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Lorenz Hirt

Coordonnées Enseignements Publications  

Publications

Articles

Altinbas A., Algra A., Bonati L.H., Brown M.M., Kappelle L.J., de Borst G.J., Hendrikse J., van der Tweel I., van der Worp H.B., ICSS Investigators, Periprocedural Hemodynamic Depression Is Associated With a Higher Number of New Ischemic Brain Lesions After Stenting in the International Carotid Stenting Study-MRI Substudy. Stroke 45(1), pp. 146-151, 2014. [DOI] [Web of Science] [Pubmed] ok

Yiallourou T.I., Odier C., Heinzer R., Hirt L., Martin B.A., Stergiopulos N., Haba-Rubio J., The effect of continuous positive airway pressure on total cerebral blood flow in healthy awake volunteers. Sleep and Breathing = Schlaf and Atmung 17(1), pp. 289-296, 2013. [DOI] [Web of Science] [Pubmed] ok

Ederle J., Davagnanam I., van der Worp H.B., Venables G.S., Lyrer P.A., Featherstone R.L., Brown M.M., Jäger H.R., ICSS investigators, Effect of white-matter lesions on the risk of periprocedural stroke after carotid artery stenting versus endarterectomy in the International Carotid Stenting Study (ICSS): a prespecified analysis of data from a randomised trial. Lancet Neurology 12(9), pp. 866-872, 2013. [DOI] [Web of Science] [Pubmed] ok

Mirante O., Price M., Puentes W., Castillo X., Benakis C., Thevenet J., Monard D., Hirt L., Endogenous protease nexin-1 protects against cerebral ischemia. International Journal of Molecular Sciences 14(8), pp. 16719-16731, 2013. [Document] [DOI] [Web of Science] [Pubmed] ok

Diserens Karin, Moreira Tiago, Hirt Lorenz, Faouzi Mohamed, Grujic Jelena, Bieler Gilles, Vuadens Philippe, Michel Patrik, Early mobilization out of bed after ischaemic stroke reduces severe complications but not cerebral blood flow: a randomized controlled pilot trial. Clinical Rehabilitation 26(5), pp. 451-459, 2012. [DOI] [Web of Science] [Pubmed] ok

Benakis C., Vaslin A., Pasquali C., Hirt L., Neuroprotection by inhibiting the c-Jun N-terminal kinase pathway after cerebral ischemia occurs independently of interleukin-6 and keratinocyte-derived chemokine (KC/CXCL1) secretion. Journal of Neuroinflammation 9, p. 76, 2012. [DOI] [Web of Science] [Pubmed] ok

Alf M.F., Lei H., Berthet C., Hirt L., Gruetter R., Mlynarik V., High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice. NMR in Biomedicine 25(2), pp. 247-254, 2012. [DOI] [Pubmed] ok

Moreira T., Michel P., Binaghi S., Hirt L., Risk factor impact on blood flow velocities and clinical outcomes of stented cervical and intracranial stenoses: preliminary observations. Clinical Neurology and Neurosurgery 114(7), pp. 922-929, 2012. [DOI] [Pubmed] ok

Chabwine J.N., Rossetti A.R., Hirt L., Kuntzer T., Schluep M., Michel P., Démonet J.F., du Pasquier R.A., Vingerhoets F.G., Neurologie [Neurology]. Revue Médicale Suisse 8(323), pp. 46-50, 2012. [Pubmed]

Berthet C., Castillo X., Magistretti P.J., Hirt L., New evidence of neuroprotection by lactate after transient focal cerebral ischaemia: extended benefit after intracerebroventricular injection and efficacy of intravenous administration. Cerebrovascular Diseases 34(5-6), pp. 329-335, 2012. [DOI] [Web of Science] [Pubmed] ok

Berthet C., Lei H., Gruetter R., Hirt L., Early predictive biomarkers for lesion after transient cerebral ischemia. Stroke 42(3), pp. 799-805, 03-2011. [DOI] [Pubmed] ok

Price Melanie, Badaut Jerome, Thevenet Jonathan, Hirt Lorenz, Activation of c-Jun in the nuclei of neurons of the CA-1 in thrombin preconditioning occurs via PAR-1. Journal of Neuroscience Research 88(6), pp. 1338-1347, 2010. [DOI] [Web of Science] [Pubmed]

International Carotid Stenting Study investigators, Ederle J., Ederle J., Dobson J., Featherstone R.L., Bonati L.H., van der Worp H.B., de Borst G.J., Lo T.H., Gaines P. et al., Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial. Lancet 375(9719), pp. 985-997, 2010. [DOI] [Web of Science] [Pubmed] ok

Benakis Corinne, Bonny Christophe, Hirt Lorenz, JNK inhibition and inflammation after cerebral ischemia. Brain, Behavior, and Immunity 24(5), pp. 800-811, 2010. [DOI] [Web of Science] [Pubmed]

Michel-Monigadon Delphine, Bonny Christophe, Hirt Lorenz, c-Jun N-terminal kinase pathway inhibition in intracerebral hemorrhage. Cerebrovascular Diseases 29(6), pp. 564-570, 2010. [DOI] [Web of Science] [Pubmed]

Bousser M.G., Amarenco P., Chamorro A., Fisher M., Ford I., Fox K., Hennerici M.G., Mattle H.P., Rothwell P.M., PERFORM Study Investigators, Rationale and design of a randomized, double-blind, parallel-group study of terutroban 30 mg/day versus aspirin 100 mg/day in stroke patients: the prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) study. Cerebrovascular Diseases 27(5), pp. 509-518, 2009. [DOI] [Web of Science] [Pubmed] ok

Hirt L., Ternon B., Price M., Mastour N., Brunet J.F., Badaut J., Protective role of early aquaporin 4 induction against postischemic edema formation. Journal of cerebral blood flow and metabolism 29(2), pp. 423-433, 2009. [DOI] [Web of Science] [Pubmed] ok

Lei H., Berthet C., Hirt L., Gruetter R., Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain. Journal of Cerebral Blood Flow and Metabolism 29(4), pp. 811-819, 2009. [DOI] [Pubmed] ok

Thevenet J., Angelillo-Scherrer A., Price M., Hirt L., Coagulation factor Xa activates thrombin in ischemic neural tissue. Journal of Neurochemistry 111(3), pp. 828-836, 2009. [DOI] [Web of Science] [Pubmed]

Berthet C., Lei H., Thevenet J., Gruetter R., Magistretti P.J., Hirt L., Neuroprotective role of lactate after cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism 29(11), pp. 1780-1789, 2009. [DOI] [Web of Science] [Pubmed] ok

Wiegler K., Bonny C., Coquoz D., Hirt L., The JNK inhibitor XG-102 protects from ischemic damage with delayed intravenous administration also in the presence of recombinant tissue plasminogen activator. Cerebrovascular Diseases (basel, Switzerland) 26(4), pp. 360-366, 2008. [DOI] [Web of Science] [Pubmed] ok

Granziera C., Thevenet J., Price M., Wiegler K., Magistretti P.J., Badaut J., Hirt L., Thrombin-induced ischemic tolerance is prevented by inhibiting c-jun N-terminal kinase. Brain research 1148, pp. 217-25, 2007. [DOI] [Web of Science] [Pubmed] ok

McRae A., Martins R.N., Fonte J., Kraftsik R., Hirt L., Miklossy J., Cerebrospinal fluid antimicroglial antibodies in Alzheimer disease: a putative marker of an ongoing inflammatory process. Experimental gerontology 42(4), pp. 355-63, 2007. [DOI] [Web of Science] [Pubmed] ok

de Castro Ribeiro M., Badaut J., Price M., Meins M., Bogousslavsky J., Monard D., Hirt L., Thrombin in ischemic neuronal death. Experimental Neurology 198(1), pp. 199-203, 03-2006. [DOI] [Web of Science] [Pubmed] ok

Ribeiro Mde C., Hirt L., Bogousslavsky J., Regli L., Badaut J., Time course of aquaporin expression after transient focal cerebral ischemia in mice. Journal of Neuroscience Research 83(7), pp. 1231-40, 05-2006. [DOI] [Web of Science] [Pubmed] ok

Badaut J., Hirt L., Price M., de Castro Ribeiro M., Magistretti P.J., Regli L., Hypoxia/hypoglycemia preconditioning prevents the loss of functional electrical activity in organotypic slice cultures. Brain research 1051(1-2), pp. 117-22, 2005. [DOI] [Web of Science] [Pubmed] ok

Devuyst G., Piechowski-Józwiak B., Karapanayiotides T., Fitting J.W., Kémeny V., Hirt L., Urbano L.A., Arnold P., van Melle G., Despland P.A. et al., Controlled contrast transcranial Doppler and arterial blood gas analysis to quantify shunt through patent foramen ovale. Stroke 35(4), pp. 859-863, 2004. [DOI] [Web of Science] [Pubmed]

Hirt L., Badaut J., Thevenet J., Granziera C., Regli L., Maurer F., Bonny C., Bogousslavsky J., D-JNKI1, a cell-penetrating c-Jun-N-terminal kinase inhibitor, protects against cell death in severe cerebral ischemia. Stroke 35(7), pp. 1738-43, 07-2004. [DOI] [Web of Science] [Pubmed] ok

Borsello T., Clarke P.G.H., Hirt L., Vercelli A., Repici M., Schorderet D.F., Bogousslavsky J., Bonny C., A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nature Medicine 9(9), pp. 1180-1186, 2003. [DOI] [Web of Science] [Pubmed] ok

Endres M., Fan G., Hirt L., Jaenisch R., Stroke damage in mice after knocking the neutrophin-4 gene into the brain-derived neurotrophic factor locus. Journal of Cerebral Blood Flow and Metabolism 23(2), pp. 150-3, 02-2003. [DOI] [Web of Science] [Pubmed] ok

Namura S., Hirt L., Wheeler V. C., McGinnis K. M., Hilditch-Maguire P., Moskowitz M. A., MacDonald M. E., Persichetti F., The HD mutation does not alter neuronal death in the striatum of Hdh(Q92) knock-in mice after mild focal ischemia. Neurobiology of Disease 11(1), pp. 147-54, 10-2002. [DOI] [Web of Science] [Pubmed] ok

Bates B., Hirt L., Thomas S. S., Akbarian S., Le D., Amin-Hanjani S., Whalen M., Jaenisch R., Moskowitz M. A., Neurotrophin-3 promotes cell death induced in cerebral ischemia, oxygen-glucose deprivation, and oxidative stress: possible involvement of oxygen free radicals. Neurobiology of Disease 9(1), pp. 24-37, 02-2002. [DOI] [Web of Science] [Pubmed] ok

Katchanov J., Harms C., Gertz K., Hauck L., Waeber C., Hirt L., Priller J., von Harsdorf R., Bruck W., Hortnagl H. et al., Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death. Journal of Neuroscience 21(14), pp. 5045-53, 07-2001. [Web of Science] [Pubmed] ok

Badaut J., Hirt L., Granziera C., Bogousslavsky J., Magistretti P. J., Regli L., Astrocyte-specific expression of aquaporin-9 in mouse brain is increased after transient focal cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism 21(5), pp. 477-82, 05-2001. [DOI] [Web of Science] [Pubmed] ok

Elibol B., Soylemezoglu F., Unal I., Fujii M., Hirt L., Huang P. L., Moskowitz M. A., Dalkara T., Nitric oxide is involved in ischemia-induced apoptosis in brain: a study in neuronal nitric oxide synthase null mice. Neuroscience 105(1), pp. 79-86, 2001. [DOI] [Web of Science] [Pubmed] ok

Ma J., Qiu J., Hirt L., Dalkara T., Moskowitz M. A., Synergistic protective effect of caspase inhibitors and bFGF against brain injury induced by transient focal ischaemia. British Journal of Pharmacology 133(3), pp. 345-50, 06-2001. [DOI] [Web of Science] [Pubmed] ok

Endres M., Fan G., Hirt L., Fujii M., Matsushita K., Liu X., Jaenisch R., Moskowitz M. A., Ischemic brain damage in mice after selectively modifying BDNF or NT4 gene expression. Journal of Cerebral Blood Flow and Metabolism 20(1), pp. 139-44, 01-2000. [DOI] [Web of Science] [Pubmed] ok

Matsushita K., Wu Y., Qiu J., Lang-Lazdunski L., Hirt L., Waeber C., Hyman B. T., Yuan J., Moskowitz M. A., Fas receptor and neuronal cell death after spinal cord ischemia. Journal of Neuroscience 20(18), pp. 6879-87, 09-2000. [Web of Science] [Pubmed] ok

Lang-Lazdunski L., Matsushita K., Hirt L., Waeber C., Vonsattel J. P., Moskowitz M. A., Dietrich W. D., Spinal cord ischemia. Development of a model in the mouse. Stroke 31(1), pp. 208-13, 01-2000. [Web of Science] [Pubmed] ok

Fitting J. W., Paillex R., Hirt L., Aebischer P., Schluep M., Sniff nasal pressure: a sensitive respiratory test to assess progression of amyotrophic lateral sclerosis. Annals of Neurology 46(6), pp. 887-93, 12-1999. [Web of Science] [Pubmed] ok

Glutz von Blotzheim S., Borruat F. X., Hirt L., Myopathies mitochondriales oculaires: un eventail de presentations cliniques. [Ocular mitochondrial myopathies: a spectrum of clinical presentations]. Klinische Monatsblatter fur Augenheilkunde 212(5), pp. 299-300, 05-1998. [Pubmed]

Aebischer P., Pochon N. A., Heyd B., Deglon N., Joseph J. M., Zurn A. D., Baetge E. E., Hammang J. P., Goddard M., Lysaght M. et al., Gene therapy for amyotrophic lateral sclerosis (ALS) using a polymer encapsulated xenogenic cell line engineered to secrete hCNTF. Human Gene Therapy 7(7), pp. 851-60, 05-1996. [Web of Science] [Pubmed] ok

Aebischer P., Schluep M., Deglon N., Joseph J. M., Hirt L., Heyd B., Goddard M., Hammang J. P., Zurn A. D., Kato A. C. et al., Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients. Nature Medicine 2(6), pp. 696-9, 06-1996. [DOI] [Web of Science] [Pubmed] ok

Hirt L., Hirsch-Behnam A., de Villiers E.M., Nucleotide sequence of human papillomavirus (HPV) type 41: an unusual HPV type without a typical E2 binding site consensus sequence. Virus Research 18(2-3), pp. 179-189, 03-1991. [DOI] [Web of Science] [Pubmed] ok

Articles - Etudes de cas

Alvarez V., Morier J., Hirt L., An episode mimicking a versive seizure in acute bilateral pontine stroke. Journal of Clinical Neuroscience 18(8), pp. 1141-2, 2011. [DOI] [Web of Science] [Pubmed]

Bron Cedric, Hirt Lorenz, Halabi Georges, Saucy Francois, Qanadli Salah D., Haesler Erik, Asymptomatic high flow subclavian steal in a patient with hemodialysis access. Journal of Vascular Access 11(1), pp. 63-65, 2010. [Web of Science] [Pubmed]

Siclari F., Hirt L., Meuli R., Fellmann F., Gailloud P., Michel P., Bilateral carotid thrombus formation after strenuous coughing. European Journal of Neurology 16(7), pp. e122-e123, 2009. [DOI] [Web of Science] [Pubmed]

Hirt L., Maréchal C., Ghika J.A., Magistretti P.J., Bogousslavsky J., Ocular mitochondrial myopathy evolving late in life into a disabling proximal myopathy associated with the mitochondrial DNA 3243 A to G mutation. Journal of neurology 248(4), pp. 332-3, 2001. [DOI] [Web of Science] [Pubmed] ok

Laubscher B., Janzer R. C., Krahenbuhl S., Hirt L., Deonna T., Ragged-red fibers and complex I deficiency in a neonate with arthrogryposis congenita. Pediatric Neurology 17(3), pp. 249-51, 10-1997. [DOI] [Web of Science] [Pubmed] ok

Borruat F. X., Hirt L., Regli F., Neuropathie optique alcoolo-tabagique: un piege diagnostique de la neuropathie optique de Leber. [Optic neuropathy caused by alcoholism and smoking: a diagnostic pitfall of Leber's optic neuropathy]. Revue Neurologique 150(11), pp. 799-801, 11-1994. [Web of Science] [Pubmed] ok

Articles - Lettres

Hirt L., Magistretti P.J., Hirt L., Bogousslavsky J., Boulat O., Borruat F.X., Large deletion (7.2 kb) of mitochondrial DNA with novel boundaries in a case of progressive external ophthalmoplegia. Journal of neurology, neurosurgery, and psychiatry 61(4), pp. 422-3, 1996. [DOI] [Pubmed] ok

Articles - Synthèses (review)

Déglise S., Dubuis C., Mosimann P., Saucy F., Engelberger S., Hirt L., Michel P., Corpataux J.M., Prise en charge des sténoses carotidiennes [Management of the carotid artery stenosis]. Revue Médicale Suisse 9(391), pp. 1305-1311, 2013. [Pubmed]

Siclari F., Du Pasquier R.A., Schluep M., Michel P., Hirt L., Kuntzer T., Rossetti A.O., Ghika J., Nater B., Vingerhoets F.J., Neurologie [Therapeutic advances in neurology]. Revue Médicale Suisse 7(277), pp. 50-56, 2011. [Pubmed]

Hirt L., Price M., Bogousslavsky J., Apoptose et ischemie cerebrale [Cerebral ischemia and apoptosis]. Revue Médicale Suisse 1(17), pp. 1149-52, 04-2005. [Pubmed]

Barber P. A., Demchuk A. M., Hirt L., Buchan A. M., Biochemistry of ischemic stroke. Advances in Neurology 92, pp. 151-64, 2003. [Pubmed]

Kuntzer T., Hirt L., Bogousslavsky J., Atteintes nerf-muscle et accidents cerebrovasculaires. [Neuromuscular involvement and cerebrovascular accidents]. Revue Médicale de la Suisse Romande 116(8), pp. 605-9, 08-1996. [Pubmed]

Actes de conférences (partie)

Bron C., Hirt L., Qanadli S, Halabi G., Saucy F., Haesler E., Asymptomatic high flow subclavian steal in a patient with hemodialysis access. In: USSG 2007 8ème Congrès de l'Union des Sociétés Suisses des Maladies Vasculaires (Un. Schweiz. Gesellsch. für Gefässkrankheiten)., 11-2007.

Actes de conférences (partie) - Abstracts

Cali C., Marchaland J., Ginet L., Hirt L., Truttmann A.C., Puyal J., Bezzi P., Role of homer 1 proteins in the calcium signaling pathway(s) underlying exo-endocytosis processes of glutamatergic slmvs in astrocytes. In: 10th European Meeting on Glial Cells in Health and Disease. GLIA 59(1),, p. S127, 2011. [Web of Science] ok

Hirt L., Berthet C., Lei H., Gruetter R., Prognostic in Vivo Biomarkers for Lesion Development after Cerebral Ischemia. In: 20th European Stroke Conference. Cerebrovascular Diseases 31(Suppl. 2),, p. 27, 2011. ok

Thevenet J., Angelillo-Scherrer A., Badaut J., Price M., Hirt L., Coagulation Factor Xa Activates Thrombin and Signals Ischemic Neuronal Death Via Par-1 and JNK in Ischemic Neural Tissue. In: 19th European Stroke Conference. Cerebrovascular Diseases 29(Suppl. 2),, p. 315, 2010. ok

Michel-Monigadon D., Mottier V., Bonny C., Hirt L., The role of C-Jun N-terminal kinase in a mouse model of intracerebral hemorrhage. In: 24th International Symposium on Cerebral Blood Flow and Metabolism/9th International Conference on Quantification of Brain Function with PET. Journal of Cerebral Blood Flow and Metabolism 29(Suppl. S1),, pp. 490-491, 2009. [Web of Science] ok

Berthet C., Lei H., Gruetter R., Hirt L., Identification of early metabolic markers of various degrees of ischemia in the mouse brain by localized H-1 magnetic resonance spectroscopy. In: 24th International Symposium on Cerebral Blood Flow and Metabolism/9th International Conference on Quantification of Brain Function with PET. Journal of Cerebral Blood Flow and Metabolism 29(Suppl. 1),, p. S239, 2009. [Web of Science] ok

Michel-Monigadon D., Mottier V., Bonny C., Hirt L., The C-Jun N-Terminal Kinase Inhibition in Intracerebral Hemorrhage. In: 18th European Stroke Conference. Cerebrovascular Diseases 27(Suppl. 6),, p. 109, 2009. ok

Hirt L., Price M., Wiegler K., Mastour N., Brunet J.F., Badaut J., Aquaporin expression after thrombin preconditioning in ischemic mouse brain. In: 16th European Stroke Conference. Cerebrovascular Diseases 23(Suppl. 2),, pp. 22-23, 2007. ok

Actes de conférences (partie) - Posters

Berthet C., Lei H., Gruetter R., Hirt L., 14.1T magnetic resonance spectroscopic evaluation of metabolic changes in the mouse striatum following transient middle cerebral artery occlusion. In: 18th European Stroke Conference. Cerebrovascular Diseases 27(Suppl. 6),, p. 108, 2009. ok

Morier J., Goncalves-Matoso V., Doenz F., Jeanrenaud X., Hirt L., Michel P., REDUCTION OF MIGRAINES AFTER TREATMENT OF HEREDITARYHEMORRHAGIC TELANGIECTASIA (HHT). In: 17th European Stroke Conference. Cerebrovascular Diseases 25(Suppl. 2),, p. 109, 2008. ok

Thèses (doctorat)

Benakis C., Neuroprotection in cerebral ischemia : an effect of c-Jun N-terminal kinase inhibition on the inflammatory response., Université de Lausanne, Faculté de biologie et médecine, Hirt L. (dir.), 102 p., 05-2011. [Document]

Wiegler K., Neuroprotection in cerebral ischemia with XG-102, a new peptide inhibitor of JNK., Université de Lausanne, Faculté de biologie et médecine, Hirt L. (dir.), 121 p., 2007.

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