Département de pharmacologie et toxicologie

Equipe principale | Groupe Bonny | Groupe Broillet | Groupe Cotecchia | Groupe Diviani | Groupe Firsov | Groupe Hummler | Groupe Katanaev | Groupe Kellenberger | Groupe Ocampo | Groupe Rossier | Groupe Schild | Groupe Staub
Publications | Mémoires et thèses

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41 publications

2018 | 2017 | 2015 | 2014 | 2013 | 2012 | 2010 | 2009 | 2008 | 2007 | 2005 | 2004 | 2003 | 2002 | 2001 | 1999 | 1998 | 1997 | 1996 |
 
Circadian rhythms and the kidney.
Firsov D., Bonny O., 2018/10. Nature reviews. Nephrology, 14 (10) pp. 626-635. Peer-reviewed.
 
Redox-Dependent Bone Alkaline Phosphatase Dysfunction Drives Part of the Complex Bone Phenotype in Mice Deficient for <i>Memo1</i>.
Moor M.B., Ramakrishnan S.K., Legrand F., Dolder S., Siegrist M., Durussel F., Centeno G., Firsov D., Hynes N.E., Hofstetter W. et al., 2018/07. JBMR plus, 2 (4) pp. 195-205. Peer-reviewed.
Renal Fanconi Syndrome and Hypophosphatemic Rickets in the Absence of Xenotropic and Polytropic Retroviral Receptor in the Nephron.
Ansermet C., Moor M.B., Centeno G., Auberson M., Hu D.Z., Baron R., Nikolaeva S., Haenzi B., Katanaeva N., Gautschi I. et al., 2017/04. Journal of the American Society of Nephrology : JASN, 28 (4) pp. 1073-1078. Peer-reviewed.
Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression.
Piazzon N., Bernet F., Guihard L., Leonhard W.N., Urfer S., Firsov D., Chehade H., Vogt B., Piergiovanni S., Peters D.J. et al., 2015/03. Journal of Translational Medicine, 13 p. 103. Peer-reviewed.
 
No development of hypertension in the hyperuricemic liver-Glut9 knockout mouse.
Preitner F., Pimentel A., Metref S., Berthonneche C., Sarre A., Moret C., Rotman S., Centeno G., Firsov D., Thorens B., 2015. Kidney International, 87 (5) pp. 940-947.
Circadian glomerular function: from physiology to molecular and therapeutical aspects.
Wuerzner G., Firsov D., Bonny O., 2014/08. Nephrology, Dialysis, Transplantation, 29 (8) pp. 1475-1480. Peer-reviewed.
BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis.
Béguin P., Nagashima K., Mahalakshmi R.N., Vigot R., Matsunaga A., Miki T., Ng M.Y., Ng Y.J., Lim C.H., Tay H.S. et al., 2014. Journal of Cell Biology, 205 (2) pp. 233-249. Peer-reviewed.
Local Renal Circadian Clocks Control Fluid-Electrolyte Homeostasis and BP.
Tokonami N., Mordasini D., Pradervand S., Centeno G., Jouffe C., Maillard M., Bonny O., Gachon F., Gomez R.A., Sequeira-Lopez M.L. et al., 2014. Journal of the American Society of Nephrology, 25 (7) pp. 1430-1439.
Circadian regulation of renal function and potential role in hypertension.
Bonny O., Firsov D., 2013. Current Opinion In Nephrology and Hypertension, 22 (4) pp. 439-444.
Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.
O'Seaghdha C.M., Wu H., Yang Q., Kapur K., Guessous I., Zuber A.M., Köttgen A., Stoudmann C., Teumer A., Kutalik Z. et al., 2013. Plos Genetics, 9 (9) pp. e1003796.
α-Ketoglutarate regulates acid-base balance through an intrarenal paracrine mechanism.
Tokonami N., Morla L., Centeno G., Mordasini D., Ramakrishnan S.K., Nikolaeva S., Wagner C.A., Bonny O., Houillier P., Doucet A. et al., 2013. Journal of Clinical Investigation, 123 (7) pp. 3166-3171. Peer-reviewed.
 
Circadian expression of H,K-ATPase type 2 contributes to the stability of plasma K⁺ levels.
Salhi A., Centeno G., Firsov D., Crambert G., 2012. FASEB Journal, 26 (7) pp. 2859-2867.
Role of the renal circadian timing system in maintaining water and electrolytes homeostasis.
Firsov D., Tokonami N., Bonny O., 2012. Molecular and Cellular Endocrinology, 349 (1) pp. 51-55.
The circadian clock modulates renal sodium handling.
Nikolaeva S., Pradervand S., Centeno G., Zavadova V., Tokonami N., Maillard M., Bonny O., Firsov D., 2012. Journal of the American Society of Nephrology, 23 (6) pp. 1019-1026. Peer-reviewed.
A comprehensive analysis of gene expression profiles in distal parts of the mouse renal tubule.
Pradervand S., Zuber Mercier A., Centeno G., Bonny O., Firsov D., 2010. Pflügers Archiv, 460 (6) pp. 925-952.
Circadian regulation of renal function.
Firsov D., Bonny O., 2010. Kidney International, 78 (7) pp. 640-645.
 
Molecular clock is involved in predictive circadian adjustment of renal function.
Zuber A.M., Centeno G., Pradervand S., Nikolaeva S., Maquelin L., Cardinaux L., Bonny O., Firsov D., 2009. Proceedings of the National Academy of Sciences of the United States of America, 106 (38) pp. 16523-16528. Peer-reviewed.
Mineralocorticoid receptor is essential for corticosteroid-induced up-regulation of L-type calcium currents in cultured neonatal cardiomyocytes.
Rougier J.S., Muller O., Berger S., Centeno G., Schütz G., Firsov D., Abriel H., 2008. Pflügers Archiv, 456 (2) pp. 407-412. Peer-reviewed.
 
Preferential assembly of epithelial sodium channel (ENaC) subunits in Xenopus oocytes: role of furin-mediated endogenous proteolysis.
Harris M., Garcia-Caballero A., Stutts M.J., Firsov D., Rossier B.C., 2008. Journal of Biological Chemistry, 283 (12) pp. 7455-7463. Peer-reviewed.
 
Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3
Boulkroun S., Ruffieux-Daidie D., Vitagliano J. J., Poirot O., Charles R. P., Lagnaz D., Firsov D., Kellenberger S., Staub O., 2008. American Journal of Physiology - Renal Physiology, 295 (4) pp. F889-F900. Peer-reviewed.
 
A novel neutrophil elastase inhibitor prevents elastase activation and surface cleavage of the epithelial sodium channel expressed in Xenopus laevis oocytes.
Harris M., Firsov D., Vuagniaux G., Stutts M.J., Rossier B.C., 2007. Journal of Biological Chemistry, 282 (1) pp. 58-64. Peer-reviewed.
 
Identification of corticosteroid-regulated genes in cardiomyocytes by serial analysis of gene expression.
Muller O., Pradervand S., Berger S., Centeno G., Milet A., Nicod P., Pedrazzini T., Tronche F., Schütz G., Chien K. et al., 2007. Genomics, 89 (3) pp. 370-377.
 
Increased renal responsiveness to vasopressin and enhanced V2 receptor signaling in RGS2-/- mice.
Zuber A.M., Singer D., Penninger J.M., Rossier B.C., Firsov D., 2007. Journal of the American Society of Nephrology, 18 (6) pp. 1672-1678.
 
Les antagonistes du récepteur minératocorticoïde
Muller O., Firsov D., Seydoux C., 2007. Revue Médicale Suisse, 3 (113) pp. 1401-1404.
 
Progesterone down-regulates the open probability of the amiloride-sensitive epithelial sodium channel via a Nedd4-2-dependent mechanism.
Michlig S., Harris M., Loffing J., Rossier B.C., Firsov D., 2005. Journal of Biological Chemistry, 280 (46) pp. 38264-38270. Peer-reviewed.
 
ERK1/2 controls Na,K-ATPase activity and transepithelial sodium transport in the principal cell of the cortical collecting duct of the mouse kidney.
Michlig S., Mercier A., Doucet A., Schild L., Horisberger J.D., Rossier B.C., Firsov D., 2004. Journal of Biological Chemistry, 279 (49) pp. 51002-51012. Peer-reviewed.
 
Revisiting sodium and water reabsorption with functional genomics tools.
Firsov D., 2004. Current Opinion in Nephrology and Hypertension, 13 (1) pp. 59-65.
 
Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein.
Pradervand S., Yasukawa H., Muller O.G., Kjekshus H., Nakamura T., St Amand T.R., Yajima T., Matsumura K., Duplain H., Iwatate M. et al., 2004. EMBO Journal, 23 (22) pp. 4517-4525.
 
Aldosterone action in the heart.
Firsov D., Muller O.G., 2003/06. Pflügers Archiv, 446 (3) pp. 328-333.
 
Mineralocorticoid effects in the kidney: correlation between alphaENaC, GILZ, and Sgk-1 mRNA expression and urinary excretion of Na+ and K+.
Muller O.G., Parnova R.G., Centeno G., Rossier B.C., Firsov D., Horisberger J.D., 2003. Journal of the American Society of Nephrology, 14 (5) pp. 1107-1115.
 
N-Glycosylation and conserved cysteine residues in RAMP3 play a critical role for the functional expression of CRLR/RAMP3 adrenomedullin receptor.
Flahaut M., Pfister C., Rossier B.C., Firsov D., 2003. Biochemistry, 42 (34) pp. 10333-10341.
 
A novel vasopressin-induced transcript promotes MAP kinase activation and ENaC downregulation.
Nicod M., Michlig S., Flahaut M., Salinas M., Fowler Jaeger N., Horisberger J.D., Rossier B.C., Firsov D., 2002. EMBO Journal, 21 (19) pp. 5109-5117.
 
Respective roles of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMP) in cell surface expression of CRLR/RAMP heterodimeric receptors.
Flahaut M., Rossier B.C., Firsov D., 2002. Journal of Biological Chemistry, 277 (17) pp. 14731-14737. Peer-reviewed.
 
Transcriptome of a mouse kidney cortical collecting duct cell line: effects of aldosterone and vasopressin.
Robert-Nicoud M., Flahaut M., Elalouf J.M., Nicod M., Salinas M., Bens M., Doucet A., Wincker P., Artiguenave F., Horisberger J.D. et al., 2001. Proceedings of the National Academy of Sciences of the United States of America, 98 (5) pp. 2712-2716.
 
Mutational analysis of cysteine-rich domains of the epithelium sodium channel (ENaC). Identification of cysteines essential for channel expression at the cell surface.
Firsov D., Robert-Nicoud M., Gruender S., Schild L., Rossier B.C., 1999. Journal of Biological Chemistry, 274 (5) pp. 2743-2749.
Protease modulation of the activity of the epithelial sodium channel expressed in Xenopus oocytes.
Chraïbi A., Vallet V., Firsov D., Hess S.K., Horisberger J.D., 1998. Journal of General Physiology, 111 (1) pp. 127-138.
 
The heterotetrameric architecture of the epithelial sodium channel (ENaC).
Firsov D., Gautschi I., Merillat A.M., Rossier B.C., Schild L., 1998. EMBO Journal, 17 (2) pp. 344-352.
 
A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel.
Gründer S., Firsov D., Chang S.S., Jaeger N.F., Gautschi I., Schild L., Lifton R.P., Rossier B.C., 1997. EMBO Journal, 16 (5) pp. 899-907.
Identification of amino acid residues in the alpha, beta, and gamma subunits of the epithelial sodium channel (ENaC) involved in amiloride block and ion permeation.
Schild L., Schneeberger E., Gautschi I., Firsov D., 1997. Journal of General Physiology, 109 (1) pp. 15-26.
 
The gamma subunit is a specific component of the Na,K-ATPase and modulates its transport function.
Béguin P., Wang X., Firsov D., Puoti A., Claeys D., Horisberger J.D., Geering K., 1997. EMBO Journal, 16 (14) pp. 4250-4260.
 
Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: a quantitative approach.
Firsov D., Schild L., Gautschi I., Mérillat A.M., Schneeberger E., Rossier B.C., 1996. Proceedings of the National Academy of Sciences of the United States of America, 93 (26) pp. 15370-15375.
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