Béatrice Desvergne - ARCHIVE

Publications | Mémoires et thèses

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157 publications

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Visualization and normalization of drift effect across batches in metabolome-wide association studies
Bararpour Nasim, Gilardi Federica, Carmeli Cristian, Sidibe Jonathan, Ivanisevic Julijana, Caputo Tiziana, Augsburger Marc, Grabherr Silke, Desvergne Beatrice, Guex Nicolas et al., 2020/01/22. bioRxiv. Peer-reviewed.
Systemic PPARγ deletion in mice provokes lipoatrophy, organomegaly, severe type 2 diabetes and metabolic inflexibility.
Gilardi F., Winkler C., Quignodon L., Diserens J.G., Toffoli B., Schiffrin M., Sardella C., Preitner F., Desvergne B., 2019/06. Metabolism, 95 pp. 8-20. Peer-reviewed.
Differential regulation of RNA polymerase III genes during liver regeneration.
Yeganeh M., Praz V., Carmeli C., Villeneuve D., Rib L., Guex N., Herr W., Delorenzi M., Hernandez N., CycliX consortium, 2019/02/28. Nucleic Acids Research, 47 (4) pp. 1786-1796. Peer-reviewed.
Renal mineralocorticoid receptor expression is reduced in lipoatrophy.
Toffoli B., Bernardi S., Winkler C., Carrascosa C., Gilardi F., Desvergne B., 2019/02. FEBS open bio, 9 (2) pp. 328-334. Peer-reviewed.
 
Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion.
Sardella C., Winkler C., Quignodon L., Hardman J.A., Toffoli B., Giordano Attianese GMP, Hundt J.E., Michalik L., Vinson C.R., Paus R. et al., 2018/03. The Journal of investigative dermatology, 138 (3) pp. 500-510. Peer-reviewed.
 
Hemicentin 1 influences podocyte dynamic changes in glomerular diseases.
Toffoli B., Zennaro C., Winkler C., Giordano Attianese GMP, Bernardi S., Carraro M., Gilardi F., Desvergne B., 2018. American Journal of Physiology. Renal physiology, 314 (6) pp. F1154-F1165. Peer-reviewed.
Lack of Adipocytes Alters Hematopoiesis in Lipodystrophic Mice.
Wilson A., Fu H., Schiffrin M., Winkler C., Koufany M., Jouzeau J.Y., Bonnet N., Gilardi F., Renevey F., Luther S.A. et al., 2018. Frontiers in immunology, 9 p. 2573. Peer-reviewed.
PPARγ Controls Ectopic Adipogenesis and Cross-Talks with Myogenesis During Skeletal Muscle Regeneration.
Dammone G., Karaz S., Lukjanenko L., Winkler C., Sizzano F., Jacot G., Migliavacca E., Palini A., Desvergne B., Gilardi F. et al., 2018. InternationalJjournal of Molecular Sciences, 19 (7) p. 2044. Peer-reviewed.
 
From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions.
Caputo T., Gilardi F., Desvergne B., 2017. FEBS Letters, 591 (19) pp. 3061-3088. Peer-reviewed.
HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning.
Ferrari A., Longo R., Fiorino E., Silva R., Mitro N., Cermenati G., Gilardi F., Desvergne B., Andolfo A., Magagnotti C. et al., 2017. Nature Communications, 8 (1) p. 93. Peer-reviewed.
Nephropathy in Pparg-null mice highlights PPARγ systemic activities in metabolism and in the immune system.
Toffoli B., Gilardi F., Winkler C., Soderberg M., Kowalczuk L., Arsenijevic Y., Bamberg K., Bonny O., Desvergne B., 2017. PLoS One, 12 (2) pp. e0171474. Peer-reviewed.
 
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175.
Piemontese L., Fracchiolla G., Carrieri A., Parente M., Laghezza A., Carbonara G., Sblano S., Tauro M., Gilardi F., Tortorella P. et al., 2015. European Journal of Medicinal Chemistry, 90 pp. 583-594. Peer-reviewed.
Integrative and systemic approaches for evaluating PPARβ/δ (PPARD) function.
Giordano Attianese G.M., Desvergne B., 2015. Nuclear Receptor Signaling, 13 pp. e001.
 
PPAR Gamma Receptor, Skin Lipids and Hair
Toffoli B., Desvergne B., 2015. pp. 277-288 dans Pappas A. (eds.) Lipids and skin health chap. 18, Springer.
 
PPARγ controls pregnancy outcome through activation of EG-VEGF: new insights into the mechanism of placental development.
Garnier V., Traboulsi W., Salomon A., Brouillet S., Fournier T., Winkler C., Desvergne B., Hoffmann P., Zhou Q.Y., Congiu C. et al., 2015. American Journal of Physiology. Endocrinology and Metabolism, 309 (4) pp. E357-E369.
Genome-wide analysis of SREBP1 activity around the clock reveals its combined dependency on nutrient and circadian signals.
Gilardi F., Migliavacca E., Naldi A., Baruchet M., Canella D., Le Martelot G., Guex N., Desvergne B., CycliX Consortium, 2014. PLoS Genetics, 10 (3) pp. e1004155. Peer-reviewed.
Impaired musculoskeletal response to age and exercise in PPARβ(-/-) diabetic mice.
Fu H., Desvergne B., Ferrari S., Bonnet N., 2014. Endocrinology, 155 (12) pp. 4686-4696.
 
RXRs: collegial partners.
Gilardi F., Desvergne B., 2014. pp. 75-102 dans Asson-Batres M.A., Rochette-Egly C. (eds.) The biochemistry of retinoic acid receptors I: structure, activation, and function at the molecular level chap. 5, Springer.
 
PPARβ/δ governs Wnt signaling and bone turnover.
Scholtysek C., Katzenbeisser J., Fu H., Uderhardt S., Ipseiz N., Stoll C., Zaiss M.M., Stock M., Donhauser L., Böhm C. et al., 2013. Nature Medicine, 19 (5) pp. 608-613.
 
SOCS3 Transactivation by PPARγ Prevents IL-17-Driven Cancer Growth.
Berger H., Végran F., Chikh M., Gilardi F., Ladoire S., Bugaut H., Mignot G., Chalmin F., Bruchard M., Derangère V. et al., 2013. Cancer Research, 73 (12) pp. 3578-3590. Peer-reviewed.
A multiplicity of factors contributes to selective RNA polymerase III occupancy of a subset of RNA polymerase III genes in mouse liver.
Canella D., Bernasconi D., Gilardi F., LeMartelot G., Migliavacca E., Praz V., Cousin P., Delorenzi M., Hernandez N., CycliX Consortium, 2012. Genome Research, 22 (4) pp. 666-680. Peer-reviewed.
 
Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue.
Nadra K., Médard J.J., Mul J.D., Han G.S., Grès S., Pende M., Metzger D., Chambon P., Cuppen E., Saulnier-Blache J.S. et al., 2012. Molecular and Cellular Biology, 32 (23) pp. 4794-4810. Peer-reviewed.
 
Epineurial adipocytes are dispensable for Schwann cell myelination.
Nadra K., Médard J.J., Quignodon L., Verheijen M.H., Desvergne B., Chrast R., 2012. Journal of Neurochemistry, 123 (5) pp. 662-667.
Genome-wide RNA polymerase II profiles and RNA accumulation reveal kinetics of transcription and associated epigenetic changes during diurnal cycles.
Le Martelot G., Canella D., Symul L., Migliavacca E., Gilardi F., Liechti R., Martin O., Harshman K., Delorenzi M., Desvergne B. et al., 2012. PLoS Biology, 10 (11) pp. e1001442. Peer-reviewed.
Morbillivirus glycoprotein expression induces ER stress, alters Ca2+ homeostasis and results in the release of vasostatin.
Brunner J.M., Plattet P., Doucey M.A., Rosso L., Curie T., Montagner A., Wittek R., Vandelvelde M., Zurbriggen A., Hirling H. et al., 2012. PLoS One, 7 (3) pp. e32803.
 
Endocrine disruptors: from endocrine to metabolic disruption.
Casals-Casas C., Desvergne B., 2011. Annual Review of Physiology, 73 pp. 135-162.
NCoR1 is a conserved physiological modulator of muscle mass and oxidative function.
Yamamoto H., Williams E.G., Mouchiroud L., Cantó C., Fan W., Downes M., Héligon C., Barish G.D., Desvergne B., Evans R.M. et al., 2011. Cell, 147 (4) pp. 827-839.
 
EuroPhenome: a repository for high-throughput mouse phenotyping data.
Morgan H., Beck T., Blake A., Gates H., Adams N., Debouzy G., Leblanc S., Lengger C., Maier H., Melvin D. et al., 2010. Nucleic Acids Research, 38 (Database issue) pp. D577-D585. Peer-reviewed.
 
Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress.
Georgiadi A., Lichtenstein L., Degenhardt T., Boekschoten M.V., van Bilsen M., Desvergne B., Müller M., Kersten S., 2010. Circulation Research, 106 (11) pp. 1712-1721. Peer-reviewed.
 
Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon.
Peyrin-Biroulet L., Beisner J., Wang G., Nuding S., Oommen S.T., Kelly D., Parmentier-Decrucq E., Dessein R., Merour E., Chavatte P. et al., 2010. Proceedings of the National Academy of Sciences of the United States of America, 107 (19) pp. 8772-8777. Peer-reviewed.
 
PPARgamma in placental angiogenesis.
Nadra K., Quignodon L., Sardella C., Joye E., Mucciolo A., Chrast R., Desvergne B., 2010. Endocrinology, 151 (10) pp. 4969-4981. Peer-reviewed.
 
Protective role of peroxisome proliferator-activated receptor-β/δ in septic shock.
Kapoor A., Shintani Y., Collino M., Osuchowski M.F., Busch D., Patel N.S., Sepodes B., Castiglia S., Fantozzi R., Bishop-Bailey D. et al., 2010. American Journal of Respiratory and Critical Care Medicine, 182 (12) pp. 1506-1515.
The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms.
Feige J.N., Gerber A., Casals-Casas C., Yang Q., Winkler C., Bedu E., Bueno M., Gelman L., Auwerx J., Gonzalez F.J. et al., 2010. Environmental Health Perspectives, 118 (2) pp. 234-241. Peer-reviewed.
The PPARbeta/delta agonist GW0742 relaxes pulmonary vessels and limits right heart hypertrophy in rats with hypoxia-induced pulmonary hypertension.
Harrington L.S., Moreno L., Reed A., Wort S.J., Desvergne B., Garland C., Zhao L., Mitchell J.A., 2010. PLoS One, 5 (3) pp. e9526. Peer-reviewed.
 
Transcriptional profiling reveals divergent roles of PPARalpha and PPARbeta/delta in regulation of gene expression in mouse liver.
Sanderson L.M., Boekschoten M.V., Desvergne B., Müller M., Kersten S., 2010. Physiological Genomics, 41 (1) pp. 42-52.
 
PPAR-mediated activity of phthalates: A link to the obesity epidemic?
Desvergne B., Feige J.N., Casals-Casas C., 2009/05. Molecular and cellular endocrinology, 304 (1-2) pp. 43-48. Peer-reviewed.
 
Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver.
Sanderson L.M., Degenhardt T., Koppen A., Kalkhoven E., Desvergne B., Müller M., Kersten S., 2009. Molecular and Cellular Biology, 29 (23) pp. 6257-6267. Peer-reviewed.
 
PPAR beta/delta Agonists Modulate Platelet Function via a Mechanism Involving PPAR Receptors and Specific Association/Repression of PKC alpha-Brief Report
Ali F.Y., Hall M.G., Desvergne B., Warner T.D., Mitchell J.A., 2009. Arteriosclerosis Thrombosis and Vascular Biology, 29 (11) pp. 1871-1873. Peer-reviewed.
 
Steroid hormone pulsing drives cyclic gene expression.
Desvergne B., Héligon C., 2009. Nature Cell Biology, 11 (9) pp. 1051-1053.
 
Interference of pollutants with PPARs: endocrine disruption meets metabolism.
Casals-Casas C., Feige J.N., Desvergne B., 2008. International Journal of Obesity, 32 Suppl 6 pp. S53-S61. Peer-reviewed.
Peroxisome Proliferator-Activated Receptor beta/delta in the Brain: Facts and Hypothesis.
Hall M.G., Quignodon L., Desvergne B., 2008. PPAR Research, 2008 p. 780452.
 
PPAR disruption: Cellular mechanisms and physiological consequences
Rotman N., Haftek-Terreau Z., Luecke S., Feige J., Gelman L., Desvergne B., Wahli W., 2008. CHIMIA, 62 (5) pp. 340-344. Peer-reviewed.
 
PPARdelta/beta: the lobbyist switching macrophage allegiance in favor of metabolism.
Desvergne B., 2008. Cell Metabolism, 7 (6) pp. 467-469. Peer-reviewed.
 
Double gene deletion reveals the lack of cooperation between PPARalpha and PPARbeta in skeletal muscle.
Bedu E., Desplanches D., Pequignot J., Bordier B., Desvergne B., 2007/06. Biochemical and Biophysical Research Communications, 357 (4) pp. 877-881. Peer-reviewed.
 
Adipose tissue integrity as a prerequisite for systemic energy balance: a critical role for peroxisome proliferator-activated receptor gamma.
Anghel S.I., Bedu E., Vivier C.D., Descombes P., Desvergne B., Wahli W., 2007. Journal of Biological Chemistry, 282 (41) pp. 29946-29957. Peer-reviewed.
 
Association with coregulators is the major determinant governing peroxisome proliferator-activated receptor mobility in living cells.
Tudor C., Feige J.N., Pingali H., Lohray V.B., Wahli W., Desvergne B., Engelborghs Y., Gelman L., 2007. Journal of Biological Chemistry, 282 (7) pp. 4417-4426. Peer-reviewed.
 
Combined simulation and mutagenesis analyses reveal the involvement of key residues for peroxisome proliferator-activated receptor alpha helix 12 dynamic behavior.
Michalik L., Zoete V., Krey G., Grosdidier A., Gelman L., Chodanowski P., Feige J.N., Desvergne B., Wahli W., Michielin O., 2007. Journal of Biological Chemistry, 282 (13) pp. 9666-9677. Peer-reviewed.
Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors.
Mandard S., Stienstra R., Escher P., Tan N.S., Kim I., Gonzalez F.J., Wahli W., Desvergne B., Müller M., Kersten S., 2007. Cellular and Molecular Life Sciences, 64 (9) pp. 1145-1157. Peer-reviewed.
 
IL-13 induces expression of CD36 in human monocytes through PPARgamma activation.
Berry A., Balard P., Coste A., Olagnier D., Lagane C., Authier H., Benoit-Vical F., Lepert J.C., Séguéla J.P., Magnaval J.F. et al., 2007. European Journal of Immunology, 37 (6) pp. 1642-1652. Peer-reviewed.
 
Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes.
Indra A.K., Castaneda E., Antal M.C., Jiang M., Messaddeq N., Meng X., Loehr C.V., Gariglio P., Kato S., Wahli W. et al., 2007. Journal of Investigative Dermatology, 127 (5) pp. 1250-1260. Peer-reviewed.
 
Molecular basis of selective PPARgamma modulation for the treatment of Type 2 diabetes.
Gelman L., Feige J.N., Desvergne B., 2007. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1771 (8) pp. 1094-1107. Peer-reviewed.
 
MRI monitoring of focal cerebral ischemia in peroxisome proliferator-activated receptor (PPAR)-deficient mice.
Pialat J.B., Cho T.H., Beuf O., Joye E., Moucharrafie S., Moucharaffie S., Langlois J.B., Nemoz C., Janier M., Berthezene Y. et al., 2007. NMR in Biomedicine, 20 (3) pp. 335-342. Peer-reviewed.
 
PPARs special issue: anchoring the present to explore the future.
Desvergne B., 2007. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1771 (8) pp. 913-914. Peer-reviewed.
 
Retinaldehyde: more than meets the eye.
Desvergne B., 2007. Nature Medicine, 13 (6) pp. 671-673. Peer-reviewed.
 
RXR: from partnership to leadership in metabolic regulations.
Desvergne B., 2007. Vitamins and Hormones, 75 pp. 1-32. Peer-reviewed.
 
Stage-specific integration of maternal and embryonic peroxisome proliferator-activated receptor delta signaling is critical to pregnancy success.
Wang H., Xie H., Sun X., Tranguch S., Zhang H., Jia X., Wang D., Das S.K., Desvergne B., Wahli W. et al., 2007. Journal of Biological Chemistry, 282 (52) pp. 37770-37782. Peer-reviewed.
 
The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis.
Feige J.N., Gelman L., Rossi D., Zoete V., Métivier R., Tudor C., Anghel S.I., Grosdidier A., Lathion C., Engelborghs Y. et al., 2007. Journal of Biological Chemistry, 282 (26) pp. 19152-19166. Peer-reviewed.
 
Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression.
Wang D., Wang H., Guo Y., Ning W., Katkuri S., Wahli W., Desvergne B., Dey S.K., DuBois R.N., 2006. Proceedings of the National Academy of Sciences of the United States of America, 103 (50) pp. 19069-19074. Peer-reviewed.
 
Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta.
Nadra K., Anghel S.I., Joye E., Tan N.S., Basu-Modak S., Trono D., Wahli W., Desvergne B., 2006. Molecular and Cellular Biology, 26 (8) pp. 3266-3281. Peer-reviewed.
 
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
Feige J.N., Gelman L., Michalik L., Desvergne B., Wahli W., 2006. Progress in Lipid Research, 45 (2) pp. 120-159. Peer-reviewed.
Integrating nuclear receptor mobility in models of gene regulation.
Gelman L., Feige J.N., Tudor C., Engelborghs Y., Wahli W., Desvergne B., 2006. Nuclear Receptor Signaling, 4 pp. e010. Peer-reviewed.
 
Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain.
Knauf C., Rieusset J., Foretz M., Cani P.D., Uldry M., Hosokawa M., Martinez E., Bringart M., Waget A., Kersten S. et al., 2006. Endocrinology, 147 (9) pp. 4067-4078. Peer-reviewed.
 
PGC1alpha expression is controlled in skeletal muscles by PPARbeta, whose ablation results in fiber-type switching, obesity, and type 2 diabetes.
Schuler M., Ali F., Chambon C., Duteil D., Bornert J.M., Tardivel A., Desvergne B., Wahli W., Chambon P., Metzger D., 2006. Cell Metabolism, 4 (5) pp. 407-414. Peer-reviewed.
PPARbeta/delta regulates paneth cell differentiation via controlling the hedgehog signaling pathway
Varnat F., Desvergne B., 2006. Gastroenterology, 131 (5) pp. 1658-1659. Peer-reviewed.
 
PPARbeta/delta regulates paneth cell differentiation via controlling the hedgehog signaling pathway.
Varnat F., Heggeler B.B., Grisel P., Boucard N., Corthésy-Theulaz I., Wahli W., Desvergne B., 2006. Gastroenterology, 131 (2) pp. 538-553. Peer-reviewed.
 
PPARs in fetal and early postnatal development
Rotman N., Michalik L., Desvergne B., Wahli W., 2006. pp. 33-64 dans Tanejah R. (eds.) Nuclear receptors in development chap. 2, Elsevier.
 
PPARs: lipid sensors that regulate cell differentiation processes
Varnat F., Michalik L., Desvergne B., Wahli W., 2006. pp. 117-131 dans Brigelius-Flohé R., Joost H.G. (eds.) Nutritional genomics : impact on health and disease chap. 7, Wiley-VCH.
 
Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts.
Ali F.Y., Egan K., FitzGerald G.A., Desvergne B., Wahli W., Bishop-Bailey D., Warner T.D., Mitchell J.A., 2006. American Journal of Respiratory Cell and Molecular Biology, 34 (2) pp. 242-246. Peer-reviewed.
 
Transcriptional regulation of metabolism.
Desvergne B., Michalik L., Wahli W., 2006. Physiological Reviews, 86 (2) pp. 465-514. Peer-reviewed.
 
EMPReSS: standardised phenotype screens for functional annotation of the mouse genome
Eumorphia_Consortium, Wahli W., Delgado MB., Desvergne B., Michalik L., Bedu E., 2005. Nature Genetics, 37 (11) p. 1155. Peer-reviewed.
 
Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development.
Di-Poï N., Ng C.Y., Tan N.S., Yang Z., Hemmings B.A., Desvergne B., Michalik L., Wahli W., 2005. Molecular and Cellular Biology, 25 (5) pp. 1696-1712. Peer-reviewed.
 
Fluorescence imaging reveals the nuclear behavior of peroxisome proliferator-activated receptor/retinoid X receptor heterodimers in the absence and presence of ligand.
Feige J.N., Gelman L., Tudor C., Engelborghs Y., Wahli W., Desvergne B., 2005. Journal of Biological Chemistry, 280 (18) pp. 17880-17890. Peer-reviewed.
 
Functional role of RXRs and PPARgamma in mature adipocytes.
Metzger D., Imai T., Jiang M., Takukawa R., Desvergne B., Wahli W., Chambon P., 2005. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 73 (1) pp. 51-58. Peer-reviewed.
 
Genetic- or transforming growth factor-beta 1-induced changes in epidermal peroxisome proliferator-activated receptor beta/delta expression dictate wound repair kinetics.
Tan N.S., Michalik L., Desvergne B., Wahli W., 2005. Journal of Biological Chemistry, 280 (18) pp. 18163-18170. Peer-reviewed.
Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma.
Rousseaux C., Lefebvre B., Dubuquoy L., Lefebvre P., Romano O., Auwerx J., Metzger D., Wahli W., Desvergne B., Naccari G.C. et al., 2005. Journal of Experimental Medicine, 201 (8) pp. 1205-1215. Peer-reviewed.
 
Kinase signaling cascades that modulate peroxisome proliferator-activated receptors.
Gelman L., Michalik L., Desvergne B., Wahli W., 2005. Current Opinion in Cell Biology, 17 (2) pp. 216-222. Peer-reviewed.
 
Multiple expression control mechanisms of peroxisome proliferator-activated receptors and their target genes.
Tan N.S., Michalik L., Desvergne B., Wahli W., 2005. Journal of Steroid Biochemistry and Molecular Biology, 93 (2-5) pp. 99-105. Peer-reviewed.
 
Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidation.
Gremlich S., Nolan C., Roduit R., Burcelin R., Peyot M.L., Delghingaro-Augusto V., Desvergne B., Michalik L., Prentki M., Wahli W., 2005. Endocrinology, 146 (1) pp. 375-382. Peer-reviewed.
 
Peroxisome proliferator-activated receptor beta/delta as a therapeutic target for metabolic diseases.
Bedu E., Wahli W., Desvergne B., 2005. Expert Opinion On Therapeutic Targets, 9 (4) pp. 861-873. Peer-reviewed.
 
Peroxisome proliferator-activated receptor beta/delta exerts a strong protection from ischemic acute renal failure.
Letavernier E., Perez J., Joye E., Bellocq A., Fouqueray B., Haymann J.P., Heudes D., Wahli W., Desvergne B., Baud L., 2005. Journal of the American Society of Nephrology, 16 (8) pp. 2395-2402. Peer-reviewed.
 
PixFRET, an ImageJ plug-in for FRET calculation that can accommodate variations in spectral bleed-throughs.
Feige J.N., Sage D., Wahli W., Desvergne B., Gelman L., 2005. Microscopy Research and Technique, 68 (1) pp. 51-58. Peer-reviewed.
 
Promoter rearrangements cause species-specific hepatic regulation of the glyoxylate reductase/hydroxypyruvate reductase gene by the peroxisome proliferator-activated receptor alpha.
Genolet R., Kersten S., Braissant O., Mandard S., Tan N.S., Bucher P., Desvergne B., Michalik L., Wahli W., 2005. Journal of Biological Chemistry, 280 (25) pp. 24143-24152. Peer-reviewed.
 
Scaffold attachment factor B1 directly interacts with nuclear receptors in living cells and represses transcriptional activity.
Debril M.B., Dubuquoy L., Feige J.N., Wahli W., Desvergne B., Auwerx J., Gelman L., 2005. Journal of Molecular Endocrinology, 35 (3) pp. 503-517. Peer-reviewed.
 
Selective expression of a dominant-negative form of peroxisome proliferator-activated receptor in keratinocytes leads to impaired epidermal healing.
Michalik L., Feige J.N., Gelman L., Pedrazzini T., Keller H., Desvergne B., Wahli W., 2005. Molecular Endocrinology, 19 (9) pp. 2335-2348. Peer-reviewed.
 
Transcriptional repression of peroxisome proliferator-activated receptor beta/delta in murine keratinocytes by CCAAT/enhancer-binding proteins.
Di-Poï N., Desvergne B., Michalik L., Wahli W., 2005. Journal of Biological Chemistry, 280 (46) pp. 38700-38710. Peer-reviewed.
 
Altered growth in male peroxisome proliferator-activated receptor gamma (PPARgamma) heterozygous mice: involvement of PPARgamma in a negative feedback regulation of growth hormone action.
Rieusset J., Seydoux J., Anghel S.I., Escher P., Michalik L., Soon Tan N., Metzger D., Chambon P., Wahli W., Desvergne B., 2004. Molecular Endocrinology, 18 (10) pp. 2363-2377. Peer-reviewed.
 
Be fit or be sick: peroxisome proliferator-activated receptors are down the road.
Desvergne B., Michalik L., Wahli W., 2004. Molecular Endocrinology, 18 (6) pp. 1321-1332. Peer-reviewed.
 
Critical roles of the nuclear receptor PPARbeta (peroxisome-proliferator-activated receptor beta) in skin wound healing.
Tan N.S., Michalik L., Di-Poï N., Desvergne B., Wahli W., 2004. Biochemical Society Transactions, 32 (Pt 1) pp. 97-102. Peer-reviewed.
 
Essential role of Smad3 in the inhibition of inflammation-induced PPARbeta/delta expression.
Tan N.S., Michalik L., Di-Poï N., Ng C.Y., Mermod N., Roberts A.B., Desvergne B., Wahli W., 2004. EMBO Journal, 23 (21) pp. 4211-4221. Peer-reviewed.
Functions of peroxisome proliferator-activated receptors (PPAR) in skin homeostasis.
Di-Poï N., Michalik L., Desvergne B., Wahli W., 2004. Lipids, 39 (11) pp. 1093-1099. Peer-reviewed.
 
In vivo activation of PPAR target genes by RXR homodimers.
Ijpenberg A., Tan N.S., Gelman L., Kersten S., Seydoux J., Xu J., Metzger D., Canaple L., Chambon P., Wahli W. et al., 2004. EMBO Journal, 23 (10) pp. 2083-2091. Peer-reviewed.
 
Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse.
Imai T., Takakuwa R., Marchand S., Dentz E., Bornert J.M., Messaddeq N., Wendling O., Mark M., Desvergne B., Wahli W. et al., 2004. Proceedings of the National Academy of Sciences of the United States of America, 101 (13) pp. 4543-4547. Peer-reviewed.
 
Peroxisome proliferator-activated receptor-beta as a target for wound healing drugs.
Tan N.S., Michalik L., Desvergne B., Wahli W., 2004. Expert Opinion on Therapeutic Targets, 8 (1) pp. 39-48. Peer-reviewed.
 
Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation.
Mao-Qiang M., Fowler A.J., Schmuth M., Lau P., Chang S., Brown B.E., Moser A.H., Michalik L., Desvergne B., Wahli W. et al., 2004. Journal of Investigative Dermatology, 123 (2) pp. 305-312. Peer-reviewed.
 
Peroxisome-proliferator-activated receptors and cancers: complex stories.
Michalik L., Desvergne B., Wahli W., 2004. Nature Reviews. Cancer, 4 (1) pp. 61-70. Peer-reviewed.
 
PPARs in health and disease : central roles in energy homeostasis and tissue repair.
Wahli W, Michalik L, Desvergne B, 2004. BIO, 11 pp. 26-31. Peer-reviewed.
 
Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta.
Wang D., Wang H., Shi Q., Katkuri S., Walhi W., Desvergne B., Das S.K., Dey S.K., DuBois R.N., 2004. Cancer Cell, 6 (3) pp. 285-295. Peer-reviewed.
 
Peroxisome proliferator-activated receptor (PPAR)-beta as a target for wound healing drugs: what is possible?
Tan N.S., Michalik L., Desvergne B., Wahli W., 2003. American Journal of Clinical Dermatology, 4 (8) pp. 523-530.
 
Peroxisome proliferator-activated receptors beta/delta: emerging roles for a previously neglected third family member.
Michalik L., Desvergne B., Wahli W., 2003. Current Opinion in Lipidology, 14 (2) pp. 129-135.
 
PPARs: nuclear receptors involved in the control of inflammation
Michalik L., Tan N. S., Wahli W., Desvergne B., 2003. pp. 419-435 dans Duttaroy A.K., Spener F. (eds.) Cellular proteins and their fatty acids in health and disease chap. 24, Wiley VCH.
 
The anti-apoptotic role of PPARbeta contributes to efficient skin wound healing.
Di-Poï N., Michalik L., Tan N.S., Desvergne B., Wahli W., 2003. Journal of Steroid Biochemistry and Molecular Biology, 85 (2-5) pp. 257-265.
 
Feedback on hypothalamic TRH transcription is dependent on thyroid hormone receptor N terminus.
Guissouma H., Dupré S.M., Becker N., Jeannin E., Seugnet I., Desvergne B., Demeneix B.A., 2002/07. Molecular Endocrinology, 16 (7) pp. 1652-1666.
 
A new selective peroxisome proliferator-activated receptor gamma antagonist with antiobesity and antidiabetic activity.
Rieusset J., Touri F., Michalik L., Escher P., Desvergne B., Niesor E., Wahli W., 2002. Molecular Endocrinology, 16 (11) pp. 2628-2644.
 
Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway.
Di-Poï N., Tan N.S., Michalik L., Wahli W., Desvergne B., 2002. Molecular Cell, 10 (4) pp. 721-733.
 
Differential regulation of vascular endothelial growth factor expression by peroxisome proliferator-activated receptors in bladder cancer cells.
Fauconnet S., Lascombe I., Chabannes E., Adessi G.L., Desvergne B., Wahli W., Bittard H., 2002. Journal of Biological Chemistry, 277 (26) pp. 23534-23543. Peer-reviewed.
 
High risk for hyperlipidemia and the metabolic syndrome after an episode of hypertriglyceridemia during 13-cis retinoic acid therapy for acne: a pharmacogenetic study.
Rodondi N., Darioli R., Ramelet A.A., Hohl D., Lenain V., Perdrix J., Wietlisbach V., Riesen W.F., Walther T., Medinger L. et al., 2002. Annals of Internal Medicine, 136 (8) pp. 582-589. Peer-reviewed.
 
Peroxisome Proliferator Activated Receptor alpha coordinates intermediary metabolism during fasting.
Kersten S., Desvergne B., Wahli W., 2002. pp. 1-4 dans Fruchart J.C., Gotto A.M., Paoletti R., Staels B., Catapano A.L. (eds.) PPARs : from basic science to clinical applications chap. 1, Kluwer Academics Publishers.
 
PPAR expression and function during vertebrate development.
Michalik L., Desvergne B., Dreyer C., Gavillet M., Laurini R.N., Wahli W., 2002/01. International Journal of Developmental Biology, 46 (1) pp. 105-114.
 
Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription.
Tan N.S., Shaw N.S., Vinckenbosch N., Liu P., Yasmin R., Desvergne B., Wahli W., Noy N., 2002. Molecular and Cellular Biology, 22 (14) pp. 5114-5127.
 
Sensors for metabolic control : a regulatory network of nuclear receptors
Desvergne B., Michalik L., Wahli W., 2002. pp. 283-304 dans Goffin V., Kelly P.A. (eds.) Hormone signaling chap. 14, Kluwer Academic Publishers.
 
Critical roles of PPAR beta/delta in keratinocyte response to inflammation.
Tan N.S., Michalik L., Noy N., Yasmin R., Pacot C., Heim M., Flühmann B., Desvergne B., Wahli W., 2001/12. Genes and Development, 15 (24) pp. 3263-3277.
 
Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding.
Escher P., Braissant O., Basu-Modak S., Michalik L., Wahli W., Desvergne B., 2001/10. Endocrinology, 142 (10) pp. 4195-4202.
Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies.
Desreumaux P., Dubuquoy L., Nutten S., Peuchmaur M., Englaro W., Schoonjans K., Derijard B., Desvergne B., Wahli W., Chambon P. et al., 2001. Journal of Experimental Medicine, 193 (7) pp. 827-838.
 
Development of a coculture model of encapsulated cells.
Canaple L., Nurdin N., Angelova N., Hunkeler D., Desvergne B., 2001. Annals of the New York Academy of Sciences, 944 pp. 350-361.
Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice.
Michalik L., Desvergne B., Tan N.S., Basu-Modak S., Escher P., Rieusset J., Peters J.M., Kaya G., Gonzalez F.J., Zakany J. et al., 2001. Journal of Cell Biology, 154 (4) pp. 799-814.
 
Les récepteurs nucléaires PPARs (Peroxisome Proliferator Activated Receptors) : Trois isotypes pour de multiples fonctions.
Rieusset J., Wahli W., Desvergne B., 2001. Médecine Thérapeutique Endocinologie et Reproduction, 3 pp. 4-12.
 
Maintenance of primary murine hepatocyte functions in multicomponent polymer capsules-in vitro cryopreservation studies.
Canaple L., Nurdin N., Angelova N., Saugy D., Hunkeler D., Desvergne B., 2001. Journal of Hepatology, 34 (1) pp. 11-18.
 
The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism.
Kersten S., Mandard S., Escher P., Gonzalez F.J., Tafuri S., Desvergne B., Wahli W., 2001. FASEB Journal, 15 (11) pp. 1971-1978.
 
Roles of PPARs in health and disease.
Kersten S., Desvergne B., Wahli W., 2000/05. Nature, 405 (6785) pp. 421-424.
 
Capsule permeability via polymer and protein ingress/egress.
Nurdin N., Canaple L., Bartkowiak A., Desvergne B., Hunkeler D., 2000. Journal of Applied Polymers Science, 75 (9) pp. 1165-1175. Peer-reviewed.
 
Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene.
Kersten S., Mandard S., Tan N.S., Escher P., Metzger D., Chambon P., Gonzalez F.J., Desvergne B., Wahli W., 2000. Journal of Biological Chemistry, 275 (37) pp. 28488-28493.
 
Les bases moléculaires de l'obésité : vers de nouvelles thérapeutiques ?
Michalik L., Desvergne B., Wahli W., 2000. Medecine Sciences, 16 (10) pp. 1030-1039. Peer-reviewed.
 
Nuclear hormone receptors and mouse skin homeostasis: implication of PPARbeta.
Michalik L., Desvergne B., Basu-Modak S., Tan N.S., Wahli W., 2000. Hormone Research, 54 (5-6) pp. 263-268.
 
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
Desvergne B., Wahli W., 1999/10. Endocrine Reviews, 20 (5) pp. 649-688.
 
Activation of the mouse TATA-less and human TATA-containing UDP-glucuronosyltransferase 1A1 promoters by hepatocyte nuclear factor 1.
Bernard P., Goudonnet H., Artur Y., Desvergne B., Wahli W., 1999/09. Molecular Pharmacology, 56 (3) pp. 526-536.
 
New multicomponent capsules for immunoisolation.
Bartkowiak A., Canaple L., Ceausoglu I., Nurdin N., Renken A., Rindisbacher L., Wandrey C., Desvergne B., Hunkeler D., 1999/06. Annals of the New York Academy of Sciences, 875 pp. 135-145.
 
Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting.
Kersten S., Seydoux J., Peters J.M., Gonzalez F.J., Desvergne B., Wahli W., 1999/06. Journal of Clinical Investigation, 103 (11) pp. 1489-1498.
 
Fatty acids, eicosanoids, and hypolipidemic agents regulate gene expression through direct binding to peroxisome proliferator-activated receptors.
Wahli W., Devchand P.R., IJpenberg A., Desvergne B., 1999. Advances in Experimental Medicine and Biology, 447 pp. 199-209.
Peroxisome proliferator-activated receptor beta regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures.
Basu-Modak S., Braissant O., Escher P., Desvergne B., Honegger P., Wahli W., 1999. Journal of Biological Chemistry, 274 (50) pp. 35881-35888.
 
PPARs: nuclear receptors for fatty acids, eicosanoids, and xenobiotics.
Devchand P.R., Ijpenberg A., Devesvergne B., Wahli W., 1999. Advances in Experimental Medicine and Biology, 469 pp. 231-236.
 
PPARα : cross-talk with membrane receptors and control of energy homeostasis
Wahli W., Kersten S., Devchand P., Desvergne B., 1999., Uehara Memorial Foundation symposium on common disease, Tokyo , JAPON (30/06/1999) pp. 159-167 dans Imura H., Kasuga M, Nakao K. (eds.) Common disease : genetic and pathogenetic aspects of multifactorial diseases, Excerpta Medica. International Congress Series, Elsevier.
 
Transcriptional regulatory patterns of the myelin basic protein and malic enzyme genes by the thyroid hormone receptors alpha1 and beta1.
Jeannin E., Robyr D., Desvergne B., 1998/09. Journal of Biological Chemistry, 273 (37) pp. 24239-24248.
 
The peroxisome proliferator-activated receptors at the cross-road of diet and hormonal signalling.
Desvergne B., IJpenberg A., Devchand P.R., Wahli W., 1998/04. Journal of Steroid Biochemistry and Molecular Biology, 65 (1-6) pp. 65-74.
 
DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5'-flanking region.
Juge-Aubry C., Pernin A., Favez T., Burger A.G., Wahli W., Meier C.A., Desvergne B., 1997/10. Journal of Biological Chemistry, 272 (40) pp. 25252-25259.
The major transcription initiation site of the SV40 late promoter is a potent thyroid hormone response element.
Desvergne B., Favez T., 1997/05. Nucleic Acids Research, 25 (9) pp. 1774-1781.
 
Polarity and specific sequence requirements of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor heterodimer binding to DNA. A functional analysis of the malic enzyme gene PPAR response element.
IJpenberg A., Jeannin E., Wahli W., Desvergne B., 1997. Journal of Biological Chemistry, 272 (32) pp. 20108-20117.
 
Transcriptional regulation by triiodothyronine of the UDP-glucuronosyltransferase family 1 gene complex in rat liver. Comparison with induction by 3-methylcholanthrene.
Masmoudi T., Hihi A.K., Vázquez M., Artur Y., Desvergne B., Wahli W., Goudonnet H., 1997. Journal of Biological Chemistry, 272 (27) pp. 17171-17175.
 
Expression of the peroxisome proliferator-activated receptor alpha gene is stimulated by stress and follows a diurnal rhythm.
Lemberger T., Saladin R., Vázquez M., Assimacopoulos F., Staels B., Desvergne B., Wahli W., Auwerx J., 1996/01. Journal of Biological Chemistry, 271 (3) pp. 1764-1769.
 
Peroxisome proliferation and its role in carcinogenesis.
Desvergne B., 1996. ISSX Newsletter, 16 p. 29.
 
Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology.
Lemberger T., Desvergne B., Wahli W., 1996. Annual Review of Cell and Developmental Biology, 12 pp. 335-363.
 
Peroxisome proliferator activated receptors: transcriptional regulators of adipogenesis, lipid metabolism and more....
Wahli W., Braissant O., Desvergne B., 1995/05. Chemistry and Biology, 2 (5) pp. 261-266.
 
PPAR: a key nuclear factor in nutrient/gene interactions ?
Desvergne B., Wahli W., 1995. pp. 142-176 dans Baeuerle P. A. (eds.) Inducible gene expression. Vol. 1, environmental stresses and nutrients, Birkhäuser.
 
Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids.
Lemberger T., Staels B., Saladin R., Desvergne B., Auwerx J., Wahli W., 1994/10. Journal of Biological Chemistry, 269 (40) pp. 24527-24530.
 
A role for intronic sequences on expression of thyroid hormone receptor alpha gene.
Lazar J., Desvergne B., Zimmerman E.C., Zimmer D.B., Magnuson M.A., Nikodem V.M., 1994/08. Journal of Biological Chemistry, 269 (32) pp. 20352-20359. Peer-reviewed.
 
How do thyroid hormone receptors bind to structurally diverse response elements?
Desvergne B., 1994/04. Molecular and Cellular Endocrinology, 100 (1-2) pp. 125-131.
 
Characterization of myelin basic protein thyroid hormone response element and its function in the context of native and heterologous promoter.
Farsetti A., Desvergne B., Hallenbeck P., Robbins J., Nikodem V.M., 1992/08. Journal of Biological Chemistry, 267 (22) pp. 15784-15788. Peer-reviewed.
 
Molecular basis of thyroid hormone regulation of myelin basic protein gene expression in rodent brain.
Farsetti A., Mitsuhashi T., Desvergne B., Robbins J., Nikodem V.M., 1991/12. Journal of Biological Chemistry, 266 (34) pp. 23226-23232. Peer-reviewed.
 
Functional characterization and receptor binding studies of the malic enzyme thyroid hormone response element.
Desvergne B., Petty K.J., Nikodem V.M., 1991/01. Journal of Biological Chemistry, 266 (2) pp. 1008-1013. Peer-reviewed.
 
Identification of a thyroid hormone response element in the malic enzyme gene.
Petty K.J., Desvergne B., Mitsuhashi T., Nikodem V.M., 1990/05. Journal of Biological Chemistry, 265 (13) pp. 7395-7400. Peer-reviewed.
 
Structure and mechanism of action of thyroid hormone receptors
Nikodem V.M., Petty K.J., Mitsuhashi T., Desvergne B., 1990. pp. 307-321 dans Greer M. A. (eds.) The thyroid gland, Raven Press.
 
Chronic iron overload inhibits protein secretion by adult rat hepatocytes maintained in long-term primary culture.
Desvergne B., Baffet G., Loyer P., Rissel M., Lescoat G., Guguen-Guillouzo C., Brissot P., 1989/06. European journal of cell biology, 49 (1) pp. 162-170. Peer-reviewed.
 
Effects of iron overload on transferrin secretion by cultured fetal rat hepatocytes.
Lescoat G., Jouanolle H., Desvergne B., Pasdeloup N., Kneip B., Deugnier Y., Guillouzo A., Brissot P., 1989. Biology of the Cell, 65 (3) pp. 221-229.
 
Modulation of albumin secretion by ornithine alpha-ketoglutarate in adult rat hepatocyte cultures and a human hepatoma cell line (HepG2).
Lescoat G., Desvergne B., Loreal O., Pasdeloup N., Deugnier Y., Bourel M., Brissot P., 1989. Annals of Nutrition and Metabolism, 33 (5) pp. 252-260.
 
Effect of ornithine on transferrin secretion of rat and human hepatocyte cultures.
Lescoat G., Loreal O., Desvergne B., Pasdeloup N., Deugnier Y., Brissot P., 1988/12. Liver, 8 (6) pp. 360-365.
 
Transient expression of c-fos and constant expression of c-myc in freshly isolated and cultured normal adult rat hepatocytes.
Etienne P.L., Baffet G., Desvergne B., Boisnard-Rissel M., Glaise D., Guguen-Guillouzo C., 1988. Oncogene Research, 3 (3) pp. 255-262.
 
Surcharge hépatique en fer et synthèse protéique progrès apportés par les modèles expérimentaux
Jouanolle H., Lescoat G., Desvergne B., Deugnier Y., Brissot P., Bourel M., 1987/10. Annales de gastroentérologie et d'hépatologie, 23 (5) pp. 269-272. Peer-reviewed.
 
Chronic liver iron overload in the baboon by ferric nitrilotriacetate. Morphologic and functional changes with special reference to collagen synthesis enzymes.
Brissot P., Farjanel J., Bourel D., Campion J.P., Guillouzo A., Rattner A., Deugnier Y., Desvergne B., Ferrand B., Simon M. et al., 1987/06. Digestive Diseases and Sciences, 32 (6) pp. 620-627.
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