Giuseppina Milano

Publications | Mémoires et thèses

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70 publications

2023 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2013 | 2012 | 2011 | 2010 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 |
The systemic deletion of interleukin-1α reduces myocardial inflammation and attenuates ventricular remodeling in murine myocardial infarction.
Lugrin J., Parapanov R., Milano G., Cavin S., Debonneville A., Krueger T., Liaudet L., 2023/03/10. Scientific reports, 13 (1) p. 4006. Peer-reviewed.
 
Erratum: Inflammatory extracellular vesicles prompt heart dysfunction via TLR4-dependent NF-κB activation: Erratum.
Biemmi V., Milano G., Ciullo A., Cervio E., Burrello J., Dei Cas M., Paroni R., Tallone T., Moccetti T., Pedrazzini G. et al., 2023. Theranostics, 13 (4) p. 1286. Peer-reviewed.
Nitric Oxide-cGMP Pathway Modulation in an Experimental Model of Hypoxic Pulmonary Hypertension.
Reinero M., Beghetti M., Tozzi P., Segesser LKV, Samaja M., Milano G., 2021/11. Journal of cardiovascular pharmacology and therapeutics, 26 (6) pp. 665-676. Peer-reviewed.
 
Oxidized LDL-dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy.
Sommariva E., Stadiotti I., Casella M., Catto V., Dello Russo A., Carbucicchio C., Arnaboldi L., De Metrio S., Milano G., Scopece A. et al., 2021/09/07. EMBO molecular medicine, 13 (9) pp. e14365. Peer-reviewed.
 
Performance characteristics of the new Eurosets magnetically suspended centrifugal pump.
Berdajs D., von Segesser L.K., Maisano F., Milano G., Ferrari E., 2021/03. Perfusion, 36 (2) pp. 183-189. Peer-reviewed.
 
An exosomal-carried short periostin isoform induces cardiomyocyte proliferation.
Balbi C., Milano G., Fertig T.E., Lazzarini E., Bolis S., Taniyama Y., Sanada F., Di Silvestre D., Mauri P., Gherghiceanu M. et al., 2021. Theranostics, 11 (12) pp. 5634-5649. Peer-reviewed.
 
Can Erythropoietin Reduce Hypoxemic Neurological Damages in Neonates With Congenital Heart Defects?
Ottolenghi S., Milano G., Cas M.D., Findley T.O., Paroni R., Corno A.F., 2021. Frontiers in pharmacology, 12 p. 770590. Peer-reviewed.
Structural and Electrophysiological Changes in a Model of Cardiotoxicity Induced by Anthracycline Combined With Trastuzumab.
Altomare C., Lodrini A.M., Milano G., Biemmi V., Lazzarini E., Bolis S., Pernigoni N., Torre E., Arici M., Ferrandi M. et al., 2021. Frontiers in physiology, 12 p. 658790. Peer-reviewed.
Adaptation to Hypoxia: A Chimera?
Samaja M., Milano G., 2020/02/24. International journal of molecular sciences, 21 (4) p. 1527. Peer-reviewed.
 
Intravenous administration of cardiac progenitor cell-derived exosomes protects against doxorubicin/trastuzumab-induced cardiac toxicity.
Milano G., Biemmi V., Lazzarini E., Balbi C., Ciullo A., Bolis S., Ameri P., Di Silvestre D., Mauri P., Barile L. et al., 2020/02/01. Cardiovascular research, 116 (2) pp. 383-392. Peer-reviewed.
Inflammatory extracellular vesicles prompt heart dysfunction via TRL4-dependent NF-κB activation.
Biemmi V., Milano G., Ciullo A., Cervio E., Burrello J., Dei Cas M., Paroni R., Tallone T., Moccetti T., Pedrazzini G. et al., 2020. Theranostics, 10 (6) pp. 2773-2790. Peer-reviewed.
Effects of PDE-5 Inhibition on the Cardiopulmonary System After 2 or 4 Weeks of Chronic Hypoxia.
Nydegger C., Corno A.F., von Segesser L.K., Beghetti M., Samaja M., Milano G., 2019/08. Cardiovascular drugs and therapy, 33 (4) pp. 407-414. Peer-reviewed.
 
Fibrosis Rescue Improves Cardiac Function in Dystrophin-Deficient Mice and Duchenne Patient-Specific Cardiomyocytes by Immunoproteasome Modulation.
Farini A., Gowran A., Bella P., Sitzia C., Scopece A., Castiglioni E., Rovina D., Nigro P., Villa C., Fortunato F. et al., 2019/02. The American journal of pathology, 189 (2) pp. 339-353. Peer-reviewed.
 
Plasmatic and chamber-specific modulation of cardiac microRNAs in an acute model of DOX-induced cardiotoxicity.
Gioffré S., Ricci V., Vavassori C., Ruggeri C., Chiesa M., Alfieri I., Zorzan S., Buzzetti M., Milano G., Scopece A. et al., 2019/02. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 110 pp. 1-8. Peer-reviewed.
Exosomal Expression of CXCR4 Targets Cardioprotective Vesicles to Myocardial Infarction and Improves Outcome after Systemic Administration.
Ciullo A., Biemmi V., Milano G., Bolis S., Cervio E., Fertig E.T., Gherghiceanu M., Moccetti T., Camici G.G., Vassalli G. et al., 2019/01/22. International journal of molecular sciences, 20 (3). Peer-reviewed.
miR-34a Promotes Vascular Smooth Muscle Cell Calcification by Downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase).
Badi I., Mancinelli L., Polizzotto A., Ferri D., Zeni F., Burba I., Milano G., Brambilla F., Saccu C., Bianchi M.E. et al., 2018/09. Arteriosclerosis, thrombosis, and vascular biology, 38 (9) pp. 2079-2090. Peer-reviewed.
 
Cardioprotection by cardiac progenitor cell-secreted exosomes: role of pregnancy-associated plasma protein-A.
Barile L., Cervio E., Lionetti V., Milano G., Ciullo A., Biemmi V., Bolis S., Altomare C., Matteucci M., Di Silvestre D. et al., 2018/06/01. Cardiovascular research, 114 (7) pp. 992-1005. Peer-reviewed.
A Specific Circulating MicroRNA Cluster Is Associated to Late Differential Cardiac Response to Doxorubicin-Induced Cardiotoxicity In Vivo.
Ruggeri C., Gioffré S., Chiesa M., Buzzetti M., Milano G., Scopece A., Castiglioni L., Pontremoli M., Sironi L., Pompilio G. et al., 2018. Disease markers, 2018 p. 8395651. Peer-reviewed.
ALDH1A3 Is the Key Isoform That Contributes to Aldehyde Dehydrogenase Activity and Affects <i>in Vitro</i> Proliferation in Cardiac Atrial Appendage Progenitor Cells.
Puttini S., Plaisance I., Barile L., Cervio E., Milano G., Marcato P., Pedrazzini T., Vassalli G., 2018. Frontiers in cardiovascular medicine, 5 p. 90. Peer-reviewed.
Exosomes From Human Cardiac Progenitor Cells for Therapeutic Applications: Development of a GMP-Grade Manufacturing Method.
Andriolo G., Provasi E., Lo Cicero V., Brambilla A., Soncin S., Torre T., Milano G., Biemmi V., Vassalli G., Turchetto L. et al., 2018. Frontiers in physiology, 9 p. 1169. Peer-reviewed.
Phosphodiesterase-5 Inhibition Alleviates Pulmonary Hypertension and Basal Lamina Thickening in Rats Challenged by Chronic Hypoxia.
Nydegger C., Martinelli C., Di Marco F., Bulfamante G., von Segesser L., Tozzi P., Samaja M., Milano G., 2018. Frontiers in physiology, 9 p. 289. Peer-reviewed.
Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health.
Heid J., Cencioni C., Ripa R., Baumgart M., Atlante S., Milano G., Scopece A., Kuenne C., Guenther S., Azzimato V. et al., 2017/12/04. Scientific reports, 7 (1) p. 16839. Peer-reviewed.
 
Non-oxidizable HMGB1 induces cardiac fibroblasts migration via CXCR4 in a CXCL12-independent manner and worsens tissue remodeling after myocardial infarction.
Di Maggio S., Milano G., De Marchis F., D'Ambrosio A., Bertolotti M., Palacios B.S., Badi I., Sommariva E., Pompilio G., Capogrossi M.C. et al., 2017/11. Biochimica et biophysica acta, 1863 (11) pp. 2693-2704. Peer-reviewed.
Doxorubicin upregulates CXCR4 via miR-200c/ZEB1-dependent mechanism in human cardiac mesenchymal progenitor cells.
Beji S., Milano G., Scopece A., Cicchillitti L., Cencioni C., Picozza M., D'Alessandra Y., Pizzolato S., Bertolotti M., Spaltro G. et al., 2017/08/24. Cell death & disease, 8 (8) pp. e3020. Peer-reviewed.
 
Beneficial effects of exosomes secreted by cardiac-derived progenitor cells and other cell types in myocardial ischemia.
Barile L., Milano G., Vassalli G., 2017. Stem cell investigation, 4 p. 93. Peer-reviewed.
 
Inhibition of ceramide de novo synthesis as a postischemic strategy to reduce myocardial reperfusion injury.
Reforgiato M.R., Milano G., Fabriàs G., Casas J., Gasco P., Paroni R., Samaja M., Ghidoni R., Caretti A., Signorelli P., 2016. Basic Research In Cardiology, 111 (2) p. 12. Peer-reviewed.
Editorial - Hypoxia and Reoxygenation: From Basic Science to Bedside.
Samaja M., Milano G., 2015. Frontiers In Pediatrics, 3 p. 86. Peer-reviewed.
 
Toll-like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia-reperfusion in the mouse.
Parapanov R., Lugrin J., Rosenblatt-Velin N., Feihl F., Waeber B., Milano G., Vergely C., Li N., Pacher P., Liaudet L., 2015. Clinical Science, 129 (2) pp. 187-198. Peer-reviewed.
 
An Investigation into the Genetic and Phenotypic Determinants of Blood Pressure and Other Cardiovascular Risk Factors
Taylor J., Conen D., Milano G., 2013..
Characterization of cardiac-resident progenitor cells expressing high aldehyde dehydrogenase activity.
Roehrich M.E., Spicher A., Milano G., Vassalli G., 2013. Biomed Research International, 2013 (S9) p. 503047.
Impact of the phosphatidylinositide 3-kinase signaling pathway on the cardioprotection induced by intermittent hypoxia.
Milano G., Abruzzo P.M., Bolotta A., Marini M., Terraneo L., Ravara B., Gorza L., Vitadello M., Burattini S., Curzi D. et al., 2013. Plos One, 8 (10) pp. e76659.
 
Investigating the Role of Nitric Oxide Donors in the Recruitment of Haematopoietic Progenitor Cells in Hypoxia-Induced Pulmonary Hypertension
Taylor J., Milano G., 2013..
Role of Mitogen-Activated Protein Kinases in Myocardial Ischemia-Reperfusion Injury during Heart Transplantation.
Vassalli G., Milano G., Moccetti T., 2012. Journal of Transplantation, 2012 (928954) pp. 1-16.
 
Myocardial tolerance to ischemia-reperfusion injury, training intensity and cessation.
Esposito F., Ronchi R., Milano G., Margonato V., Di Tullio S., Marini M., Veicsteinas A., Samaja M., 2011. European Journal of Applied Physiology, 111 (5) pp. 859-868.
Phosphodiesterase-5 inhibition mimics intermittent reoxygenation and improves cardioprotection in the hypoxic myocardium.
Milano G., Bianciardi P., Rochemont V., Vassalli G., Segesser L.K., Corno A.F., Guazzi M., Samaja M., 2011. Plos One, 6 (11) pp. e27910.
Daily reoxygenation decreases myocardial injury and improves post-ischaemic recovery after chronic hypoxia.
Milano G., Corno A.F., Samaja M., Morel S., Vassalli G., von Segesser L.K., 2010. European Journal of Cardio-thoracic Surgery, 37 (4) pp. 942-949.
 
Phosphorylation of phosphatidylinositol-3-kinase-protein kinase B and extracellular signal-regulated kinases 1/2 mediate reoxygenation-induced cardioprotection during hypoxia.
Milano G., von Segesser L.K., Morel S., Joncic A., Bianciardi P., Vassalli G., Samaja M., 2010. Experimental Biology and Medicine, 235 (3) pp. 401-410.
 
Cellular distribution of Hsp70 expression in rat skeletal muscles. Effects of moderate exercise training and chronic hypoxia.
Tarricone E., Scapin C., Vitadello M., Esposito F., Margonato V., Milano G., Samaja M., Gorza L., 2008. Cell Stress and Chaperones, 13 (4) pp. 483-495. Peer-reviewed.
 
Heart HIF-1alpha and MAP kinases during hypoxia: are they associated in vivo?
Caretti A., Morel S., Milano G., Fantacci M., Bianciardi P., Ronchi R., Vassalli G., von Segesser L.K., Samaja M., 2007/07. Experimental Biology And Medicine, 232 (7) pp. 887-894. Peer-reviewed.
 
Metabolic modulation induced by chronic hypoxia in rats using a comparative proteomic analysis of skeletal muscle tissue
De Palma S., Ripamonti M., Vigano A., Moriggi M., Capitanio D., Samaja M., Milano G., Cerretelli P., Wait R., Gelfi C., 2007/05. Journal of Proteome Research, 6 (5) pp. 1974-84. Peer-reviewed.
 
A peptide inhibitor of c-Jun NH2-terminal kinase reduces myocardial ischemia-reperfusion injury and infarct size in vivo.
Milano G., Morel S., Bonny C., Samaja M., von Segesser L.K., Nicod P., Vassalli G., 2007/04. American Journal of Physiology. Heart and Circulatory Physiology, 292 (4) pp. H1828-1835. Peer-reviewed.
 
Cytochrome c oxidase expression in chronic and intermittent hypoxia rat gastrocnemius muscle quantitated by CE
Ripamonti M., Vigano A., Moriggi M., Milano G., von Segesser L. K., Samaja M., Gelfi C., 2006/10. Electrophoresis, 27 (19) pp. 3897-903. Peer-reviewed.
Brief reoxygenation episodes during chronic hypoxia enhance posthypoxic recovery of LV function: role of mitogen-activated protein kinase signaling pathways
Morel S., Milano G., Ludunge K. M., Corno A. F., Samaja M., Fleury S., Bonny C., Kappenberger L., von Segesser L. K., Vassalli G., 2006/07. Basic Research in Cardiology, 101 (4) pp. 336-45.
 
Chronic in vivo hypoxia in various organs: hypoxia-inducible factor-1alpha and apoptosis
Bianciardi P., Fantacci M., Caretti A., Ronchi R., Milano G., Morel S., von Segesser L., Corno A., Samaja M., 2006/04. Biochemical and Biophysical Research Communications, 342 (3) pp. 875-80. Peer-reviewed.
 
A peptide inhibitor of c-Jun N-terminal kinase protects the myocardium, against hypoxia/reoxygenation and ischeamia/reperfusion injuries
Milano G., Morel S., Bonny C., Corno A., Kappenberger L., von Segesser L., Vassalli G., 2005. Kardiovaskuläre Medizin 8 pp. S37.
 
Daily normoxic aeration of chronic hypoxic rats improve myocardial function through in P38 mitogen-activated protein kinase
Morel S., Milano G., Ludunge K., Corno A., Samaja M., Fleury S., KappenbergerL. , von Segesser L., Bonny C., Vassalli G., 2005. pp. S12 dans Assemblée Annuelle de la Société Suisse de Cardiologie, Kardiovaskuläre Medizin = Médecine Cardiovasculaire.
 
Intermittent episodes of brief reoxygenation improve posthypoxic functional recovery in chronically hypoxic rat hearts through regulation of p38 mitogen-activated protein kinase
Morel S., Milano G., Ludunge K., Corno A., Samaja M., Fleury S., Kappenberger L., von Segesser L., Vassalli G., 2005. Kardiovaskuläre Medizin, 8 pp. S37.
 
Are ATP-sensitive potassium channels (KATP) implicated in hypoxic preconditioning ? [PP-25]
Morel S., Milano G., Corno A., Samaja M., von Segesser L.K., 2004. pp. S85 dans 4th Joint Meeting - German, Austrian and Swiss Society for Thoracic and Cardiovascular Surgery, Thoracic and Cardiovascular Surgeon. Peer-reviewed.
 
Cyanotic hearts are less tolerant to standard cardiopulmonary bypass techniques
Corno A., Morel S., Milano G., Samaja M., von Segesser L., 2004. p. 53 dans 39th Annual Meeting Association for European Paediatric Cardiology, Association Européene pour la Cardiologie Pédiatrique, Cardiology in the Young.
 
Differential activation of mitogen-activated protein kinases in acute, intermittent and chronic myocardial hypoxia in vivo
Morel S., Milano G., Corno A., Samaja M., von Segesser L., Kappenberger L., Bonny C., Vassalli G., 2004. pp. 374-375 dans ESC Congress 2004, European Society of Cardiology, European Heart Journal.
 
Hypoxia: unique myocardial morphology?
Corno A.F., Milano G., Morel S., Tozzi P., Genton C.Y., Samaja M., von Segesser L.K., 2004. The Journal of thoracic and cardiovascular surgery, 127 (5) pp. 1301-8. Peer-reviewed.
 
Myocardial impairment in chronic hypoxia is abolished by short aeration episodes: involvement of K+ATP channels.
Milano G., Bianciardi P., Corno A.F., Raddatz E., Morel S., von Segesser L.K., Samaja M., 2004. Experimental Biology and Medicine, 229 (11) pp. 1196-1205. Peer-reviewed.
 
Myocardial function in chronic and intermittent hypoxia effects of mitrochondrial ATP-sensitive Potassium channel
Milano G., Corno A., Samaja M., Morel S., von Segesser L., 2003. pp. 77S dans Assemblée Annuelle de la Société Suisse de Cardiologie, Kardiovaskuläre Medizin = Médecine Cardiovasculaire.
 
Chronic hypoxia: a model for cyanotic congenital heart defects
Corno A. F., Milano G., Samaja M., Tozzi P., von Segesser L. K., 2002/07. Journal of Thoracic and Cardiovascular Surgery, 124 (1) pp. 105-12. Peer-reviewed.
 
Chronic and intermittent hypoxia induce different degrees of myocardial tolerance to hypoxia-induced dysfunction.
Milano G., Corno A.F., Lippa S., Von Segesser L.K., Samaja M., 2002/06. Experimental Biology and Medicine, 227 (6) pp. 389-397. Peer-reviewed.
 
Cardiovascular response to chronic and intermittent hypoxia
Milano G., Corno A., Genton C., Samaja M., von Segesser L.K., 2002. pp. 47S dans Assemblée Annuelle de la Société Suisse de Cardiologie, Kardiovaskuläre Medizin = Médecine Cardiovasculaire.
 
Tolerance of isolated rat hearts to low-flow ischemia and hypoxia of increasing duration: protective role of down-regulation and ATP during ischemia
Milano G., Corno A. F., de Jong J. W., von Segesser L. K., Samaja M., 2001/10. Molecular and Cellular Biochemistry, 226 (1-2) pp. 141-51. Peer-reviewed.
 
Anti-apoptotic and cardioprotective effects of a novel cell-permeable peptide in the isolated rate heart. Experimental Biology 2001 Orlando, Florida
Milano G., Corno A., Bonny C., Samaja M., von Segesser L., Schorderet D., 2001. pp. A941 dans Experimental Biology 2001, Federation of American Societies for Experimental Biology (FASEB), FASEB Journal.
 
Hypoxic hearts: effective myocardial protection provided by an antiapoptotic cell-permeable peptide.
Corno A., Milano G., Samaja M., von Segesser L., 2001. p. 187 dans 3rd World Congress of Pediatric Cardiology and Cardiac Surgery, Cardiology in the Young.
 
Liver and brain apoptosis in rats exposed to chronic hypoxia (10 % 02) for 2 weeks.
Pozzi S., Milano G., Corno A., von Segesser L., Samaja M., 2001. pp. A155 dans Experimental Biology 2001, Federation of American Societies for Experimental Biology (FASEB), FASEB Journal.
 
Myocardial protection provided to hypoxic hearts by an anti-apoptotic pectide
Corno A., Milano G., Bonny C., Samaja M., von Segesser L., Schorderet D., 2001. pp. 30S dans Assemblée Annuelle Commune de la Société Suisse de Cardiologie (SSC) et de la Société Suisse d'Angiologie (SSA), Kardiovaskuläre Medizin = Médecine Cardiovasculaire.
 
Pre-exposure to chronic hypoxia impairs performance in the isolated rat heart.
Samaja M., Milano G., Corno A., von Segesser L., 2001. pp. A155 dans Experimental Biology 2001, Federation of American Societies for Experimental Biology (FASEB), FASEB Journal.
 
Re-oxygenation does not reverse chronic hypoxia.
Corno A., Milano G., Samaja M., von Segesser L., 2001. p. 323 dans 3rd World Congress of Pediatric Cardiology and Cardiac Surgery, Cardiology in the Young.
 
Swim training improves myocardial resistance to ischemia in rats
Margonato V., Milano G., Allibardi S., Merati G., de Jonge R., Samaja M., 2000/04. International Journal of Sports Medicine, 21 (3) pp. 163-7. Peer-reviewed.
 
Hollow fiber microoxygenator gas transfer evaluation with an in vitro system
Mallabiabarrena I., Corno A., Milano G., Samaja M., von Segesser L.K., 2000. p. 579 dans 27th ESAO (European Society for Artificial Organs) Congress in co-operation with the ESEM (European Society for Engineering and Medecine), International Journal of Artificial Organs.
 
Hypoxia-reoxygenation is worse than ischemia-reperfusion. [vo 21]
Milano G., Corno A., Samaja M., Tozzi P., von Segesser L. K., 2000. p. 26 dans 3th Joint Meeting of the German, the Austrian and the Swiss Societies for Thoracic and Cardiovascular Surgery. Peer-reviewed.
 
Myocardial damage induced by uncontrolled reoxygenation
Corno A., G. Milano , M. Samaja , Segesser L.v., 2000. Journal of the Asian Society for Cardiovascular Surgery, 8 pp. 34-37.
 
The effect of the duration of ischemia and hypoxia on the recovery of isolated rate heart
Corno A., Milano G., Samaja M., von Segesser L.K., 2000. p. 35 dans 35th Annual Meeting of the Association for European Paediatric Cardiology, Cardiology in the Young.
 
The effects of ischemia and hypoxia of varying duration on the recovery of isolated rat hearts
Milano G., Corno A., Samaja M., von Segesser L.K., 2000. pp. A683 dans Research Conference of the Federation of American Societies for Experimental Biology (FASEB), FASEB Journal.
 
Differential depression of myocardial function and metabolism by lactate and H+
Samaja M., Allibardi S., Milano G., Neri G., Grassi B., Gladden L. B., Hogan M. C., 1999/01. American Journal of Physiology. Heart and Circulatory Physiology, 276 (1 Pt 2) pp. H3-8.
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