Pascal Schneider

Publications | Mémoires et thèses

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257 publications

2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | ...
 
Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells.
Staniek J., Kalina T., Andrieux G., Boerries M., Janowska I., Fuentes M., Díez P., Bakardjieva M., Stancikova J., Raabe J. et al., 2024/01/12. Science immunology, 9 (91) pp. eadj5948. Peer-reviewed.
A Missense Mutation in the Collagen Triple Helix of EDA Is Associated with X-Linked Recessive Hypohidrotic Ectodermal Dysplasia in Fleckvieh Cattle.
Reinartz S., Weiß C., Heppelmann M., Hewicker-Trautwein M., Hellige M., Willen L., Feige K., Schneider P., Distl O., 2023/12/20. Genes, 15 (1) p. 8. Peer-reviewed.
 
Features of Isoforms of Human Soluble TACI.
Fichtner M.L., Rübsamen H., Smolle M., Schaller J., Feederle R., Bültmann A., Kümpfel T., Schneider P., Thaler F.S., Meinl E., 2023/07/15. Journal of immunology, 211 (2) pp. 199-208. Peer-reviewed.
Turing's turtles all the way down: A conserved role of EDAR in the carapacial ridge suggests a deep homology of prepatterns across ectodermal appendages.
Zimm R., Oberdick D., Gnetneva A., Schneider P., Cebra-Thomas J., Moustakas-Verho J.E., 2023/06. Anatomical record, 306 (6) pp. 1201-1213. Peer-reviewed.
 
Revisiting autoimmune lymphoproliferative syndrome caused by Fas ligand mutations.
Maccari M.E., Schneider P., Smulski C.R., Meinhardt A., Pinto F., Gonzalez-Granado L.I., Schuetz C., Sica M.P., Gross M., Fuchs I. et al., 2023/05. The Journal of allergy and clinical immunology, 151 (5) pp. 1391-1401.e7. Peer-reviewed.
A Causal Treatment for X-Linked Hypohidrotic Ectodermal Dysplasia: Long-Term Results of Short-Term Perinatal Ectodysplasin A1 Replacement.
Schneider H., Schweikl C., Faschingbauer F., Hadj-Rabia S., Schneider P., 2023/04/12. International journal of molecular sciences, 24 (8) p. 7155. Peer-reviewed.
CVID-Associated B Cell Activating Factor Receptor Variants Change Receptor Oligomerization, Ligand Binding, and Signaling Responses.
Block V., Sevdali E., Recher M., Abolhassani H., Hammarstrom L., Smulski C.R., Baronio M., Plebani A., Proietti M., Speletas M. et al., 2023/02. Journal of clinical immunology, 43 (2) pp. 391-405. Peer-reviewed.
Protein kinase B (AKT) upregulation and Thy-1-α<sub>v</sub>β<sub>3</sub> integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis.
Pérez-Núñez R., Chamorro A., González M.F., Contreras P., Artigas R., Corvalán A.H., van Zundert B., Reyes C., Moya P.R., Avalos A.M. et al., 2023/01/06. Journal of neuroinflammation, 20 (1) p. 5. Peer-reviewed.
BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors.
Sevdali E., Block V., Lataretu M., Li H., Smulski C.R., Briem J.S., Heitz Y., Fischer B., Ramirez N.J., Grimbacher B. et al., 2022/06/28. Cell reports, 39 (13) p. 111019. Peer-reviewed.
Sialic acids on B cells are crucial for their survival and provide protection against apoptosis.
Linder A.T., Schmidt M., Hitschfel J., Abeln M., Schneider P., Gerardy-Schahn R., Münster-Kühnel A.K., Nitschke L., 2022/06/21. Proceedings of the National Academy of Sciences of the United States of America, 119 (25) pp. e2201129119. Peer-reviewed.
LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity.
Bombaci G., Sarangdhar M.A., Andina N., Tardivel A., Yu E.C., Mackie G.M., Pugh M., Ozan V.B., Banz Y., Spinetti T. et al., 2022/06. Life science alliance, 5 (6) pp. e202101226. Peer-reviewed.
Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells.
Smulski C.R., Zhang L., Burek M., Teixidó Rubio A., Briem J.S., Sica M.P., Sevdali E., Vigolo M., Willen L., Odermatt P. et al., 2022/03/29. Cell reports, 38 (13) p. 110583. Peer-reviewed.
The EDA-deficient mouse has Zymbal's gland hypoplasia and acute otitis externa.
Del-Pozo J., Headon D.J., Glover J.D., Azar A., Schuepbach-Mallepell S., Bhutta M.F., Riddell J., Maxwell S., Milne E., Schneider P. et al., 2022/03/01. Disease models & mechanisms, 15 (3) pp. dmm049034. Peer-reviewed.
 
Functional and clinical analysis of five EDA variants associated with ectodermal dysplasia but with a hard-to-predict significance.
Gökdere S., Schneider H., Hehr U., Willen L., Schneider P., Maier-Wohlfart S., 2022. Frontiers in genetics, 13 p. 934395. Peer-reviewed.
Kinetics of free and ligand-bound atacicept in human serum.
Eslami M., Willen D., Papasouliotis O., Schuepbach-Mallpell S., Willen L., Donzé O., Yalkinoglu Ö., Schneider P., 2022. Frontiers in immunology, 13 p. 1035556. Peer-reviewed.
Receptor Activator of NF-κB (RANK) Confers Resistance to Chemotherapy in AML and Associates with Dismal Disease Course.
Clar K.L., Weber L.M., Schmied B.J., Heitmann J.S., Marconato M., Tandler C., Schneider P., Salih H.R., 2021/12/04. Cancers, 13 (23) p. 6122. Peer-reviewed.
APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans.
Tsiantoulas D., Eslami M., Obermayer G., Clement M., Smeets D., Mayer F.J., Kiss M.G., Enders L., Weißer J., Göderle L. et al., 2021/08/25. Nature, 597 (7874) pp. 92-96. Peer-reviewed.
Function, occurrence and inhibition of different forms of BAFF.
Eslami M., Schneider P., 2021/08. Current opinion in immunology, 71 pp. 75-80. Peer-reviewed.
 
Human primed ILCPs support endothelial activation through NF-κB signaling.
Vanoni G., Ercolano G., Candiani S., Rutigliani M., Lanata M., Derré L., Marcenaro E., Schneider P., Romero P., Jandus C. et al., 2021/02/08. eLife, 10 pp. e58838. Peer-reviewed.
A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS.
Maccari M.E., Fuchs S., Kury P., Andrieux G., Völkl S., Bengsch B., Lorenz M.R., Heeg M., Rohr J., Jägle S. et al., 2021/02/01. The Journal of experimental medicine, 218 (2) pp. e20192191. Peer-reviewed.
An Outside-In Switch in Integrin Signaling Caused by Chemical and Mechanical Signals in Reactive Astrocytes.
Pérez L.A., Rashid A., Combs J.D., Schneider P., Rodríguez A., Salaita K., Leyton L., 2021. Frontiers in cell and developmental biology, 9 p. 712627. Peer-reviewed.
Correction of Vertebral Bone Development in Ectodysplasin A1-Deficient Mice by Prenatal Treatment With a Replacement Protein.
Kossel C.S., Wahlbuhl M., Schuepbach-Mallepell S., Park J., Kowalczyk-Quintas C., Seeling M., von der Mark K., Schneider P., Schneider H., 2021. Frontiers in genetics, 12 p. 709736. Peer-reviewed.
 
Methods for the Administration of EDAR Pathway Modulators in Mice.
Schuepbach-Mallepell S., Kowalczyk-Quintas C., Dick A., Eslami M., Vigolo M., Headon D.J., Cheeseman M., Schneider H., Schneider P., 2021. pp. 167-183 dans The TNF Superfamily, Springer.
Molecular Diagnostics and In Utero Therapeutics for Orofacial Clefts.
Oliver J.D., Turner E.C., Halpern L.R., Jia S., Schneider P., D'Souza R.N., 2020/10. Journal of dental research, 99 (11) pp. 1221-1227. Peer-reviewed.
Neutralization of B-Cell Activating Factor (BAFF) by Belimumab Reinforces Small Molecule Inhibitor Treatment in Chronic Lymphocytic Leukemia.
Tandler C., Schmidt M., Heitmann J.S., Hierold J., Schmidt J., Schneider P., Dörfel D., Walz J., Salih H.R., 2020/09/23. Cancers, 12 (10) pp. E2725. Peer-reviewed.
Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells.
Valdivia A., Cárdenas A., Brenet M., Maldonado H., Kong M., Díaz J., Burridge K., Schneider P., San Martín A., García-Mata R. et al., 2020/08/18. Cell communication and signaling, 18 (1) p. 129. Peer-reviewed.
The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens.
Rodriguez-Barbosa J.I., Schneider P., Graca L., Bühler L., Perez-Simon J.A., Del Rio M.L., 2020/05/09. International journal of molecular sciences, 21 (9) p. 3347. Peer-reviewed.
Novel strategies for expansion of tooth epithelial stem cells and ameloblast generation.
Binder M., Biggs L.C., Kronenberg M.S., Schneider P., Thesleff I., Balic A., 2020/03/18. Scientific reports, 10 (1) p. 4963. Peer-reviewed.
B-Cell Activating Factor Secreted by Neutrophils Is a Critical Player in Lung Inflammation to Cigarette Smoke Exposure.
Nascimento M., Huot-Marchand S., Gombault A., Panek C., Bourinet M., Fanny M., Savigny F., Schneider P., Le Bert M., Ryffel B. et al., 2020. Frontiers in immunology, 11 p. 1622. Peer-reviewed.
BAFF 60-mer, and Differential BAFF 60-mer Dissociating Activities in Human Serum, Cord Blood and Cerebrospinal Fluid.
Eslami M., Meinl E., Eibel H., Willen L., Donzé O., Distl O., Schneider H., Speiser D.E., Tsiantoulas D., Yalkinoglu Ö. et al., 2020. Frontiers in cell and developmental biology, 8 p. 577662. Peer-reviewed.
Thy-1 (CD90)-Induced Metastatic Cancer Cell Migration and Invasion Are β3 Integrin-Dependent and Involve a Ca<sup>2+</sup>/P2X7 Receptor Signaling Axis.
Brenet M., Martínez S., Pérez-Nuñez R., Pérez L.A., Contreras P., Díaz J., Avalos A.M., Schneider P., Quest AFG, Leyton L., 2020. Frontiers in cell and developmental biology, 8 p. 592442. Peer-reviewed.
No interactions between heparin and atacicept, an antagonist of B cell survival cytokines.
Kowalczyk-Quintas C., Willen D., Willen L., Golob M., Schuepbach-Mallepell S., Peter B., Eslami M., Vigolo M., Broly H., Samy E. et al., 2019/10. British journal of pharmacology, 176 (20) pp. 4019-4033. Peer-reviewed.
 
Prenatal Treatment of X-Linked Hypohidrotic Ectodermal Dysplasia using Recombinant Ectodysplasin in a Canine Model.
Margolis C.A., Schneider P., Huttner K., Kirby N., Houser T.P., Wildman L., Grove G.L., Schneider H., Casal M.L., 2019/09. The Journal of pharmacology and experimental therapeutics, 370 (3) pp. 806-813. Peer-reviewed.
HVEM, a cosignaling molecular switch, and its interactions with BTLA, CD160 and LIGHT.
Rodriguez-Barbosa J.I., Schneider P., Weigert A., Lee K.M., Kim T.J., Perez-Simon J.A., Del Rio M.L., 2019/07. Cellular & molecular immunology, 16 (7) pp. 679-682. Peer-reviewed.
Role of ectodysplasin signalling in middle ear and nasal pathology in rat and mouse models of hypohidrotic ectodermal dysplasia.
Del-Pozo J., MacIntyre N., Azar A., Headon D., Schneider P., Cheeseman M., 2019/04/25. Disease models & mechanisms, 12 (4). Peer-reviewed.
A proliferation-inducing ligand-mediated anti-inflammatory response of astrocytes in multiple sclerosis.
Baert L., Benkhoucha M., Popa N., Ahmed M.C., Manfroi B., Boutonnat J., Sturm N., Raguenez G., Tessier M., Casez O. et al., 2019/03. Annals of neurology, 85 (3) pp. 406-420. Peer-reviewed.
Inhibition of NK Reactivity Against Solid Tumors by Platelet-Derived RANKL.
Clar K.L., Hinterleitner C., Schneider P., Salih H.R., Maurer S., 2019/02/26. Cancers, 11 (3). Peer-reviewed.
Feather arrays are patterned by interacting signalling and cell density waves.
Ho WKW, Freem L., Zhao D., Painter K.J., Woolley T.E., Gaffney E.A., McGrew M.J., Tzika A., Milinkovitch M.C., Schneider P. et al., 2019. PLoS Biology, 17 (2) pp. e3000132. Peer-reviewed.
Modeling Edar expression reveals the hidden dynamics of tooth signaling center patterning.
Sadier A., Twarogowska M., Steklikova K., Hayden L., Lambert A., Schneider P., Laudet V., Hovorakova M., Calvez V., Pantalacci S., 2019. PLoS Biology, 17 (2) pp. e3000064. Peer-reviewed.
TRAIL-R1 and TRAIL-R2 Mediate TRAIL-Dependent Apoptosis in Activated Primary Human B Lymphocytes.
Staniek J., Lorenzetti R., Heller B., Janowska I., Schneider P., Unger S., Warnatz K., Seidl M., Venhoff N., Thiel J. et al., 2019. Frontiers in immunology, 10 p. 951. Peer-reviewed.
B Cell-Activating Factor Neutralization Aggravates Atherosclerosis.
Tsiantoulas D., Sage A.P., Göderle L., Ozsvar-Kozma M., Murphy D., Porsch F., Pasterkamp G., Menche J., Schneider P., Mallat Z. et al., 2018/11/13. Circulation, 138 (20) pp. 2263-2273. Peer-reviewed.
Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation.
Rodriguez-Barbosa J.I., Ferreras M.C., Buhler L., Jones N.D., Schneider P., Perez-Simon J.A., Del Rio M.L., 2018/10. mAbs, 10 (7) pp. 1030-1044. Peer-reviewed.
Attenuation of Mammary Gland Dysplasia and Feeding Difficulties in Tabby Mice by Fetal Therapy.
Wahlbuhl M., Schuepbach-Mallepell S., Kowalczyk-Quintas C., Dick A., Fahlbusch F.B., Schneider P., Schneider H., 2018/09. Journal of mammary gland biology and neoplasia, 23 (3) pp. 125-138. Peer-reviewed.
B2-Lymphocyte responses to oxidative stress-derived antigens contribute to the evolution of nonalcoholic fatty liver disease (NAFLD).
Bruzzì S., Sutti S., Giudici G., Burlone M.E., Ramavath N.N., Toscani A., Bozzola C., Schneider P., Morello E., Parola M. et al., 2018/08/20. Free radical biology & medicine, 124 pp. 249-259. Peer-reviewed.
Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.
Robak O.H., Heimesaat M.M., Kruglov A.A., Prepens S., Ninnemann J., Gutbier B., Reppe K., Hochrein H., Suter M., Kirschning C.J. et al., 2018/08/01. The Journal of clinical investigation, 128 (8) pp. 3535-3545. Peer-reviewed.
CART cells are prone to Fas- and DR5-mediated cell death.
Tschumi B.O., Dumauthioz N., Marti B., Zhang L., Lanitis E., Irving M., Schneider P., Mach J.P., Coukos George, Romero P. et al., 2018/07/13. Journal for immunotherapy of cancer, 6 (1) p. 71. Peer-reviewed.
A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors.
Vigolo M., Chambers M.G., Willen L., Chevalley D., Maskos K., Lammens A., Tardivel A., Das D., Kowalczyk-Quintas C., Schuepbach-Mallepell S. et al., 2018/03/23. Nature communications, 9 (1) p. 1199. Peer-reviewed.
The Immune Checkpoint Modulator OX40 and Its Ligand OX40L in NK-Cell Immunosurveillance and Acute Myeloid Leukemia
Nuebling Tina, Schumacher Carla Emilia, Hofmann Martin, Hagelstein Ilona, Schmiedel Benjamin Joachim, Maurer Stefanie, Federmann Birgit, Rothfelder Kathrin, Roerden Malte, Dörfel Daniela et al., 2018/02. Cancer Immunology Research, 6 (2) pp. 209-221.
Correction to: CART cells are prone to Fas- and DR5-mediated cell death.
Tschumi B.O., Dumauthioz N., Marti B., Zhang L., Lanitis E., Irving M., Schneider P., Mach J.P., Coukos G., Romero P. et al., 2018. Journal for Immunotherapy of Cancer, 6 (1) p. 92. Peer-reviewed.
 
Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis.
Huang H.Y., Rivas-Caicedo A., Renevey F., Cannelle H., Peranzoni E., Scarpellino L., Hardie D.L., Pommier A., Schaeuble K., Favre S. et al., 2018. Proceedings of the National Academy of Sciences of the United States of America, 115 (29) pp. E6826-E6835. Peer-reviewed.
Inhibition of Membrane-Bound BAFF by the Anti-BAFF Antibody Belimumab.
Kowalczyk-Quintas C., Chevalley D., Willen L., Jandus C., Vigolo M., Schneider P., 2018. Frontiers in immunology, 9 p. 2698. Peer-reviewed.
Prenatal Correction of X-Linked Hypohidrotic Ectodermal Dysplasia.
Schneider H., Faschingbauer F., Schuepbach-Mallepell S., Körber I., Wohlfart S., Dick A., Wahlbuhl M., Kowalczyk-Quintas C., Vigolo M., Kirby N. et al., 2018. The New England Journal of Medicine, 378 (17) pp. 1604-1610. Peer-reviewed.
Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.
Chennupati V., Veiga D.F., Maslowski K.M., Andina N., Tardivel A., Yu E.C., Stilinovic M., Simillion C., Duchosal M.A., Quadroni M. et al., 2018. The Journal of Clinical Investigation, 128 (4) pp. 1597-1614. Peer-reviewed.
α<sub>V</sub>β<sub>3</sub> Integrin regulates astrocyte reactivity.
Lagos-Cabré R., Alvarez A., Kong M., Burgos-Bravo F., Cárdenas A., Rojas-Mancilla E., Pérez-Nuñez R., Herrera-Molina R., Rojas F., Schneider P. et al., 2017/09/29. Journal of neuroinflammation, 14 (1) p. 194. Peer-reviewed.
TACI-dependent APRIL signaling maintains autoreactive B cells in a mouse model of systemic lupus erythematosus.
Tran N.L., Schneider P., Santiago-Raber M.L., 2017/04. European journal of immunology, 47 (4) pp. 713-723. Peer-reviewed.
CXCL-8/IL8 Produced by Diffuse Large B-cell Lymphomas Recruits Neutrophils Expressing a Proliferation-Inducing Ligand APRIL.
Manfroi B., McKee T., Mayol J.F., Tabruyn S., Moret S., Villiers C., Righini C., Dyer M., Callanan M., Schneider P. et al., 2017/03/01. Cancer research, 77 (5) pp. 1097-1107. Peer-reviewed.
N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death.
Dufour F., Rattier T., Shirley S., Picarda G., Constantinescu A.A., Morlé A., Zakaria A.B., Marcion G., Causse S., Szegezdi E. et al., 2017/03. Cell death and differentiation, 24 (3) pp. 500-510. Peer-reviewed.
BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases Regulates the Survival of B Cells.
Smulski C.R., Kury P., Seidel L.M., Staiger H.S., Edinger A.K., Willen L., Seidl M., Hess H., Salzer U., Rolink A.G. et al., 2017/02/28. Cell reports, 18 (9) pp. 2189-2202. Peer-reviewed.
Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling.
Smulski C.R., Decossas M., Chekkat N., Beyrath J., Willen L., Guichard G., Lorenzetti R., Rizzi M., Eibel H., Schneider P. et al., 2017/02/09. Cell death & disease, 8 (2) pp. e2601. Peer-reviewed.
A mouse model of systemic lupus erythematosus responds better to soluble TACI than to soluble BAFFR, correlating with depletion of plasma cells.
Haselmayer P., Vigolo M., Nys J., Schneider P., Hess H., 2017. European Journal of Immunology, 47 (6) pp. 1075-1085. Peer-reviewed.
Anti-EDAR Agonist Antibody Therapy Resolves Palate Defects in Pax9(-/-) Mice.
Jia S., Zhou J., Wee Y., Mikkola M.L., Schneider P., D'Souza R.N., 2017. Journal of Dental Research, 96 (11) pp. 1282-1289. Peer-reviewed.
Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway.
Maldonado H., Calderon C., Burgos-Bravo F., Kobler O., Zuschratter W., Ramirez O., Härtel S., Schneider P., Quest A.F., Herrera-Molina R. et al., 2017. Biochimica et Biophysica Acta. Molecular Cell Research, 1864 (2) pp. 243-254. Peer-reviewed.
Ectodysplasin A in Biological Fluids and Diagnosis of Ectodermal Dysplasia.
Podzus J., Kowalczyk-Quintas C., Schuepbach-Mallepell S., Willen L., Staehlin G., Vigolo M., Tardivel A., Headon D., Kirby N., Mikkola M.L. et al., 2017. Journal of Dental Research, 96 (2) pp. 217-224. Peer-reviewed.
Small-molecule Wnt agonists correct cleft palates in Pax9 mutant mice in utero.
Jia S., Zhou J., Fanelli C., Wee Y., Bonds J., Schneider P., Mues G., D'Souza R.N., 2017. Development, 144 (20) pp. 3819-3828. Peer-reviewed.
Targeting BAFF and APRIL in systemic lupus erythematosus and other antibody-associated diseases.
Samy E., Wax S., Huard B., Hess H., Schneider P., 2017. International Reviews of Immunology, 36 (1) pp. 3-19. Peer-reviewed.
Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.
Kowalczyk-Quintas C., Schuepbach-Mallepell S., Vigolo M., Willen L., Tardivel A., Smulski C.R., Zheng T.S., Gommerman J., Hess H., Gottenberg J.E. et al., 2016/09/16. The Journal of biological chemistry, 291 (38) pp. 19826-19834. Peer-reviewed.
Characterization and application of two RANK-specific antibodies with different biological activities.
Chypre M., Seaman J., Cordeiro O.G., Willen L., Knoop K.A., Buchanan A., Sainson R.C., Williams I.R., Yagita H., Schneider P. et al., 2016. Immunology Letters, 171 pp. 5-14. Peer-reviewed.
Data for the crystal structure of APRIL-BAFF-BAFF heterotrimer.
Maskos K., Lammens A., Tan S.L., Hess H., Palinsky W., Schneider P., Jiang X., 2016. Data in Brief, 6 pp. 438-444. Peer-reviewed.
Ectodysplasin a pathway contributes to human and murine skin repair.
Garcin C.L., Huttner K.M., Kirby N., Schneider P., Hardman M.J., 2016. Journal of Investigative Dermatology, 136 (5) pp. 1022-1030.
Immunotherapeutic targeting of LIGHT/LTβR/HVEM pathway fully recapitulates the reduced cytotoxic phenotype of LIGHT-deficient T cells.
Del Rio M.L., Fernandez-Renedo C., Chaloin O., Scheu S., Pfeffer K., Shintani Y., Perez-Simon J.A., Schneider P., Rodriguez-Barbosa J.I., 2016. mAbs, 8 (3) pp. 478-490. Peer-reviewed.
Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration.
Alvarez A., Lagos-Cabré R., Kong M., Cárdenas A., Burgos-Bravo F., Schneider P., Quest A.F., Leyton L., 2016. Biochimica et Biophysica Acta. Molecular Cell Research, 1863 (9) pp. 2175-2188. Peer-reviewed.
B cell activating factor is central to bleomycin- and IL-17-mediated experimental pulmonary fibrosis.
François A., Gombault A., Villeret B., Alsaleh G., Fanny M., Gasse P., Adam S.M., Crestani B., Sibilia J., Schneider P. et al., 2015. Journal of Autoimmunity, 56 pp. 1-11.
Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic mice.
Woess C., Tuzlak S., Labi V., Drach M., Bertele D., Schneider P., Villunger A., 2015. Cell Death and Differentiation, 22 (9) pp. 1477-1488.
Cutting edge: IL-1α is a crucial danger signal triggering acute myocardial inflammation during myocardial infarction.
Lugrin J., Parapanov R., Rosenblatt-Velin N., Rignault-Clerc S., Feihl F., Waeber B., Müller O., Vergely C., Zeller M., Tardivel A. et al., 2015. Journal of Immunology, 194 (2) pp. 499-503. Peer-reviewed.
Dendritic Cells Cause Bone Lesions in a New Mouse Model of Histiocytosis.
Grosjean F., Nasi S., Schneider P., Chobaz V., Liu A., Mordasini V., Moullec K., Vezzoni P., Lavanchy C., Busso N. et al., 2015. Plos One, 10 (8) pp. e0133917. Peer-reviewed.
Ectodysplasin/NF-κB Promotes Mammary Cell Fate via Wnt/β-catenin Pathway.
Voutilainen M., Lindfors P.H., Trela E., Lönnblad D., Shirokova V., Elo T., Rysti E., Schmidt-Ullrich R., Schneider P., Mikkola M.L., 2015. Plos Genetics, 11 (11) pp. e1005676. Peer-reviewed.
Epithelial NAIPs protect against colonic tumorigenesis.
Allam R., Maillard M.H., Tardivel A., Chennupati V., Bega H., Yu C.W., Velin D., Schneider P., Maslowski K.M., 2015. Journal of Experimental Medicine, 212 (3) pp. 369-383.
Neutralization of (NK-cell-derived) B-cell activating factor by Belimumab restores sensitivity of chronic lymphoid leukemia cells to direct and Rituximab-induced NK lysis.
Wild J., Schmiedel B.J., Maurer A., Raab S., Prokop L., Stevanović S., Dörfel D., Schneider P., Salih H.R., 2015. Leukemia, 29 (8) pp. 1676-1683. Peer-reviewed.
Pharmacological stimulation of edar signaling in the adult enhances sebaceous gland size and function.
Kowalczyk-Quintas C., Schuepbach-Mallepell S., Willen L., Smith T.K., Huttner K., Kirby N., Headon D.J., Schneider P., 2015. Journal of Investigative Dermatology, 135 (2) pp. 359-368.
Stoichiometry of heteromeric BAFF and APRIL cytokines dictates their receptor binding and signaling properties.
Schuepbach-Mallepell S., Das D., Willen L., Vigolo M., Tardivel A., Lebon L., Kowalczyk-Quintas C., Nys J., Smulski C., Zheng T.S. et al., 2015. Journal of Biological Chemistry, 290 (26) pp. 16330-16342. Peer-reviewed.
Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival.
Johnston A.J., Murphy K.T., Jenkinson L., Laine D., Emmrich K., Faou P., Weston R., Jayatilleke K.M., Schloegel J., Talbo G. et al., 2015. Cell, 162 (6) pp. 1365-1378.
A common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency.
Pieper K., Rizzi M., Speletas M., Smulski C.R., Sic H., Kraus H., Salzer U., Fiala G.J., Schamel W.W., Lougaris V. et al., 2014. Journal of Allergy and Clinical Immunology, 133 (4) pp. 1222-1225.e10. Peer-reviewed.
Ectodysplasin A (EDA) - EDA receptor signalling and its pharmacological modulation.
Kowalczyk-Quintas C., Schneider P., 2014. Cytokine and Growth Factor Reviews, 25 (2) pp. 195-203.
Generation and characterization of function-blocking anti-ectodysplasin A (EDA) monoclonal antibodies that induce ectodermal dysplasia.
Kowalczyk-Quintas C., Willen L., Dang A.T., Sarrasin H., Tardivel A., Hermes K., Schneider H., Gaide O., Donzé O., Kirby N. et al., 2014. Journal of Biological Chemistry, 289 (7) pp. 4273-4285. Peer-reviewed.
Prenatal therapy in developmental disorders: drug targeting via intra-amniotic injection to treat X-linked hypohidrotic ectodermal dysplasia
Hermes K., Schneider P., Krieg P., Dang A.T., Huttner K., Schneider H., 2014. Journal of Investigative Dermatology, 134 (12) pp. 2985-2987. Peer-reviewed.
The BAFF/APRIL system in SLE pathogenesis.
Vincent F.B., Morand E.F., Schneider P., Mackay F., 2014. Nature Reviews. Rheumatology, 10 (6) pp. 365-373.
Therapeutic Blockade of LIGHT Interaction With Herpesvirus Entry Mediator and Lymphotoxin β Receptor Attenuates In Vivo Cytotoxic Allogeneic Responses.
Del Rio M.L., Fernandez-Renedo C., Scheu S., Pfeffer K., Shintani Y., Kronenberg M., Chaloin O., Schneider P., Rodriguez-Barbosa J.I., 2014. Transplantation, 98 (11) pp. 1165-1174. Peer-reviewed.
 
Tools and techniques to study ligand-receptor interactions and receptor activation by TNF superfamily members.
Schneider P., Willen L., Smulski C.R., 2014. Methods in Enzymology, 545 pp. 103-125.
Cysteine-rich Domain 1 of CD40 Mediates Receptor Self-assembly.
Smulski C.R., Beyrath J., Decossas M., Chekkat N., Wolff P., Estieu-Gionnet K., Guichard G., Speiser D., Schneider P., Fournel S., 2013. Journal of Biological Chemistry, 288 (15) pp. 10914-10922.
Effects of fructose-containing caloric sweeteners on resting energy expenditure and energy efficiency: a review of human trials.
Tappy L., Egli L., Lecoultre V., Schneider P., 2013. Nutrition and Metabolism, 10 (1) p. 54.
Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.
Smith W., Tomasec P., Aicheler R., Loewendorf A., Nemčovičová I., Wang E.C., Stanton R.J., Macauley M., Norris P., Willen L. et al., 2013. Cell Host and Microbe, 13 (3) pp. 324-335.
 
LIGHT/HVEM/LTβR interaction as a target for the modulation of the allogeneic immune response in transplantation.
del Rio M.L., Schneider P., Fernandez-Renedo C., Perez-Simon J.A., Rodriguez-Barbosa J.I., 2013. American Journal of Transplantation, 13 (3) pp. 541-551.
No Evidence That Soluble TACI Induces Signalling via Membrane-Expressed BAFF and APRIL in Myeloid Cells.
Nys J., Smulski C.R., Tardivel A., Willen L., Kowalczyk C., Donzé O., Huard B., Hess H., Schneider P., 2013. PLoS One, 8 (4) pp. e61350.
 
Progesterone/RANKL is a major regulatory axis in the human breast.
Tanos T., Sflomos G., Echeverria P.C., Ayyanan A., Gutierrez M., Delaloye J.F., Raffoul W., Fiche M., Dougall W., Schneider P. et al., 2013. Science Translational Medicine, 5 (182) pp. 182ra55. Peer-reviewed.
 
RANKL expression, function, and therapeutic targeting in multiple myeloma and chronic lymphocytic leukemia.
Schmiedel B.J., Scheible C.A., Nuebling T., Kopp H.G., Wirths S., Azuma M., Schneider P., Jung G., Grosse-Hovest L., Salih H.R., 2013. Cancer Research, 73 (2) pp. 683-694.
 
Receptor activator for NF-κB ligand in acute myeloid leukemia: expression, function, and modulation of NK cell immunosurveillance.
Schmiedel B.J., Nuebling T., Steinbacher J., Malinovska A., Wende C.M., Azuma M., Schneider P., Grosse-Hovest L., Salih H.R., 2013. Journal of Immunology, 190 (2) pp. 821-831.
Structure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactions.
Pellegrini M., Willen L., Perroud M., Krushinskie D., Strauch K., Cuervo H., Day E.S., Schneider P., Zheng T.S., 2013. FEBS Journal, 280 (8) pp. 1818-1829.
The Oncogene Metadherin Modulates the Apoptotic Pathway Based on the Tumor Necrosis Factor Superfamily Member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in Breast Cancer.
Zhang N., Wang X., Huo Q., Li X., Wang H., Schneider P., Hu G., Yang Q., 2013. Journal of Biological Chemistry, 288 (13) pp. 9396-9407.
Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4.
Kong M., Muñoz N., Valdivia A., Alvarez A., Herrera-Molina R., Cárdenas A., Schneider P., Burridge K., Quest A.F., Leyton L., 2013. Biochimica et Biophysica Acta. Molecular Cell Research, 1833 (6) pp. 1409-1420. Peer-reviewed.
Astrocytic αVβ3 integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by clustering Thy-1.
Herrera-Molina R., Frischknecht R., Maldonado H., Seidenbecher C.I., Gundelfinger E.D., Hetz C., Aylwin Mde L, Schneider P., Quest A.F., Leyton L., 2012. PLoS One, 7 (3) pp. e34295.
Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-κB.
Voutilainen M., Lindfors P.H., Lefebvre S., Ahtiainen L., Fliniaux I., Rysti E., Murtoniemi M., Schneider P., Schmidt-Ullrich R., Mikkola M.L., 2012. Proceedings of the National Academy of Sciences of the United States of America, 109 (15) pp. 5744-5749. Peer-reviewed.
 
Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development.
Lefebvre S., Fliniaux I., Schneider P., Mikkola M.L., 2012. Journal of Investigative Dermatology, 132 (4) pp. 1094-1102.
 
The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade.
Heinz L.X., Rebsamen M., Rossi D.C., Staehli F., Schroder K., Quadroni M., Gross O., Schneider P., Tschopp J., 2012. Cell Death and Differentiation, 19 (4) pp. 722-731.
 
The design and characterization of receptor-selective APRIL variants.
Kimberley F.C., van der Sloot A.M., Guadagnoli M., Cameron K., Schneider P., Marquart J.A., Versloot M., Serrano L., Medema J.P., 2012. Journal of Biological Chemistry, 287 (44) pp. 37434-37446.
 
Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis.
Drexler S.K., Bonsignore L., Masin M., Tardivel A., Jackstadt R., Hermeking H., Schneider P., Gross O., Tschopp J., Yazdi A.S., 2012. Proceedings of the National Academy of Sciences of the United States of America, 109 (45) pp. 18384-18389.
ATP release due to Thy-1-integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation.
Henríquez M., Herrera-Molina R., Valdivia A., Alvarez A., Kong M., Muñoz N., Eisner V., Jaimovich E., Schneider P., Quest A.F. et al., 2011. Journal of Cell Science, 124 (Pt 9) pp. 1581-1588.
 
Development of an Fn14 agonistic antibody as an anti-tumor agent.
Michaelson J.S., Amatucci A., Kelly R., Su L., Garber E., Day E.S., Berquist L., Cho S., Li Y., Parr M. et al., 2011. mAbs, 3 (4) pp. 362-375.
 
Induction of the alternative NF-κB pathway by lymphotoxin αβ (LTαβ) relies on internalization of LTβ receptor.
Ganeff C., Remouchamps C., Boutaffala L., Benezech C., Galopin G., Vandepaer S., Bouillenne F., Ormenese S., Chariot A., Schneider P. et al., 2011. Molecular and Cellular Biology, 31 (21) pp. 4319-4334.
Molecular and therapeutic characterization of anti-ectodysplasin A receptor (EDAR) agonist monoclonal antibodies.
Kowalczyk C., Dunkel N., Willen L., Casal M.L., Mauldin E.A., Gaide O., Tardivel A., Badic G., Etter A.L., Favre M. et al., 2011. Journal of Biological Chemistry, 286 (35) pp. 30769-30779.
 
Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses.
Bossen C., Tardivel A., Willen L., Fletcher C.A., Perroud M., Beermann F., Rolink A.G., Scott M.L., Mackay F., Schneider P., 2011. European Journal of Immunology, 41 (3) pp. 787-797.
 
Programming of marginal zone B-cell fate by basic Kruppel-like factor (BKLF/KLF3).
Turchinovich G., Vu T.T., Frommer F., Kranich J., Schmid S., Alles M., Loubert J.B., Goulet J.P., Zimber-Strobl U., Schneider P. et al., 2011. Blood, 117 (14) pp. 3780-3792.
The C76R transmembrane activator and calcium modulator cyclophilin ligand interactor mutation disrupts antibody production and B-cell homeostasis in heterozygous and homozygous mice.
Bacchelli C., Buckland K.F., Buckridge S., Salzer U., Schneider P., Thrasher A.J., Gaspar H.B., 2011. Journal of Allergy and Clinical Immunology, 127 (5) pp. 1253-9.e13.
Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells.
Boeglin E., Smulski C.R., Brun S., Milosevic S., Schneider P., Fournel S., 2011. PLoS One, 6 (10) pp. e25542.
Type I interferon drives dendritic cell apoptosis via multiple BH3-only proteins following activation by PolyIC in vivo.
Fuertes Marraco S.A., Scott C.L., Bouillet P., Ives A., Masina S., Vremec D., Jansen E.S., O'Reilly L.A., Schneider P., Fasel N. et al., 2011. PLoS One, 6 (6) pp. e20189.
Buffy's, B-cells, and membrane BAFF
Schneider P., Huard B., 2010. Arthritis & Rheumatism, 62 (5) pp. 1557-1558.
Functional analysis of Ectodysplasin-A mutations causing selective tooth agenesis.
Mues G., Tardivel A., Willen L., Kapadia H., Seaman R., Frazier-Bowers S., Schneider P., D'Souza R.N., 2010. European Journal of Human Genetics, 18 (1) pp. 19-25. Peer-reviewed.
Rescue of the mature B cell compartment in BAFF-deficient mice by treatment with recombinant Fc-BAFF.
Swee L.K., Tardivel A., Schneider P., Rolink A., 2010. Immunology Letters, 131 (1) pp. 40-48. Peer-reviewed.
The beautiful structures of BAFF, APRIL and their receptors.
Schneider P., 2010. pp. 1-18 dans Cancro M.P. (eds.) BLyS ligands and receptors. chap. 1, Humana Press.
Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland.
Beleut M., Rajaram R.D., Caikovski M., Ayyanan A., Germano D., Choi Y., Schneider P., Brisken C., 2010. Proceedings of the National Academy of Sciences of the United States of America, 107 (7) pp. 2989-2994. Peer-reviewed.
Biological activity of ectodysplasin A is conditioned by its collagen and heparan sulfate proteoglycan-binding domains.
Swee L.K., Ingold-Salamin K., Tardivel A., Willen L., Gaide O., Favre M., Demotz S., Mikkola M., Schneider P., 2009/10. Journal of Biological Chemistry, 284 (40) pp. 27567-27576. Peer-reviewed.
 
Structure-function analysis of Eiger, the Drosophila TNF homolog.
Narasimamurthy R., Geuking P., Ingold K., Willen L., Schneider P., Basler K., 2009/02. Cell Research, 19 (3) pp. 392-394. Peer-reviewed.
 
Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses.
Bessa J., Jegerlehner A., Hinton H.J., Pumpens P., Saudan P., Schneider P., Bachmann M.F., 2009. Journal of Immunology, 183 (6) pp. 3788-3799. Peer-reviewed.
Cracking the BAFF code.
Mackay F., Schneider P., 2009. Nature reviews. Immunology, 9 (7) pp. 491-502. Peer-reviewed.
Distinct conformations of Ly49 natural killer cell receptors mediate MHC class I recognition in trans and cis.
Back J., Malchiodi E.L., Cho S., Scarpellino L., Schneider P., Kerzic M.C., Mariuzza R.A., Held W., 2009. Immunity, 31 (4) pp. 598-608. Peer-reviewed.
 
Distinct requirements for activation-induced cell surface expression of preformed Fas/CD95 ligand and cytolytic granule markers in T cells.
Kassahn D., Nachbur U., Conus S., Micheau O., Schneider P., Simon H.U., Brunner T., 2009/01. Cell Death and Differentiation, 16 (1) pp. 115-124. Peer-reviewed.
Enforced covalent trimerisation of soluble feline CD134 (OX40)-ligand generates a functional antagonist of feline immunodeficiency virus.
Willett B.J., McMonagle E.L., Logan N., Schneider P., Hosie M.J., 2009. Molecular Immunology, 46 (6) pp. 1020-1030. Peer-reviewed.
Neonatal treatment with recombinant ectodysplasin prevents respiratory disease in dogs with X-linked ectodermal dysplasia.
Mauldin E.A., Gaide O., Schneider P., Casal M.L., 2009. American Journal of Medical Genetics. Part A, 149A (9) pp. 2045-2049. Peer-reviewed.
 
Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alphavbeta3 integrin that activates PKCalpha and RhoA.
Avalos A.M., Valdivia A.D., Muñoz N., Herrera-Molina R., Tapia J.C., Lavandero S., Chiong M., Burridge K., Schneider P., Quest A.F. et al., 2009. Journal of Cell Science, 122 (Pt 19) pp. 3462-3471.
 
Rationally-designed multivalent architectures for mimicking homotrimers of CD40L, a member of the TNF superfamily.
Guichard G., Trouche N., Wieckowski S., Sun W., Chaloin O., Bianco A., Hoebeke J., Schneider P., Fournel S., 2009. pp. 355-357 dans Del Valle S., Escher E., Lubell W.D. (eds.) Peptides for youth chap. 7, Springer.
 
Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes.
Salzer U., Bacchelli C., Buckridge S., Pan-Hammarström Q., Jennings S., Lougaris V., Bergbreiter A., Hagena T., Birmelin J., Plebani A. et al., 2009. Blood, 113 (9) pp. 1967-1976. Peer-reviewed.
 
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes.
Guarda G., Dostert C., Staehli F., Cabalzar K., Castillo R., Tardivel A., Schneider P., Tschopp J., 2009. Nature, 460 (7252) pp. 269-273. Peer-reviewed.
Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naive precursors by CD40-activated B cells.
Tu W., Lau Y.L., Zheng J., Liu Y., Chan P.L., Mao H., Dionis K., Schneider P., Lewis D.B., 2008/09. Blood, 112 (6) pp. 2554-62. Peer-reviewed.
 
Heparan sulfate proteoglycans, Fc receptors, and DC suppression.
Roosnek E., Schneider P., Huard B., 2008/08. Blood, 112 (3) pp. 915-6; author reply 916-7. Peer-reviewed.
Direct Thy-1/alphaVbeta3 integrin interaction mediates neuron to astrocyte communication.
Hermosilla T., Muñoz D., Herrera-Molina R., Valdivia A., Muñoz N., Nham S.U., Schneider P., Burridge K., Quest A.F., Leyton L., 2008/06. Biochimica et Biophysica Acta-Molecular Cell Research, 1783 (6) pp. 1111-1120. Peer-reviewed.
TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease.
Pappu B.P., Borodovsky A., Zheng T.S., Yang X., Wu P., Dong X., Weng S., Browning B., Scott M.L., Ma L. et al., 2008/05. Journal of Experimental Medicine, 205 (5) pp. 1049-1062. Peer-reviewed.
APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells.
Belnoue E., Pihlgren M., McGaha T.L., Tougne C., Rochat A.F., Bossen C., Schneider P., Huard B., Lambert P.H., Siegrist C.A., 2008. Blood, 111 (5) pp. 2755-2764.
APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa.
Huard B., McKee T., Bosshard C., Durual S., Matthes T., Myit S., Donze O., Frossard C., Chizzolini C., Favre C. et al., 2008. Journal of Clinical Investigation, 118 (8) pp. 2887-2895. Peer-reviewed.
Fas ligand-induced proinflammatory transcriptional responses in reconstructed human epidermis. Recruitment of the epidermal growth factor receptor and activation of MAP kinases.
Farley S.M., Purdy D.E., Ryabinina O.P., Schneider P., Magun B.E., Iordanov M.S., 2008. Journal of Biological Chemistry, 283 (2) pp. 919-928.
Intestinal bacteria condition dendritic cells to promote IgA production.
Massacand J.C., Kaiser P., Ernst B., Tardivel A., Bürki K., Schneider P., Harris N.L., 2008. PLoS ONE, 3 (7) pp. e2588. Peer-reviewed.
 
Signaling by TNF and related ligands
Schneider P., 2008. pp. 433-441 dans Epstein C., Erickson R., Wynshaw-Boris A. (eds.) Inborn Errors of Development chap. 41, Oxford University Press.
 
TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties.
Mackay F., Schneider P., 2008. Cytokine and Growth Factor Reviews, 19 (3-4) pp. 263-276.
TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts.
Bossen C., Cachero T.G., Tardivel A., Ingold K., Willen L., Dobles M., Scott M.L., Maquelin A., Belnoue E., Siegrist C.A. et al., 2008. Blood, 111 (3) pp. 1004-1012. Peer-reviewed.
TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.
Vince J.E., Chau D., Callus B., Wong W.W., Hawkins C.J., Schneider P., McKinlay M., Benetatos C.A., Condon S.M., Chunduru S.K. et al., 2008. Journal of Cell Biology, 182 (1) pp. 171-184. Peer-reviewed.
Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression.
Pummila M., Fliniaux I., Jaatinen R., James M.J., Laurikkala J., Schneider P., Thesleff I., Mikkola M.L., 2007. Development, 134 (1) pp. 117-125. Peer-reviewed.
Ectopic expression of the serine protease inhibitor PI9 modulates death receptor-mediated apoptosis.
Kummer J.A., Micheau O., Schneider P., Bovenschen N., Broekhuizen R., Quadir R., Strik M.C., Hack C.E., Tschopp J., 2007. Cell Death and Differentiation, 14 (8) pp. 1486-1496.
 
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.
Vince J.E., Wong W.W., Khan N., Feltham R., Chau D., Ahmed A.U., Benetatos C.A., Chunduru S.K., Condon S.M., McKinlay M. et al., 2007. Cell, 131 (4) pp. 682-693.
Neutrophil-derived APRIL concentrated in tumor lesions by proteoglycans correlates with human B-cell lymphoma aggressiveness.
Schwaller J., Schneider P., Mhawech-Fauceglia P., McKee T., Myit S., Matthes T., Tschopp J., Donze O., Le Gal F.A., Huard B., 2007. Blood, 109 (1) pp. 331-338. Peer-reviewed.
Probing the interaction between feline immunodeficiency virus and CD134 by using the novel monoclonal antibody 7D6 and the CD134 (Ox40) ligand.
Willett B.J., McMonagle E.L., Logan N., Spiller O.B., Schneider P., Hosie M.J., 2007. Journal of Virology, 81 (18) pp. 9665-9679.
Significant correction of disease after postnatal administration of recombinant ectodysplasin A in canine X-linked ectodermal dysplasia.
Casal M.L., Lewis J.R., Mauldin E.A., Tardivel A., Ingold K., Favre M., Paradies F., Demotz S., Gaide O., Schneider P., 2007. American Journal of Human Genetics, 81 (5) pp. 1050-1056.
Unique and conserved functions of B cell-activating factor of the TNF family (BAFF) in the chicken.
Kothlow S., Morgenroth I., Graef Y., Schneider K., Riehl I., Staeheli P., Schneider P., Kaspers B., 2007. International Immunology, 19 (2) pp. 203-215.
BAFF, APRIL and their receptors: structure, function and signaling.
Bossen C., Schneider P., 2006. Seminars in Immunology, 18 (5) pp. 263-275.
Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2.
Mérino D., Lalaoui N., Morizot A., Schneider P., Solary E., Micheau O., 2006. Molecular and Cellular Biology, 26 (19) pp. 7046-7055. Peer-reviewed.
Fas ligand elicits a caspase-independent proinflammatory response in human keratinocytes: implications for dermatitis.
Farley S.M., Dotson A.D., Purdy D.E., Sundholm A.J., Schneider P., Magun B.E., Iordanov M.S., 2006. Journal of Investigative Dermatology, 126 (11) pp. 2438-2451. Peer-reviewed.
Formation of virus-like clusters is an intrinsic property of the tumor necrosis factor family member BAFF (B cell activating factor).
Cachero T.G., Schwartz I.M., Qian F., Day E.S., Bossen C., Ingold K., Tardivel A., Krushinskie D., Eldredge J., Silvian L. et al., 2006. Biochemistry, 45 (7) pp. 2006-2013.
Generation of the primary hair follicle pattern.
Mou C., Jackson B., Schneider P., Overbeek P.A., Headon D.J., 2006. Proceedings of the National Academy of Sciences of the United States of America, 103 (24) pp. 9075-9080. Peer-reviewed.
Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human.
Bossen C., Ingold K., Tardivel A., Bodmer J.L., Gaide O., Hertig S., Ambrose C., Tschopp J., Schneider P., 2006. Journal of Biological Chemistry, 281 (20) pp. 13964-13971.
NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth.
Schmidt-Ullrich R., Tobin D.J., Lenhard D., Schneider P., Paus R., Scheidereit C., 2006. Development, 133 (6) pp. 1045-1057.
TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality.
Corazza N., Jakob S., Schaer C., Frese S., Keogh A., Stroka D., Kassahn D., Torgler R., Mueller C., Schneider P. et al., 2006. Journal of Clinical Investigation, 116 (9) pp. 2493-2499. Peer-reviewed.
TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration.
Girgenrath M., Weng S., Kostek C.A., Browning B., Wang M., Brown S.A., Winkles J.A., Michaelson J.S., Allaire N., Schneider P. et al., 2006. EMBO Journal, 25 (24) pp. 5826-5839.
C3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L.
Fournel S., Wieckowski S., Sun W., Trouche N., Dumortier H., Bianco A., Chaloin O., Habib M., Peter J.C., Schneider P. et al., 2005. Nature Chemical Biology, 1 (7) pp. 377-382.
Cell death-induced activation of epidermal growth factor receptor in keratinocytes: implications for restricting epidermal damage in dermatitis.
Iordanov M.S., Sundholm A.J., Simpson E.L., Hanifin J.M., Ryabinina O.P., Choi R.J., Korcheva V.B., Schneider P., Magun B.E., 2005. Journal of Investigative Dermatology, 125 (1) pp. 134-142.
Differential insertion of GPI-anchored GFPs into lipid rafts of live cells.
Legler D.F., Doucey M.A., Schneider P., Chapatte L., Bender F.C., Bron C., 2005. FASEB Journal, 19 (1) pp. 73-75.
Identification of proteoglycans as the APRIL-specific binding partners.
Ingold K., Zumsteg A., Tardivel A., Huard B., Steiner Q.G., Cachero T.G., Qiang F., Gorelik L., Kalled S.L., Acha-Orbea H. et al., 2005. Journal of Experimental Medicine, 201 (9) pp. 1375-1383.
 
Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans.
Salzer U., Chapel H.M., Webster A.D., Pan-Hammarström Q., Schmitt-Graeff A., Schlesier M., Peter H.H., Rockstroh J.K., Schneider P., Schäffer A.A. et al., 2005. Nature Genetics, 37 (8) pp. 820-828.
Soluble MHC-peptide complexes induce rapid death of CD8+ CTL.
Cebecauer M., Guillaume P., Hozák P., Mark S., Everett H., Schneider P., Luescher I.F., 2005. Journal of immunology, 174 (11) pp. 6809-6819. Peer-reviewed.
The human cytomegalovirus-encoded chemokine receptor US28 induces caspase-dependent apoptosis.
Pleskoff O., Casarosa P., Verneuil L., Ainoun F., Beisser P., Smit M., Leurs R., Schneider P., Michelson S., Ameisen J.C., 2005. FEBS Journal, 272 (16) pp. 4163-4177.
The role of APRIL and BAFF in lymphocyte activation.
Schneider P., 2005. Current Opinion in Immunology, 17 (3) pp. 282-289.
Transduction of CpG DNA-stimulated primary human B cells with bicistronic lentivectors.
Kvell K., Nguyen T.H., Salmon P., Glauser F., Werner-Favre C., Barnet M., Schneider P., Trono D., Zubler R.H., 2005. Molecular Therapy, 12 (5) pp. 892-899.
Two mechanisms of caspase 9 processing in double-stranded RNA- and virus-triggered apoptosis.
Iordanov M.S., Ryabinina O.P., Schneider P., Magun B.E., 2005. Apoptosis, 10 (1) pp. 153-166.
 
Aggregation of integrins and RhoA activation are required for Thy-1-induced morphological changes in astrocytes.
Avalos A.M., Arthur W.T., Schneider P., Quest A.F., Burridge K., Leyton L., 2004. Journal of Biological Chemistry, 279 (37) pp. 39139-39145.
BAFF production by antigen-presenting cells provides T cell co-stimulation.
Huard B., Arlettaz L., Ambrose C., Kindler V., Mauri D., Roosnek E., Tschopp J., Schneider P., French L.E., 2004. International Immunology, 16 (3) pp. 467-475.
Chicken BAFF--a highly conserved cytokine that mediates B cell survival.
Schneider K., Kothlow S., Schneider P., Tardivel A., Göbel T., Kaspers B., Staeheli P., 2004. International Immunology, 16 (1) pp. 139-148.
Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages.
Mustonen T., Ilmonen M., Pummila M., Kangas A.T., Laurikkala J., Jaatinen R., Pispa J., Gaide O., Schneider P., Thesleff I. et al., 2004. Development, 131 (20) pp. 4907-4919.
The anti-apoptotic factor Bcl-2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF.
Tardivel A., Tinel A., Lens S., Steiner Q.G., Sauberli E., Wilson A., Mackay F., Rolink A.G., Beermann F., Tschopp J. et al., 2004. European Journal of Immunology, 34 (2) pp. 509-518.
 
TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma.
Batten M., Fletcher C., Ng L.G., Groom J., Wheway J., Laâbi Y., Xin X., Schneider P., Tschopp J., Mackay C.R. et al., 2004. Journal of Immunology, 172 (2) pp. 812-822.
A secreted high-affinity inhibitor of human TNF from Tanapox virus.
Brunetti C.R., Paulose-Murphy M., Singh R., Qin J., Barrett J.W., Tardivel A., Schneider P., Essani K., McFadden G., 2003. Proceedings of the National Academy of Sciences of the United States of America, 100 (8) pp. 4831-4836.
 
BAFF AND APRIL: a tutorial on B cell survival.
Mackay F., Schneider P., Rennert P., Browning J., 2003. Annual Review of Immunology, 21 pp. 231-264.
 
BAFF and the regulation of B cell survival.
Schneider P., Tschopp J., 2003. Immunology Letters, 88 (1) pp. 57-62.
Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Schneider P., Olson D., Tardivel A., Browning B., Lugovskoy A., Gong D., Dobles M., Hertig S., Hofmann K., Van Vlijmen H. et al., 2003. Journal of Biological Chemistry, 278 (7) pp. 5444-5454.
Permanent correction of an inherited ectodermal dysplasia with recombinant EDA.
Gaide O., Schneider P., 2003. Nature Medicine, 9 (5) pp. 614-618.
 
Theileria parva-transformed T cells show enhanced resistance to Fas/Fas ligand-induced apoptosis.
Küenzi P., Schneider P., Dobbelaere D.A., 2003. Journal of Immunology, 171 (3) pp. 1224-1231.
Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex.
Holler N., Tardivel A., Kovacsovics-Bankowski M., Hertig S., Gaide O., Martinon F., Tinel A., Deperthes D., Calderara S., Schulthess T. et al., 2003. Molecular and Cellular Biology, 23 (4) pp. 1428-1440.
 
A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors.
Lowin-Kropf B., Kunz B., Schneider P., Held W., 2002. European Journal of Immunology, 32 (3) pp. 773-782. Peer-reviewed.
 
Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome.
Groom J., Kalled S.L., Cutler A.H., Olson C., Woodcock S.A., Schneider P., Tschopp J., Cachero T.G., Batten M., Wheway J. et al., 2002. Journal of Clinical Investigation, 109 (1) pp. 59-68.
 
BAFF is a survival and maturation factor for mouse B cells.
Rolink A.G., Tschopp J., Schneider P., Melchers F., 2002. European Journal of Immunology, 32 (7) pp. 2004-2010.
 
Distribution of the human intracellular serpin protease inhibitor 8 in human tissues.
Strik M.C., Bladergroen B.A., Wouters D., Kisiel W., Hooijberg J.H., Verlaan A.R., Hordijk P.L., Schneider P., Hack C.E., Kummer J.A., 2002. Journal of Histochemistry and Cytochemistry, 50 (11) pp. 1443-1454.
Productive HIV-1 infection of primary CD4+ T cells induces mitochondrial membrane permeabilization leading to a caspase-independent cell death.
Petit F., Arnoult D., Lelièvre J.D., Moutouh-de Parseval L., Hance A.J., Schneider P., Corbeil J., Ameisen J.C., Estaquier J., 2002. Journal of Biological Chemistry, 277 (2) pp. 1477-1487.
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex.
Micheau O., Thome M., Schneider P., Holler N., Tschopp J., Nicholson D.W., Briand C., Grütter M.G., 2002. Journal of Biological Chemistry, 277 (47) pp. 45162-45171.
The molecular architecture of the TNF superfamily.
Bodmer J.L., Schneider P., Tschopp J., 2002. Trends in Biochemical Sciences, 27 (1) pp. 19-26.
 
BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF.
Thompson J.S., Bixler S.A., Qian F., Vora K., Scott M.L., Cachero T.G., Hession C., Schneider P., Sizing I.D., Mullen C. et al., 2001. Science, 293 (5537) pp. 2108-2111.
Discordant increases in CD4+ T cells in human immunodeficiency virus-infected patients experiencing virologic treatment failure: role of changes in thymic output and T cell death.
Lecossier D., Bouchonnet F., Schneider P., Clavel F., Hance A.J., Centre de Recherche Integré sur le VIH Bichat-Claude Bernard, 2001. Journal of Infectious Diseases, 183 (7) pp. 1009-1016.
 
IgG subclass switch capacity is low in switched and in IgM-only, but high in IgD+IgM+, post-germinal center (CD27+) human B cells.
Werner-Favre C., Bovia F., Schneider P., Holler N., Barnet M., Kindler V., Tschopp J., Zubler R.H., 2001. European Journal of Immunology, 31 (1) pp. 243-249.
Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen.
Schneider P., Takatsuka H., Wilson A., Mackay F., Tardivel A., Lens S., Cachero T.G., Finke D., Beermann F., Tschopp J., 2001. Journal of Experimental Medicine, 194 (11) pp. 1691-1697.
Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A.
Schneider P., Street S.L., Gaide O., Hertig S., Tardivel A., Tschopp J., Runkel L., Alevizopoulos K., Ferguson B.M., Zonana J., 2001. Journal of Biological Chemistry, 276 (22) pp. 18819-18827.
 
Selection of peptides and synthesis of pentameric peptabody molecules reacting specifically with ErbB-2 receptor.
Houimel M., Schneider P., Terskikh A., Mach J.P., 2001. International Journal of Cancer, 92 (5) pp. 748-755.
 
T cell costimulation by the TNF ligand BAFF.
Huard B., Schneider P., Mauri D., Tschopp J., French L.E., 2001. Journal of Immunology, 167 (11) pp. 6225-6231.
 
Thy-1 binds to integrin beta(3) on astrocytes and triggers formation of focal contact sites.
Leyton L., Schneider P., Labra C.V., Rüegg C., Hetz C.A., Quest A.F., Bron C., 2001. Current Biology, 11 (13) pp. 1028-1038.
A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth.
Rennert P., Schneider P., Cachero T.G., Thompson J., Trabach L., Hertig S., Holler N., Qian F., Mullen C., Strauch K. et al., 2000. Journal of Experimental Medicine, 192 (11) pp. 1677-1684.
 
Apoptosis induced by death receptors.
Schneider P., Tschopp J., 2000. Pharmaceutica Acta Helvetiae, 74 (2-3) pp. 281-286.
BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population.
Thompson J.S., Schneider P., Kalled S.L., Wang L., Lefevre E.A., Cachero T.G., MacKay F., Bixler S.A., Zafari M., Liu Z.Y. et al., 2000. Journal of Experimental Medicine, 192 (1) pp. 129-135.
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