Christian Widmann

Axes de recherche |

Axes de recherche

Cellular uptake and actions of cell-permeable peptides (CPPs)

Cell-permeable peptides (CPPs) allow the intracellular delivery of cargo molecules that are hooked to them. CPPs provide an efficient mode of transfer for bioactive molecules inside cells, especially in conditions when transcription or translation of these cargo-encoding sequences is undesirable or hard to achieve. CPP sequences are ubiquitous and are often detected in both anti-cancer and anti-microbial peptides. Despite their potential practical applications, the mechanisms of CPP entry inside cells are ill-defined and even controversial. No genes have been described that regulate the intracellular delivery of CPPs. The current focus of our laboratory is to characterize the mechanism of CPP cell entry and CPP mode of action using as an example, the anti-cancer and anti-microbial CPP TAT-RasGAP317-326. Our research is relevant to the bioengineering, oncology and microbiology fields. Please check this website for details: https://www.unil.ch/physiologie/christian-widmann

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