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AFFICHER LES DONNEES
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Gian-Paolo Dotto

Coordonnées Enseignements Publications  

Publications

Articles

Lefort K., Brooks Y., Ostano P., Cario-André M., Calpini V., Guinea-Viniegra J., Albinger-Hegyi A., Hoetzenecker W., Kolfschoten I., Wagner E.F. et al., A miR-34a-SIRT6 axis in the squamous cell differentiation network. EMBO Journal 32(16), pp. 2248-2263, 2013. [DOI] [Web of Science] [Pubmed]

Dai J., Brooks Y., Lefort K., Getsios S., Dotto G.P., The retinoid-related orphan receptor RORα promotes keratinocyte differentiation via FOXN1. PLoS One 8(7), p. e70392, 2013. [DOI] [Web of Science] [Pubmed]

Ferrándiz N., Caraballo J.M., García-Gutierrez L., Devgan V., Rodriguez-Paredes M., Lafita M.C., Bretones G., Quintanilla A., Muñoz-Alonso M.J., Blanco R. et al., p21 as a transcriptional co-repressor of S-phase and mitotic control genes. PLoS One 7(5), p. e37759, 2012. [DOI] [Web of Science] [Pubmed]

Hu B., Castillo E., Harewood L., Ostano P., Reymond A., Dummer R., Raffoul W., Hoetzenecker W., Hofbauer G.F., Dotto G.P., Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell 149(6), pp. 1207-1220, 2012. [DOI] [Web of Science] [Pubmed]

Restivo G., Nguyen B.C., Dziunycz P., Ristorcelli E., Ryan R.J., Özuysal Ö.Y., Di Piazza M., Radtke F., Dixon M.J., Hofbauer G.F. et al., IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes. EMBO Journal 30(22), pp. 4571-4585, 2011. [DOI] [Web of Science] [Pubmed]

Wu X., Nguyen B.C., Dziunycz P., Chang S., Brooks Y., Lefort K., Hofbauer G.F., Dotto G.P., Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature 465(7296), pp. 368-372, 2010. [DOI] [Web of Science] [Pubmed] ok

Lyubimova A., Garber J.J., Upadhyay G., Sharov A., Anastasoaie F., Yajnik V., Cotsarelis G., Dotto G.P., Botchkarev V., Snapper S.B., Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice. Journal of Clinical Investigation 120(2), pp. 446-456, 2010. [DOI] [Web of Science] [Pubmed] ok

Hu B., Lefort K., Qiu W., Nguyen B.C., Rajaram R.D., Castillo E., He F., Chen Y., Angel P., Brisken C. et al., Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis. Genes and Development 24(14), pp. 1519-1532, 2010. [DOI] [Web of Science] [Pubmed] ok

Borrelli S., Candi E., Hu B., Dolfini D., Ravo M., Grober O.M., Weisz A., Dotto G.P., Melino G., Viganò M.A. et al., The p63 target HBP1 is required for skin differentiation and stratification. Cell Death and Differentiation 17(12), pp. 1896-1907, 2010. [DOI] [Web of Science] [Pubmed]

Thomason H.A., Zhou H., Kouwenhoven E.N., Dotto G.P., Restivo G., Nguyen B.C., Little H., Dixon M.J., van Bokhoven H., Dixon J., Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice. Journal of Clinical Investigation 120(5), pp. 1561-1569, 2010. [DOI] [Web of Science] [Pubmed] ok

Lambertini C., Pantano S., Dotto G.P., Differential control of Notch1 gene transcription by Klf4 and Sp3 transcription factors in normal versus cancer-derived keratinocytes. PLoS One 5(4), p. e10369, 2010. [DOI] [Web of Science] [Pubmed] ok

Kang J., Yoo J., Lee S., Tang W., Aguilar B., Ramu S., Choi I., Otu H.H., Shin J.W., Dotto G.P. et al., An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells. Blood 116(1), pp. 140-150, 2010. [DOI] [Web of Science] [Pubmed] ok

Mandinova A., Kolev V., Neel V., Hu B., Stonely W., Lieb J., Wu X., Colli C., Han R., Pazin M.J. et al., A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans. Journal of Clinical Investigation 119(10), pp. 3127-3137, 2009. [DOI] [Web of Science] [Pubmed]

Pradervand S., Weber J., Thomas J., Bueno M., Wirapati P., Lefort K., Dotto G.P., Harshman K., Impact of normalization on miRNA microarray expression profiling. RNA 15(3), pp. 493-501, 2009. [DOI] [Web of Science] [Pubmed] ok

Kolev V., Mandinova A., Guinea-Viniegra J., Hu B., Lefort K., Lambertini C., Neel V., Dummer R., Wagner E.F., Dotto G.P., EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer. Nature cell biology 10(8), pp. 902-911, 2008. [DOI] [Pubmed]

Mandinova A., Lefort K., Tommasi di Vignano A., Stonely W., Ostano P., Chiorino G., Iwaki H., Nakanishi J., Dotto G.P., The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response. EMBO journal 27(8), pp. 1243-1254, 2008. [DOI] [Web of Science] [Pubmed]

Lefort K., Mandinova A., Ostano P., Kolev V., Calpini V., Kolfschoten I., Devgan V., Lieb J., Raffoul W., Hohl D. et al., Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases. Genes and Development 21(5), pp. 562-77, 03-2007. [DOI] [Web of Science] [Pubmed]

Ayyanan A., Civenni G., Ciarloni L., Morel C., Mueller N., Lefort K., Mandinova A., Raffoul W., Fiche M., Dotto G.P. et al., Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proceedings of the National Academy of Sciences of the United States of America 103(10), pp. 3799-3804, 2006. [DOI] [Web of Science] [Pubmed]

Sharov A. A., Sharova T. Y., Mardaryev A. N., Tommasi di Vignano A., Atoyan R., Weiner L., Yang S., Brissette J. L., Dotto G. P., Botchkarev V. A., Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes. Proceedings of the National Academy of Sciences of the United States of America 103(48), pp. 18166-71, 11-2006. [DOI] [Web of Science] [Pubmed]

Devgan V., Nguyen B.C., Oh H., Dotto G.P., p21WAF1/Cip1 suppresses keratinocyte differentiation independently of the cell cycle through transcriptional up-regulation of the IGF-I gene. Journal of Biological Chemistry 281(41), pp. 30463-30470, 10-2006. [DOI] [Web of Science] [Pubmed] ok

Ongusaha P. P., Kim H. G., Boswell S. A., Ridley A. J., Der C. J., Dotto G. P., Kim Y. B., Aaronson S. A., Lee S. W., RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress. Current Biology 16(24), pp. 2466-72, 12-2006. [DOI] [Web of Science] [Pubmed]

Nguyen B. C., Lefort K., Mandinova A., Antonini D., Devgan V., Della Gatta G., Koster M. I., Zhang Z., Wang J., Tommasi di Vignano A. et al., Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes and Development 20(8), pp. 1028-42, 04-2006. [DOI] [Web of Science] [Pubmed]

Devgan V., Mammucari C., Millar S.E., Brisken C., Dotto G.P., p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes and Development 19(12), pp. 1485-1495, 2005. [DOI] [Web of Science] [Pubmed]

Mammucari C., Tommasi di Vignano A., Sharov A.A., Neilson J., Havrda M.C., Roop D.R., Botchkarev V.A., Crabtree G.R., Dotto G.P., Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. Developmental Cell 8(5), pp. 665-676, 2005. [DOI] [Web of Science] [Pubmed]

Wang J., Devgan V., Corrado M., Prabhu N.S., El-Deiry W.S., Riccardi C., Pandolfi P.P., Missero C., Dotto G.P., Glucocorticoid-induced tumor necrosis factor receptor is a p21Cip1/WAF1 transcriptional target conferring resistance of keratinocytes to UV light-induced apoptosis. Journal of Biological Chemistry 280(45), pp. 37725-37731, 2005. [DOI] [Web of Science] [Pubmed]

Grossi M., Hiou-Feige A., Tommasi Di Vignano A., Calautti E., Ostano P., Lee S., Chiorino G., Dotto G.P., Negative control of keratinocyte differentiation by Rho/CRIK signaling coupled with up-regulation of KyoT1/2 (FHL1) expression. Proceedings of the National Academy of Sciences of the United States of America 102(32), pp. 11313-11318, 2005. [DOI] [Web of Science] [Pubmed]

Okuyama R., Nguyen B.C., Talora C., Ogawa E., Tommasi di Vignano A., Lioumi M., Chiorino G., Tagami H., Woo M., Dotto G.P., High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism. Developmental Cell 6(4), pp. 551-562, 2004. [DOI] [Web of Science] [Pubmed]

Itoh F., Itoh S., Goumans M.J., Valdimarsdottir G., Iso T., Dotto G.P., Hamamori Y., Kedes L., Kato M., ten Dijke Pt P., Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. EMBO Journal 23(3), pp. 541-551, 2004. [DOI] [Web of Science] [Pubmed]

Nicolas M., Wolfer A., Raj K., Kummer J.A., Mill P., van Noort M., Hui C.C., Clevers H., Dotto G.P., Radtke F., Notch1 functions as a tumor suppressor in mouse skin. Nature Genetics 33(3), pp. 416-421, 2003. [DOI] [Web of Science] [Pubmed]

Liu Z.J., Shirakawa T., Li Y., Soma A., Oka M., Dotto G.P., Fairman R.M., Velazquez O.C., Herlyn M., Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Molecular and Cellular Biology 23(1), pp. 14-25, 2003. [DOI] [Web of Science] [Pubmed]

Oh H., Mammucari C., Nenci A., Cabodi S., Cohen S.N., Dotto G.P., Negative regulation of cell growth and differentiation by TSG101 through association with p21(Cip1/WAF1). Proceedings of the National Academy of Sciences of the United States of America 99(8), pp. 5430-5435, 2002. [DOI] [Web of Science] [Pubmed]

Seykora J.T., Mei L., Dotto G.P., Stein P.L., 'Srcasm: a novel Src activating and signaling molecule. Journal of Biological Chemistry 277(4), pp. 2812-2822, 2002. [DOI] [Web of Science] [Pubmed]

Talora C., Sgroi D.C., Crum C.P., Dotto G.P., Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes and Development 16(17), pp. 2252-2263, 2002. [DOI] [Web of Science] [Pubmed]

Brisken C., Ayyannan A., Nguyen C., Heineman A., Reinhardt F., Tan J., Dey S.K., Dotto G.P., Weinberg R.A., Jan T., IGF-2 is a mediator of prolactin-induced morphogenesis in the breast. Developmental Cell 3(6), pp. 877-887, 2002. [DOI] [Web of Science] [Pubmed]

Calautti E., Grossi M., Mammucari C., Aoyama Y., Pirro M., Ono Y., Li J., Dotto G.P., Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion. Journal of Cell Biology 156(1), pp. 137-148, 2002. [DOI] [Web of Science] [Pubmed]

Rangarajan A., Talora C., Okuyama R., Nicolas M., Mammucari C., Oh H., Aster J.C., Krishna S., Metzger D., Chambon P. et al., Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO Journal 20(13), pp. 3427-3436, 2001. [DOI] [Web of Science] [Pubmed]

Santini M.P., Talora C., Seki T., Bolgan L., Dotto G.P., Cross talk among calcineurin, Sp1/Sp3, and NFAT in control of p21(WAF1/CIP1) expression in keratinocyte differentiation. Proceedings of the National Academy of Sciences of the United States of America 98(17), pp. 9575-9580, 2001. [DOI] [Web of Science] [Pubmed]

Di Cunto F., Imarisio S., Hirsch E., Broccoli V., Bulfone A., Migheli A., Atzori C., Turco E., Triolo R., Dotto G.P. et al., Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis. Neuron 28(1), pp. 115-127, 2000. [DOI] [Web of Science] [Pubmed]

Foitzik K., Lindner G., Mueller-Roever S., Maurer M., Botchkareva N., Botchkarev V., Handjiski B., Metz M., Hibino T., Soma T. et al., Control of murine hair follicle regression (catagen) by TGF-beta1 in vivo. FASEB Journal 14(5), pp. 752-760, 2000. [Web of Science] [Pubmed]

Cabodi S., Calautti E., Talora C., Kuroki T., Stein P.L., Dotto G.P., A PKC-eta/Fyn-dependent pathway leading to keratinocyte growth arrest and differentiation. Molecular Cell 6(5), pp. 1121-1129, 2000. [DOI] [Web of Science] [Pubmed]

Foitzik K., Paus R., Doetschman T., Dotto G.P., The TGF-beta2 isoform is both a required and sufficient inducer of murine hair follicle morphogenesis. Developmental Biology 212(2), pp. 278-289, 1999. [DOI] [Web of Science] [Pubmed]

Topley G.I., Okuyama R., Gonzales J.G., Conti C., Dotto G.P., p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential. Proceedings of the National Academy of Sciences of the United States of America 96(16), pp. 9089-9094, 1999. [DOI] [Web of Science] [Pubmed]

Li J., Foitzik K., Calautti E., Baden H., Doetschman T., Dotto G.P., TGF-beta3, but not TGF-beta1, protects keratinocytes against 12-O-tetradecanoylphorbol-13-acetate-induced cell death in vitro and in vivo. Journal of Biological Chemistry 274(7), pp. 4213-4219, 1999. [DOI] [Web of Science] [Pubmed]

Calautti E., Cabodi S., Stein P.L., Hatzfeld M., Kedersha N., Paolo Dotto G., Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion. Journal of Cell Biology 141(6), pp. 1449-1465, 1998. [DOI] [Web of Science] [Pubmed]

Ortel B., Chen N., Brissette J., Dotto G.P., Maytin E., Hasan T., Differentiation-specific increase in ALA-induced protoporphyrin IX accumulation in primary mouse keratinocytes. British Journal of Cancer 77(11), pp. 1744-1751, 1998. [Web of Science] [Pubmed]

Sánchez-Prieto R., Quintanilla M., Martín P., Lleonart M., Cano A., Dotto G.P., Ramón y Cajal S., In vivo antitumor effect of retrovirus-mediated gene transfer of the adenovirus E1a gene. Cancer Gene Therapy 5(4), pp. 215-224, 1998. [Web of Science] [Pubmed]

Di Cunto F., Topley G., Calautti E., Hsiao J., Ong L., Seth P.K., Dotto G.P., Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control. Science 280(5366), pp. 1069-1072, 1998. [DOI] [Web of Science] [Pubmed]

Di Cunto F., Calautti E., Hsiao J., Ong L., Topley G., Turco E., Dotto G.P., Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron. Journal of Biological Chemistry 273(45), pp. 29706-29711, 1998. [DOI] [Web of Science] [Pubmed]

Kamimura J., Lee D., Baden H.P., Brissette J., Dotto G.P., Primary mouse keratinocyte cultures contain hair follicle progenitor cells with multiple differentiation potential. Journal of Investigative Dermatology 109(4), pp. 534-540, 1997. [DOI] [Web of Science] [Pubmed]

Prowse D.M., Bolgan L., Molnár A., Dotto G.P., Involvement of the Sp3 transcription factor in induction of p21Cip1/WAF1 in keratinocyte differentiation. Journal of Biological Chemistry 272(2), pp. 1308-1314, 1997. [Web of Science] [Pubmed]

Halaban R., Böhm M., Dotto P., Moellmann G., Cheng E., Zhang Y., Growth regulatory proteins that repress differentiation markers in melanocytes also downregulate the transcription factor microphthalmia. Journal of Investigative Dermatology 106(6), pp. 1266-1272, 1996. [DOI] [Web of Science] [Pubmed]

Missero C., Dotto G.P., p21(WAF1/CIP1) and terminal differentiation control of normal epithelia. Molecular and Cellular Differentiation 4(1), pp. 1-16, 1996. [Web of Science]

Missero C., Di Cunto F., Kiyokawa H., Koff A., Dotto G.P., The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression. Genes and Development 10(23), pp. 3065-3075, 1996. [DOI] [Web of Science] [Pubmed]

Brissette J.L., Li J., Kamimura J., Lee D., Dotto G.P., The product of the mouse nude locus, Whn, regulates the balance between epithelial cell growth and differentiation. Genes and Development 10(17), pp. 2212-2221, 1996. [DOI] [Web of Science] [Pubmed]

Calautti E., Missero C., Stein P.L., Ezzell R.M., Dotto G.P., fyn tyrosine kinase is involved in keratinocyte differentiation control. Genes and Development 9(18), pp. 2279-2291, 1995. [DOI] [Web of Science] [Pubmed]

Missero C., Calautti E., Eckner R., Chin J., Tsai L.H., Livingston D.M., Dotto G.P., Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation. Proceedings of the National Academy of Sciences of the United States of America 92(12), pp. 5451-5455, 1995. [DOI] [Web of Science] [Pubmed]

Filvaroff E., Calautti E., Reiss M., Dotto G.P., Functional evidence for an extracellular calcium receptor mechanism triggering tyrosine kinase activation associated with mouse keratinocyte differentiation. Journal of Biological Chemistry 269(34), pp. 21735-21740, 1994. [Web of Science] [Pubmed]

Ramón y Cajal S., Missero C., Marchetti E., Dotto G.P., Dermal fibroblasts tumor suppression of ras-transformed keratinocytes is associated with induction of squamous cell differentiation. American Journal of Pathology 145(4), pp. 846-855, 1994. [Pubmed]

Brissette J.L., Kumar N.M., Gilula N.B., Hall J.E., Dotto G.P., Switch in gap junction protein expression is associated with selective changes in junctional permeability during keratinocyte differentiation. Proceedings of the National Academy of Sciences of the United States of America 91(14), pp. 6453-6457, 1994. [DOI] [Web of Science] [Pubmed]

Park K., Bae H., Heydemann A., Roberts A.B., Dotto G.P., Sporn M.B., Kim S.J., The E1A oncogene induces resistance to the effects of 1,25-dihydroxyvitamin D3 on inhibition of growth of mouse keratinocytes. Cancer Research 54(23), pp. 6087-6089, 1994. [Web of Science] [Pubmed]

Brissette J.L., Missero C., Yuspa S.H., Dotto G.P., Different levels of v-Ha-ras p21 expression in primary keratinocytes transformed with Harvey sarcoma virus correlate with benign versus malignant behavior. Molecular Carcinogenesis 7(1), pp. 21-25, 1993. [DOI] [Web of Science] [Pubmed]

Florin-Christensen M., Missero C., Florin-Christensen J., Tranque P., Ramon y Cajal S., Dotto G.P., Counteracting effects of E1a transformation on cAMP growth inhibition. Experimental Cell Research 207(1), pp. 57-61, 1993. [DOI] [Web of Science] [Pubmed]

Escherick J.S., DiCunto F., Flanders K.C., Missero C., Dotto G.P., Transforming growth factor beta 1 induction is associated with transforming growth factors beta 2 and beta 3 down-modulation in 12-O-tetradecanoylphorbol-13-acetate-induced skin hyperplasia. Cancer Research 53(22), pp. 5517-5522, 1993. [Web of Science] [Pubmed]

Missero C., Serra C., Stenn K., Dotto G.P., Skin-specific expression of a truncated E1a oncoprotein binding to p105-Rb leads to abnormal hair follicle maturation without increased epidermal proliferation. Journal of Cell Biology 121(5), pp. 1109-1120, 1993. [DOI] [Web of Science] [Pubmed]

Filvaroff E., Calautti E., McCormick F., Dotto G.P., Specific changes of Ras GTPase-activating protein (GAP) and a GAP-associated p62 protein during calcium-induced keratinocyte differentiation. Molecular and Cellular Biology 12(12), pp. 5319-5328, 1992. [Web of Science] [Pubmed]

Florin-Christensen M., Missero C., Dotto G.P., Florin-Christensen J., The E1a gene prevents inhibition of keratinocyte proliferation by dexamethasone. Experimental Cell Research 203(1), pp. 285-288, 1992. [DOI] [Web of Science] [Pubmed]

Brissette J.L., Kumar N.M., Gilula N.B., Dotto G.P., The tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the ras oncogene modulate expression and phosphorylation of gap junction proteins. Molecular and Cellular Biology 11(10), pp. 5364-5371, 1991. [Web of Science] [Pubmed]

Missero C., Ramon y Cajal S., Dotto G.P., Escape from transforming growth factor beta control and oncogene cooperation in skin tumor development. Proceedings of the National Academy of Sciences of the United States of America 88(21), pp. 9613-9617, 1991. [DOI] [Web of Science] [Pubmed]

Ramon y Cajal S., Suster S., Halaban R., Filvaroff E., Dotto G.P., Induction of different morphologic features of malignant melanoma and pigmented lesions after transformation of murine melanocytes with bFGF-cDNA and H-ras, myc, neu, and E1a oncogenes. American Journal of Pathology 138(2), pp. 349-358, 1991. [Pubmed]

Leptak C., Ramon y Cajal S., Kulke R., Horwitz B.H., Riese D.J., Dotto G.P., DiMaio D., Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16. Journal of Virology 65(12), pp. 7078-7083, 1991. [Web of Science] [Pubmed]

Missero C., Filvaroff E., Dotto G.P., Induction of transforming growth factor beta 1 resistance by the E1A oncogene requires binding to a specific set of cellular proteins. Proceedings of the National Academy of Sciences of the United States of America 88(8), pp. 3489-3493, 1991. [DOI] [Web of Science] [Pubmed]

Filvaroff E., Stern D.F., Dotto G.P., Tyrosine phosphorylation is an early and specific event involved in primary keratinocyte differentiation. Molecular and Cellular Biology 10(3), pp. 1164-1173, 1990. [Web of Science] [Pubmed]

Dotto G.P., el-Fouly M.H., Nelson C., Trosko J.E., Similar and synergistic inhibition of gap-junctional communication by ras transformation and tumor promoter treatment of mouse primary keratinocytes. Oncogene 4(5), pp. 637-641, 1989. [Web of Science] [Pubmed]

Dotto G.P., Moellmann G., Ghosh S., Edwards M., Halaban R., Transformation of murine melanocytes by basic fibroblast growth factor cDNA and oncogenes and selective suppression of the transformed phenotype in a reconstituted cutaneous environment. Journal of Cell Biology 109(6 Pt 1), pp. 3115-3128, 1989. [DOI] [Web of Science] [Pubmed]

Seremetis S., Inghirami G., Ferrero D., Newcomb E.W., Knowles D.M., Dotto G.P., Dalla-Favera R., Transformation and plasmacytoid differentiation of EBV-infected human B lymphoblasts by ras oncogenes. Science 243(4891), pp. 660-663, 1989. [DOI] [Web of Science] [Pubmed]

Dotto G.P., O'Connell J., Patskan G., Conti C., Ariza A., Slaga T.J., Malignant progression of papilloma-derived keratinocytes: differential effects of the ras, neu, and p53 oncogenes. Molecular Carcinogenesis 1(3), pp. 171-179, 1988. [DOI] [Web of Science] [Pubmed]

Dotto G.P., Weinberg R.A., Ariza A., Malignant transformation of mouse primary keratinocytes by Harvey sarcoma virus and its modulation by surrounding normal cells. Proceedings of the National Academy of Sciences of the United States of America 85(17), pp. 6389-6393, 1988. [DOI] [Web of Science] [Pubmed]

Dotto G.P., Gilman M.Z., Maruyama M., Weinberg R.A., c-myc and c-fos expression in differentiating mouse primary keratinocytes. EMBO Journal 5(11), pp. 2853-2857, 1986. [Web of Science] [Pubmed]

Dotto G.P., Parada L.F., Weinberg R.A., Specific growth response of ras-transformed embryo fibroblasts to tumour promoters. Nature 318(6045), pp. 472-475, 1985. [DOI] [Web of Science] [Pubmed]

Dotto G.P., Zinder N.D., Reduction of the minimal sequence for initiation of DNA synthesis by qualitative or quantitative changes of an initiator protein. Nature 311(5983), pp. 279-280, 1984. [DOI] [Web of Science] [Pubmed]

Dotto G.P., Horiuchi K., Zinder N.D., The functional origin of bacteriophage f1 DNA replication. Its signals and domains. Journal of Molecular Biology 172(4), pp. 507-521, 1984. [DOI] [Web of Science] [Pubmed]

Dotto G.P., Zinder N.D., Increased intracellular concentration of an initiator protein markedly reduces the minimal sequence required for initiation of DNA synthesis. Proceedings of the National Academy of Sciences of the United States of America 81(5), pp. 1336-1340, 1984. [DOI] [Web of Science] [Pubmed]

Dotto G.P., Zinder N.D., The morphogenetic signal of bacteriophage f1. Virology 130(1), pp. 252-256, 1983. [DOI] [Web of Science] [Pubmed]

Dotto G.P., Horiuchi K., Jakes K.S., Zinder N.D., Signals for the initiation and termination of synthesis of the viral strand of bacteriophage f1. Cold Spring Harbor Symposia on Quantitative Biology 47(Pt 2), pp. 717-722, 1983. [Pubmed]

Dotto G.P., Horiuchi K., Jakes K.S., Zinder N.D., Replication origin of bacteriophage f1. Two signals required for its function. Journal of Molecular Biology 162(2), pp. 335-343, 1982. [DOI] [Web of Science] [Pubmed]

Dotto G.P., Horiuchi K., Zinder N.D., Initiation and termination of phage f1 plus-strand synthesis. Proceedings of the National Academy of Sciences of the United States of America 79(23), pp. 7122-7126, 1982. [DOI] [Web of Science] [Pubmed]

Dotto G.P., Horiuchi K., Replication of a plasmid containing two origins of bacteriophage. Journal of Molecular Biology 153(1), pp. 169-176, 1981. [DOI] [Web of Science] [Pubmed]

Dotto G.P., Enea V., Zinder N.D., Gene II of phage f1: its functions and its products. Proceedings of the National Academy of Sciences of the United States of America 78(9), pp. 5421-5424, 1981. [DOI] [Web of Science] [Pubmed]

Dotto G.P., Enea V., Zinder N.D., Functional analysis of bacteriophage f1 intergenic region. Virology 114(2), pp. 463-473, 1981. [DOI] [Web of Science] [Pubmed]

Articles - Editoriaux

Lefort K., Dotto G.P., p63 and epithelial metaplasia: a gutsy choice. Cell 145(7), pp. 1003-1005, 2011. [DOI] [Web of Science] [Pubmed]

Dotto G.P., Crosstalk of Notch with p53 and p63 in cancer growth control. Nature reviews. Cancer 9(8), pp. 587-595, 2009. [DOI] [Web of Science] [Pubmed] ok

Dotto G.P., Cotsarelis G., Developmental biology. Rac1 up for epidermal stem cells. Science 309(5736), pp. 890-891, 2005. [DOI] [Web of Science] [Pubmed]

Dotto G.P., Silke J., More than cell death: caspases and caspase inhibitors on the move. Developmental Cell 7(1), pp. 2-3, 2004. [DOI] [Web of Science] [Pubmed]

Articles - Lettres

Dotto G.P., p63 and FGFR: when development meets proliferation. EMBO Molecular Medicine 4(3), pp. 165-167, 2012. [DOI] [Web of Science] [Pubmed]

Articles - Synthèses (review)

Goruppi S., Dotto G.P., Mesenchymal stroma: primary determinant and therapeutic target for epithelial cancer. Trends in Cell Biology 23(12), pp. 593-602, 2013. [DOI] [Web of Science] [Pubmed]

Dotto G.P., Calcineurin signaling as a negative determinant of keratinocyte cancer stem cell potential and carcinogenesis. Cancer Research 71(6), pp. 2029-2033, 2011. [DOI] [Web of Science] [Pubmed]

Dotto G. P., Notch tumor suppressor function. Oncogene 27(38), pp. 5115-5123, 2008. [DOI] [Web of Science] [Pubmed] ok

Okuyama R., LeFort K., Dotto G.P., A dynamic model of keratinocyte stem cell renewal and differentiation: role of the p21WAF1/Cip1 and Notch1 signaling pathways. Journal of Investigative Dermatology Symposium Proceedings 9(3), pp. 248-252, 2004. [DOI] [Web of Science] [Pubmed]

Lefort K., Dotto G.P., Notch signaling in the integrated control of keratinocyte growth/differentiation and tumor suppression. Seminars in Cancer Biology 14(5), pp. 374-386, 2004. [DOI] [Web of Science] [Pubmed]

Dotto G.P., p21(WAF1/Cip1): more than a break to the cell cycle? Biochimica et Biophysica Acta-Reviews on Cancer 1471(1), pp. M43-M56, 2000. [DOI] [Web of Science] [Pubmed] ok

Dotto G.P., Signal transduction pathways controlling the switch between keratinocyte growth and differentiation. Critical Reviews in Oral Biology and Medicine 10(4), pp. 442-457, 1999. [Web of Science] [Pubmed]

Dotto P., The keratinocyte growth-differentiation switch. Frontiers in Bioscience 3, pp. d502-d508, 1998. [Document] [Pubmed]

Seremetis S., Inghirami G., Ferrero D., Lombardi L., Knowlest D.M., Dotto G.P., Dalla-Favera R., Different biological effects of c-myc and H-ras oncogene expression in EBV-infected human lymphoblasts. Current Topics in Microbiology and Immunology 141, pp. 290-297, 1988. [Web of Science] [Pubmed]

Dotto G.P., Horiuchi K., Zinder N.D., The origin of DNA replication of bacteriophage f1 and its interaction with the phage gene II protein. Advances in Experimental Medicine and Biology 179, pp. 185-191, 1984. [Web of Science] [Pubmed]

Parties de livre

Dotto G.P., Gilman M.Z., Weinberg R.A., Multistep carcinogenesis: studies with primary fibroblasts and keratinocytes. In: Langenbach R., Elmore E., Barrett J.C. (eds.) Tumor promoters: biological approaches for mechanistic studies and assay systems. Progress in Cancer Research and Therapy 34, Raven Press, New York, pp. 317-329, 1988.

Parties de livre - Chapitres

Missero C., D'Errico M., Dotto G.P., Dogliotti E., The molecular basis of skin carcinogenesis. In: Coleman W.B., Tsongalis G.J. (eds.) The molecular basis of human cancer. Humana Press, Totowa, pp. 407-426, 2002.

Thèses (doctorat)

Restivo G., IRF6 is a mediator of the Notch pro-differentiation and tumour suppressive function in keratinocytes., Université de Lausanne, Faculté de biologie et médecine, Dotto, G.-P. (dir.), 95 p., 2010.

Link A., Lymphoid stroma in health and disease., Université de Lausanne, Faculté de biologie et médecine, Luther S. (dir.), 91 p., 2007.

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