Département de pharmacologie et toxicologie

Equipe principale | Groupe Bonny | Groupe Broillet | Groupe Cotecchia | Groupe Diviani | Groupe Firsov | Groupe Hummler | Groupe Katanaev | Groupe Kellenberger | Groupe Ocampo | Groupe Rossier | Groupe Schild | Groupe Staub
Publications | Mémoires et thèses

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106 publications

2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 |
Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive Na<sup>+</sup>/Cl<sup>-</sup> Cotransporter NCC and Transiently Affects Sodium Handling.
Canonica J., Frateschi S., Boscardin E., Ebering A., Sergi C., Jäger Y., Peyrollaz T., Mérillat A.M., Maillard M., Klusonova P. et al., 2019. Frontiers in physiology, 10 p. 989. Peer-reviewed.
A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors.
Vigolo M., Chambers M.G., Willen L., Chevalley D., Maskos K., Lammens A., Tardivel A., Das D., Kowalczyk-Quintas C., Schuepbach-Mallepell S. et al., 2018/03/23. Nature communications, 9 (1) p. 1199. Peer-reviewed.
Selective Deletion of Sodium Salt Taste during Development Leads to Expanded Terminal Fields of Gustatory Nerves in the Adult Mouse Nucleus of the Solitary Tract.
Sun C., Hummler E., Hill D.L., 2017/01/18. The Journal of neuroscience, 37 (3) pp. 660-672. Peer-reviewed.
Altered Prostasin (CAP1/Prss8) Expression Favors Inflammation and Tissue Remodeling in DSS-induced Colitis.
Keppner A., Malsure S., Nobile A., Auberson M., Bonny O., Hummler E., 2016/12. Inflammatory bowel diseases, 22 (12) pp. 2824-2839. Peer-reviewed.
The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19.
Boscardin E., Alijevic O., Hummler E., Frateschi S., Kellenberger S., 2016/09. British Journal of Pharmacology, 173 (18) pp. 2671-2701. Peer-reviewed.
Severe Salt-Losing Syndrome and Hyperkalemia Induced by Adult Nephron-Specific Knockout of the Epithelial Sodium Channel α-Subunit.
Perrier R., Boscardin E., Malsure S., Sergi C., Maillard M.P., Loffing J., Loffing-Cueni D., Sørensen M.V., Koesters R., Rossier B.C. et al., 2016/08. Journal of the American Society of Nephrology, 27 (8) pp. 2309-2318. Peer-reviewed.
Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype.
Canonica J., Sergi C., Maillard M., Klusonova P., Odermatt A., Koesters R., Loffing-Cueni D., Loffing J., Rossier B., Frateschi S. et al., 2016/05. Pflugers Archiv : European journal of physiology, 468 (5) pp. 895-908. Peer-reviewed.
Reducing αENaC expression in the kidney connecting tubule induces pseudohypoaldosteronism type 1 symptoms during K+ loading.
Poulsen S.B., Praetorius J., Damkier H.H., Miller L., Nelson R.D., Hummler E., Christensen B.M., 2016. American Journal of Physiology. Renal Physiology, 310 (4) pp. F300-F310. Peer-reviewed.
The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases.
Kühn N., Bergmann S., Kösterke N., Lambertz R.L., Keppner A., van den Brand J.M., Pöhlmann S., Weiß S., Hummler E., Hatesuer B. et al., 2016. Journal of Virology, 90 (9) pp. 4298-4307. Peer-reviewed.
ENaC activity in collecting ducts modulates NCC in cirrhotic mice.
Mordasini D., Loffing-Cueni D., Loffing J., Beatrice R., Maillard M.P., Hummler E., Burnier M., Escher G., Vogt B., 2015. Pflügers Archiv : European Journal of Physiology, 467 (12) pp. 2529-2539. Peer-reviewed.
Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4.
Keppner A., Andreasen D., Mérillat A.M., Bapst J., Ansermet C., Wang Q., Maillard M., Malsure S., Nobile A., Hummler E., 2015. Plos One, 10 (8) pp. e0135224. Peer-reviewed.
PPARγ Agonist-Induced Fluid Retention Depends on αENaC Expression in Connecting Tubules.
Fu Y., Gerasimova M., Batz F., Kuczkowski A., Alam Y., Sanders P.W., Ronzaud C., Hummler E., Vallon V., 2015. Nephron. Physiology, 129 (1) pp. 68-74. Peer-reviewed.
Regulation of blood pressure and renal function by NCC and ENaC: lessons from genetically engineered mice.
Verouti S.N., Boscardin E., Hummler E., Frateschi S., 2015. Current Opinion in Pharmacology, 21C pp. 60-72. Peer-reviewed.
Tgfbi/Bigh3 silencing activates ERK in mouse retina.
Allaman-Pillet N., Oberson A., Bustamante M., Tasinato A., Hummler E., Schorderet D.F., 2015. Experimental Eye Research, 140 pp. 159-170. Peer-reviewed.
The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin.
Brunati M., Perucca S., Han L., Cattaneo A., Consolato F., Andolfo A., Schaeffer C., Olinger E., Peng J., Santambrogio S. et al., 2015. Elife, 4 pp. e08887. Peer-reviewed.
The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin-1 (PN-1) inhibition.
Crisante G., Battista L., Iwaszkiewicz J., Nesca V., Mérillat A.M., Sergi C., Zoete V., Frateschi S., Hummler E., 2014/11. Faseb Journal, 28 pp. 1-14. Peer-reviewed.
Generation of TALEN-mediated GRdim knock-in rats by homologous recombination.
Ponce de León V., Mérillat A.M., Tesson L., Anegón I., Hummler E., 2014/02. Plos One, 9 (2) pp. e88146. Peer-reviewed.
Colon-specific deletion of epithelial sodium channel causes sodium loss and aldosterone resistance.
Malsure S., Wang Q., Charles R.P., Sergi C., Perrier R., Christensen B.M., Maillard M., Rossier B.C., Hummler E., 2014. Journal of the American Society of Nephrology, 25 (7) pp. 1453-1464. Peer-reviewed.
Hypoxia-induced inhibition of epithelial Na(+) channels in the lung. Role of Nedd4-2 and the ubiquitin-proteasome pathway.
Gille T., Randrianarison-Pellan N., Goolaerts A., Dard N., Uzunhan Y., Ferrary E., Hummler E., Clerici C., Planès C., 2014. American Journal of Respiratory Cell and Molecular Biology, 50 (3) pp. 526-537. Peer-reviewed.
Nitric oxide reduces Cl- absorption in the mouse cortical collecting duct through an ENaC-dependent mechanism.
Pech V., Thumova M., Dikalov S.I., Hummler E., Rossier B.C., Harrison D.G., Wall S.M., 2013/06. American Journal of Physiology. Renal Physiology, 304 (11) pp. F1390-F1397. Peer-reviewed.
Genetic dissection of sodium and potassium transport along the aldosterone-sensitive distal nephron: Importance in the control of blood pressure and hypertension.
Rossier B.C., Staub O., Hummler E., 2013. Febs Letters, 587 (13) pp. 1929-1941. Peer-reviewed.
Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension.
Ronzaud C., Loffing-Cueni D., Hausel P., Debonneville A., Malsure S.R., Fowler-Jaeger N., Boase N.A., Perrier R., Maillard M., Yang B. et al., 2013. Journal of Clinical Investigation, 123 (2) pp. 657-665.
The channel-activating protease CAP1/Prss8 is required for placental labyrinth maturation.
Hummler E., Dousse A., Rieder A., Stehle J.C., Rubera I., Osterheld M.C., Beermann F., Frateschi S., Charles R.P., 2013. Plos One, 8 (2) pp. e55796.
The epithelial sodium channel mediates the directionality of galvanotaxis in human keratinocytes.
Yang H.Y., Charles R.P., Hummler E., Baines D.L., Isseroff R.R., 2013. Journal of Cell Science, 126 (Pt 9) pp. 1942-1951.
Coat color dilution in mice because of inactivation of the melanoma antigen MART-1.
Aydin I.T., Hummler E., Smit N.P., Beermann F., 2012/10. Pigment Cell and Melanoma Research, 25 (1) pp. 37-46. Peer-reviewed.
The Glucocorticoid-induced leucine zipper (GILZ) Is essential for spermatogonial survival and spermatogenesis.
Romero Y., Vuandaba M., Suarez P., Grey C., Calvel P., Conne B., Pearce D., de Massy B., Hummler E., Nef S., 2012/05. Sexual Development, 6 (4) pp. 169-177. Peer-reviewed.
ENaC inhibition stimulates Cl- secretion in the mouse cortical collecting duct through an NKCC1-dependent mechanism.
Pech V., Thumova M., Kim Y.H., Agazatian D., Hummler E., Rossier B.C., Weinstein A.M., Nanami M., Wall S.M., 2012/04. American Journal of Physiology. Renal Physiology, 303 (1) pp. F45-F55. Peer-reviewed.
Sodium channels and mammalian sensory mechanotransduction.
Raouf R., Rugiero F., Kiesewetter H., Hatch R., Hummler E., Nassar M.A., Wang F., Wood J.N., 2012/03. Molecular Pain, 8 (1) p. 21. Peer-reviewed.
Mutations of the Serine Protease CAP1/Prss8 Lead to Reduced Embryonic Viability, Skin Defects, and Decreased ENaC Activity.
Frateschi S., Keppner A., Malsure S., Iwaszkiewicz J., Sergi C., Merillat A.M., Fowler-Jaeger N., Randrianarison N., Planès C., Hummler E., 2012. American Journal of Pathology, 181 (2) pp. 605-615. Peer-reviewed.
Reduced Prostasin (CAP1/PRSS8) Activity Eliminates HAI-1 and HAI-2 Deficiency-Associated Developmental Defects by Preventing Matriptase Activation.
Szabo R., Uzzun Sales K., Kosa P., Shylo N.A., Godiksen S., Hansen K.K., Friis S., Gutkind J.S., Vogel L.K., Hummler E. et al., 2012. Plos Genetics, 8 (8) pp. e1002937. Peer-reviewed.
The glucocorticoid-induced leucine zipper (gilz/tsc22d3-2) gene locus plays a crucial role in male fertility.
Suarez P.E., Rodriguez E.G., Soundararajan R., Mérillat A.M., Stehle J.C., Rotman S., Roger T., Voirol M.J., Wang J., Gross O. et al., 2012. Molecular Endocrinology, 26 (6) pp. 1000-1013.
alphaENaC-mediated lithium absorption promotes nephrogenic diabetes insipidus.
Christensen B.M., Zuber A.M., Loffing J., Stehle J.C., Deen P.M., Rossier B.C., Hummler E., 2011. Journal of the American Society of Nephrology, 22 (2) pp. 253-261.
PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin.
Frateschi S., Camerer E., Crisante G., Rieser S., Membrez M., Charles R.P., Beermann F., Stehle J.C., Breiden B., Sandhoff K. et al., 2011. Nature Communications, 2 p. 161.
Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice.
Mall M.A., Button B., Johannesson B., Zhou Z., Livraghi A., Caldwell R.A., Schubert S.C., Schultz C., O'Neal W.K., Pradervand S. et al., 2010. Journal of Biological Chemistry, 285 (35) pp. 26945-26955. Peer-reviewed.
ENaC-mediated alveolar fluid clearance and lung fluid balance depend on the channel-activating protease 1.
Planès C., Randrianarison N.H., Charles R.P., Frateschi S., Cluzeaud F., Vuagniaux G., Soler P., Clerici C., Rossier B.C., Hummler E., 2010. EMBO Molecular Medicine, 2 (1) pp. 26-37. Peer-reviewed.
Importance of ENaC-mediated sodium transport in alveolar fluid clearance using genetically-engineered mice.
Hummler E., Planès C., 2010. Cellular physiology and biochemistry, 25 (1) pp. 63-70. Peer-reviewed.
Sodium and potassium balance depends on αENaC expression in connecting tubule.
Christensen B.M., Perrier R., Wang Q., Zuber A.M., Maillard M., Mordasini D., Malsure S., Ronzaud C., Stehle J.C., Rossier B.C. et al., 2010. Journal of the American Society of Nephrology : Jasn, 21 (11) pp. 1942-1951. Peer-reviewed.
The cells and peripheral representation of sodium taste in mice.
Chandrashekar J., Kuhn C., Oka Y., Yarmolinsky D.A., Hummler E., Ryba N.J., Zuker C.S., 2010. Nature, 464 (7286) pp. 297-301. Peer-reviewed.
The epidthelial sodium channel ENaC and its regulators in the epidermal permeability barrier function
Frateschi S., Charles R-P., Hummler E., 2010. The Open Dermatology Journal, 4 pp. 27-35. Peer-reviewed.
The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice.
Leviel F., Hübner C.A., Houillier P., Morla L., El Moghrabi S., Brideau G., Hatim H., Parker M.D., Kurth I., Kougioumtzes A. et al., 2010. Journal of Clinical Investigation, 120 (5) pp. 1627-1635. Peer-reviewed.
Transgenic mice and their impact on kidney research.
Rubera I., Hummler E., Beermann F., 2009/12. Pflügers Archiv, 458 (1) pp. 211-222.
Conditional gene targeting of the ENaC subunit genes Scnn1b and Scnn1g.
Mérillat A.M., Charles R.P., Porret A., Maillard M., Rossier B., Beermann F., Hummler E., 2009/02. American Journal of Physiology. Renal physiology, 296 (2) pp. F249-F256. Peer-reviewed.
Interspecies crosses: aspects of animal protection.
Kamber M.G., Steiger A., Aus der Au C., Baertschi B., Bondolfi A., Brenner A., Bürki K., Durrer H., Guztwiller A., Heiniger B. et al., 2009. ALTEX : Alternativen zu Tierexperimenten, 26 (3) pp. 227-31. Peer-reviewed.
Thiazolidinedione-induced fluid retention is independent of collecting duct alphaENaC activity.
Vallon V., Hummler E., Rieg T., Pochynyuk O., Bugaj V., Schroth J., Dechenes G., Rossier B., Cunard R., Stockand J., 2009. Journal of the American Society of Nephrology, 20 (4) pp. 721-729.
Low expression of the beta-ENaC subunit impairs lung fluid clearance in the mouse.
Randrianarison N., Clerici C., Ferreira C., Fontayne A., Pradervand S., Fowler-Jaeger N., Hummler E., Rossier B.C., Planès C., 2008/11. American Journal of Physiology. Lung Cellular and Molecular Physiology, 294 (3) pp. L409-416. Peer-reviewed.
Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome
Bertog M., Cuffe J. E., Pradervand S., Hummler E., Hartner A., Porst M., Hilgers K. F., Rossier B. C., Korbmacher C., 2008/01. Journal of Physiology, 586 (2) pp. 459-75. Peer-reviewed.
Postnatal requirement of the epithelial sodium channel for maintenance of epidermal barrier function.
Charles R.P., Guitard M., Leyvraz C., Breiden B., Haftek M., Haftek-Terreau Z., Stehle J.C., Sandhoff K., Hummler E., 2008. Journal of Biological Chemistry, 283 (5) pp. 2622-2630. Peer-reviewed.
beta-Liddle mutation of the epithelial sodium channel increases alveolar fluid clearance and reduces the severity of hydrostatic pulmonary oedema in mice
Randrianarison N., Escoubet B., Ferreira C., Fontayne A., Fowler-Jaeger N., Clerici C., Hummler E., Rossier B. C., Planes C., 2007/07. Journal of Physiology, 582 (Pt 2) pp. 777-88. Peer-reviewed.
Mineralocorticoid action in the aldosterone-sensitive distal nephron
Verrey F., Hummler E., Schild L., Rossier B.C., 2007. pp. 889-924 dans Alpern R.J., Herbert S.C. (eds.) The Kidney, Alpern R.J. Herbert S.C..
The connecting tubule is the main site of the furosemide-induced urinary acidification by the vacuolar H+-ATPase
Kovacikova J., Winter C., Loffing-Cueni D., Loffing J., Finberg K. E., Lifton R. P., Hummler E., Rossier B., Wagner C. A., 2006/11. Kidney International, 70 (10) pp. 1706-16. Peer-reviewed.
Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene
Oskarsson T., Essers M. A., Dubois N., Offner S., Dubey C., Roger C., Metzger D., Chambon P., Hummler E., Beard P. et al., 2006/08. Genes & Development, 20 (15) pp. 2024-29.
Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1
Andreasen D., Vuagniaux G., Fowler-Jaeger N., Hummler E., Rossier B. C., 2006/04. Journal of the American Society of Nephrology, 17 (4) pp. 968-76. Peer-reviewed.
GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function.
Membrez M., Hummler E., Beermann F., Haefliger J.A., Savioz R., Pedrazzini T., Thorens B., 2006. Molecular and Cellular Biology, 26 (11) pp. 4268-4276. Peer-reviewed.
Tissue-specific transgenic and knockout mice
Porret A., Mérillat A. M., Guichard S., Beermann F., Hummler E., 2006. Methods in Molecular Biology, 337 pp. 185-205.
A direct relationship between plasma aldosterone and cardiac L-type Ca2+ current in mice
Perrier R., Richard S., Sainte-Marie Y., Rossier B. C., Jaisser F., Hummler E., Bénitah J. P., 2005/11. Journal of Physiology, 569 (Pt 1) pp. 153-62. Peer-reviewed.
Lessons from mouse mutants of epithelial sodium channel and its regulatory proteins
Hummler E., Vallon V., 2005/11. Journal of the American Society of Nephrology, 16 (11) pp. 3160-66.
The epidermal barrier function is dependent on the serine protease CAP1/Prss8
Leyvraz C., Charles R. P., Rubera I., Guitard M., Rotman S., Breiden B., Sandhoff K., Hummler E., 2005/08. Journal of Cell Biology, 170 (3) pp. 487-96.
In vitro and in vivo regulation of transepithelial lung alveolar sodium transport by serine proteases
Planès C., Leyvraz C., Uchida T., Angelova M. A., Vuagniaux G., Hummler E., Matthay M., Clerici C., Rossier B., 2005/06. American Journal of Physiology Lung Cellular and Molecular Physiology, 288 (6) pp. L1099-109. Peer-reviewed.
Vasopressin-stimulated CFTR Cl- currents are increased in the renal collecting duct cells of a mouse model of Liddle's syndrome.
Chang C.T., Bens M., Hummler E., Boulkroun S., Schild L., Teulon J., Rossier B.C., Vandewalle A., 2005. Journal of Physiology, 562 (1) pp. 271-284. Peer-reviewed.
Defective respiratory amiloride-sensitive sodium transport predisposes to pulmonary oedema and delays its resolution in mice
Egli M., Duplain H., Lepori M., Cook S., Nicod P., Hummler E., Sartori C., Scherrer U., 2004/11. Journal of Physiology, 560 (Pt 3) pp. 857-65. Peer-reviewed.
Chronic hyperaldosteronism in a transgenic mouse model fails to induce cardiac remodeling and fibrosis under a normal-salt diet
Wang Q., Clement S., Gabbiani G., Horisberger J. D., Burnier M., Rossier B. C., Hummler E., 2004/06. American Journal of Physiology Renal Physiology, 286 (6) pp. F1178-84.
A nonconventional look at ionic fluxes in the skin: lessons from genetically modified mice
Guitard M., Leyvraz C., Hummler E., 2004/04. News in Physiological Sciences, 19 pp. 75-79.
Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5
Hoenderop J. G., van Leeuwen J. P., van der Eerden B. C., Kersten F. F., van der Kemp A. W., Mérillat A. M., Waarsing J. H., Rossier B. C., Vallon V., Hummler E. et al., 2003/12. Journal of Clinical Investigation, 112 (12) pp. 1906-14. Peer-reviewed.
Dysfunction of the epithelial sodium channel expressed in the kidney of a mouse model for Liddle syndrome
Pradervand S., Vandewalle A., Bens M., Gautschi I., Loffing J., Hummler E., Schild L., Rossier B. C., 2003/09. Journal of the American Society of Nephrology, 14 (9) pp. 2219-28. Peer-reviewed.
Mineralocorticoid regulation of epithelial Na+ channels is maintained in a mouse model of Liddle's syndrome
Dahlmann A., Pradervand S., Hummler E., Rossier B. C., Frindt G., Palmer L. G., 2003/08. American Journal of Physiology Renal Physiology, 285 (2) pp. F310-18. Peer-reviewed.
Epithelial sodium channel, salt intake, and hypertension.
Hummler E., 2003/02. Current Hypertension Reports, 5 (1) pp. 11-18. Peer-reviewed.
Inactivation of sodium-transporting proteins in the kidney
Rubera I., Rossier B. C., Hummler E., 2003/01. Pflügers Archiv (European Journal of Physiology), 445 (4) pp. 463-69. Peer-reviewed.
Selected contribution: limiting Na(+) transport rate in airway epithelia from alpha-ENaC transgenic mice: a model for pulmonary edema
Olivier R., Scherrer U., Horisberger J. D., Rossier B. C., Hummler E., 2002/11. Journal of Applied Physiology, 93 (5) pp. 1881-87.
Expression of Cre recombinase in pigment cells
Guyonneau L., Rossier A., Richard C., Hummler E., Beermann F., 2002/08. Pigment Cell Research, 15 (4) pp. 305-9.
Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus oocytes
Vuagniaux G., Vallet V., Jaeger N. F., Hummler E., Rossier B. C., 2002/08. Journal of General Physiology, 120 (2) pp. 191-201. Peer-reviewed.
The ENaC channel is required for normal epidermal differentiation
Mauro T., Guitard M., Behne M., Oda Y., Crumrine D., Komuves L., Rassner U., Elias P. M., Hummler E., 2002/04. Journal of Investigative Dermatology, 118 (4) pp. 589-94.
Absence of fibroblast growth factor 2 does not prevent tumor formation originating from the RPE
Foletti A., Ackermann J., Schmidt A., Hummler E., Beermann F., 2002/03. Oncogene, 21 (12) pp. 1841-47.
A conditional allele at the mouse channel activating protease 1 (Prss8) gene locus
Rubera I., Meier E., Vuagniaux G., Mérillat A. M., Beermann F., Rossier B. C., Hummler E., 2002/02. Genesis, 32 (2) pp. 173-76. Peer-reviewed.
Conditional gene targeting of the Scnn1a (alphaENaC) gene locus
Hummler E., Mérillat A. M., Rubera I., Rossier B. C., Beermann F., 2002/02. Genesis, 32 (2) pp. 169-72. Peer-reviewed.
Blood pressure, cardiac, and renal responses to salt and deoxycorticosterone acetate in mice: role of Renin genes.
Wang Q., Hummler E., Nussberger J., Clément S., Gabbiani G., Brunner H.R., Burnier M., 2002. Journal of the American Society of Nephrology, 13 (6) pp. 1509-1516. Peer-reviewed.
Epithelial sodium channel and the control of sodium balance: interaction between genetic and environmental factors.
Rossier B.C., Pradervand S., Schild L., Hummler E., 2002. Annual Review of Physiology, 64 pp. 877-897. Peer-reviewed.
The transmembrane serine protease (TMPRSS3) mutated in deafness DFNB8/10 activates the epithelial sodium channel (ENaC) in vitro.
Guipponi M., Vuagniaux G., Wattenhofer M., Shibuya K., Vazquez M., Dougherty L., Scamuffa N., Guida E., Okui M., Rossier C. et al., 2002. Human Molecular Genetics, 11 (23) pp. 2829-2836.
Analysis of the mouse Scnn1a promoter in cortical collecting duct cells and in transgenic mice
Kohler S., Pradervand S., Verdumo C., Mérillat A. M., Bens M., Vandewalle A., Beermann F., Hummler E., 2001/05. Biochimica et Biophysica Acta-Gene Structure and Expression, 1519 (1-2) pp. 106-10. Peer-reviewed.
Coordinate control of Na,K-atpase mRNA expression by aldosterone, vasopressin and cell sodium delivery in the cortical collecting duct
Blot-Chabaud M., Djelidi S., Courtois-Coutry N., Fay M., Cluzeaud F., Hummler E., Farman N., 2001/03. Cellular and Molecular Biololgy, 47 (2) pp. 247-53.
Compensatory up-regulation of angiotensin II subtype 1 receptors in alpha ENaC knockout heterozygous mice.
Wang Q., Hummler E., Maillard M., Nussberger J., Rossier B.C., Brunner H.R., Burnier M., 2001. Kidney international, 59 (6) pp. 2216-21. Peer-reviewed.
Functional analyses of a N-terminal splice variant of the alpha subunit of the epithelial sodium channel
Chraibi A., Verdumo C., Mérillat A. M., Rossier B. C., Horisberger J. D., Hummler E., 2001. Cellular Physiology and Biochemistry, 11 (3) pp. 115-22.
Activation of the amiloride-sensitive epithelial sodium channel by the serine protease mCAP1 expressed in a mouse cortical collecting duct cell line
Vuagniaux G., Vallet V., Jaeger N. F., Pfister C., Bens M., Farman N., Courtois-Coutry N., Vandewalle A., Rossier B. C., Hummler E., 2000/05. Journal of the American Society of Nephrology, 11 (5) pp. 828-34. Peer-reviewed.
Control of Na+ Transport by Aldosterone.
Verrey F., Hummler E., Schild L., Rossier B.C., 2000. pp. 1441-1472 dans Seldin D.W., Giebisch G.H. (eds.) The Kidney, Lippincott Williams & Wilkins.
Dysfunction of epithelial sodium transport: from human to mouse.
Bonny O., Hummler E., 2000. Kidney International, 57 (4) pp. 1313-1318.
Scnn1 sodium channel gene family in genetically engineered mice.
Hummler E., Beermann F., 2000. Journal of the American Society of Nephrology, 11 (Suppl 16) pp. S129-S134. Peer-reviewed.
A mouse model for Liddle's syndrome
Pradervand S., Wang Q., Burnier M., Beermann F., Horisberger J. D., Hummler E., Rossier B. C., 1999/12. Journal of the American Society of Nephrology, 10 (12) pp. 2527-33.
Implication of ENaC in salt-sensitive hypertension
Hummler E., 1999/06. Journal of Steroid Biochemistry and Molecular Biology, 69 (1-6) pp. 385-90.
Mechano-electrical transduction in mice lacking the alpha-subunit of the epithelial sodium channel
Rüsch A., Hummler E., 1999/05. Hearing Research, 131 (1-2) pp. 170-76.
Genetic disorders of membrane transport. V. The epithelial sodium channel and its implication in human diseases
Hummler E., Horisberger J. D., 1999/03. American Journal of Physiology, 276 (3 Pt 1) pp. G567-71.
Salt restriction induces pseudohypoaldosteronism type 1 in mice expressing low levels of the beta-subunit of the amiloride-sensitive epithelial sodium channel
Pradervand S., Barker P. M., Wang Q., Ernst S. A., Beermann F., Grubb B. R., Burnier M., Schmidt A., Bindels R. J., Gatzy J. T. et al., 1999/02. Proceedings of the National Academy of Sciences of the United States of America, 96 (4) pp. 1732-37. Peer-reviewed.
Role of gammaENaC subunit in lung liquid clearance and electrolyte balance in newborn mice. Insights into perinatal adaptation and pseudohypoaldosteronism
Barker P. M., Nguyen M. S., Gatzy J. T., Grubb B., Norman H., Hummler E., Rossier B., Boucher R. C., Koller B., 1998/10. Journal of Clinical Investigation, 102 (8) pp. 1634-40. Peer-reviewed.
lacZ transgenic mice to monitor gene expression in embryo and adult
Schmidt A., Tief K., Foletti A., Hunziker A., Penna D., Hummler E., Beermann F., 1998/09. Brain Research Brain Research Protocols, 3 (1) pp. 54-60.
Reversal of convention: from man to experimental animal in elucidating the function of the renal amiloride-sensitive sodium channel
Hummler E., 1998/08. Experimental Nephrology, 6 (4) pp. 265-71.
Epithelial sodium channel and its implication in the control of blood pressure
Hummler E., 1998. Kidney & Blood Pressure Research, 21 (2-4) pp. 253-55.
Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2.
Guillam M.T., Hümmler E., Schaerer E., Yeh J.I., Birnbaum M.J., Beermann F., Schmidt A., Dériaz N., Thorens B., Wu J.Y., 1997/11. Nature Genetics, 17 (3) pp. 327-330.
A mouse model for the renal salt-wasting syndrome pseudohypoaldosteronism
Hummler E., Barker P., Talbot C., Wang Q., Verdumo C., Grubb B., Gatzy J., Burnier M., Horisberger J. D., Beermann F. et al., 1997/10. Proceedings of the National Academy of Sciences of the United States of America, 94 (21) pp. 11710-15.
Role of the epithelial sodium channel in lung liquid clearance
Hummler E., Barker P., Beermann F., Gatzy J., Verdumo C., Boucher R., Rossier B. C., 1997/06. Chest, 111 (6 Suppl) pp. 113S. Peer-reviewed.
Decreased blood pressure response in mice deficient of the alpha1b-adrenergic receptor.
Cavalli A., Lattion A.L., Hummler E., Nenniger M., Pedrazzini T., Aubert J.F., Michel M.C., Yang M., Lembo G., Vecchione C. et al., 1997. Proceedings of the National Academy of Sciences of the United States of America, 94 (21) pp. 11589-11594. Peer-reviewed.
Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice
Hummler E., Barker P., Gatzy J., Beermann F., Verdumo C., Schmidt A., Boucher R., Rossier B. C., 1996/03. Nature Genetics, 12 (3) pp. 325-28. Peer-reviewed.
Génétique du canal sodium épithélial: nouveaux développements dans la compréhension du contrôle de la pression sanguine et de la réabsorption de liquide dans les voies aériennes et le poumon
Rossier B.C., Hummler E., Horisberger J.-D., Schild L., 1996. Médecine / Sciences, 12 pp. 795-97.
Physiological and pathophysiological role of the epithelial sodium channel in the control of blood pressure
Hummler E., Rossier B. C., 1996. Kidney and Blood Pressure Research, 19 (3-4) pp. 160-65. Peer-reviewed.
Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation
Cole T. J., Blendy J. A., Monaghan A. P., Krieglstein K., Schmid W., Aguzzi A., Fantuzzi G., Hummler E., Unsicker K., Schütz G., 1995/07. Genes & Development, 9 (13) pp. 1608-21.
Molecular genetic analysis of cAMP and glucocorticoid signaling in development
Blendy J. A., Cole T. J., Montoliu L., Hummler E., Ganss R., Aguzzi A., Schmid W., Schütz G., 1995. Recent Progress in Hormone Research, 50 pp. 97-108.
Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors
Hummler E., Cole T. J., Blendy J. A., Ganss R., Aguzzi A., Schmid W., Beermann F., Schütz G., 1994/06. Proceedings of the National Academy of Sciences of the United States of America, 91 (12) pp. 5647-51.
Perinatal activation of a tyrosine aminotransferase fusion gene does not occur in albino lethal mice
Beermann F., Hummler E., Schmid E., Schütz G., 1993/07. Mechanisms of Development, 42 (1-2) pp. 59-65.
The mouse tyrosinase gene: pigment cell-specific gene expression in transgenic mice
Beermann F., Schedl A., Ruppert S., Ganss R., Schmid E., Klüppel M., Hummler E., Schütz G., 1993. pp. 57-62 dans From Molecular Biology to Therapeutics. Pharmacology and the Skin, Bernard B.A., Shroot B. (eds.).
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