Jacques-Antoine Haefliger

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127 publications

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Targeting connexin37 alters angiogenesis and arteriovenous differentiation in the developing mouse retina.
Hamard L., Santoro T., Allagnat F., Meda P., Nardelli-Haefliger D., Alonso F., Haefliger J.A., 2020/06. FASEB journal, 34 (6) pp. 8234-8249. Peer-reviewed.
Impaired SMAD1/5 Mechanotransduction and Cx37 (Connexin37) Expression Enable Pathological Vessel Enlargement and Shunting.
Peacock H.M., Tabibian A., Criem N., Caolo V., Hamard L., Deryckere A., Haefliger J.A., Kwak B.R., Zwijsen A., Jones EAV, 2020/04. Arteriosclerosis, thrombosis, and vascular biology, 40 (4) pp. e87-e104. Peer-reviewed.
Connexin37-Dependent Mechanisms Selectively Contribute to Modulate Angiotensin II -Mediated Hypertension.
Le Gal L., Pellegrin M., Santoro T., Mazzolai L., Kurtz A., Meda P., Wagner C., Haefliger J.A., 2019/04/16. Journal of the American Heart Association, 8 (8) pp. e010823. Peer-reviewed.
Intravesical Ty21a Vaccine Promotes Dendritic Cells and T Cell-Mediated Tumor Regression in the MB49 Bladder Cancer Model.
Domingos-Pereira S., Sathiyanadan K., La Rosa S., Polák L., Chevalier M.F., Martel P., Hojeij R., Derré L., Haefliger J.A., Jichlinski P. et al., 2019/04. Cancer immunology research, 7 (4) pp. 621-629. Peer-reviewed.
Evaluating intimal hyperplasia under clinical conditions.
Mylonaki I., Allain E., Strano F., Allémann E., Corpataux J.M., Meda P., Jordan O., Delie F., Rougemont A.L., Haefliger J.A. et al., 2018/09/01. Interactive cardiovascular and thoracic surgery, 27 (3) pp. 427-436. Peer-reviewed.
Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H<sub>2</sub>S Production.
Longchamp A., Mirabella T., Arduini A., MacArthur M.R., Das A., Treviño-Villarreal J.H., Hine C., Ben-Sahra I., Knudsen N.H., Brace L.E. et al., 2018/03/22. Cell, 173 (1) pp. 117-129.e14. Peer-reviewed.
Versican is differentially regulated in the adventitial and medial layers of human vein grafts.
Kenagy R.D., Kikuchi S., Evanko S.P., Ruiter M.S., Piola M., Longchamp A., Pesce M., Soncini M., Deglise S., Fiore G.B. et al., 2018. PloS one, 13 (9) pp. e0204045. Peer-reviewed.
Targeting Cx40 (Connexin40) Expression or Function Reduces Angiogenesis in the Developing Mouse Retina.
Haefliger J.A., Allagnat F., Hamard L., Le Gal L., Meda P., Nardelli-Haefliger D., Génot E., Alonso F., 2017/11. Arteriosclerosis, thrombosis, and vascular biology, 37 (11) pp. 2136-2146. Peer-reviewed.
Connexin37 reduces smooth muscle cell proliferation and intimal hyperplasia in a mouse model of carotid artery ligation.
Allagnat F., Dubuis C., Lambelet M., Le Gal L., Alonso F., Corpataux J.M., Déglise S., Haefliger J.A., 2017/06/01. Cardiovascular research, 113 (7) pp. 805-816. Peer-reviewed.
Perivascular medical devices and drug delivery systems: Making the right choices.
Mylonaki I., Allémann É., Saucy F., Haefliger J.A., Delie F., Jordan O., 2017/06. Biomaterials, 128 pp. 56-68. Peer-reviewed.
Perivascular sustained release of atorvastatin from a hydrogel-microparticle delivery system decreases intimal hyperplasia.
Mylonaki I., Strano F., Deglise S., Allémann E., Alonso F., Corpataux J.M., Dubuis C., Haefliger J.A., Jordan O., Saucy F. et al., 2016/06/28. Journal of controlled release, 232 pp. 93-102. Peer-reviewed.
Nitric Oxide Deficit Drives Intimal Hyperplasia in Mouse Models of Hypertension.
Allagnat F., Haefliger J.A., Lambelet M., Longchamp A., Bérard X., Mazzolai L., Corpataux J.M., Déglise S., 2016/05. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 51 (5) pp. 733-742. Peer-reviewed.
Targeting endothelial connexin40 inhibits tumor growth by reducing angiogenesis and improving vessel perfusion.
Alonso F., Domingos-Pereira S., Le Gal L., Derré L., Meda P., Jichlinski P., Nardelli-Haefliger D., Haefliger J.A., 2016/03/22. Oncotarget, 7 (12) pp. 14015-14028. Peer-reviewed.
A Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells.
Cigliola V., Populaire C., Pierri C.L., Deutsch S., Haefliger J.A., Fadista J., Lyssenko V., Groop L., Rueedi R., Thorel F. et al., 2016. Plos One, 11 (3) pp. e0150880. Peer-reviewed.
Connexins and pannexins: from biology towards clinical targets.
Meda P., Haefliger J.A., 2016. Swiss medical weekly, 146 pp. w14365. Peer-reviewed.
Connexin43 Inhibition Prevents Human Vein Grafts Intimal Hyperplasia.
Longchamp A., Allagnat F., Alonso F., Kuppler C., Dubuis C., Ozaki C.K., Mitchell J.R., Berceli S., Corpataux J.M., Déglise S. et al., 2015. Plos One, 10 (9) pp. e0138847. Peer-reviewed.
Endothelial Connexin37 and Connexin40 participate in basal but not agonist-induced NO release.
Meens M.J., Alonso F., Le Gal L., Kwak B.R., Haefliger J.A., 2015. Cell Communication and Signaling : Ccs, 13 p. 34. Peer-reviewed.
Interplay between connexin40 and nitric oxide signaling during hypertension.
Le Gal L., Alonso F., Mazzolai L., Meda P., Haefliger J.A., 2015. Hypertension, 65 (4) pp. 910-915. Peer-reviewed.
REST represses a subset of the pancreatic endocrine differentiation program.
Martin D., Kim Y.H., Sever D., Mao C.A., Haefliger J.A., Grapin-Botton A., 2015. Developmental Biology, 405 (2) pp. 316-327. Peer-reviewed.
Role of Connexins and Pannexins in the Pancreas.
Cigliola V., Allagnat F., Berchtold L.A., Lamprianou S., Haefliger J.A., Meda P., 2015. Pancreas, 44 (8) pp. 1234-1244. Peer-reviewed.
Store-operated Ca2+ Entry Mediated by Orai1 and TRPC1 Participates to Insulin Secretion in Rat β-Cells.
Sabourin J., Le Gal L., Saurwein L., Haefliger J.A., Raddatz E., Allagnat F., 2015. Journal of Biological Chemistry, 290 (51) pp. 30530-30539. Peer-reviewed.
Intravaginal and subcutaneous immunization induced vaccine specific CD8 T cells and tumor regression in the bladder.
Domingos-Pereira S., Derré L., Warpelin-Decrausaz L., Haefliger J.A., Romero P., Jichlinski P., Nardelli-Haefliger D., 2014. Journal of Urology, 191 (3) pp. 814-822.
Procedure for human saphenous veins ex vivo perfusion and external reinforcement.
Longchamp A., Allagnat F., Berard X., Alonso F., Haefliger J.A., Deglise S., Corpataux J.M., 2014. Journal of Visualized Experiments : Jove 92 pp. e52079.
Restoration of connexin 40 (cx40) in Renin-producing cells reduces the hypertension of cx40 null mice.
Le Gal L., Alonso F., Wagner C., Germain S., Nardelli Haefliger D., Meda P., Haefliger J.A., 2014. Hypertension, 63 (6) pp. 1198-1204. Peer-reviewed.
The use of external mesh reinforcement to reduce intimal hyperplasia and preserve the structure of human saphenous veins.
Longchamp A., Alonso F., Dubuis C., Allagnat F., Berard X., Meda P., Saucy F., Corpataux J.M., Déglise S., Haefliger J.A., 2014. Biomaterials, 35 (9) pp. 2588-2599. Peer-reviewed.
Atorvastatin-loaded hydrogel affects the smooth muscle cells of human veins.
Dubuis C., May L., Alonso F., Luca L., Mylonaki I., Meda P., Delie F., Jordan O., Déglise S., Corpataux J.M. et al., 2013. Journal of Pharmacology and Experimental Therapeutics, 347 (3) pp. 574-581.
Connexin36 contributes to INS-1E cells survival through modulation of cytokine-induced oxidative stress, ER stress and AMPK activity.
Allagnat F., Klee P., Cardozo A.K., Meda P., Haefliger J.A., 2013. Cell Death and Differentiation, 20 (12) pp. 1742-1752.
Connexins and M3 muscarinic receptors contribute to heterogeneous Ca(2+) signaling in mouse aortic endothelium.
Boittin F.X., Alonso F., Le Gal L., Allagnat F., Bény J.L., Haefliger J.A., 2013. Cellular physiology and biochemistry, 31 (1) pp. 166-178. Peer-reviewed.
Hyperglycemia downregulates Connexin36 in pancreatic islets via the upregulation of ICER-1/ICER-1γ.
Haefliger J.A., Rohner-Jeanrenaud F., Caille D., Charollais A., Meda P., Allagnat F., 2013. Journal of Molecular Endocrinology, 51 (1) pp. 49-58. Peer-reviewed.
Reduction of connexin36 content by ICER-1 contributes to insulin-secreting cells apoptosis induced by oxidized LDL particles.
Haefliger J.A., Martin D., Favre D., Petremand Y., Mazzolai L., Abderrahmani A., Meda P., Waeber G., Allagnat F., 2013. PLOS One, 8 (1) pp. e55198.
Release of macrophage migration inhibitory factor by neuroendocrine-differentiated LNCaP cells sustains the proliferation and survival of prostate cancer cells.
Tawadros T., Alonso F., Jichlinski P., Clarke N., Calandra T., Haefliger J.A., Roger T., 2013. Endocrine-Related Cancer, 20 (1) pp. 137-149.
Role of hemodynamic forces in the ex vivo arterialization of human saphenous veins.
Berard X., Déglise S., Alonso F., Saucy F., Meda P., Bordenave L., Corpataux J.M., Haefliger J.A., 2013. Journal of Vascular Surgery, 57 (5) pp. 1371-1382. Peer-reviewed.
An adapted model of ex vivo vein perfusion: the key to understand vessel wall remodeling
May L., Deglise S., Berard X., Dubuis C., Saucy F., Haefliger J.A., Corpataux J.M., 2012. p. 20 dans 99th Annual Congress of the Swiss Society of Surgery, British Journal of Surgery.
C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells.
Allagnat F., Fukaya M., Nogueira T.C., Delaroche D., Welsh N., Marselli L., Marchetti P., Haefliger J.A., Eizirik D.L., Cardozo A.K., 2012. Cell Death and Differentiation, 19 (11) pp. 1836-1846.
Cx36 Is a Target of Beta2/NeuroD1, Which Associates with Prenatal Differentiation of Insulin-producing β Cells.
Nlend R.N., Aït-Lounis A., Allagnat F., Cigliola V., Charollais A., Reith W., Haefliger J.A., Meda P., 2012. Journal of Membrane Biology, 245 (5-6) pp. 263-273. Peer-reviewed.
Intercellular calcium waves in primary cultured rat mesenteric smooth muscle cells are mediated by connexin43.
Halidi N., Alonso F., Burt J.M., Bény J.L., Haefliger J.A., Meister J.J., 2012. Cell Communication and Adhesion, 19 (2) pp. 25-37.
Lack of association between connexin40 polymorphisms and coronary artery disease.
Pfenniger A., van der Laan S.W., Foglia B., Dunoyer-Geindre S., Haefliger J.A., Winnik S., Mach F., Pasterkamp G., James R.W., Kwak B.R., 2012. Atherosclerosis, 222 (1) pp. 148-153.
Regulation of the vascular gap junctions in a mouse model of intimal hyperplasia
Dubuis C., Alonso F., Lambelet M., Saucy F., Haefliger J.A., Corpataux J.M., Deglise S., 2012. p. 21 dans 99th Annual Congress of the Swiss Society of Surgery, Britische Journal of Surgery.
Specific Silencing of the REST Target Genes in Insulin-Secreting Cells Uncovers Their Participation in Beta Cell Survival.
Martin D., Allagnat F., Gesina E., Caille D., Gjinovci A., Waeber G., Meda P., Haefliger J.A., 2012. Plos One, 7 (9) pp. e45844. Peer-reviewed.
Connexin implication in the control of the murine beta-cell mass.
Klee P., Lamprianou S., Charollais A., Caille D., Sarro R., Cederroth M., Haefliger J.A., Meda P., 2011. Pediatric Research, 70 (2) pp. 142-147.
Connexins protect mouse pancreatic β cells against apoptosis.
Klee P., Allagnat F., Pontes H., Cederroth M., Charollais A., Caille D., Britan A., Haefliger J.A., Meda P., 2011. Journal of Clinical Investigation, 121 (12) pp. 4870-4879.
Connexins: key mediators of endocrine function.
Bosco D., Haefliger J.A., Meda P., 2011. Physiological Reviews, 91 (4) pp. 1393-1445.
Role for inducible cAMP early repressor in promoting pancreatic beta cell dysfunction evoked by oxidative stress in human and rat islets.
Favre D., Niederhauser G., Fahmi D., Plaisance V., Brajkovic S., Beeler N., Allagnat F., Haefliger J.A., Regazzi R., Waeber G. et al., 2011. Diabetologia, 54 (9) pp. 2337-2346.
An angiotensin II- and NF-kappaB-dependent mechanism increases connexin 43 in murine arteries targeted by renin-dependent hypertension.
Alonso F., Krattinger N., Mazzolai L., Simon A., Waeber G., Meda P., Haefliger J.A., 2010. Cardiovascular Research, 87 (1) pp. 166-176.
Connexin 43 expression in human hypertrophied heart due to pressure and volume overload.
Vetter C., Zweifel M., Zuppinger C., Carrel T., Martin D., Haefliger J.A., Delacrétaz E., 2010. Physiological Research / Academia Scientiarum Bohemoslovaca, 59 (1) pp. 35-42. Peer-reviewed.
Ex vivo Pulsatile Perfusion of Human Saphenous Veins Induces Intimal Hyperplasia and Increased Levels of the Plasminogen Activator Inhibitor 1.
Saucy F., Probst H., Alonso F., Bérard X., Déglise S., Dunoyer-Geindre S., Mazzolai L., Kruithof E., Haefliger J.A., Corpataux J.M., 2010. European Surgical Research, 45 (1) pp. 50-59.
Loss of connexin40 is associated with decreased endothelium-dependent relaxations and eNOS levels in the mouse aorta.
Alonso Florian, Boittin Francois-Xavier, Beny Jean-Louis, Haefliger Jacques-Antoine, 2010. American Journal of Physiology. Heart and Circulatory Physiology, 299 (5) pp. 1365-1373.
Connexins, diabetes and the metabolic syndrome.
Hamelin R., Allagnat F., Haefliger J.A., Meda P., 2009. Current Protein & Peptide Science, 10 (1) pp. 18-29. Peer-reviewed.
Long-term exercise stabilizes atherosclerotic plaque in apolipoprotein-E deficient mice
Pellegrin M., Miguet-Alfonsi C., Bouzourene K., Aubert J.F., Deckert V., Berthelot A., Mazzolai L., Mach F., Haefliger J.A., Alonso F. et al., 2009. Medicine and Science in Sports and Exercise, 41 (12) pp. 2128-2135. Peer-reviewed.
Swimming prevents vulnerable atherosclerotic plaque development in hypertensive 2-kidney, 1-clip mice by modulating angiotensin II type 1 receptor expression independently from hemodynamic changes.
Pellegrin M., Alonso F., Aubert J.F., Bouzourene K., Braunersreuther V., Mach F., Haefliger J.A., Hayoz D., Berthelot A., Nussberger J. et al., 2009. Hypertension, 53 (5) pp. 782-789.
Functional significance of repressor element 1 silencing transcription factor (REST) target genes in pancreatic beta cells
Martin D., Allagnat F., Chaffard G., Caille D., Fukuda M., Regazzi R., Abderrahmani A., Waeber G., Meda P., Maechler P. et al., 2008/08. Diabetologia, 51 (8) pp. 1429-1439. Peer-reviewed.
Expression of the master repressor RE-1 silencing transcription factor (REST) in beta cells leads to diabetes : 455
Martin D., Caille D., Meda R., Haefliger J.A., 2008. pp. S189 dans Minutes of the 43rd General Assembly of the European Association for the Study of Diabetes, Diabetologia. Peer-reviewed.
ICER-1gamma overexpression drives palmitate-mediated connexin36 down-regulation in insulin-secreting cells.
Allagnat F., Alonso F., Martin D., Abderrahmani A., Waeber G., Haefliger J.A., 2008. Journal of Biological Chemistry, 283 (9) pp. 5226-5234. Peer-reviewed.
Increased Expression of Renal Cyclooxygenase-2 and Neuronal Nitric Oxide Synthase in Hypertensive Cx40-Deficient Mice.
Krattinger N., Alonso F., Capponi A., Mazzolai L., Nicod P., Meda P., Haefliger J.A., 2008. Journal of Vascular Research, 46 (3) pp. 188-198.
Acute inflammation decreases the expression of connexin 40 in mouse lung
Rignault S., Haefliger J. A., Waeber B., Liaudet L., Feihl F., 2007/07. Shock, 28 (1) pp. 78-85.
Connexin40 regulates renin production and blood pressure.
Krattinger N., Capponi A., Mazzolai L., Aubert J.F., Caille D., Nicod P., Waeber G., Meda P., Haefliger J.A., 2007. Kidney international, 72 (7) pp. 814-22. Peer-reviewed.
Phosphorylation-dependent dimerization and subcellular localization of islet-brain 1/c-Jun N-terminal kinase-interacting protein 1.
Borsello T., Centeno C., Riederer I.M., Haefliger J.A., Riederer B.M., 2007. Journal of Neuroscience Research, 85 (16) pp. 3632-3641. Peer-reviewed.
Splice variant-specific stabilization of JNKs by IB1/JIP1.
Yang J.Y., Moulin N., van Bemmelen M.X., Dubuis G., Tawadros T., Haefliger J.A., Waeber G., Widmann C., 2007. Cellular signalling, 19 (10) pp. 2201-7. Peer-reviewed.
Connexines, rénine et hypertension [Connexins, renin and hypertension]
Haefliger J.A., Meda P., 2006/10. Médecine Sciences, 22 (10) pp. 826-827. Peer-reviewed.
Connexin43-dependent mechanism modulates renin secretion and hypertension
Haefliger J. A., Krattinger N., Martin D., Pedrazzini T., Capponi A., Doring B., Plum A., Charollais A., Willecke K., Meda P., 2006/02. Journal of Clinical Investigation, 116 (2) pp. 405-13.
GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function.
Membrez M., Hummler E., Beermann F., Haefliger J.A., Savioz R., Pedrazzini T., Thorens B., 2006. Molecular and Cellular Biology, 26 (11) pp. 4268-4276. Peer-reviewed.
Sepsis up-regulates the expression of connexin 40 in rat aortic endothelium
Rignault S., Haefliger J. A., Gasser D., Markert M., Nicod P., Liaudet L., Waeber B., Feihl F., 2005/06. Critical Care Medicine, 33 (6) pp. 1302-10.
Jonctions communicantes et pathologies. [Gap functions and diseases]
Allagnat F., Krattinger N., Nicod P., Meda P., Haefliger J. A., 2005/04. Revue Médicale Suisse, 1 (17) pp. 1126-30, 1132-3.
Fibrinogen and fibronectin binding cooperate for valve infection and invasion in Staphylococcus aureus experimental endocarditis.
Que Y.A., Haefliger J.A., Piroth L., François P., Widmer E., Entenza J.M., Sinha B., Herrmann M., Francioli P., Vaudaux P. et al., 2005. Journal of Experimental Medicine, 201 (10) pp. 1627-1635. Peer-reviewed.
Glucose represses connexin36 in insulin-secreting cells.
Allagnat F., Martin D., Condorelli D.F., Waeber G., Haefliger J.A., 2005. Journal of cell science, 118 (Pt 22) pp. 5335-44. Peer-reviewed.
IB1/JIP-1 controls JNK activation and increased during prostatic LNCaP cells neuroendocrine differentiation.
Tawadros T., Martin D., Abderrahmani A., Leisinger H.J., Waeber G., Haefliger J.A., 2005. Cellular Signalling, 17 (8) pp. 929-939. Peer-reviewed.
Increased connexin43 expression in human saphenous veins in culture is associated with intimal hyperplasia.
Déglise S., Martin D., Probst H., Saucy F., Hayoz D., Waeber G., Nicod P., Ris H.B., Corpataux J.M., Haefliger J.A., 2005. Journal of Vascular Surgery, 41 (6) pp. 1043-1052. Peer-reviewed.
Jonctions communicantes et sécrétion [Gap junctions and secretion]
Haefliger J.A., Allagnat F., Krattinger N., Martin D., Waeber G., Nicod P., Meda P., 2005. Revue médicale suisse, 1 (17) pp. 1134-9.
The repressor element silencing transcription factor (REST)-mediated transcriptional repression requires the inhibition of Sp1.
Plaisance V., Niederhauser G., Azzouz F., Lenain V., Haefliger J.A., Waeber G., Abderrahmani A., 2005. Journal of Biological Chemistry, 280 (1) pp. 401-407. Peer-reviewed.
Contribution of connexins to the function of the vascular wall
Haefliger J. A., Nicod P., Meda P., 2004/05. Cardiovascular Research, 62 (2) pp. 345-56.
Neuronal traits are required for glucose-induced insulin secretion.
Abderrahmani A., Niederhauser G., Plaisance V., Haefliger J.A., Regazzi R., Waeber G., 2004. FEBS letters, 565 (1-3) pp. 133-8. Peer-reviewed.
Thyrotropin-releasing hormone-stimulated thyrotropin expression involves islet-brain-1/c-Jun N-terminal kinase interacting protein-1.
Abe H., Murao K., Imachi H., Cao W.M., Yu X., Yoshida K., Wong N.C., Shupnik M.A., Haefliger J.A., Waeber G. et al., 2004. Endocrinology, 145 (12) pp. 5623-8. Peer-reviewed.
Connexin-36 contributes to control function of insulin-producing cells.
Le Gurun S., Martin D., Formenton A., Maechler P., Caille D., Waeber G., Meda P., Haefliger J.A., 2003. Journal of Biological Chemistry, 278 (39) pp. 37690-37697. Peer-reviewed.
Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines.
Martin D., Tawadros T., Meylan L., Abderrahmani A., Condorelli D.F., Waeber G., Haefliger J.A., 2003. Journal of Biological Chemistry, 278 (52) pp. 53082-53089. Peer-reviewed.
Increased vulnerability to kainic acid-induced epileptic seizures in mice underexpressing the scaffold protein Islet-Brain 1/JIP-1.
Magara F., Haefliger J.A., Thompson N., Riederer B., Welker E., Nicod P., Waeber G., 2003. European Journal of Neuroscience, 17 (12) pp. 2602-2610. Peer-reviewed.
Insulin-secreting beta-cell dysfunction induced by human lipoproteins.
Roehrich M.E., Mooser V., Lenain V., Herz J., Nimpf J., Azhar S., Bideau M., Capponi A., Nicod P., Haefliger J.A. et al., 2003. Journal of Biological Chemistry, 278 (20) pp. 18368-18375. Peer-reviewed.
Islet-brain1/C-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease.
Helbecque N., Abderrahamani A., Meylan L., Riederer B., Mooser V., Miklossy J., Delplanque J., Boutin P., Nicod P., Haefliger J.A. et al., 2003. Molecular psychiatry, 8 (4) pp. 413-422, 363. Peer-reviewed.
The scaffold protein IB1/JIP-1 is a critical mediator of cytokine-induced apoptosis in pancreatic beta cells.
Haefliger J.A., Tawadros T., Meylan L., Gurun S.L., Roehrich M.E., Martin D., Thorens B., Waeber G., 2003. Journal of Cell Science, 116 (Pt 8) pp. 1463-1469.
Variations in IB1/JIP1 expression regulate susceptibility of beta-cells to cytokine-induced apoptosis irrespective of C-Jun NH2-terminal kinase signaling.
Ling Z., Van de Casteele M., Dong J., Heimberg H., Haefliger J.A., Waeber G., Schuit F., Pipeleers D., 2003. Diabetes, 52 (10) pp. 2497-502. Peer-reviewed.
Pharmacological modulation and differential regulation of the cardiac gap junction proteins connexin 43 and connexin 40
Dhein S., Polontchouk L., Salameh A., Haefliger J. A., 2002/11. Biologie Cellulaire, 94 (7-8) pp. 409-22.
Expression and regulation of connexins in cultured ventricular myocytes isolated from adult rat hearts
Polontchouk L. O., Valiunas V., Haefliger J. A., Eppenberger H. M., Weingart R., 2002/03. Pflügers Archiv : European Journal of Physiology, 443 (5-6) pp. 676-689.
Connexins 43 and 26 are differentially increased after rat bladder outlet obstruction.
Haefliger J.A., Tissières P., Tawadros T., Formenton A., Bény J.L., Nicod P., Frey P., Meda P., 2002. Experimental cell research, 274 (2) pp. 216-25. Peer-reviewed.
The mif gene is transcriptionally regulated by glucose in insulin-secreting cells.
Plaisance V., Thompson N., Niederhauser G., Haefliger J.A., Nicod P., Waeber G., Abderrahmani A., 2002. Biochemical and biophysical research communications, 295 (1) pp. 174-81. Peer-reviewed.
The scaffold protein IB1/JIP-1 controls the activation of JNK in rat stressed urothelium.
Tawadros T., Formenton A., Dudler J., Thompson N., Nicod P., Leisinger H.J., Waeber G., Haefliger J.A., 2002. Journal of cell science, 115 (Pt 2) pp. 385-93. Peer-reviewed.
Effects of chronic atrial fibrillation on gap junction distribution in human and rat atria
Polontchouk L., Haefliger J. A., Ebelt B., Schaefer T., Stuhlmann D., Mehlhorn U., Kuhn-Regnier F., De Vivie E. R., Dhein S., 2001/09. Journal of the American College of Cardiology, 38 (3) pp. 883-91.
Connexins 40 and 43 are differentially regulated within the kidneys of rats with renovascular hypertension.
Haefliger J.A., Demotz S., Braissant O., Suter E., Waeber B., Nicod P., Meda P., 2001/07. Kidney International, 60 (1) pp. 190-201. Peer-reviewed.
Connexin26 is regulated in rat urothelium by the scaffold protein IB1/JIP-1.
Tawadros T., Meda P., Leisinger H.J., Waeber G., Haefliger J.A., 2001. Cell communication & adhesion, 8 (4-6) pp. 303-6. Peer-reviewed.
Cx36 and the function of endocrine pancreas
Calabrese A., Guldenagel M., Charollais A., Mas C., Caton D., Bauquis J., Serre-Beinier V., Caille D., Sohl G., Teubner B. et al., 2001. Cell Communication and Adhesion, 8 (4-6) pp. 387-91.
Involvement of connexin 43 in meiotic maturation of bovine oocytes.
Vozzi C., Formenton A., Chanson A., Senn A., Sahli R., Shaw P., Nicod P., Germond M., Haefliger J.A., 2001. Reproduction, 122 (4) pp. 619-628.
Islet-brain1/JNK-interacting protein-1 is required for early embryogenesis in mice.
Thompson N.A., Haefliger J.A., Senn A., Tawadros T., Magara F., Ledermann B., Nicod P., Waeber G., 2001. Journal of Biological Chemistry, 276 (30) pp. 27745-27748. Peer-reviewed.
Reassessing the role of Staphylococcus aureus clumping factor and fibronectin-binding protein by expression in Lactococcus lactis.
Que Y.A., François P., Haefliger J.A., Entenza J.M., Vaudaux P., Moreillon P., 2001. Infection and Immunity, 69 (10) pp. 6296-6302.
The transcriptional repressor REST determines the cell-specific expression of the human MAPK8IP1 gene encoding IB1 (JIP-1).
Abderrahmani A., Steinmann M., Plaisance V., Niederhauser G., Haefliger J.A., Mooser V., Bonny C., Nicod P., Waeber G., 2001. Molecular and cellular biology, 21 (21) pp. 7256-67. Peer-reviewed.
Cell-to-cell communications via connexins: function and alterations in endothelial and smooth muscle cells of vessels
Meda P., Haefliger J. A., 2000/09. Italian Heart Journal, 1 Suppl 3 pp. S30-1.
Connexin37 in normal and pathological development of mouse heart and great arteries
Haefliger J. A., Polikar R., Schnyder G., Burdet M., Sutter E., Pexieder T., Nicod P., Meda P., 2000/06. Developmental Dynamics, 218 (2) pp. 331-44.
Cx36 preferentially connects beta-cells within pancreatic islets
Serre-Beinier V., Le Gurun S., Belluardo N., Trovato-Salinaro A., Charollais A., Haefliger J. A., Condorelli D. F., Meda P., 2000/05. Diabetes, 49 (5) pp. 727-34.
Expression of connexin36 in the adult and developing rat brain
Belluardo N., Mudo G., Trovato-Salinaro A., Le Gurun S., Charollais A., Serre-Beinier V., Amato G., Haefliger J. A., Meda P., Condorelli D. F., 2000/05. Brain Research, 865 (1) pp. 121-38.
Chronic hypertension alters the expression of Cx43 in cardiovascular muscle cells
Haefliger J. A., Meda P., 2000/04. Brazilian Journal of Medical and Biological Research, 33 (4) pp. 431-8.
Expression of Staphylococcus aureus clumping factor A in Lactococcus lactis subsp. cremoris using a new shuttle vector.
Que Y.A., Haefliger J.A., Francioli P., Moreillon P., 2000. Infection and Immunity, 68 (6) pp. 3516-3522.
Spatial, temporal and subcellular localization of islet-brain 1 (IB1), a homologue of JIP-1, in mouse brain.
Pellet J.B., Haefliger J.A., Staple J.K., Widmann C., Welker E., Hirling H., Bonny C., Nicod P., Catsicas S., Waeber G. et al., 2000. European Journal of Neuroscience, 12 (2) pp. 621-632. Peer-reviewed.
Aortic connexin43 is decreased during hypertension induced by inhibition of nitric oxide synthase
Haefliger J. A., Meda P., Formenton A., Wiesel P., Zanchi A., Brunner H. R., Nicod P., Hayoz D., 1999/07. Arteriosclerosis, Thrombosis, and Vascular Biology, 19 (7) pp. 1615-22.
Cellular localization, expression and regulation of neuropeptide Y in kidneys of hypertensive rats.
Haefliger J.A., Waeber B., Grouzmann E., Braissant O., Nussberger J., Nicod P., Waeber G., 1999. Regulatory peptides, 82 (1-3) pp. 35-43. Peer-reviewed.
Hypoxic contraction of small pulmonary arteries from normal and endotoxemic rats: fundamental role of NO.
Terraz S., Baechtold F., Renard D., Barsi A., Rosselet A., Gnaegi A., Liaudet L., Lazor R., Haefliger J.A., Schaad N. et al., 1999. AJP: Heart and Circulatory Physiology, 276 (4) pp. H1207-H1214.
Sporadic cases of dilated cardiomyopathies associated with atrioventricular conduction defects are not linked to mutation within the connexins 40 and 43 genes.
Haefliger J.A., Goy J.J., Waeber G., 1999. European heart journal, 20 (24) p. 1843. Peer-reviewed.
Psychosomatik chronischer Schmerzsyndrome. Eine Einfuhrung in Diagnostik und Therapie. [Psychosomatic aspects of chronic pain syndromes. An introduction to diagnosis and therapy]
Haefliger J., 1998/02. Schweizerische Rundschau fur Medizin Praxis, 87 (7) pp. 246-50.
The processing routes determined by negatively charged residues in DR1-restricted T cell determinants
Robadey C., Ammerlaan W., Muller C., Cloutier I., Sekaly R. P., Haefliger J. A., Demotz S., 1997/10. Journal of Immunology, 159 (7) pp. 3238-46.
Hypertension differentially affects the expression of the gap junction protein connexin43 in cardiac myocytes and aortic smooth muscle cells.
Haefliger J.A., Castillo E., Waeber G., Aubert J.F., Nicod P., Waeber B., Meda P., 1997. Advances in experimental medicine and biology, 432 pp. 71-82. Peer-reviewed.
Hypertension increases connexin43 in a tissue-specific manner.
Haefliger J.A., Castillo E., Waeber G., Bergonzelli G.E., Aubert J.F., Sutter E., Nicod P., Waeber B., Meda P., 1997. Circulation, 95 (4) pp. 1007-14. Peer-reviewed.
In vivo and in vitro effects of somatostatin and insulin on glucagon release in a human glucagonoma.
Waeber G., Gomez F., Chaubert P., Temler E., Chapuis G., Boulat O., Nicod P., Haefliger J.A., 1997. Clinical endocrinology, 46 (5) pp. 637-42. Peer-reviewed.
Insulin secretion is regulated by the glucose-dependent production of islet beta cell macrophage migration inhibitory factor.
Waeber G., Calandra T., Roduit R., Haefliger J.A., Bonny C., Thompson N., Thorens B., Temler E., Meinhardt A., Bacher M. et al., 1997. Proceedings of the National Academy of Sciences of the United States of America, 94 (9) pp. 4782-4787. Peer-reviewed.
Insulinoma associated with a case of multiple endocrine neoplasia type I: Functional somatostatin receptors and abnormal glucose-induced insulin secretion.
Waeber G., Gomez F., Bishof-Delaloye A., Chaubert P., Francke M.L., Haefliger J.A., Scherrer U., Centeno G., Temler E., Nicod P., 1997. Hormone research, 48 (2) pp. 76-82. Peer-reviewed.
La biologie moléculaire est-elle utile au praticien [Is molecular biology useful to the practitioner?]
Waeber G., Haefliger J.A., 1997. Schweizerische medizinische Wochenschrift, 127 (13) pp. 554-60. Peer-reviewed.
Neuropeptide Y secretion from a human insulinoma.
Waeber G., Hurlimann J., Haefliger J.A., Gomez F., Nicod P., Grouzmann E., 1996. Journal of endocrinological investigation, 19 (3) pp. 190-5. Peer-reviewed.
A 338-bp proximal fragment of the glucose transporter type 2 (GLUT2) promoter drives reporter gene expression in the pancreatic islets of transgenic mice.
Waeber G., Pedrazzini T., Bonny O., Bonny C., Steinmann M., Nicod P., Haefliger J.A., 1995. Molecular and cellular endocrinology, 114 (1-2) pp. 205-15. Peer-reviewed.
Renin and angiotensin II receptor gene expression in kidneys of renal hypertensive rats.
Haefliger J.A., Bergonzelli G., Waeber G., Aubert J.F., Nussberger J., Gavras H., Nicod P., Waeber B., 1995. Hypertension, 26 (5) pp. 733-7. Peer-reviewed.
Characterization of the murine high Km glucose transporter GLUT2 gene and its transcriptional regulation by glucose in a differentiated insulin-secreting cell line.
Waeber G., Thompson N., Haefliger J.A., Nicod P., 1994. Journal of Biological Chemistry, 269 (43) pp. 26912-26919. Peer-reviewed.
Der Fall aus der Praxis (276). Posttraumatischen Belastungsstorung. [A case from practice (276). Post-traumatic stress syndrome]
Haefliger J., 1993/08. Schweizerische Rundschau fur Medizin Praxis, 82 (35) pp. 949-51.
Connexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexins
Bruzzone R., Haefliger J. A., Gimlich R. L., Paul D. L., 1993/01. Molecular Biology of the Cell, 4 (1) pp. 7-20.
Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping.
Haefliger J.A., Bruzzone R., Jenkins N.A., Gilbert D.J., Copeland N.G., Paul D.L., 1992/01. Journal of Biological Chemistry, 267 (3) pp. 2057-2064. Peer-reviewed.
Therapieresistente Unfallpatienten und die Posttraumatische Belastungsstorung (PTBS). [Therapy refractory accident patients and post-traumatic stress disorder]
Haefliger J., 1992. Zeitschrift fur Unfallchirurgie und Versicherungsmedizin, 85 (1) pp. 27-34.
Structural and functional characterization of complement C8 gamma, a member of the lipocalin protein family
Haefliger J. A., Peitsch M. C., Jenne D. E., Tschopp J., 1991/02. Molecular Immunology, 28 (1-2) pp. 123-31.
Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6.
Haefliger J.A., Tschopp J., Vial N., Jenne D.E., 1989/10. Journal of Biological Chemistry, 264 (30) pp. 18041-18051. Peer-reviewed.
Isolation and complete structure of the lymphocyte serine protease granzyme G, a novel member of the granzyme multigene family in murine cytolytic T lymphocytes. Evolutionary origin of lymphocyte proteases
Jenne D. E., Masson D., Zimmer M., Haefliger J. A., Li W. H., Tschopp J., 1989/09. Biochemistry, 28 (19) pp. 7953-61.
Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes
Jenne D., Rey C., Haefliger J. A., Qiao B. Y., Groscurth P., Tschopp J., 1988/07. Proceedings of the National Academy of Sciences of the United States of America, 85 (13) pp. 4814-8.
Structural homology of human complement component C8 gamma and plasma protein HC: identity of the cysteine bond pattern
Haefliger J. A., Jenne D., Stanley K. K., Tschopp J., 1987/12. Biochemical and Biophysical Research Communications, 149 (2) pp. 750-4.
Complementary DNA cloning of complement C8 beta and its sequence homology to C9.
Haefliger J.A., Tschopp J., Nardelli D., Wahli W., Kocher H.P., Tosi M., Stanley K.K., 1987/06. Biochemistry, 26 (12) pp. 3551-3556.
Comparison of the organization and fine structure of a chicken and a Xenopus laevis vitellogenin gene.
Nardelli D., van het Schip F.D., Gerber-Huber S., Haefliger J.A., Gruber M., Ab G., Wahli W., 1987. Journal of Biological Chemistry, 262 (32) pp. 15377-15385.
Precursor-product relationship between vitellogenin and the yolk proteins as derived from the complete sequence of a Xenopus vitellogenin gene.
Gerber-Huber S., Nardelli D., Haefliger J.A., Cooper D.N., Givel F., Germond J.E., Engel J., Green N.M., Wahli W., 1987. Nucleic Acids Research, 15 (12) pp. 4737-4760.
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