Département de pharmacologie et toxicologie

Equipe principale | Groupe Bonny | Groupe Broillet | Groupe Cotecchia | Groupe Diviani | Groupe Firsov | Groupe Hummler | Groupe Katanaev | Groupe Kellenberger | Groupe Ocampo | Groupe Rossier | Groupe Schild | Groupe Staub
Publications | Mémoires et thèses

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25 publications

2019 | 2017 | 2016 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 |
 
Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive Na<sup>+</sup>/Cl<sup>-</sup> Cotransporter NCC and Transiently Affects Sodium Handling.
Canonica J., Frateschi S., Boscardin E., Ebering A., Sergi C., Jäger Y., Peyrollaz T., Mérillat A.M., Maillard M., Klusonova P. et al., 2019. Frontiers in physiology, 10 p. 989. Peer-reviewed.
Functional assessment of sodium chloride cotransporter NCC mutants in polarized mammalian epithelial cells.
Rosenbaek L.L., Rizzo F., MacAulay N., Staub O., Fenton R.A., 2017/08/01. American journal of physiology. Renal physiology, 313 (2) pp. F495-F504. Peer-reviewed.
AQP2 Abundance is Regulated by the E3-Ligase CHIP Via HSP70.
Centrone M., Ranieri M., Di Mise A., Berlingerio S.P., Russo A., Deen PMT, Staub O., Valenti G., Tamma G., 2017. Cellular Physiology and Biochemistry, 44 (2) pp. 515-531. Peer-reviewed.
Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC.
Al-Qusairi L., Basquin D., Roy A., Stifanelli M., Rajaram R.D., Debonneville A., Nita I., Maillard M., Loffing J., Subramanya A.R. et al., 2016/08/01. American journal of physiology. Renal physiology, 311 (2) pp. F330-42. Peer-reviewed.
USP2-45 Is a Circadian Clock Output Effector Regulating Calcium Absorption at the Post-Translational Level.
Pouly D., Chenaux S., Martin V., Babis M., Koch R., Nagoshi E., Katanaev V.L., Gachon F., Staub O., 2016. Plos One, 11 (1) pp. e0145155. Peer-reviewed.
 
A primary culture system of mouse thick ascending limb cells with preserved function and uromodulin processing.
Glaudemans B., Terryn S., Gölz N., Brunati M., Cattaneo A., Bachi A., Al-Qusairi L., Ziegler U., Staub O., Rampoldi L. et al., 2014. Pflügers Archiv : European Journal of Physiology, 466 (2) pp. 343-356. Peer-reviewed.
 
Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension.
Ronzaud C., Loffing-Cueni D., Hausel P., Debonneville A., Malsure S.R., Fowler-Jaeger N., Boase N.A., Perrier R., Maillard M., Yang B. et al., 2013. Journal of Clinical Investigation, 123 (2) pp. 657-665.
 
USP2-45 represses aldosterone mediated responses by decreasing mineralocorticoid receptor availability.
Faresse N., Debonneville A., Staub O., 2013. Cellular Physiology and Biochemistry, 31 (2-3) pp. 462-472.
 
Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype.
Faresse N., Lagnaz D., Debonneville A., Ismailji A., Maillard M., Fejes-Toth G., Náray-Fejes-Tóth A., Staub O., 2012. American Journal of Physiology. Renal Physiology, 302 (8) pp. F977-F985.
Nedd4-2 and the regulation of epithelial sodium transport.
Rotin D., Staub O., 2012. Frontiers In Physiology, 3 p. 212. Peer-reviewed.
 
Aldosterone paradox: differential regulation of ion transport in distal nephron.
Arroyo J.P., Ronzaud C., Lagnaz D., Staub O., Gamba G., 2011. Physiology, 26 (2) pp. 115-123.
 
Alveolar epithelial CNGA1 channels mediate cGMP-stimulated, amiloride-insensitive, lung liquid absorption.
Wilkinson W.J., Benjamin A.R., De Proost I., Orogo-Wenn M.C., Yamazaki Y., Staub O., Morita T., Adriaensen D., Riccardi D., Walters D.V. et al., 2011. Pflügers Archiv, 462 (2) pp. 267-279.
 
Intracellular ubiquitylation of the epithelial Na+ channel controls extracellular proteolytic channel activation via conformational change.
Ruffieux-Daidié D., Staub O., 2011. Journal of Biological Chemistry, 286 (4) pp. 2416-2424.
 
Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.
Arroyo J.P., Lagnaz D., Ronzaud C., Vázquez N., Ko B.S., Moddes L., Ruffieux-Daidié D., Hausel P., Koesters R., Yang B. et al., 2011. Journal of the American Society of Nephrology, 22 (9) pp. 1707-1719.
Role of the ubiquitin system in regulating ion transport.
Rotin D., Staub O., 2011. Pflügers Archiv, 461 (1) pp. 1-21.
 
Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2.
Oberfeld B., Ruffieux-Daidié D., Vitagliano J.J., Pos K.M., Verrey F., Staub O., 2011. American Journal of Physiology. Renal Physiology, 301 (1) pp. F189-F196.
 
Mineralocorticoid receptor degradation is promoted by Hsp90 inhibition and the ubiquitin-protein ligase CHIP.
Faresse N., Ruffieux-Daidie D., Salamin M., Gomez-Sanchez C.E., Staub O., 2010/12. American Journal of Physiology. Renal Physiology, 299 (6) pp. F1462-F1472. Peer-reviewed.
 
Stimulation of ENaC activity by rosiglitazone is PPARγ-dependent and correlates with SGK1 expression increase.
Renauld S., Tremblay K., Ait-Benichou S., Simoneau-Roy M., Garneau H., Staub O., Chraïbi A., 2010. Journal of Membrane Biology, 236 (3) pp. 259-270. Peer-reviewed.
 
Characterization and binding affinities of SmLANP: a new Schistosoma mansoni member of the ANP32 family of regulatory proteins.
Pinheiro C.S., Staub O., Mulvenna J., Loukas A., Jones M.K., Rabelo E.M., 2009. Molecular and Biochemical Parasitology, 165 (2) pp. 95-102.
 
hShroom1 links a membrane bound protein to the actin cytoskeleton.
Dye D.E., Karlen S., Rohrbach B., Staub O., Braathen L.R., Eidne K.A., Coombe D.R., 2009. Cellular and molecular life sciences : CMLS, 66 (4) pp. 681-696.
 
Deubiquitylation regulates activation and proteolytic cleavage of ENaC
Ruffieux-Daidie D., Poirot O., Boulkroun S., Verrey F., Kellenberger S., Staub O., 2008. Journal of the American Society of Nephrology, 19 (11) pp. 2170-2180. Peer-reviewed.
 
Liddle's syndrome caused by a novel missense mutation (P617L) of the epithelial sodium channel beta subunit.
Rossi E., Farnetti E., Debonneville A., Nicoli D., Grasselli C., Regolisti G., Negro A., Perazzoli F., Casali B., Mantero F. et al., 2008. Journal of Hypertension, 26 (5) pp. 921-927. Peer-reviewed.
 
Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain.
Bruce M.C., Kanelis V., Fouladkou F., Debonneville A., Staub O., Rotin D., 2008. Biochemical Journal, 415 (1) pp. 155-163.
 
Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2.
Shi P.P., Cao X.R., Sweezer E.M., Kinney T.S., Williams N.R., Husted R.F., Nair R., Weiss R.M., Williamson R.A., Sigmund C.D. et al., 2008. American Journal of Physiology. Renal physiology, 295 (2) pp. F462-F470. Peer-reviewed.
 
Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3
Boulkroun S., Ruffieux-Daidie D., Vitagliano J. J., Poirot O., Charles R. P., Lagnaz D., Firsov D., Kellenberger S., Staub O., 2008. American Journal of Physiology - Renal Physiology, 295 (4) pp. F889-F900. Peer-reviewed.
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