
 
Constitutively active mutants of the alpha 1B-adrenergic receptor: role of highly conserved polar amino acids in receptor activation.
Scheer A., Fanelli F., Costa T., De Benedetti P.G., Cotecchia S., 1996/07. EMBO Journal, 15 (14) pp. 3566-3578.
 
A constitutively active mutant of the alpha 1B-adrenergic receptor can cause greater agonist-dependent down-regulation of the G-proteins G9 alpha and G11 alpha than the wild-type receptor.
Lee T.W., Wise A., Cotecchia S., Milligan G., 1996. Biochemical Journal, 320 (1) pp. 79-86.
 
Adrenergic, dopaminergic, and muscarinic receptor stimulation leads to PKA phosphorylation of Na-K-ATPase.
Beguin P., Beggah A., Cotecchia S., Geering K., 1996. American Journal of Physiology, 270 (1 Pt 1) pp. C131-C137.
 
Amino acids of the alpha1B-adrenergic receptor involved in agonist binding: differences in docking catecholamines to receptor subtypes.
Cavalli A., Fanelli F., Taddei C., De Benedetti P.G., Cotecchia S., 1996. FEBS Letters, 399 (1-2) pp. 9-13.
 
Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor.
Diviani D., Lattion A.L., Larbi N., Kunapuli P., Pronin A., Benovic J.L., Cotecchia S., 1996. Journal of Biological Chemistry, 271 (9) pp. 5049-5058.
 
Molecular mechanisms underlying the activation and regulation of the alpha 1B-adrenergic receptor.
Cotecchia S., Scheer A., Fanelli F., Costa T., 1996. Biochemical Society Transactions, 24 (4) pp. 959-963.
 
Signalling and regulation of the alpha 1B-adrenergic receptor.
Cotecchia S., Lattion A.L., Diviani D., Cavalli A., 1995. Biochemical Society Transactions, 23 (1) pp. 121-125.
 
Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor.
Samama P., Pei G., Costa T., Cotecchia S., Lefkowitz R.J., 1994. Molecular Pharmacology, 45 (3) pp. 390-394.
 
Phosphorylation of the Na,K-ATPase alpha-subunit by protein kinase A and C in vitro and in intact cells. Identification of a novel motif for PKC-mediated phosphorylation.
Beguin P., Beggah A.T., Chibalin A.V., Burgener-Kairuz P., Jaisser F., Mathews P.M., Rossier B.C., Cotecchia S., Geering K., 1994. Journal of Biological Chemistry, 269 (39) pp. 24437-24445.
 
Truncation of the receptor carboxyl terminus impairs agonist-dependent phosphorylation and desensitization of the alpha 1B-adrenergic receptor.
Lattion A.L., Diviani D., Cotecchia S., 1994. Journal of Biological Chemistry, 269 (36) pp. 22887-22893.
 
A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.
Samama P., Cotecchia S., Costa T., Lefkowitz R.J., 1993. Journal of Biological Chemistry, 268 (7) pp. 4625-4636. Peer-reviewed.
 
Adrenergic receptors: recent insights into their mechanism of activation and desensitization.
Lefkowitz R.J., Cotecchia S., Kjelsberg M.A., Pitcher J., Koch W.J., Inglese J., Caron M.G., 1993. Advances in Second Messenger and Phosphoprotein Research, 28 pp. 1-9.
 
Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors.
Luttrell L.M., Ostrowski J., Cotecchia S., Kendall H., Lefkowitz R.J., 1993. Science, 259 (5100) pp. 1453-1457.
 
B2 kinin receptor-mediated internalization of bradykinin in DDT1 MF-2 smooth muscle cells is paralleled by sequestration of the occupied receptors.
Munoz C.M., Cotecchia S., Leeb-Lundberg L.M., 1993. Archives of Biochemistry and Biophysics, 301 (2) pp. 336-344.
 
Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins.
Lefkowitz R.J., Cotecchia S., Samama P., Costa T., 1993. Trends in Pharmacological Sciences, 14 (8) pp. 303-307.
 
Constitutively active mutants of the alpha 2-adrenergic receptor.
Ren Q., Kurose H., Lefkowitz R.J., Cotecchia S., 1993. Journal of Biological Chemistry, 268 (22) pp. 16483-16487. Peer-reviewed.
 
Coupling of the expressed alpha 1B-adrenergic receptor to the phospholipase C pathway in Xenopus oocytes. The role of Go.
Blitzer R.D., Omri G., De Vivo M., Carty D.J., Premont R.T., Codina J., Birnbaumer L., Cotecchia S., Caron M.G., Lefkowitz R.J. et al., 1993. Journal of Biological Chemistry, 268 (10) pp. 7532-7537. Peer-reviewed.
 
Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.
Kjelsberg M.A., Cotecchia S., Ostrowski J., Caron M.G., Lefkowitz R.J., 1992. Journal of Biological Chemistry, 267 (3) pp. 1430-1433. Peer-reviewed.
 
Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis.
Cotecchia S., Ostrowski J., Kjelsberg M.A., Caron M.G., Lefkowitz R.J., 1992. Journal of Biological Chemistry, 267 (3) pp. 1633-1639. Peer-reviewed.
 
Molecular biology of α-adrenergic receptors: implications for receptor classification and for structure-function relationships
Lomasney Jon W., Cotecchia Susanna, Lefkowitz Robert J., Caron Marc G., 1991/10. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1095 (2) pp. 127-139.
 
Altered catecholamine receptor affinity in rabbit aortic intimal hyperplasia.
O'Malley M.K., Cotecchia S., Hagen P.O., 1991. Journal of Surgical Research, 51 (2) pp. 148-153.
 
Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein.
Fargin A., Yamamoto K., Cotecchia S., Goldsmith P.K., Spiegel A.M., Lapetina E.G., Caron M.G., Lefkowitz R.J., 1991. Cellular Signalling, 3 (6) pp. 547-557.
 
G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.
Allen L.F., Lefkowitz R.J., Caron M.G., Cotecchia S., 1991. Proceedings of the National Academy of Sciences of the United States of America, 88 (24) pp. 11354-11358.
 
Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5.
Lomasney J.W., Cotecchia S., Lorenz W., Leung W.Y., Schwinn D.A., Yang-Feng T.L., Brownstein M., Lefkowitz R.J., Caron M.G., 1991. Journal of Biological Chemistry, 266 (10) pp. 6365-6369. Peer-reviewed.
 
The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity.
Schwinn D.A., Page S.O., Middleton J.P., Lorenz W., Liggett S.B., Yamamoto K., Lapetina E.G., Caron M.G., Lefkowitz R.J., Cotecchia S., 1991. Molecular Pharmacology, 40 (5) pp. 619-626.
 
Chromosomal organization of adrenergic receptor genes.
Yang-Feng T.L., Xue F.Y., Zhong W.W., Cotecchia S., Frielle T., Caron M.G., Lefkowitz R.J., Francke U., 1990. Proceedings of the National Academy of Sciences of the United States of America, 87 (4) pp. 1516-1520.
 
Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype.
Schwinn D.A., Lomasney J.W., Lorenz W., Szklut P.J., Fremeau R.T., Yang-Feng T.L., Caron M.G., Lefkowitz R.J., Cotecchia S., 1990. Journal of Biological Chemistry, 265 (14) pp. 8183-8189. Peer-reviewed.
 
Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.
Cotecchia S., Kobilka B.K., Daniel K.W., Nolan R.D., Lapetina E.Y., Caron M.G., Lefkowitz R.J., Regan J.W., 1990. Journal of Biological Chemistry, 265 (1) pp. 63-69. Peer-reviewed.
 
Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function.
Cotecchia S., Exum S., Caron M.G., Lefkowitz R.J., 1990. Proceedings of the National Academy of Sciences of the United States of America, 87 (8) pp. 2896-2900.
 
The alpha 1C-adrenergic receptor: a new member in the alpha 1-adrenergic receptor family.
Schwinn D.A., Cotecchia S., Lorenz W., Caron M.G., Lefkowitz R.J., 1990. Transactions of the Association of American Physicians, 103 pp. 112-118.
 
Adrenergic receptor homologies in vertebrate and invertebrate species examined by DNA hybridization.
Palacios J.M., O'Dowd B.F., Cotecchia S., Hnatowich M., Caron M.G., Lefkowitz R.J., 1989. Life Sciences, 44 (26) pp. 2057-2065.
 
Effector coupling mechanisms of the cloned 5-HT1A receptor.
Fargin A., Raymond J.R., Regan J.W., Cotecchia S., Lefkowitz R.J., Caron M.G., 1989. Journal of Biological Chemistry, 264 (25) pp. 14848-14852. Peer-reviewed.
 
Molecular biology of adrenergic receptors.
Lefkowitz R.J., Kobilka B.K., Benovic J.L., Bouvier M., Cotecchia S., Hausdorff W.P., Dohlman H.G., Regan J.W., Caron M.G., 1988. Cold Spring Harbor Symposia on Quantitative Biology, 53 Pt 1 pp. 507-514.
 
Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.
Cotecchia S., Schwinn D.A., Randall R.R., Lefkowitz R.J., Caron M.G., Kobilka B.K., 1988. Proceedings of the National Academy of Sciences of the United States of America, 85 (19) pp. 7159-7163.
 
Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase.
Benovic J.L., Regan J.W., Matsui H., Mayor F., Cotecchia S., Leeb-Lundberg L.M., Caron M.G., Lefkowitz R.J., 1987. Journal of Biological Chemistry, 262 (36) pp. 17251-17253. Peer-reviewed.
 
Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells.
Leeb-Lundberg L.M., Cotecchia S., DeBlasi A., Caron M.G., Lefkowitz R.J., 1987. Journal of Biological Chemistry, 262 (7) pp. 3098-3105. Peer-reviewed.
 
Agonist-induced beta-adrenergic receptor internalization on intact human mononuclear leukocytes: effect of temperature of mononuclear leukocyte separation.
De Blasi A., Cotecchia S., Fratelli M., Lipartiti M., 1986. Journal of Laboratory and Clinical Medicine, 107 (1) pp. 86-94.
 
Mammalian alpha 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit.
Lomasney J.W., Leeb-Lundberg L.M., Cotecchia S., Regan J.W., DeBernardis J.F., Caron M.G., Lefkowitz R.J., 1986. Journal of Biological Chemistry, 261 (17) pp. 7710-7716. Peer-reviewed.
 
Norepinephrine decreases EGF binding in primary rat hepatocyte cultures.
Cruise J.L., Cotecchia S., Michalopoulos G., 1986. Journal of Cellular Physiology, 127 (1) pp. 39-44.
 
Stress induced desensitization of lymphocyte beta-adrenoceptors in young and aged rats.
De Blasi A., Lipartiti M., Algeri S., Sacchetti G., Costantini C., Fratelli M., Cotecchia S., 1986. Pharmacology, Biochemistry, and Behavior, 24 (4) pp. 991-998.
 
Phorbol ester effects on alpha 1-adrenoceptor binding and phosphatidylinositol metabolism in cultured vascular smooth muscle cells.
Cotecchia S., Leeb-Lundberg L.M., Hagen P.O., Lefkowitz R.J., Caron M.G., 1985. Life Sciences, 37 (25) pp. 2389-2398.
 
Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.
Leeb-Lundberg L.M., Cotecchia S., Lomasney J.W., DeBernardis J.F., Lefkowitz R.J., Caron M.G., 1985. Proceedings of the National Academy of Sciences of the United States of America, 82 (17) pp. 5651-5655.
 
Drugs: guide and caveats to explanatory and descriptive approaches--II. Drugs in psychiatric research.
Bollini P., Cotecchia S., De Blasi A., Romandini S., Tognoni G., 1984. Journal of Psychiatric Research, 18 (4) pp. 391-400.
 
Glucocorticoids increase beta-adrenoceptors on human intact lymphocytes in vitro.
Cotecchia S., De Blasi A., 1984. Life Sciences, 35 (23) pp. 2359-2364.
 
Sulphinpyrazone increases lymphocyte beta-adrenoceptors in man.
De Blasi A., Cotecchia S., 1984. British Journal of Clinical Pharmacology, 18 (6) pp. 963-964.
 
Benzodiazepines: relationship between pharmacological activity in the rat and in vivo receptor binding.
Mennini T., Cotecchia S., Caccia S., Garattini S., 1982. Pharmacology, Biochemistry, and Behavior, 16 (4) pp. 529-532.
 
Brain levels of tofizopam in the rat and relationship with benzodiazepine receptors.
Mennini T., Abbiati A., Caccia S., Cotecchia S., Gomez A., Garattini S., 1982. Naunyn-Schmiedeberg's Archives of Pharmacology, 321 (2) pp. 112-115.
 
d-Amphetamine-induced anorexia and motor behavior after chronic treatment in rats: relationship with changes in the number of catecholamine receptor sites in the brain.
Bendotti C., Borsini F., Cotecchia S., De Blasi A., Mennini T., Samanin R., 1982. Archives Internationales de Pharmacodynamie et de Thérapie, 260 (1) pp. 36-49.
 
Does ethyl-beta-carboline-3-carboxylate interact with mouse brain benzodiazepine receptors in vivo?
Mennini T., Cotecchia S., Caccia S., Garattini S., 1982. Journal of Pharmacy and Pharmacology, 34 (6) pp. 394-395.
 
Selective changes of receptor binding in brain regions of aged rats.
De Blasi A., Cotecchia S., Mennini T., 1982. Life Sciences, 31 (4) pp. 335-340.
 
Changes in serotonin, but not catecholamine, receptor binding in the brain of morphine-dependent rats.
Mennini T., Poggesi E., Cotecchia S., De Blasi A., Samanin R., 1981. Molecular Pharmacology, 20 (2) pp. 237-239.
 
Livelli sierici di farmaci anticonvulsivanti in pazienti con epilessia non controllata. Risultati preliminari
Lepore V., Pedone D., Lanzi C., Trizio M., Lamontanara G., Leante R., Cotecchia S., Livrea P., 1981. Acta Neurologica. Quaderni, 42 pp. 51-60.
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