Département de pharmacologie et toxicologie

Equipe principale | Groupe Bonny | Groupe Broillet | Groupe Cotecchia | Groupe Diviani | Groupe Firsov | Groupe Hummler | Groupe Kellenberger | Groupe Ocampo | Groupe Rossier | Groupe Schild | Groupe Staub
Publications | Mémoires et thèses

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54 publications

Sous presse | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 1999 | 1998 |
A molecular view of the function and pharmacology of acid-sensing ion channels.
Vullo S., Kellenberger S. Pharmacological research. Peer-reviewed.
 
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels
Alexander Stephen P H, Mathie Alistair, Peters John A, Veale Emma L, Striessnig Jörg, Kelly Eamonn, Armstrong Jane F, Faccenda Elena, Harding Simon D, Pawson Adam J et al., 2019/12. British Journal of Pharmacology, 176 (S1).
 
SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1-Nrf2.
Burgener A.V., Bantug G.R., Meyer B.J., Higgins R., Ghosh A., Bignucolo O., Ma E.H., Loeliger J., Unterstab G., Geigges M. et al., 2019/10. Nature immunology, 20 (10) pp. 1311-1321. Peer-reviewed.
Mutations in the palm domain disrupt modulation of acid-sensing ion channel 1a currents by neuropeptides.
Bargeton B., Iwaszkiewicz J., Bonifacio G., Roy S., Zoete V., Kellenberger S., 2019/02/22. Scientific reports, 9 (1) p. 2599. Peer-reviewed.
Accelerated Current Decay Kinetics of a Rare Human Acid-Sensing ion Channel 1a Variant That Is Used in Many Studies as Wild Type.
Vaithia A., Vullo S., Peng Z., Alijevic O., Kellenberger S., 2019. Frontiers in molecular neuroscience, 12 p. 133. Peer-reviewed.
Heteroarylguanidines as Allosteric Modulators of ASIC1a and ASIC3 Channels.
Alijevic O., Hammoud H., Vaithia A., Trendafilov V., Bollenbach M., Schmitt M., Bihel F., Kellenberger S., 2018/06/20. ACS chemical neuroscience, 9 (6) pp. 1357-1365. Peer-reviewed.
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview.
Alexander S.P., Kelly E., Marrion N.V., Peters J.A., Faccenda E., Harding S.D., Pawson A.J., Sharman J.L., Southan C., Buneman O.P. et al., 2017/12. British journal of pharmacology, 174 Suppl 1 pp. S1-S16. Peer-reviewed.
 
Conformational dynamics and role of the acidic pocket in ASIC pH-dependent gating.
Vullo S., Bonifacio G., Roy S., Johner N., Bernèche S., Kellenberger S., 2017/04/04. Proceedings of the National Academy of Sciences of the United States of America, 114 (14) pp. 3768-3773. Peer-reviewed.
The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19.
Boscardin E., Alijevic O., Hummler E., Frateschi S., Kellenberger S., 2016/09. British Journal of Pharmacology, 173 (18) pp. 2671-2701. Peer-reviewed.
Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischemia and acidosis in hippocampal CA1 neurons
Quintana P., Soto D., Poirot O., Zonouzi M., Kellenberger S., Muller D., Chrast R., Cull-Candy S.G., 2015. Journal of Physiology, 593 (19) pp. 4373-4386. Peer-reviewed.
Architectural and Functional Similarities between Trimeric ATP-Gated P2X Receptors and Acid-Sensing Ion Channels
Kellenberger S., Grutter T., 2015. Journal of Molecular Biology, 427 (1) pp. 54-66. Peer-reviewed.
Extracellular Subunit Interactions Control Transitions between Functional States of Acid-sensing Ion Channel 1a.
Gwiazda K., Bonifacio G., Vullo S., Kellenberger S., 2015. Journal of Biological Chemistry, 290 (29) pp. 17956-17966. Peer-reviewed.
 
International union of basic and clinical pharmacology. XCI. structure, function, and pharmacology of acid-sensing ion channels and the epithelial Na+ channel.
Kellenberger S., Schild L., 2015. Pharmacological Reviews, 67 (1) pp. 1-35. Peer-reviewed.
Calcium entry via TRPV1 but not ASICs induces neuropeptide release from sensory neurons
Boillat A., Alijevic O., Kellenberger S., 2014/04. Molecular and Cellular Neuroscience, 61 pp. 13-22. Peer-reviewed.
Heterotrimeric Go protein links Wnt-Frizzled signaling with ankyrins to regulate the neuronal microtubule cytoskeleton.
Lüchtenborg A.M., Solis G.P., Egger-Adam D., Koval A., Lin C., Blanchard M.G., Kellenberger S., Katanaev V.L., 2014. Development, 141 (17) pp. 3399-3409. Peer-reviewed.
Measuring surface potential changes on leaves.
Mousavi S.A., Nguyen C.T., Farmer E.E., Kellenberger S., 2014. Nature Protocols, 9 (8) pp. 1997-2004. Peer-reviewed.
Protonation controls ASIC1a activity via coordinated movements in multiple domains.
Bonifacio G., Lelli C.I., Kellenberger S., 2014. Journal of General Physiology, 143 (1) pp. 105-118.
Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain.
Laedermann C.J., Cachemaille M., Kirschmann G., Pertin M., Gosselin R.D., Chang I., Albesa M., Towne C., Schneider B.L., Kellenberger S. et al., 2013. Journal of Clinical Investigation, 123 (7) pp. 3002-3013. Peer-reviewed.
GLUTAMATE RECEPTOR-LIKE genes mediate leaf-to-leaf wound signalling.
Mousavi S.A., Chauvin A., Pascaud F., Kellenberger S., Farmer E.E., 2013. Nature, 500 (7463) pp. 422-426. Peer-reviewed.
Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures.
Hobbs C.A., Blanchard M.G., Alijevic O., Tan C.D., Kellenberger S., Bencharit S., Cao R., Kesimer M., Walton W.G., Henderson A.G. et al., 2013. American Journal of Physiology. Lung Cellular and Molecular Physiology, 305 (12) pp. L990-L1001. Peer-reviewed.
Molecular determinants of desensitization in an ENaC/degenerin channel.
Roy S., Boiteux C., Alijevic O., Liang C., Bernèche S., Kellenberger S., 2013. Faseb Journal, 27 (12) pp. 5034-5045.
Ein schmerzhafter Säuremelder
Kellenberger S., 2012/11. Swiss Medical Forum, 12 (46) pp. 903-905.
Inhibition of voltage-gated Na(+) currents in sensory neurones by the sea anemone toxin APETx2.
Blanchard M.G., Rash L.D., Kellenberger S., 2012. British Journal of Pharmacology, 165 (7) pp. 2167-2177. Peer-reviewed.
Subtype-specific Modulation of Acid-sensing Ion Channel (ASIC) Function by 2-Guanidine-4-methylquinazoline.
Alijevic O., Kellenberger S., 2012. Journal of Biological Chemistry, 287 (43) pp. 36059-36070. Peer-reviewed.
Acid-sensing channels in human bladder: expression, function and alterations during bladder pain syndrome.
Sánchez-Freire V., Blanchard M.G., Burkhard F.C., Kessler T.M., Kellenberger S., Monastyrskaya K., 2011. Journal of Urology, 186 (4) pp. 1509-1516. Peer-reviewed.
Effect of a temperature increase in the non-noxious range on proton-evoked ASIC and TRPV1 activity.
Blanchard M.G., Kellenberger S., 2011. Pflügers Archiv, 461 (1) pp. 123-139. Peer-reviewed.
Functional architecture of olfactory ionotropic glutamate receptors.
Abuin L., Bargeton B., Ulbrich M.H., Isacoff E.Y., Kellenberger S., Benton R., 2011. Neuron, 69 (1) pp. 44-60.
A combined computational and functional approach identifies new residues involved in pH-dependent gating of ASIC1a.
Liechti L.A., Bernèche S., Bargeton B., Iwaszkiewicz J., Roy S., Michielin O., Kellenberger S., 2010. Journal of Biological Chemistry, 285 (21) pp. 16315-16329.
 
Rapid, simple and high yield production of recombinant proteins in mammalian cells using a versatile episomal system.
Magistrelli G., Malinge P., Lissilaa R., Fagète S., Guilhot F., Moine V., Buatois V., Delneste Y., Kellenberger S., Gueneau F. et al., 2010. Protein Expression and Purification, 72 (2) pp. 209-216. Peer-reviewed.
The contact region between three domains of the extracellular loop of ASIC1a is critical for channel function.
Bargeton B., Kellenberger S., 2010. Journal of Biological Chemistry, 285 (18) pp. 13816-13826. Peer-reviewed.
 
The 19th Ion Channel Meeting. September 2008, France.
Bichet D., Duranton C., Hirbec H., Kellenberger S., Mérot J., Ulmann L., Van Coppenolle F., 2009. pp. 69-72 dans Channels (Austin), Channels.
 
Deubiquitylation regulates activation and proteolytic cleavage of ENaC
Ruffieux-Daidie D., Poirot O., Boulkroun S., Verrey F., Kellenberger S., Staub O., 2008. Journal of the American Society of Nephrology, 19 (11) pp. 2170-2180. Peer-reviewed.
 
Epithelial Sodium and Acid-sensing Ion Channels
Kellenberger S., 2008. pp. 225-246 dans Martinac B. (eds.) Sensing with ion channels chap. 11, Springer Verlag.
 
Transcriptional and functional profiles of voltage-gated Na(+) channels in injured and non-injured DRG neurons in the SNI model of neuropathic pain.
Berta T., Poirot O., Pertin M., Ji R.R., Kellenberger S., Decosterd I., 2008. Molecular and Cellular Neuroscience, 37 (2) pp. 196-208. Peer-reviewed.
 
Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3
Boulkroun S., Ruffieux-Daidie D., Vitagliano J. J., Poirot O., Charles R. P., Lagnaz D., Firsov D., Kellenberger S., Staub O., 2008. American Journal of Physiology - Renal Physiology, 295 (4) pp. F889-F900. Peer-reviewed.
 
Cell-permeable peptides induce dose- and length-dependent cytotoxic effects.
Cardozo A.K., Buchillier V., Mathieu M., Chen J., Ortis F., Ladrière L., Allaman-Pillet N., Poirot O., Kellenberger S., Beckmann J.S. et al., 2007. Biochimica et Biophysica Acta-Bioenergetics, 1768 (9) pp. 2222-2234. Peer-reviewed.
 
A gating mutation in the internal pore of ASIC1a.
Pfister Y., Gautschi I., Takeda A.N., van Bemmelen M., Kellenberger S., Schild L., 2006. Journal of Biological Chemistry, 281 (17) pp. 11787-11791.
 
Distinct ASIC currents are expressed in rat putative nociceptors and are modulated by nerve injury.
Poirot O., Berta T., Decosterd I., Kellenberger S., 2006. Journal of Physiology, 576 (Pt 1) pp. 215-234.
 
Trypsin cleaves acid-sensing ion channel 1a in a domain that is critical for channel gating.
Vukicevic M., Weder G., Boillat A., Boesch A., Kellenberger S., 2006. Journal of Biological Chemistry, 281 (2) pp. 714-722.
 
Intracellular thiol-mediated modulation of epithelial sodium channel activity.
Kellenberger S., Gautschi I., Pfister Y., Schild L., 2005. Journal of Biological Chemistry, 280 (9) pp. 7739-7747.
 
Ligand binding transmits conformational changes across the membrane-spanning region to the intracellular side of the 5-HT3 serotonin receptor.
Ilegems E., Pick H., Deluz C., Kellenberger S., Vogel H., 2005. ChemBioChem, 6 (12) pp. 2180-2185.
 
Modulatory effects of acid-sensing ion channels on action potential generation in hippocampal neurons.
Vukicevic M., Kellenberger S., 2004. American Journal of Physiology. Cell Physiology, 287 (3) pp. C682-C690.
 
Noninvasive imaging of 5-HT3 receptor trafficking in live cells: from biosynthesis to endocytosis.
Ilegems E., Pick H.M., Deluz C., Kellenberger S., Vogel H., 2004. Journal of Biological Chemistry, 279 (51) pp. 53346-53352.
 
Selective regulation of acid-sensing ion channel 1 by serine proteases.
Poirot O., Vukicevic M., Boesch A., Kellenberger S., 2004. Journal of Biological Chemistry, 279 (37) pp. 38448-38457.
 
Characterization of the ligand-binding site of the serotonin 5-HT3 receptor: the role of glutamate residues 97, 224, AND 235.
Schreiter C., Hovius R., Costioli M., Pick H., Kellenberger S., Schild L., Vogel H., 2003. Journal of Biological Chemistry, 278 (25) pp. 22709-22716.
 
Epithelial Na+ channel mutants causing Liddle's syndrome retain ability to respond to aldosterone and vasopressin.
Auberson M., Hoffmann-Pochon N., Vandewalle A., Kellenberger S., Schild L., 2003. American Journal of Physiology. Renal Physiology, 285 (3) pp. F459-F471.
 
Mutations in the epithelial Na+ channel ENaC outer pore disrupt amiloride block by increasing its dissociation rate.
Kellenberger S., Gautschi I., Schild L., 2003. Molecular Pharmacology, 64 (4) pp. 848-856.
 
An external site controls closing of the epithelial Na+ channel ENaC.
Kellenberger S., Gautschi I., Schild L., 2002. Journal of Physiology, 543 (Pt 2) pp. 413-424.
 
Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure.
Kellenberger S., Schild L., 2002. Physiological Reviews, 82 (3) pp. 735-767.
Permeability properties of ENaC selectivity filter mutants.
Kellenberger S., Auberson M., Gautschi I., Schneeberger E., Schild L., 2001. Journal of General Physiology, 118 (6) pp. 679-692.
 
Structure function relationships of ENaC and its role in sodium handling.
Schild L., Kellenberger S., 2001. Advances in Experimental Medicine and Biology, 502 pp. 305-314.
 
A single point mutation in the pore region of the epithelial Na+ channel changes ion selectivity by modifying molecular sieving.
Kellenberger S., Gautschi I., Schild L., 1999. Proceedings of the National Academy of Sciences of the United States of America, 96 (7) pp. 4170-4175.
On the molecular basis of ion permeation in the epithelial Na+ channel.
Kellenberger S., Hoffmann-Pochon N., Gautschi I., Schneeberger E., Schild L., 1999. Journal of General Physiology, 114 (1) pp. 13-30.
 
Mutations causing Liddle syndrome reduce sodium-dependent downregulation of the epithelial sodium channel in the Xenopus oocyte expression system.
Kellenberger S., Gautschi I., Rossier B.C., Schild L., 1998. Journal of Clinical Investigation, 101 (12) pp. 2741-2750.
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