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Sanjiv Luther

Coordonnées Enseignements Publications  
Publications | Mémoires et thèses

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Sous presse

Nayar S., Campos J., Chung M.M., Navarro-Núñez L., Chachlani M., Steinthal N., Gardner D.H., Rankin P., Cloake T., Caamaño J.H. et al., Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2 in Newly Formed Tertiary Lymphoid Structures. Journal of Immunology (baltimore, Md. : 1950), In Press. [DOI] [Pubmed] ok

Roufaiel M., Gracey E., Siu A., Zhu S.N., Lau A., Ibrahim H., Althagafi M., Tai K., Hyduk S.J., Cybulsky K.O. et al., CCL19-CCR7-dependent reverse transendothelial migration of myeloid cells clears Chlamydia muridarum from the arterial intima. Nature Immunology, In Press. [DOI] [Pubmed] ok



Becklund B.R., Purton J.F., Ramsey C., Favre S., Vogt T.K., Martin C.E., Spasova D.S., Sarkisyan G., LeRoy E., Tan J.T. et al., The aged lymphoid tissue environment fails to support naïve T cell homeostasis. Scientific Reports 6, p. 30842, 2016. [DOI] [Web of Science] [Pubmed]

Chennupati V., Koch U., Coutaz M., Scarpellino L., Tacchini-Cottier F., Luther S.A., Radtke F., Zehn D., MacDonald H.R., Notch Signaling Regulates the Homeostasis of Tissue-Restricted Innate-like T Cells. Journal of Immunology 197(3), pp. 771-782, 2016. [DOI] [Web of Science] [Pubmed]

Dubey L.K., Lebon L., Mosconi I., Yang C.Y., Scandella E., Ludewig B., Luther S.A., Harris N.L., Lymphotoxin-Dependent B Cell-FRC Crosstalk Promotes De Novo Follicle Formation and Antibody Production following Intestinal Helminth Infection. Cell Reports 15(7), pp. 1527-1541, 2016. [DOI] [Web of Science] [Pubmed] ok

Korniotis S., Gras C., Letscher H., Montandon R., Mégret J., Siegert S., Ezine S., Fallon P.G., Luther S.A., Fillatreau S. et al., Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells. Nature Communications 7, p. 12134, 2016. [Document] [DOI] [Web of Science] [Pubmed]

Leignadier J., Favre S., Luther S.A., Luescher I.F., CD8 engineered cytotoxic T cells reprogram melanoma tumor environment. Oncoimmunology 5(3), p. e1086861, 2016. [DOI] [Web of Science] [Pubmed]


Barone F., Nayar S., Campos J., Cloake T., Withers D.R., Toellner K.M., Zhang Y., Fouser L., Fisher B., Bowman S. et al., IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs. Proceedings of the National Academy of Sciences of the United States of America 112(35), pp. 11024-11029, 2015. [DOI] [Web of Science] [Pubmed] ok

Bernier-Latmani J., Cisarovsky C., Demir C.S., Bruand M., Jaquet M., Davanture S., Ragusa S., Siegert S., Dormond O., Benedito R. et al., DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport. Journal of Clinical Investigation 2015, pp. 4572-4586, 2015. [DOI] [Web of Science] [Pubmed] ok


Fasnacht N., Huang H.Y., Koch U., Favre S., Auderset F., Chai Q., Onder L., Kallert S., Pinschewer D.D., MacDonald H.R. et al., Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses. Journal of Experimental Medicine 211(11), pp. 2265-2279, 2014. [Document] [DOI] [Web of Science] [Pubmed]

Jaworski M., Marsland B.J., Gehrig J., Held W., Favre S., Luther S.A., Perroud M., Golshayan D., Gaide O., Thome M., Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity. EMBO Journal 33(23), pp. 2765-2781, 2014. [DOI] [Web of Science] [Pubmed]

Vanoaica L., Richman L., Jaworski M., Darshan D., Luther S.A., Kühn L.C., Conditional deletion of ferritin h in mice reduces B and T lymphocyte populations. PLoS One 9(2), p. e89270, 2014. [Document] [DOI] [Web of Science] [Pubmed]

Yang C.Y., Vogt T.K., Favre S., Scarpellino L., Huang H.Y., Tacchini-Cottier F., Luther S.A., Trapping of naive lymphocytes triggers rapid growth and remodeling of the fibroblast network in reactive murine lymph nodes. Proceedings of the National Academy of Sciences of the United States of America 111(1), pp. E109-E118, 2014. [DOI] [Web of Science] [Pubmed]


Auderset F., Schuster S., Fasnacht N., Coutaz M., Charmoy M., Koch U., Favre S., Wilson A., Trottein F., Alexander J. et al., Notch signaling regulates follicular helper T cell differentiation. Journal of Immunology 191(5), pp. 2344-2350, 2013. [DOI] [Web of Science] [Pubmed]

Chai Q., Onder L., Scandella E., Gil-Cruz C., Perez-Shibayama C., Cupovic J., Danuser R., Sparwasser T., Luther S.A., Thiel V. et al., Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity. Immunity 38(5), pp. 1013-1024, 2013. [DOI] [Web of Science] [Pubmed]

Ferrero I., Koch U., Claudinot S., Favre S., Radtke F., Luther S.A., MacDonald H.R., DL4-mediated Notch signaling is required for the development of fetal αβ and γδ T cells. European Journal of Immunology 43(11), pp. 2845-2853, 2013. [DOI] [Web of Science] [Pubmed]

Fiorini E., Ferrero I., Poisson C., Scarpellino L., Luther S.A., Macdonald H.R., Inducible gene expression in fetal thymic epithelium: A new BAC transgenic model. Genesis 51(10), pp. 717-724, 2013. [DOI] [Web of Science] [Pubmed]

Kania G., Siegert S., Behnke S., Prados-Rosales R., Casadevall A., Lüscher T.F., Luther S.A., Kopf M., Eriksson U., Blyszczuk P., Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis. Circulation 127(23), pp. 2285-2294, 2013. [DOI] [Web of Science] [Pubmed]

Weber M., Hauschild R., Schwarz J., Moussion C., de Vries I., Legler D.F., Luther S.A., Bollenbach T., Sixt M., Interstitial dendritic cell guidance by haptotactic chemokine gradients. Science 339(6117), pp. 328-332, 2013. [DOI] [Web of Science] [Pubmed]


Huang H.Y., Luther S.A., Expression and function of interleukin-7 in secondary and tertiary lymphoid organs. Seminars in Immunology 24(3), pp. 175-189, 2012. [DOI] [Web of Science] [Pubmed]

Siegert S., Luther S.A., Positive and negative regulation of T cell responses by fibroblastic reticular cells within paracortical regions of lymph nodes. Frontiers in Immunology 3(285), p. 285, 2012. [Document] [DOI] [Web of Science] [Pubmed] ok


Link A., Hardie D.L., Favre S., Britschgi M.R., Adams D.H., Sixt M., Cyster J.G., Buckley C.D., Luther S.A., Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans. American Journal of Pathology 178(4), pp. 1662-1675, 2011. [Document] [DOI] [Web of Science] [Pubmed]

Luther S.A., Vogt T.K., Siegert S., Guiding blind T cells and dendritic cells: A closer look at fibroblastic reticular cells found within lymph node T zones. Immunology Letters 138(1), pp. 9-11, 2011. [DOI] [Web of Science] [Pubmed]

Matter M.S., Hilmenyuk T., Claus C., Marone R., Schürch C., Tinguely M., Terracciano L., Luther S.A., Ochsenbein A.F., Destruction of lymphoid organ architecture and hepatitis caused by CD4 T cells. PLoS One 6(9), p. e24772, 2011. [Document] [DOI] [Web of Science] [Pubmed]

Siegert S., Huang H.Y., Yang C.Y., Scarpellino L., Carrie L., Essex S., Nelson P.J., Heikenwalder M., Acha-Orbea H., Buckley C.D. et al., Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide. PLoS One 6(11), p. e27618, 2011. [Document] [DOI] [Web of Science] [Pubmed]


Britschgi M.R., Favre S., Luther S.A., CCL21 is sufficient to mediate DC migration, maturation and function in the absence of CCL19. European Journal of Immunology 40(5), pp. 1266-1271, 2010. [DOI] [Web of Science] [Pubmed] ok

Johannsen A., Genolet R., Legler D.F., Luther S.A., Luescher I.F., Definition of key variables for the induction of optimal NY-ESO-1-specific T cells in HLA transgene mice. Journal of Immunology 185(6), pp. 3445-3455, 2010. [DOI] [Web of Science] [Pubmed] ok

Luther S.A., Plasma cell precursors: long-distance travelers looking for a home. Immunity 33(1), pp. 9-11, 2010. [DOI] [Web of Science] [Pubmed] ok


Fiorini E., Merck E., Wilson A., Ferrero I., Jiang W., Koch U., Auderset F., Laurenti E., Tacchini-Cottier F., Pierres M. et al., Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. Journal of immunology 183(11), pp. 7212-7222, 2009. [DOI] [Web of Science] [Pubmed] ok

Tomei A.A., Siegert S., Britschgi M.R., Luther S.A., Swartz M.A., Fluid flow regulates stromal cell organization and CCL21 expression in a tissue-engineered lymph node microenvironment. Journal of Immunology 183(7), pp. 4273-4283, 2009. [DOI] [Web of Science] [Pubmed]

Vogt T.K., Link A., Perrin J., Finke D., Luther S.A., Novel function for interleukin-7 in dendritic cell development. Blood 113(17), pp. 3961-3968, 2009. [DOI] [Web of Science] [Pubmed] ok


Britschgi M.R., Link A., Lissandrin T.K., Luther S.A., Dynamic modulation of CCR7 expression and function on naive T lymphocytes in vivo. Journal of Immunology 181(11), pp. 7681-7688, 2008. [Web of Science] [Pubmed]

Fiorini E., Ferrero I., Merck E., Favre S., Pierres M., Luther S.A., MacDonald H.R., Cutting edge: thymic crosstalk regulates delta-like 4 expression on cortical epithelial cells. Journal of Immunology 181(12), pp. 8199-8203, 2008. [Web of Science] [Pubmed]

Scandella E., Bolinger B., Lattmann E., Miller S., Favre S., Littman D.R., Finke D., Luther S.A., Junt T., Ludewig B., Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone. Nature immunology 9(6), pp. 667-675, 2008. [DOI] [Web of Science] [Pubmed]


Link A., Vogt T.K., Favre S., Britschgi M.R., Acha-Orbea H., Hinz B., Cyster J.G., Luther S.A., Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nature Immunology 8(11), pp. 1255-1265, 2007. [DOI] [Web of Science] [Pubmed]

Luther S.A., Serre K., Cunningham A.F., Khan M., Acha-Orbea H., MacLennan I.C., Toellner K.M., Recirculating CD4 memory T cells mount rapid secondary responses without major contributions from follicular CD4 effectors and B cells. European Journal of Immunology 37(6), pp. 1476-1484, 2007. [DOI] [Web of Science] [Pubmed]


Lang K. S., Recher M., Junt T., Navarini A. A., Harris N. L., Freigang S., Odermatt B., Conrad C., Ittner L. M., Bauer S. et al., Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nature Medicine 11(2), pp. 138-45, 02-2005. [DOI] [Web of Science] [Pubmed]


Bistrup A., Tsay D., Shenoy P., Singer M. S., Bangia N., Luther S. A., Cyster J. G., Ruddle N. H., Rosen S. D., Detection of a sulfotransferase (HEC-GlcNAc6ST) in high endothelial venules of lymph nodes and in high endothelial venule-like vessels within ectopic lymphoid aggregates: relationship to the MECA-79 epitope. American Journal of Pathology 164(5), pp. 1635-1644, 05-2004. [Web of Science] [Pubmed]


Finke D., Luther S.A., Acha-Orbea H., The role of neutralizing antibodies for mouse mammary tumor virus transmission and mammary cancer development. Proceedings of the National Academy of Sciences of the United States of America 100(1), pp. 199-204, 2003. [DOI] [Web of Science] [Pubmed]

Luther S. A., Ansel K. M., Cyster J. G., Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development. Journal of Experimental Medicine 197(9), pp. 1191-8, 05-2003. [DOI] [Web of Science] [Pubmed]


Luther S. A., Bidgol A., Hargreaves D. C., Schmidt A., Xu Y., Paniyadi J., Matloubian M., Cyster J. G., Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. Journal of Immunology 169(1), pp. 424-33, 07-2002. [Web of Science] [Pubmed]

Vacheron S., Luther S.A., Acha-Orbea H., Preferential infection of immature dendritic cells and B cells by mouse mammary tumor virus. Journal of Immunology 168(7), pp. 3470-3476, 2002. [Web of Science] [Pubmed]


Luther S. A., Cyster J. G., Chemokines as regulators of T cell differentiation. Nature Immunology 2(2), pp. 102-7, 02-2001. [DOI] [Web of Science] [Pubmed]


Ansel K. M., Ngo V. N., Hyman P. L., Luther S. A., Forster R., Sedgwick J. D., Browning J. L., Lipp M., Cyster J. G., A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 406(6793), pp. 309-14, 07-2000. [DOI] [Web of Science] [Pubmed]

Cyster J. G., Ansel K. M., Reif K., Ekland E. H., Hyman P. L., Tang H. L., Luther S. A., Ngo V. N., Follicular stromal cells and lymphocyte homing to follicles. Immunological Reviews 176, pp. 181-93, 08-2000. [Web of Science] [Pubmed]

Luther S. A., Lopez T., Bai W., Hanahan D., Cyster J. G., BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis. Immunity 12(5), pp. 471-81, 05-2000. [DOI] [Web of Science] [Pubmed]

Luther S. A., Tang H. L., Hyman P. L., Farr A. G., Cyster J. G., Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Proceedings of the National Academy of Sciences of the United States of America 97(23), pp. 12694-9, 11-2000. [DOI] [Web of Science] [Pubmed]


Acha-Orbea H., Finke D., Attinger A., Schmid S., Wehrli N., Vacheron S., Xenarios I., Scarpellino L., Toellner K.M., MacLennan I.C. et al., Interplays between mouse mammary tumor virus and the cellular and humoral immune response. Immunological Reviews 168, pp. 287-303, 1999. [DOI] [Web of Science] [Pubmed]

Ardavín C., Martín P., Ferrero I., Azcoitia I., Anjuère F., Diggelmann H., Luthi F., Luther S., Acha-Orbea H., B cell response after MMTV infection: extrafollicular plasmablasts represent the main infected population and can transmit viral infection. Journal of Immunology 162(5), pp. 2538-2545, 1999. [Web of Science] [Pubmed]


Toellner K.M., Luther S.A., Sze D.M., Choy R.K., Taylor D.R., MacLennan I.C., Acha-Orbea H., T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching. Journal of Experimental Medicine 187(8), pp. 1193-1204, 1998. [DOI] [Web of Science] [Pubmed]


Luther S.A., Acha-Orbea H., Mouse mammary tumor virus: immunological interplays between virus and host. Advances in Immunology 65, pp. 139-243, 1997. [DOI] [Web of Science] [Pubmed]

Luther S.A., Gulbranson-Judge A., Acha-Orbea H., MacLennan I.C., B cell response and histology of a retroviral infection in vivo. Annals of the New York Academy of Sciences 815, pp. 465-466, 1997. [DOI] [Web of Science] [Pubmed]

Luther S.A., Gulbranson-Judge A., Acha-Orbea H., MacLennan I.C., Viral superantigen drives extrafollicular and follicular B cell differentiation leading to virus-specific antibody production. Journal of Experimental Medicine 185(3), pp. 551-562, 1997. [DOI] [Web of Science] [Pubmed]

Luther S.A., Maillard I., Luthi F., Scarpellino L., Diggelmann H., Acha-Orbea H., Early neutralizing antibody response against mouse mammary tumor virus: critical role of viral infection and superantigen-reactive T cells. Journal of Immunology 159(6), pp. 2807-2814, 1997. [Web of Science] [Pubmed]

MacLennan I.C., Gulbranson-Judge A., Toellner K.M., Casamayor-Palleja M., Chan E., Sze D.M., Luther S.A., Orbea H.A., The changing preference of T and B cells for partners as T-dependent antibody responses develop. Immunological reviews 156, pp. 53-66, 1997. [DOI] [Web of Science] [Pubmed] ok


Luther S.A., Acha-Orbea H., Immune response to mouse mammary tumour virus. Current Opinion in Immunology 8(4), pp. 498-502, 1996. [DOI] [Web of Science] [Pubmed]


Luther S., Shakhov A.N., Xenarios I., Haga S., Imai S., Acha-Orbea H., New infectious mammary tumor virus superantigen with V beta-specificity identical to staphylococcal enterotoxin B (SEB). European Journal of Immunology 24(8), pp. 1757-1764, 1994. [DOI] [Web of Science] [Pubmed]

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