Thierry Pedrazzini

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127 publications

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The continuous heart failure spectrum: moving beyond an ejection fraction classification.
Triposkiadis F., Butler J., Abboud F.M., Armstrong P.W., Adamopoulos S., Atherton J.J., Backs J., Bauersachs J., Burkhoff D., Bonow R.O. et al., 2019/07/01. European heart journal, 40 (26) pp. 2155-2163. Peer-reviewed.
 
Inhibition of the Hypoxia-Inducible Factor 1α-Induced Cardiospecific HERNA1 Enhance-Templated RNA Protects From Heart Disease.
Mirtschink P., Bischof C., Pham M.D., Sharma R., Khadayate S., Rossi G., Fankhauser N., Traub S., Sossalla S., Hagag E. et al., 2019/06/11. Circulation, 139 (24) pp. 2778-2792. Peer-reviewed.
Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129.
Gomes CPDC, Ágg B., Andova A., Arslan S., Baker A., Barteková M., Beis D., Betsou F., Wettinger S.B., Bugarski B. et al., 2019/03/29. Non-coding RNA, 5 (2). Peer-reviewed.
ALDH1A3 Is the Key Isoform That Contributes to Aldehyde Dehydrogenase Activity and Affects <i>in Vitro</i> Proliferation in Cardiac Atrial Appendage Progenitor Cells.
Puttini S., Plaisance I., Barile L., Cervio E., Milano G., Marcato P., Pedrazzini T., Vassalli G., 2018. Frontiers in cardiovascular medicine, 5 p. 90. Peer-reviewed.
The long noncoding RNA Wisper controls cardiac fibrosis and remodeling.
Micheletti R., Plaisance I., Abraham B.J., Sarre A., Ting C.C., Alexanian M., Maric D., Maison D., Nemir M., Young R.A. et al., 2017/06/21. Science translational medicine, 9 (395) p. 395. Peer-reviewed.
New Lncs to mesendoderm specification.
Alexanian M., Pedrazzini T., Ounzain S., 2017/03. Journal of thoracic disease, 9 (Suppl 1) pp. S5-S8. Peer-reviewed.
A transcribed enhancer dictates mesendoderm specification in pluripotency.
Alexanian M., Maric D., Jenkinson S.P., Mina M., Friedman C.E., Ting C.C., Micheletti R., Plaisance I., Nemir M., Maison D. et al., 2017. Nature Communications, 8 (1) p. 1806. Peer-reviewed.
Cardiomyocyte Lineage Specification in Adult Human Cardiac Precursor Cells Via Modulation of Enhancer-Associated Long Noncoding RNA Expression.
Plaisance I., Perruchoud S., Fernandez-Tenorio M., Gonzales C., Ounzain S., Ruchat P., Nemir M., Niggli E., Pedrazzini T., 2016/10. JACC. Basic to translational science, 1 (6) pp. 472-493. Peer-reviewed.
 
Divergent Paths Lnc Cell Fates.
Ounzain S., Pedrazzini T., 2016/05/05. Cell stem cell, 18 (5) pp. 561-562. Peer-reviewed.
 
Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy.
Shende P., Xu L., Morandi C., Pentassuglia L., Heim P., Lebboukh S., Berthonneche C., Pedrazzini T., Kaufmann B.A., Hall M.N. et al., 2016. Cardiovascular Research, 109 (1) pp. 103-114. Peer-reviewed.
Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways.
Crippa S., Nemir M., Ounzain S., Ibberson M., Berthonneche C., Sarre A., Boisset G., Maison D., Harshman K., Xenarios I. et al., 2016. Cardiovascular Research, 110 (1) pp. 73-84. Peer-reviewed.
 
Long non-coding RNAs in heart failure: a promising future with much to learn.
Ounzain S., Pedrazzini T., 2016. Annals of Translational Medicine, 4 (15) p. 298. Peer-reviewed.
 
Super-enhancer lncs to cardiovascular development and disease.
Ounzain S., Pedrazzini T., 2016. BBA - Molecular Cell Research, 1863 (7 Pt B) pp. 1953-1960. Peer-reviewed.
CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis
Ounzain S., Micheletti R., Arnan C., Plaisance I., Cecchi D., Schroen B., Reverter F., Alexanian M., Gonzales C., Ng S.Y. et al., 2015. Journal of Molecular and Cellular Cardiology, 89 (Pt A) pp. 98-9112. Peer-reviewed.
Discovery and functional characterization of cardiovascular long noncoding RNAs
Ounzain S., Burdet F., Ibberson M., Pedrazzini T., 2015. Journal of Molecular and Cellular Cardiology, 89 (Pt A) pp. 17-26. Peer-reviewed.
Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs.
Ounzain S., Micheletti R., Beckmann T., Schroen B., Alexanian M., Pezzuto I., Crippa S., Nemir M., Sarre A., Johnson R. et al., 2015. European Heart Journal, 36 (6) pp. 353-68a. Peer-reviewed.
HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease.
Mirtschink P., Krishnan J., Grimm F., Sarre A., Hörl M., Kayikci M., Fankhauser N., Christinat Y., Cortijo C., Feehan O. et al., 2015. Nature, 522 (7557) pp. 444-449. Peer-reviewed.
Jagged1 intracellular domain-mediated inhibition of Notch1 signalling regulates cardiac homeostasis in the postnatal heart.
Metrich M., Bezdek Pomey A., Berthonneche C., Sarre A., Nemir M., Pedrazzini T., 2015. Cardiovascular Research, 108 (1) pp. 74-86. Peer-reviewed.
Le coeur des ARN non codants - Un long chemin à découvrir [In the heart of noncoding RNA: a long way to go].
Pedrazzini T., 2015. Médecine Sciences : M/s, 31 (3) pp. 261-267. Peer-reviewed.
 
Long noncoding RNAs in cardiac development and ageing.
Devaux Y., Zangrando J., Schroen B., Creemers E.E., Pedrazzini T., Chang C.P., Dorn G.W., Thum T., Heymans S., Cardiolinc network, 2015. Nature Reviews. Cardiology, 12 (7) pp. 415-425. Peer-reviewed.
The promise of enhancer-associated long noncoding RNAs in cardiac regeneration.
Ounzain S., Pedrazzini T., 2015. Trends in Cardiovascular Medicine, 25 (7) pp. 592-602. Peer-reviewed.
 
Ageing-related cardiomyocyte functional decline is sex and angiotensin II dependent.
Mellor K.M., Curl C.L., Chandramouli C., Pedrazzini T., Wendt I.R., Delbridge L.M., 2014. Age, 36 (3) pp. 1155-1167. Peer-reviewed.
Functional importance of cardiac enhancer-associated noncoding RNAs in heart development and disease.
Ounzain S., Pezzuto I., Micheletti R., Burdet F., Sheta R., Nemir M., Gonzales C., Sarre A., Alexanian M., Blow M.J. et al., 2014. Journal of Molecular and Cellular Cardiology, 76 pp. 55-70. Peer-reviewed.
 
Meeting highlights from the 2013 European Society of Cardiology Heart Failure Association Winter Meeting on Translational Heart Failure Research.
Hohl M., Ardehali H., Azuaje F.J., Breckenridge R.A., Doehner W., Eaton P., Ehret G.B., Fujita T., Gaetani R., Giacca M. et al., 2014. European Journal of Heart Failure, 16 (1) pp. 6-14.
The Notch pathway controls fibrotic and regenerative repair in the adult heart.
Nemir M., Metrich M., Plaisance I., Lepore M., Cruchet S., Berthonneche C., Sarre A., Radtke F., Pedrazzini T., 2014. European Heart Journal, 35 (32) pp. 2174-2185.
 
Small and long non-coding RNAs in cardiac homeostasis and regeneration
Ounzain Samir, Crippa Stefania, Pedrazzini Thierry, 2013/04. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1833 (4) pp. 923-933. Peer-reviewed.
Nitric oxide synthase 2 is required for conversion of pro-fibrogenic inflammatory CD133+ progenitors into F4/80+ macrophages in experimental autoimmune myocarditis.
Blyszczuk P., Berthonneche C., Behnke S., Glönkler M., Moch H., Pedrazzini T., Lüscher T.F., Eriksson U., Kania G., 2013. Cardiovascular Research, 97 (2) pp. 219-229. Peer-reviewed.
The AP-1 transcription factor c-Jun prevents stress-imposed maladaptive remodeling of the heart.
Windak R., Müller J., Felley A., Akhmedov A., Wagner E.F., Pedrazzini T., Sumara G., Ricci R., 2013. Plos One, 8 (9) pp. e73294. Peer-reviewed.
 
Cardiac dysfunction and impaired compensatory response to pressure overload in mice deficient in stem cell antigen-1.
Rosenblatt-Velin N., Ogay S., Felley A., Stanford W.L., Pedrazzini T., 2012. Faseb Journal, 26 (1) pp. 229-239.
 
Cardiac Lineage Protein-1 (CLP-1) Regulates Cardiac Remodeling via Transcriptional Modulation of Diverse Hypertrophic and Fibrotic Responses and Angiotensin II-transforming Growth Factor β (TGF-β1) Signaling Axis.
Mascareno E., Galatioto J., Rozenberg I., Salciccioli L., Kamran H., Lazar J.M., Liu F., Pedrazzini T., Siddiqui M.A., 2012. Journal of Biological Chemistry, 287 (16) pp. 13084-13093.
 
Dietary obesity-associated Hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system.
Krishnan J., Danzer C., Simka T., Ukropec J., Walter K.M., Kumpf S., Mirtschink P., Ukropcova B., Gasperikova D., Pedrazzini T. et al., 2012. Genes and Development, 26 (3) pp. 259-270.
 
Differential effects of high-fat diet on myocardial lipid metabolism in failing and nonfailing hearts with angiotensin II-mediated cardiac remodeling in mice.
Pellieux C., Montessuit C., Papageorgiou I., Pedrazzini T., Lerch R., 2012. American Journal of Physiology. Heart and Circulatory Physiology, 302 (9) pp. H1795-H1805.
 
Impact of salt on cardiac differential gene expression and coronary lesion in normotensive mineralocorticoid-treated mice.
Wang Q., Domenighetti A.A., Schäfer S.C., Weber J., Simon A., Maillard M.P., Pedrazzini T., Chen J., Lehr H.A., Burnier M., 2012. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 302 (9) pp. R1025-R1033.
 
Isolation of cardiovascular precursor cells from the human fetal heart.
Gonzales C., Ullrich N.D., Gerber S., Berthonneche C., Niggli E., Pedrazzini T., 2012. Tissue Engineering. Part A, 18 (1-2) pp. 198-207.
Mapping genetic variants associated with beta-adrenergic responses in inbred mice.
Hersch M., Peter B., Kang H.M., Schüpfer F., Abriel H., Pedrazzini T., Eskin E., Beckmann J.S., Bergmann S., Maurer F., 2012. Plos One, 7 (7) pp. e41032.
 
Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice.
Shende P., Plaisance I., Morandi C., Pellieux C., Berthonneche C., Zorzato F., Krishnan J., Lerch R., Hall M.N., Rüegg M.A. et al., 2011. Circulation, 123 (10) pp. 1073-1082.
EH-myomesin splice isoform is a novel marker for dilated cardiomyopathy.
Schoenauer Roman, Emmert Maximilian Y., Felley Allison, Ehler Elisabeth, Brokopp Chad, Weber Benedikt, Nemir Mohamed, Faggian Giuseppe G., Pedrazzini Thierry, Falk Volkmar et al., 2011. Basic Research in Cardiology, 106 (2) pp. 233-247.
 
Preparation with fasting and acipimox increases myocardial glucose uptake in mice during cardiac 18F-FDG microPET
Dunet V., Perruchoud S., Poitry-Yamate C., Lepore M., Gruetter R., Pedrazzini T., Prior J. O., 2011. pp. A108-A109 dans 10th International Conference of Non Invasive Cardiovascular Imaging, European Heart Journal Supplements. Peer-reviewed.
 
Angiotensin II favors progression to heart failure in diabetic hearts: role of myocardial fatty acid oxidation downregulation
Pellieux C., Pedrazzini T., Montessuit C., Papageorgiou I., Lerch R., 2010. pp. 936-937 dans ESC Congress, European Heart Journal. Peer-reviewed.
 
Cardiac raptor deletion impairs adaptive hypertrophy, alters metabolic gene expression and causes heart failure in mice
Shende P., Plaisance I., Morandi C., Pellieux C., Berthonneche C., Lerch R., Hall M., Ruegg M., Pedrazzini T., Brink M., 2010. pp. 146-146 dans ESC Congress, European Heart Journal. Peer-reviewed.
 
Sarcomeric M-band alterations as a marker for human dilated cardiomyopathy
Schoenauer R., Emmert M. Y., Felley A., Ehler E., Pedrazzini T., Falk V., Hoerstrup S. P., Agarkova I., 2010. p. 635 dans ESC Congress, European Heart Journal. Peer-reviewed.
 
Stabilised beta-catenin in postnatal ventricular myocardium leads to dilated cardiomyopathy and premature death.
Hirschy Alain, Croquelois Adrien, Perriard Evelyne, Schoenauer Roman, Agarkova Irina, Hoerstrup Simon P., Taketo Makoto M., Pedrazzini Thierry, Perriard Jean-Claude, Ehler Elisabeth, 2010. Basic Research in Cardiology, 105 (5) pp. 597-608.
Cardiovascular response to beta-adrenergic blockade or activation in 23 inbred mouse strains.
Berthonneche C., Peter B., Schüpfer F., Hayoz P., Kutalik Z., Abriel H., Pedrazzini T., Beckmann J.S., Bergmann S., Maurer F., 2009/08/12. PloS one, 4 (8) pp. e6610. Peer-reviewed.
 
Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy.
Krishnan J., Suter M., Windak R., Krebs T., Felley A., Montessuit C., Tokarska-Schlattner M., Aasum E., Bogdanova A., Perriard E. et al., 2009. Cell Metabolism, 9 (6) pp. 512-524.
 
Angiotensin II-mediated adaptive and maladaptive remodeling of cardiomyocyte excitation-contraction coupling.
Gusev K., Domenighetti A.A., Delbridge L.M., Pedrazzini T., Niggli E., Egger M., 2009. Circulation Research, 105 (1) pp. 42-50.
 
Dietary fish oil is antihypertrophic but does not enhance postischemic myocardial function in female mice.
Huggins C.E., Curl C.L., Patel R., McLennan P.L., Theiss M.L., Pedrazzini T., Pepe S., Delbridge L.M., 2009. American journal of physiology. Heart and circulatory physiology, 296 (4) pp. H957-H966.
 
Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy.
Blyszczuk P., Kania G., Dieterle T., Marty R.R., Valaperti A., Berthonneche C., Pedrazzini T., Berger C.T., Dirnhofer S., Matter C.M. et al., 2009. Circulation research, 105 (9) pp. 912-920.
 
Progenitor cell therapy for heart disease.
Gonzales C., Pedrazzini T., 2009. Experimental Cell Research, 315 (18) pp. 3077-3085.
Control of the adaptive response of the heart to stress via the Notch1 receptor pathway.
Croquelois A., Domenighetti A.A., Nemir M., Lepore M., Rosenblatt-Velin N., Radtke F., Pedrazzini T., 2008. Journal of Experimental Medicine, 205 (13) pp. 3173-3185. Peer-reviewed.
 
Functional role of Notch signaling in the developing and postnatal heart
Nemir M., Pedrazzini T., 2008. Journal of Molecular and Cellular Cardiology, 45 (4) pp. 495-504. Peer-reviewed.
Overexpression of a mutant form of TGFBI/BIGH3 induces retinal degeneration in transgenic mice.
Bustamante M., Tasinato A., Maurer F., Elkochairi I., Lepore M.G., Arsenijevic Y., Pedrazzini T., Munier F.L., Schorderet D.F., 2008. Molecular Vision, 14 pp. 1129-1137. Peer-reviewed.
 
S100A1 deficiency results in prolonged ventricular repolarization in response to sympathetic activation.
Ackermann G.E., Domenighetti A.A., Deten A., Bonath I., Marenholz I., Pedrazzini T., Erne P., Heizmann C.W., 2008. General Physiology and Biophysics, 27 (2) pp. 127-142. Peer-reviewed.
Y1 receptor knockout increases nociception and prevents the anti-allodynic actions of NPY.
Kuphal K.E., Solway B., Pedrazzini T., Taylor B.K., 2008. Nutrition, 24 (9) pp. 885-891. Peer-reviewed.
 
Control of cardiogenesis by the notch pathway
Pedrazzini T., 2007/04. Trends in Cardiovascular Medicine, 17 (3) pp. 83-90.
 
Re-expression of proteins involved in cytokinesis during cardiac hypertrophy
Ahuja P., Perriard E., Pedrazzini T., Satoh S., Perriard J. C., Ehler E., 2007/04. Experimental Cell Research, 313 (6) pp. 1270-83.
 
NPY and pain as seen from the histochemical side
Hokfelt T., Brumovsky P., Shi T., Pedrazzini T., Villar M., 2007/02. Peptides, 28 (2) pp. 365-72.
 
Augmented myocardial methionine-enkephalin in a murine model of cardiac angiotensin II-overexpression.
van den Brink O.W., Delbridge L.M., Pedrazzini T., Rosenfeldt F.L., Pepe S., 2007. Journal of the Renin-Angiotensin-Aldosterone System, 8 (4) pp. 153-159. Peer-reviewed.
 
Chronic angiotensin II stimulation in the heart produces an acquired long QT syndrome associated with IK1 potassium current downregulation.
Domenighetti A.A., Boixel C., Cefai D., Abriel H., Pedrazzini T., 2007/01. Journal of Molecular and Cellular Cardiology, 42 (1) pp. 63-70. Peer-reviewed.
 
Identification of corticosteroid-regulated genes in cardiomyocytes by serial analysis of gene expression.
Muller O., Pradervand S., Berger S., Centeno G., Milet A., Nicod P., Pedrazzini T., Tronche F., Schütz G., Chien K. et al., 2007. Genomics, 89 (3) pp. 370-377.
 
NPY Y1 receptor is not involved in the hemodynamic response to an acute cold pressor test in mice.
Cavadas C., Waeber B., Pedrazzini T., Grand D., Aubert J.F., Buclin T., Grouzmann E., 2007. Peptides, 28 (2) pp. 315-319. Peer-reviewed.
 
The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy.
Appert-Collin A., Cotecchia S., Nenniger-Tosato M., Pedrazzini T., Diviani D., 2007. Proceedings of the National Academy of Sciences of the United States of America, 104 (24) pp. 10140-10145.
Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway
Zhu M., Feng J., Lucchinetti E., Fischer G., Xu L., Pedrazzini T., Schaub M. C., Zaugg M., 2006/10. Cardiovascular Research, 72 (1) pp. 152-62.
 
Overexpression of angiotensinogen in the myocardium induces downregulation of the fatty acid oxidation pathway
Pellieux C., Aasum E., Larsen T. S., Montessuit C., Papageorgiou I., Pedrazzini T., Lerch R., 2006/09. Journal of Molecular and Cellular Cardiology, 41 (3) pp. 459-66.
 
Deletion of the neuropeptide Y Y1 receptor affects pain sensitivity, neuropeptide transport and expression, and dorsal root ganglion neuron numbers
Shi T. J., Li J., Dahlstrom A., Theodorsson E., Ceccatelli S., Decosterd I., Pedrazzini T., Hokfelt T., 2006/06. Neuroscience, 140 (1) pp. 293-304.
 
Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling
Nemir M., Croquelois A., Pedrazzini T., Radtke F., 2006/06. Circulation Research, 98 (12) pp. 1471-8.
 
Connexin43-dependent mechanism modulates renin secretion and hypertension
Haefliger J. A., Krattinger N., Martin D., Pedrazzini T., Capponi A., Doring B., Plum A., Charollais A., Willecke K., Meda P., 2006/02. Journal of Clinical Investigation, 116 (2) pp. 405-13.
 
Cardiac sodium channel Nav1.5 is regulated by a multiprotein complex composed of syntrophins and dystrophin.
Gavillet B., Rougier J.S., Domenighetti A.A., Behar R., Boixel C., Ruchat P., Lehr H.A., Pedrazzini T., Abriel H., 2006. Circulation Research, 99 (4) pp. 407-414.
 
Deletion of the neuropeptide Y (NPY) Y1 receptor gene reveals a regulatory role of NPY on catecholamine synthesis and secretion.
Cavadas C., Céfai D., Rosmaninho-Salgado J., Vieira-Coelho M.A., Moura E., Busso N., Pedrazzini T., Grand D., Rotman S., Waeber B. et al., 2006. Proceedings of the National Academy of Sciences of the United States of America, 103 (27) pp. 10497-10502. Peer-reviewed.
 
GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function.
Membrez M., Hummler E., Beermann F., Haefliger J.A., Savioz R., Pedrazzini T., Thorens B., 2006. Molecular and Cellular Biology, 26 (11) pp. 4268-4276. Peer-reviewed.
 
Potassium supplementation reduces cardiac and renal hypertrophy independent of blood pressure in DOCA/salt mice
Wang Q., Domenighetti A. A., Pedrazzini T., Burnier M., 2005/09. Hypertension, 46 (3) pp. 547-54.
 
Angiotensin II-mediated phenotypic cardiomyocyte remodeling leads to age-dependent cardiac dysfunction and failure
Domenighetti A. A., Wang Q., Egger M., Richards S. M., Pedrazzini T., Delbridge L. M., 2005/08. Hypertension, 46 (2) pp. 426-32.
 
Behavioural, neural and cardiovascular adaptations in mice lacking the NPY Y1 receptor
Costoli T., Sgoifo A., Stilli D., Flugge G., Adriani W., Laviola G., Fuchs E., Pedrazzini T., Musso E., 2005/02. Neuroscience and Biobehavioral Reviews, 29 (1) pp. 113-23.
 
FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes.
Rosenblatt-Velin N., Lepore M.G., Cartoni C., Beermann F., Pedrazzini T., 2005. Journal of Clinical Investigation, 115 (7) pp. 1724-1733. Peer-reviewed.
 
Selective expression of a dominant-negative form of peroxisome proliferator-activated receptor in keratinocytes leads to impaired epidermal healing.
Michalik L., Feige J.N., Gelman L., Pedrazzini T., Keller H., Desvergne B., Wahli W., 2005. Molecular Endocrinology, 19 (9) pp. 2335-2348. Peer-reviewed.
 
Elevated dietary sodium intake exacerbates myocardial hypertrophy associated with cardiac-specific overproduction of angiotensin II
Porrello E. R., Huggins C. E., Curl C. I., Domenighetti A. A., Pedrazzini T., Delbridge L. M., Morgan T. O., 2004/12. Journal of the Renin-Angiotensin-Aldosterone System, 5 (4) pp. 169-75.
 
Importance of NPY Y1 receptor-mediated pathways: assessment using NPY Y1 receptor knockouts
Pedrazzini T., 2004/08. Neuropeptides, 38 (4) pp. 267-75.
 
gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension
Jung O., Schreiber J. G., Geiger H., Pedrazzini T., Busse R., Brandes R. P., 2004/04. Circulation, 109 (14) pp. 1795-801.
 
Chronic neuropeptide Y infusion into the lateral ventricle induces sustained feeding and obesity in mice lacking either Npy1r or Npy5r expression
Raposinho P. D., Pedrazzini T., White R. B., Palmiter R. D., Aubert M. L., 2004/01. Endocrinology, 145 (1) pp. 304-10.
 
Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein.
Pradervand S., Yasukawa H., Muller O.G., Kjekshus H., Nakamura T., St Amand T.R., Yajima T., Matsumura K., Duplain H., Iwatate M. et al., 2004. EMBO Journal, 23 (22) pp. 4517-4525.
 
The neuropeptide Y Y1 receptor mediates NPY-induced inhibition of the gonadotrope axis under poor metabolic conditions
Gonzales C., Voirol M. J., Giacomini M., Gaillard R. C., Pedrazzini T., Pralong F. P., 2004/01. FASEB Journal, 18 (1) pp. 137-9.
 
Elevated intracardiac angiotensin II leads to cardiac hypertrophy and mechanical dysfunction in normotensive mice
Huggins C. E., Domenighetti A. A., Pedrazzini T., Pepe S., Delbridge L. M., 2003/09. Journal of the Renin-Angiotensin-Aldosterone System, 4 (3) pp. 186-90.
 
Neuropeptide Y: the universal soldier.
Pedrazzini T., Pralong F., Grouzmann E., 2003/02. Cellular and Molecular Life Sciences, 60 (2) pp. 350-377. Peer-reviewed.
 
Extracellular superoxide dismutase is a major determinant of nitric oxide bioavailability: in vivo and ex vivo evidence from ecSOD-deficient mice.
Jung O., Marklund S.L., Geiger H., Pedrazzini T., Busse R., Brandes R.P., 2003. Circulation research, 93 (7) pp. 622-9.
 
Induced down-regulation of neuropeptide Y-Y1 receptors delays initiation of kindling.
Benmaamar R., Pham-Lê B.T., Marescaux C., Pedrazzini T., Depaulis A., 2003. The European journal of neuroscience, 18 (4) pp. 768-74. Peer-reviewed.
 
Distribution of neuropeptide Y Y1 receptors in rodent peripheral tissues.
Matsuda H., Brumovsky P.R., Kopp J., Pedrazzini T., Hökfelt T., 2002. The Journal of comparative neurology, 449 (4) pp. 390-404. Peer-reviewed.
 
Expression of the neuropeptide Y Y1 receptor in the CNS of rat and of wild-type and Y1 receptor knock-out mice. Focus on immunohistochemical localization
Kopp J., Xu Z. Q., Zhang X., Pedrazzini T., Herzog H., Kresse A., Wong H., Walsh J. H., Hokfelt T., 2002. Neuroscience, 111 (3) pp. 443-532.
 
The neuropeptide Y Y1 receptor regulates leptin-mediated control of energy homeostasis and reproductive functions.
Pralong F.P., Gonzales C., Voirol M.J., Palmiter R.D., Brunner H.R., Gaillard R.C., Seydoux J., Pedrazzini T., 2002. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 16 (7) pp. 712-4.
 
Voluntary alcohol consumption is controlled via the neuropeptide Y Y1 receptor.
Thiele T.E., Koh M.T., Pedrazzini T., 2002. Journal of Neuroscience, 22 (3) p. 208.
 
Angiotensin II stimulates alpha-skeletal actin expression in cadiomyocytes in vitro and in vivo in the absence of hypertension
Clement S., Pellieux C., Chaponnier C., Pedrazzini T., Gabbiani G., 2001/12. Differentiation, 69 (1) pp. 66-74.
 
Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism
Raposinho P. D., Pierroz D. D., Broqua P., White R. B., Pedrazzini T., Aubert M. L., 2001/12. Molecular and Cellular Endocrinology, 185 (1-2) pp. 195-204.
 
Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase.
Duplain H., Burcelin R., Sartori C., Cook S., Egli M., Lepori M., Vollenweider P., Pedrazzini T., Nicod P., Thorens B. et al., 2001/07. Circulation, 104 (3) pp. 342-345.
 
Increased insulin concentrations and glucose storage in neuropeptide Y Y1 receptor-deficient mice
Burcelin R., Brunner H., Seydoux J., Thorensa B., Pedrazzini T., 2001/03. Peptides, 22 (3) pp. 421-7.
 
Dilated cardiomyopathy and impaired cardiac hypertrophic response to angiotensin II in mice lacking FGF-2.
Pellieux C., Foletti A., Peduto G., Aubert J.F., Nussberger J., Beermann F., Brunner H.R., Pedrazzini T., 2001. Journal of Clinical Investigation, 108 (12) pp. 1843-1851. Peer-reviewed.
 
Transient prenatal expression of NPY-Y1 receptor in trigeminal axons innervating the mystacial vibrissae.
Ubink R., Kopp J., Wong H., Walsh J.H., Pedrazzini T., Hökfelt T., 2001. The Journal of comparative neurology, 429 (2) pp. 183-91. Peer-reviewed.
 
Neuropeptide Y (NPY) potentiates phenylephrine-induced mitogen-activated protein kinase activation in primary cardiomyocytes via NPY Y5 receptors
Pellieux C., Sauthier T., Domenighetti A., Marsh D. J., Palmiter R. D., Brunner H. R., Pedrazzini T., 2000/02. Proceedings of the National Academy of Sciences of the United States of America, 97 (4) pp. 1595-600.
 
Angiotensin II-induced cardiac hypertrophy is associated with different mitogen-activated protein kinase activation in normotensive and hypertensive mice.
Pellieux C., Sauthier T., Aubert J.F., Brunner H.R., Pedrazzini T., 2000. Journal of hypertension, 18 (9) pp. 1307-17. Peer-reviewed.
 
Calcineurin blockade prevents cardiac mitogen-activated protein kinase activation and hypertrophy in renovascular hypertension.
Murat A., Pellieux C., Brunner H.R., Pedrazzini T., 2000. The Journal of biological chemistry, 275 (52) pp. 40867-73. Peer-reviewed.
 
Increased cardiac angiotensin II levels induce right and left ventricular hypertrophy in normotensive mice.
Mazzolai L., Pedrazzini T., Nicoud F., Gabbiani G., Brunner H.R., Nussberger J., 2000. Hypertension, 35 (4) pp. 985-91. Peer-reviewed.
 
Neuropeptide Y Y1 receptor-deficient mice. Generation and characterization
Pedrazzini T., Seydoux J., 2000. Methods in Molecular Biology, 153 pp. 91-100.
 
Role of endothelin receptor subtypes in volume-stimulated ANF secretion.
Baertschi A.J., Pedrazzini T., Aubert J.F., Roatti A., Pence R.A., 2000. American journal of physiology. Heart and circulatory physiology, 278 (2) pp. H493-9. Peer-reviewed.
 
Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice
Ledent C., Valverde O., Cossu G., Petitet F., Aubert J. F., Beslot F., Bohme G. A., Imperato A., Pedrazzini T., Roques B. P. et al., 1999. Science, 283 (5400) pp. 401-4.
 
Blood pressure-independent cardiac hypertrophy induced by locally activated renin-angiotensin system.
Mazzolai L., Nussberger J., Aubert J.F., Brunner D.B., Gabbiani G., Brunner H.R., Pedrazzini T., 1998. Hypertension, 31 (6) pp. 1324-30. Peer-reviewed.
 
Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor.
Pedrazzini T., Seydoux J., Künstner P., Aubert J.F., Grouzmann E., Beermann F., Brunner H.R., 1998. Nature Medicine, 4 (6) pp. 722-726. Peer-reviewed.
 
Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor
Ledent C., Vaugeois J. M., Schiffmann S. N., Pedrazzini T., El Yacoubi M., Vanderhaeghen J. J., Costentin J., Heath J. K., Vassart G., Parmentier M., 1997/08. Nature, 388 (6643) pp. 674-8.
 
Decreased blood pressure response in mice deficient of the alpha1b-adrenergic receptor.
Cavalli A., Lattion A.L., Hummler E., Nenniger M., Pedrazzini T., Aubert J.F., Michel M.C., Yang M., Lembo G., Vecchione C. et al., 1997. Proceedings of the National Academy of Sciences of the United States of America, 94 (21) pp. 11589-11594. Peer-reviewed.
 
Two-kidney, one clip and one-kidney, one clip hypertension in mice.
Wiesel P., Mazzolai L., Nussberger J., Pedrazzini T., 1997. Hypertension, 29 (4) pp. 1025-30. Peer-reviewed.
 
Improved fertilization and implantation rates after non-touch zona pellucida microdrilling of mouse oocytes with a 1.48 microm diode laser beam
Germond M., Nocera D., Senn A., Rink K., Delacretaz G., Pedrazzini T., Hornung J. P., 1996/05. Human Reproduction, 11 (5) pp. 1043-8.
 
A 338-bp proximal fragment of the glucose transporter type 2 (GLUT2) promoter drives reporter gene expression in the pancreatic islets of transgenic mice.
Waeber G., Pedrazzini T., Bonny O., Bonny C., Steinmann M., Nicod P., Haefliger J.A., 1995. Molecular and cellular endocrinology, 114 (1-2) pp. 205-15. Peer-reviewed.
 
Transient inhibition of angiotensinogen production in transgenic mice bearing an antisense angiotensinogen gene.
Pedrazzini T., Cousin P., Aubert J.F., Brunner H.R., 1995. Kidney International, 47 (6) pp. 1638-1346. Peer-reviewed.
 
Neuropeptide Y and cardiovascular regulation.
Pedrazzini T., Brunner H.R., Waeber B., 1993. Current Opinion in Nephrology and Hypertension, 2 (1) pp. 106-13. Peer-reviewed.
Establishment of resistance to Leishmania major infection in susceptible BALB/c mice requires parasite-specific CD8+ T cells
Muller I., Pedrazzini T., Kropf P., Louis J., Milon G., 1991/06. International Immunology, 3 (6) pp. 587-97.
 
Free ligand-induced dissociation of MHC-antigen complexes
Pedrazzini T., Sette A., Albertson M., Grey H. M., 1991/05. Journal of Immunology, 146 (10) pp. 3496-501.
 
A novel approach to the generation of high affinity class II-binding peptides
Sette A., Sidney J., Albertson M., Miles C., Colon S. M., Pedrazzini T., Lamont A. G., Grey H. M., 1990/09. Journal of Immunology, 145 (6) pp. 1809-13.
 
Postnatal disappearance of self-reactive (V beta 6+) cells from the thymus of Mlsa mice. Implications for T cell development and autoimmunity
Schneider R., Lees R. K., Pedrazzini T., Zinkernagel R. M., Hengartner H., MacDonald H. R., 1989/06. Journal of Experimental Medicine, 169 (6) pp. 2149-58.
 
T-cell reactivity and tolerance to Mlsa-encoded antigens
MacDonald H. R., Glasebrook A. L., Schneider R., Lees R. K., Pircher H., Pedrazzini T., Kanagawa O., Nicolas J. F., Howe R. C., Zinkernagel R. M. et al., 1989/02. Immunological Reviews, 107 pp. 89-108.
 
Fate of potentially self-reactive T cells in neonatal mice: analysis of V beta 6+ T cells in Mlsa mice
Schneider R., Lees R., Pedrazzini T., Odermatt B., Speiser D. E., Zinkernagel R. M., Hengartner H., MacDonald H. R., 1989. Thymus, 13 (1-2) pp. 35-43.
 
Functional responsiveness in vitro and in vivo of alpha/beta T cell receptors expressed by the B2A2 (J11d)- subset of CD4-8- thymocytes
Howe R. C., Pedrazzini T., MacDonald H. R., 1989/01. European Journal of Immunology, 19 (1) pp. 25-30.
 
T-cell responses and immunity to experimental infection with leishmania major
Muller I., Pedrazzini T., Farrell J. P., Louis J., 1989. Annual Review of Immunology, 7 pp. 561-78.
 
Experimentally induced cutaneous leishmaniasis: are L3T4+ T cells that promote parasite growth distinct from those mediating resistance?
Muller I., Pedrazzini T., Louis J. A., 1988/11. Immunology Letters, 19 (3) pp. 251-9.
 
Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment
MacDonald H. R., Hengartner H., Pedrazzini T., 1988/09. Nature, 335 (6186) pp. 174-6.
 
Aggravation of experimental cutaneous leishmaniasis in mice by administration of interleukin 3
Feng Z. Y., Louis J., Kindler V., Pedrazzini T., Eliason J. F., Behin R., Vassalli P., 1988/08. European Journal of Immunology, 18 (8) pp. 1245-51.
 
T-cell lineages, repertoire selection and tolerance induction
MacDonald H. R., Howe R. C., Pedrazzini T., Lees R. K., Budd R. C., Schneider R., Liao N. S., Zinkernagel R. M., Louis J. A., Raulet D. H. et al., 1988/08. Immunological Reviews, 104 pp. 157-82.
 
Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens
MacDonald H. R., Pedrazzini T., Schneider R., Louis J. A., Zinkernagel R. M., Hengartner H., 1988/06. Journal of Experimental Medicine, 167 (6) pp. 2005-10.
 
Subsets of specific T cells and experimental cutaneous leishmaniasis
Louis J. A., Pedrazzini T., Titus R. G., Muller I., Farrell J. P., Kindler V., Vassalli P., Marchal G., Milon G., 1987/10. Annales de l Institut Pasteur. Immunologie, 138 (5) pp. 755-8.
 
Importance of L3T4+ and Lyt-2+ cells in the immunologic control of infection with Mycobacterium bovis strain bacillus Calmette-Guerin in mice. Assessment by elimination of T cell subsets in vivo
Pedrazzini T., Hug K., Louis J. A., 1987/09. Journal of Immunology, 139 (6) pp. 2032-7.
 
Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation
Budd R. C., Cerottini J. C., Horvath C., Bron C., Pedrazzini T., Howe R. C., MacDonald H. R., 1987/05. Journal of Immunology, 138 (10) pp. 3120-9.
 
Functional analysis in vitro and in vivo of Mycobacterium bovis strain BCG-specific T cell clones
Pedrazzini T., Louis J. A., 1986/03. Journal of Immunology, 136 (5) pp. 1828-34.
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