Research directions
Role od dendritic cells in immune response and immune tolerance
Dendritic cells are important regulators of the immune response. They decide between induction of an immune response or induction of immune tolerance. Thes populations are sparse in vivo and populations with similar but not identical functions can be derived from precursor in the bone marrow in tissue culture. To obtain a renewable source of large numbers of dendritic cells we generated transgenic mice, which spontaneously develop tumors of dendritic cells. The CD8+CD11b- subpopulation transforms in these mice. We are currently trying to transform other dendritic cell subsets. Thes cells maintain all the features of ex vivo derived dendritic cells and can be activated to further differentiate. Stable cell lines can be derived easily and unlimited numbers can be produced. They grow independently without added growth factors and maintain all their functions. We are now using these mice and cells to obtain a better undersanding of their function in immune response and immune tolerance
Interactions entre virus et hôte
Interaction entre la réponse immunitaire et le virus qui induit des tumeurs de la glande mammaire (MMTV)
Réponse immunitaire contre les vaccinia virus et contre les adénovirus
Réponse immunitaire B
Du lymphocyte B naive à la cellule plasma et mémoire
Le centre germinatif
La migration cellulaire
