Département d'oncologie fondamentale

Equipe principale
Publications | Mémoires et thèses

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387 publications

 
Association of Checkpoint Inhibitor-Induced Toxic Effects With Shared Cancer and Tissue Antigens in Non-Small Cell Lung Cancer.
Berner F., Bomze D., Diem S., Ali O.H., Fässler M., Ring S., Niederer R., Ackermann C.J., Baumgaertner P., Pikor N. et al. JAMA oncology. Peer-reviewed.
 
Meta-Analysis in Metastatic Uveal Melanoma to Determine Progression-Free and Overall Survival Benchmarks: an International Rare Cancers Initiative (IRCI) Ocular Melanoma study.
Khoja L., Atenafu E.G., Suciu S., Leyvraz S., Sato T., Marshall E., Keilholz U., Zimmer L., Patel S.P., Piperno-Neumann S. et al. Annals of oncology. Peer-reviewed.
 
Diagnostic Nodes of Patient Selection for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Among Colorectal Cancer Patients: A Swiss National Multicenter Survey.
Steffen T., Putora P.M., Hübner M., Gloor B., Lehmann K., Kettelhack C., Adamina M., Peterli R., Schmidt J., Ris F. et al. Clinical colorectal cancer. Peer-reviewed.
 
The pro- and anti-tumor role of ILC2s.
Trabanelli S., Chevalier M.F., Derré L., Jandus C. Seminars in immunology. Peer-reviewed.
 
Biomodulina T partially restores immunosenescent CD4 and CD8 T cell compartments in the elderly.
Saavedra D., Fuertes S.A., Suárez G.M., González A., Lorenzo-Luaces P., García B., Aznar E., Mazorra Z., Crombet T., Speiser D.E. et al., 2019/09. Experimental gerontology, 124 p. 110633. Peer-reviewed.
 
Cancer Immunotherapy: A Simple Guide for Interventional Radiologists of New Therapeutic Approaches.
Digklia A., Duran R., Homicsko K., Kandalaft L.E., Hocquelet A., Orcurto A., Coukos G., Denys A., 2019/09. Cardiovascular and interventional radiology, 42 (9) pp. 1221-1229. Peer-reviewed.
 
CDK4 regulates lysosomal function and mTORC1 activation to promote cancer cell survival.
Martínez-Carreres L., Puyal J., Leal-Esteban L.C., Orpinell M., Castillo-Armengol J., Giralt A., Dergai O., Moret C., Barquissau V., Nasrallah A. et al., 2019/08/08. Cancer research. Peer-reviewed.
 
Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer.
Civenni G., Bosotti R., Timpanaro A., Vàzquez R., Merulla J., Pandit S., Rossi S., Albino D., Allegrini S., Mitra A. et al., 2019/08/06. Cell metabolism, 30 (2) pp. 303-318.e6. Peer-reviewed.
 
18F-FDG PET metabolic-to-morphological volume ratio predicts PD-L1 tumour expression and response to PD-1 blockade in non-small-cell lung cancer.
Jreige M., Letovanec I., Chaba K., Renaud S., Rusakiewicz S., Cristina V., Peters S., Krueger T., de Leval L., Kandalaft L.E. et al., 2019/08. European journal of nuclear medicine and molecular imaging, 46 (9) pp. 1859-1868. Peer-reviewed.
 
Rational combinations of immunotherapy with radiotherapy in ovarian cancer.
Herrera F.G., Irving M., Kandalaft L.E., Coukos G., 2019/08. The Lancet. Oncology, 20 (8) pp. e417-e433. Peer-reviewed.
 
High-throughput Screening of Human Tumor Antigen-specific CD4 T Cells, Including Neoantigen-reactive T Cells.
Costa-Nunes C., Cachot A., Bobisse S., Arnaud M., Genolet R., Baumgaertner P., Speiser D.E., Sousa Alves P.M., Sandoval F., Adotévi O. et al., 2019/07/15. Clinical cancer research, 25 (14) pp. 4320-4331. Peer-reviewed.
 
Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration of inflammatory immune cells in EGFR mutant lung tumors.
Ayeni D., Miller B., Kuhlmann A., Ho P.C., Robles-Oteiza C., Gaefele M., Levy S., de Miguel F.J., Perry C., Guan T. et al., 2019/07/10. Journal for immunotherapy of cancer, 7 (1) p. 172. Peer-reviewed.
 
SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules.
Daina A., Michielin O., Zoete V., 2019/07/02. Nucleic acids research, 47 (W1) pp. W357-W364. Peer-reviewed.
 
Attenuation of chronic antiviral T-cell responses through constitutive COX2-dependent prostanoid synthesis by lymph node fibroblasts.
Schaeuble K., Cannelle H., Favre S., Huang H.Y., Oberle S.G., Speiser D.E., Zehn D., Luther S.A., 2019/07. PLoS biology, 17 (7) pp. e3000072. Peer-reviewed.
 
Navigating metabolic pathways to enhance antitumour immunity and immunotherapy.
Li X., Wenes M., Romero P., Huang S.C., Fendt S.M., Ho P.C., 2019/07. Nature reviews. Clinical oncology, 16 (7) pp. 425-441. Peer-reviewed.
 
TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection.
Alfei F., Kanev K., Hofmann M., Wu M., Ghoneim H.E., Roelli P., Utzschneider D.T., von Hoesslin M., Cullen J.G., Fan Y. et al., 2019/07. Nature, 571 (7764) pp. 265-269. Peer-reviewed.
 
RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer.
Gbenedio O.M., Bonnans C., Grun D., Wang C.Y., Hatch A.J., Mahoney M.R., Barras D., Matli M., Miao Y., Garcia K.C. et al., 2019/06/25. JCI insight, 5. Peer-reviewed.
 
Mass spectrometry driven exploration reveals nuances of neoepitope-driven tumor rejection.
Ebrahimi-Nik H., Michaux J., Corwin W.L., Keller G.L., Shcheglova T., Pak H., Coukos G., Baker B.M., Mandoiu I.I., Bassani-Sternberg M. et al., 2019/06/20. JCI insight, 5. Peer-reviewed.
 
Internal radiation dosimetry of a <sup>152</sup>Tb-labeled antibody in tumor-bearing mice.
Cicone F., Gnesin S., Denoël T., Stora T., van der Meulen N.P., Müller C., Vermeulen C., Benešová M., Köster U., Johnston K. et al., 2019/06/11. EJNMMI research, 9 (1) p. 53. Peer-reviewed.
 
Therapeutic Regeneration of Lymphatic and Immune Cell Functions upon Lympho-organoid Transplantation.
Lenti E., Bianchessi S., Proulx S.T., Palano M.T., Genovese L., Raccosta L., Spinelli A., Drago D., Andolfo A., Alfano M. et al., 2019/06/11. Stem cell reports, 12 (6) pp. 1260-1268. Peer-reviewed.
 
Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors.
Dangaj D., Bruand M., Grimm A.J., Ronet C., Barras D., Duttagupta P.A., Lanitis E., Duraiswamy J., Tanyi J.L., Benencia F. et al., 2019/06/10. Cancer cell, 35 (6) pp. 885-900.e10. Peer-reviewed.
 
Bi-allelic Variants in DYNC1I2 Cause Syndromic Microcephaly with Intellectual Disability, Cerebral Malformations, and Dysmorphic Facial Features.
Ansar M., Ullah F., Paracha S.A., Adams D.J., Lai A., Pais L., Iwaszkiewicz J., Millan F., Sarwar M.T., Agha Z. et al., 2019/06/06. American journal of human genetics, 104 (6) pp. 1073-1087. Peer-reviewed.
 
Expression of Prox1 in Medullary Thyroid Carcinoma Is Associated with Chromogranin A and Calcitonin Expression and with Ki67 Proliferative Index, but Not with Prognosis.
Saglietti C., La Rosa S., Sykiotis G.P., Letovanec I., Bulliard J.L., Piana S., Mermod M., Petrova T., Uccella S., Sessa F. et al., 2019/06. Endocrine pathology, 30 (2) pp. 138-145. Peer-reviewed.
 
MicroRNA-155 Expression Is Enhanced by T-cell Receptor Stimulation Strength and Correlates with Improved Tumor Control in Melanoma.
Martinez-Usatorre A., Sempere L.F., Carmona S.J., Carretero-Iglesia L., Monnot G., Speiser D.E., Rufer N., Donda A., Zehn D., Jandus C. et al., 2019/06. Cancer immunology research, 7 (6) pp. 1013-1024. Peer-reviewed.
Re-education of macrophages as a therapeutic strategy in cancer.
Kowal J., Kornete M., Joyce J.A., 2019/06. Immunotherapy, 11 (8) pp. 677-689. Peer-reviewed.
 
Correction to: Vaccination with nanoparticles combined with micro-adjuvants protects against cancer.
Mohsen M.O., Heath M.D., Cabral-Miranda G., Lipp C., Zeltins A., Sande M., Stein J.V., Riether C., Roesti E., Zha L. et al., 2019/05/23..
 
Tumor Landscapes: β-Catenin Drives Immune Desertification.
Dangaj D., Barras D., Coukos G., 2019/05/15. Clinical cancer research, 25 (10) pp. 2943-2945. Peer-reviewed.
 
Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients.
Broggi MAS, Maillat L., Clement C.C., Bordry N., Corthésy P., Auger A., Matter M., Hamelin R., Potin L., Demurtas D. et al., 2019/05/06. The Journal of experimental medicine, 216 (5) pp. 1091-1107. Peer-reviewed.
 
Siglec-9 Regulates an Effector Memory CD8<sup>+</sup> T-cell Subset That Congregates in the Melanoma Tumor Microenvironment.
Haas Q., Boligan K.F., Jandus C., Schneider C., Simillion C., Stanczak M.A., Haubitz M., Seyed Jafari S.M., Zippelius A., Baerlocher G.M. et al., 2019/05. Cancer immunology research, 7 (5) pp. 707-718. Peer-reviewed.
Vaccination with nanoparticles combined with micro-adjuvants protects against cancer.
Mohsen M.O., Heath M.D., Cabral-Miranda G., Lipp C., Zeltins A., Sande M., Stein J.V., Riether C., Roesti E., Zha L. et al., 2019/04/26. Journal for immunotherapy of cancer, 7 (1) p. 114. Peer-reviewed.
The clinical application of cancer immunotherapy based on naturally circulating dendritic cells.
Bol K.F., Schreibelt G., Rabold K., Wculek S.K., Schwarze J.K., Dzionek A., Teijeira A., Kandalaft L.E., Romero P., Coukos G. et al., 2019/04/18. Journal for immunotherapy of cancer, 7 (1) p. 109. Peer-reviewed.
 
Maf deficiency in T cells dysregulates T<sub>reg</sub> - T<sub>H</sub>17 balance leading to spontaneous colitis.
Imbratta C., Leblond M.M., Bouzourène H., Speiser D.E., Velin D., Verdeil G., 2019/04/16. Scientific reports, 9 (1) p. 6135. Peer-reviewed.
 
γ-Catenin-Dependent Signals Maintain BCR-ABL1<sup>+</sup> B Cell Acute Lymphoblastic Leukemia.
Luong-Gardiol N., Siddiqui I., Pizzitola I., Jeevan-Raj B., Charmoy M., Huang Y., Irmisch A., Curtet S., Angelov G.S., Danilo M. et al., 2019/04/15. Cancer cell, 35 (4) pp. 649-663.e10. Peer-reviewed.
 
Correction: Tumour-reactive T cell subsets in the microenvironment of ovarian cancer.
Westergaard MCW, Andersen R., Chong C., Kjeldsen J.W., Pedersen M., Friese C., Hasselager T., Lajer H., Coukos G., Bassani-Sternberg M. et al., 2019/04..
 
Going Beyond the Sequences: TCR Binding Patterns at the Service of Cancer Detection.
Zoete V., Coukos G., 2019/04/01. Cancer research, 79 (7) pp. 1299-1301. Peer-reviewed.
 
Publisher Correction: Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle.
Cheng W.C., Tsui Y.C., Ragusa S., Koelzer V.H., Mina M., Franco F., Läubli H., Tschumi B., Speiser D., Romero P. et al., 2019/04..
 
Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer.
Lan Q., Peyvandi S., Duffey N., Huang Y.T., Barras D., Held W., Richard F., Delorenzi M., Sotiriou C., Desmedt C. et al., 2019/04. Oncogene, 38 (15) pp. 2814-2829. Peer-reviewed.
Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.
Niogret C., Miah SMS, Rota G., Fonta N.P., Wang H., Held W., Birchmeier W., Sexl V., Yang W., Vivier E. et al., 2019/03/29. Nature communications, 10 (1) p. 1444. Peer-reviewed.
 
Biallelic variants in FBXL3 cause intellectual disability, delayed motor development and short stature.
Ansar M., Paracha S.A., Serretti A., Sarwar M.T., Khan J., Ranza E., Falconnet E., Iwaszkiewicz J., Shah S.F., Qaisar A.A. et al., 2019/03/15. Human molecular genetics, 28 (6) pp. 972-979. Peer-reviewed.
 
Sculpting tumor microenvironment with immune system: from immunometabolism to immunoediting.
Yu Y.R., Ho P.C., 2019/03/15. Clinical and experimental immunology. Peer-reviewed.
Circulating CD56<sup>bright</sup> NK cells inversely correlate with survival of melanoma patients.
de Jonge K., Ebering A., Nassiri S., Maby-El Hajjami H., Ouertatani-Sakouhi H., Baumgaertner P., Speiser D.E., 2019/03/14. Scientific reports, 9 (1) p. 4487. Peer-reviewed.
 
The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance.
Vannini N., Campos V., Girotra M., Trachsel V., Rojas-Sutterlin S., Tratwal J., Ragusa S., Stefanidis E., Ryu D., Rainer P.Y. et al., 2019/03/07. Cell stem cell, 24 (3) pp. 405-418.e7. Peer-reviewed.
 
CD73 expression in normal and pathological human hepatobiliopancreatic tissues.
Sciarra A., Monteiro I., Ménétrier-Caux C., Caux C., Gilbert B., Halkic N., La Rosa S., Romero P., Sempoux C., de Leval L., 2019/03. Cancer immunology, immunotherapy, 68 (3) pp. 467-478. Peer-reviewed.
 
Correction to: CD73 expression in normal and pathological human hepatobiliopancreatic tissues
Sciarra Amedeo, Monteiro Inês, Ménétrier-Caux Christine, Caux Christophe, Gilbert Benoit, Halkic Nermin, La Rosa Stefano, Romero Pedro, Sempoux Christine, de Leval Laurence, 2019/03. 1.
Differential regulation of RNA polymerase III genes during liver regeneration.
Yeganeh M., Praz V., Carmeli C., Villeneuve D., Rib L., Guex N., Herr W., Delorenzi M., Hernandez N., CycliX consortium, 2019/02/28. Nucleic Acids Research, 47 (4) pp. 1786-1796. Peer-reviewed.
Mutations in the palm domain disrupt modulation of acid-sensing ion channel 1a currents by neuropeptides.
Bargeton B., Iwaszkiewicz J., Bonifacio G., Roy S., Zoete V., Kellenberger S., 2019/02/22. Scientific reports, 9 (1) p. 2599. Peer-reviewed.
50-Gy Stereotactic Body Radiation Therapy to the Dominant Intraprostatic Nodule: Results From a Phase 1a/b Trial.
Herrera F.G., Valerio M., Berthold D., Tawadros T., Meuwly J.Y., Vallet V., Baumgartner P., Thierry A.C., De Bari B., Jichlinski P. et al., 2019/02/01. International journal of radiation oncology, biology, physics, 103 (2) pp. 320-334. Peer-reviewed.
NK cells specifically TCR-dressed to kill cancer cells.
Mensali N., Dillard P., Hebeisen M., Lorenz S., Theodossiou T., Myhre M.R., Fåne A., Gaudernack G., Kvalheim G., Myklebust J.H. et al., 2019/02. EBioMedicine, 40 pp. 106-117. Peer-reviewed.
 
Prediction of Occult Lymph Node Metastasis in Head and Neck Cancer with CD31 Vessel Quantification.
Mermod M., Bongiovanni M., Petrova T., Goun E., Simon C., Tolstonog G., Monnier Y., 2019/02. Otolaryngology: head and neck surgery, 160 (2) pp. 277-283. Peer-reviewed.
 
Safety and Tolerability of Adoptive Cell Therapy in Cancer.
Wolf B., Zimmermann S., Arber C., Irving M., Trueb L., Coukos G., 2019/02. Drug safety, 42 (2) pp. 315-334. Peer-reviewed.
 
Tumour-reactive T cell subsets in the microenvironment of ovarian cancer.
Westergaard MCW, Andersen R., Chong C., Kjeldsen J.W., Pedersen M., Friese C., Hasselager T., Lajer H., Coukos G., Bassani-Sternberg M. et al., 2019/02. British journal of cancer, 120 (4) pp. 424-434. Peer-reviewed.
 
Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle.
Cheng W.C., Tsui Y.C., Ragusa S., Koelzer V.H., Mina M., Franco F., Läubli H., Tschumi B., Speiser D., Romero P. et al., 2019/02. Nature immunology, 20 (2) pp. 206-217. Peer-reviewed.
Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2.
Hendrikx S., Coso S., Prat-Luri B., Wetterwald L., Sabine A., Franco C.A., Nassiri S., Zangger N., Gerhardt H., Delorenzi M. et al., 2019/01/29. Cell reports, 26 (5) pp. 1227-1241.e6. Peer-reviewed.
Imaging endogenous macrophage iron deposits reveals a metabolic biomarker of polarized tumor macrophage infiltration and response to CSF1R breast cancer immunotherapy.
Leftin A., Ben-Chetrit N., Joyce J.A., Koutcher J.A., 2019/01/29. Scientific reports, 9 (1) p. 857. Peer-reviewed.
 
Intratumoral Tcf1<sup>+</sup>PD-1<sup>+</sup>CD8<sup>+</sup> T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy.
Siddiqui I., Schaeuble K., Chennupati V., Fuertes Marraco S.A., Calderon-Copete S., Pais Ferreira D., Carmona S.J., Scarpellino L., Gfeller D., Pradervand S. et al., 2019/01/15. Immunity, 50 (1) pp. 195-211.e10. Peer-reviewed.
 
A structural model of the immune checkpoint CD160-HVEM complex derived from HDX-mass spectrometry and molecular modeling.
Kuncewicz K., Spodzieja M., Sieradzan A., Karczyńska A., Dąbrowska K., Dadlez M., Speiser D.E., Derre L., Rodziewicz-Motowidło S., 2019/01/11. Oncotarget, 10 (4) pp. 536-550. Peer-reviewed.
 
Adrenomedullin Induces Cardiac Lymphangiogenesis After Myocardial Infarction and Regulates Cardiac Edema Via Connexin 43.
Trincot C.E., Xu W., Zhang H., Kulikauskas M.R., Caranasos T.G., Jensen B.C., Sabine A., Petrova T.V., Caron K.M., 2019/01/04. Circulation research, 124 (1) pp. 101-113. Peer-reviewed.
IL-15 and a Two-Step Maturation Process Improve Bone Marrow-Derived Dendritic Cell Cancer Vaccine
Mookerjee Ananda, Graciotti Michele, Kandalaft Lana E., 2019/01/04. Cancers, 11 (1) p. 40.
 
Addressing current challenges and future directions in immuno-oncology: expert perspectives from the 2017 NIBIT Foundation Think Tank, Siena, Italy.
Maio M., Coukos G., Ferrone S., Fox B.A., Fridman W.H., Garcia P.L., Lahn M., Provendier O., Russo V., Rüttinger D. et al., 2019/01. Cancer immunology, immunotherapy, 68 (1) pp. 1-9. Peer-reviewed.
 
Brief Report From the 3rd International Meeting on Bone Marrow Adiposity (BMA 2017).
Corsi A., Palmisano B., Tratwal J., Riminucci M., Naveiras O., 2019. Frontiers in endocrinology, 10 p. 336. Peer-reviewed.
Combination of Synthetic Long Peptides and XCL1 Fusion Proteins Results in Superior Tumor Control.
Botelho N.K., Tschumi B.O., Hubbell J.A., Swartz M.A., Donda A., Romero P., 2019. Frontiers in immunology, 10 p. 294. Peer-reviewed.
 
Determining Macrophage Polarization upon Metabolic Perturbation.
Liu P.S., Ho P.C., 2019. Methods in molecular biology, 1862 pp. 173-186. Peer-reviewed.
 
Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic β Cell Death and May Contribute to Type 1 Diabetes Development.
Guay C., Kruit J.K., Rome S., Menoud V., Mulder N.L., Jurdzinski A., Mancarella F., Sebastiani G., Donda A., Gonzalez B.J. et al., 2019. Cell Metabolism, 29 (2) pp. 348-361.e6. Peer-reviewed.
 
Nanowire Sensors in Cancer.
Doucey M.A., Carrara S., 2019/01. Trends in biotechnology, 37 (1) pp. 86-99. Peer-reviewed.
 
Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function.
Vigano S., Alatzoglou D., Irving M., Ménétrier-Caux C., Caux C., Romero P., Coukos G., 2019. Frontiers in immunology, 10 p. 925. Peer-reviewed.
 
Targeting Mutated Plus Germline Epitopes Confers Pre-clinical Efficacy of an Instantly Formulated Cancer Nano-Vaccine.
Mohsen M.O., Vogel M., Riether C., Muller J., Salatino S., Ternette N., Gomes A.C., Cabral-Miranda G., El-Turabi A., Ruedl C. et al., 2019. Frontiers in immunology, 10 p. 1015. Peer-reviewed.
 
Theranostics in Interventional Oncology: Versatile Carriers for Diagnosis and Targeted Image-Guided Minimally Invasive Procedures.
Degrauwe N., Hocquelet A., Digklia A., Schaefer N., Denys A., Duran R., 2019. Frontiers in pharmacology, 10 p. 450. Peer-reviewed.
 
Rational Design, Synthesis, and Pharmacological Characterization of Novel Ghrelin Receptor Inverse Agonists as Potential Treatment against Obesity-Related Metabolic Diseases.
Daina A., Giuliano C., Pietra C., Wang J., Chi Y., Zou Z., Li F., Yan Z., Zhou Y., Guainazzi A. et al., 2018/12/27. Journal of medicinal chemistry, 61 (24) pp. 11039-11060. Peer-reviewed.
 
Sparks Fly in PGE2-Modulated Macrophage Polarization.
Franco F., Wenes M., Ho P.C., 2018/12/18. Immunity, 49 (6) pp. 987-989. Peer-reviewed.
 
The Length Distribution and Multiple Specificity of Naturally Presented HLA-I Ligands.
Gfeller D., Guillaume P., Michaux J., Pak H.S., Daniel R.T., Racle J., Coukos G., Bassani-Sternberg M., 2018/12/15. Journal of immunology, 201 (12) pp. 3705-3716. Peer-reviewed.
 
Comprehensive Genomic Profiling of Patient-matched Head and Neck Cancer Cells: A Preclinical Pipeline for Metastatic and Recurrent Disease.
Nisa L., Barras D., Medová M., Aebersold D.M., Medo M., Poliaková M., Koch J., Bojaxhiu B., Eliçin O., Dettmer M.S. et al., 2018/12. Molecular cancer research, 16 (12) pp. 1912-1926. Peer-reviewed.
 
Estimating the Contribution of Proteasomal Spliced Peptides to the HLA-I Ligandome.
Mylonas R., Beer I., Iseli C., Chong C., Pak H.S., Gfeller D., Coukos G., Xenarios I., Müller M., Bassani-Sternberg M., 2018/12. Molecular & cellular proteomics, 17 (12) pp. 2347-2357. Peer-reviewed.
 
Two-Dimensional Label-Free Affinity Analysis of Tumor-Specific CD8 T Cells with a Biomimetic Plasmonic Sensor.
Soler M., Li X., John-Herpin A., Schmidt J., Coukos G., Altug H., 2018/11/26. ACS sensors, 3 (11) pp. 2286-2295. Peer-reviewed.
The conserved threonine-rich region of the HCF-1<sub>PRO</sub> repeat activates promiscuous OGT:UDP-GlcNAc glycosylation and proteolysis activities.
Kapuria V., Röhrig U.F., Waridel P., Lammers F., Borodkin V.S., van Aalten DMF, Zoete V., Herr W., 2018/11/16. The Journal of biological chemistry, 293 (46) pp. 17754-17768. Peer-reviewed.
 
Tannins from Syzygium guineense suppress Wnt signaling and proliferation of Wnt-dependent tumors through a direct effect on secreted Wnts.
Koval A., Pieme C.A., Queiroz E.F., Ragusa S., Ahmed K., Blagodatski A., Wolfender J.L., Petrova T.V., Katanaev V.L., 2018/10/28. Cancer letters, 435 pp. 110-120. Peer-reviewed.
Transcriptional regulation of murine natural killer cell development, differentiation and maturation.
Held W., Jeevan-Raj B., Charmoy M., 2018/09. Cellular and molecular life sciences, 75 (18) pp. 3371-3379. Peer-reviewed.
 
Immunometabolism in cancer at a glance.
Singer K., Cheng W.C., Kreutz M., Ho P.C., Siska P.J., 2018/08/02. Disease models & mechanisms, 11 (8) pp. -. Peer-reviewed.
 
Consensus guidelines for the use and interpretation of angiogenesis assays.
Nowak-Sliwinska P., Alitalo K., Allen E., Anisimov A., Aplin A.C., Auerbach R., Augustin H.G., Bates D.O., van Beijnum J.R., Bender RHF et al., 2018/08. Angiogenesis, 21 (3) pp. 425-532. Peer-reviewed.
 
The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity.
Castro W., Chelbi S.T., Niogret C., Ramon-Barros C., Welten SPM, Osterheld K., Wang H., Rota G., Morgado L., Vivier E. et al., 2018/08. Nature immunology, 19 (8) pp. 809-820. Peer-reviewed.
Formation of the Intrathymic Dendritic Cell Pool Requires CCL21-Mediated Recruitment of CCR7<sup>+</sup> Progenitors to the Thymus.
Cosway E.J., Ohigashi I., Schauble K., Parnell S.M., Jenkinson W.E., Luther S., Takahama Y., Anderson G., 2018/07/15. Journal of immunology, 201 (2) pp. 516-523. Peer-reviewed.
 
PD-1 Blockade Unleashes Effector Potential of Both High- and Low-Affinity Tumor-Infiltrating T Cells.
Martínez-Usatorre A., Donda A., Zehn D., Romero P., 2018/07/15. Journal of immunology, 201 (2) pp. 792-803. Peer-reviewed.
CART cells are prone to Fas- and DR5-mediated cell death.
Tschumi B.O., Dumauthioz N., Marti B., Zhang L., Schneider P., Mach J.P., Romero P., Donda A., 2018/07/13. Journal for immunotherapy of cancer, 6 (1) p. 71. Peer-reviewed.
 
TCR signal strength controls thymic differentiation of iNKT cell subsets.
Tuttle K.D., Krovi S.H., Zhang J., Bedel R., Harmacek L., Peterson L.K., Dragone L.L., Lefferts A., Halluszczak C., Riemondy K. et al., 2018/07/09. Nature communications, 9 (1) p. 2650. Peer-reviewed.
Autocrine Adenosine Regulates Tumor Polyfunctional CD73<sup>+</sup>CD4<sup>+</sup> Effector T Cells Devoid of Immune Checkpoints.
Gourdin N., Bossennec M., Rodriguez C., Vigano S., Machon C., Jandus C., Bauché D., Faget J., Durand I., Chopin N. et al., 2018/07/01. Cancer research, 78 (13) pp. 3604-3618. Peer-reviewed.
 
Mitochondria: A master regulator in macrophage and T cell immunity.
Liu P.S., Ho P.C., 2018/07. Mitochondrion, 41 pp. 45-50. Peer-reviewed.
 
PROX1 is a transcriptional regulator of MMP14.
Gramolelli S., Cheng J., Martinez-Corral I., Vähä-Koskela M., Elbasani E., Kaivanto E., Rantanen V., Tuohinto K., Hautaniemi S., Bower M. et al., 2018/06/22. Scientific reports, 8 (1) p. 9531. Peer-reviewed.
 
Mouse model of postsurgical primary tumor recurrence and regional lymph node metastasis progression in HPV-related head and neck cancer.
Mermod M., Hiou-Feige A., Bovay E., Roh V., Sponarova J., Bongiovanni M., Vermeer D.W., Lee J.H., Petrova T.V., Rivals J.P. et al., 2018/06/15. International journal of cancer, 142 (12) pp. 2518-2528. Peer-reviewed.
 
Gaining Insight Into Posttranslationally Modified HIV Antigens and Their Underlying Characteristics.
Marino F., 2018/06. Proteomics, 18 (12) pp. e1800041. Peer-reviewed.
 
Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness.
Costa Del Amo P., Lahoz-Beneytez J., Boelen L., Ahmed R., Miners K.L., Zhang Y., Roger L., Jones R.E., Marraco SAF, Speiser D.E. et al., 2018/06. PLoS biology, 16 (6) pp. e2005523. Peer-reviewed.
 
Label-Free Optofluidic Nanobiosensor Enables Real-Time Analysis of Single-Cell Cytokine Secretion.
Li X., Soler M., Szydzik C., Khoshmanesh K., Schmidt J., Coukos G., Mitchell A., Altug H., 2018/06. Small, 14 (26) pp. e1800698. Peer-reviewed.
Minimal Information About an Immuno-Peptidomics Experiment (MIAIPE).
Lill J.R., van Veelen P.A., Tenzer S., Admon A., Caron E., Elias J.E., Heck AJR, Marcilla M., Marino F., Müller M. et al., 2018/06. Proteomics, 18 (12) pp. e1800110. Peer-reviewed.
 
Overview of Genetically Engineered Mouse Models of Prostate Cancer and Their Applications in Drug Discovery.
Civenni G., Carbone G.M., Catapano C.V., 2018/06. Current protocols in pharmacology, 81 (1) pp. e39. Peer-reviewed.
 
Pan-SRC kinase inhibition blocks B-cell receptor oncogenic signaling in non-Hodgkin lymphoma.
Battistello E., Katanayeva N., Dheilly E., Tavernari D., Donaldson M.C., Bonsignore L., Thome M., Christie A.L., Murakami M.A., Michielin O. et al., 2018/05/24. Blood, 131 (21) pp. 2345-2356. Peer-reviewed.
The C-terminal extension landscape of naturally presented HLA-I ligands.
Guillaume P., Picaud S., Baumgaertner P., Montandon N., Schmidt J., Speiser D.E., Coukos G., Bassani-Sternberg M., Filippakopoulos P., Gfeller D., 2018/05/15. Proceedings of the National Academy of Sciences of the United States of America, 115 (20) pp. 5083-5088. Peer-reviewed.
 
Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges.
Fukumura D., Kloepper J., Amoozgar Z., Duda D.G., Jain R.K., 2018/05. Nature reviews. Clinical oncology, 15 (5) pp. 325-340. Peer-reviewed.
Human innate lymphoid cells (ILCs): Toward a uniform immune-phenotyping.
Trabanelli S., Gomez-Cadena A., Salomé B., Michaud K., Mavilio D., Landis B.N., Jandus P., Jandus C., 2018/05. Cytometry. Part B, Clinical cytometry, 94 (3) pp. 392-399. Peer-reviewed.
 
The challenges of modeling hormone receptor-positive breast cancer in mice.
Özdemir B.C., Sflomos G., Brisken C., 2018/05. Endocrine-related cancer, 25 (5) pp. R319-R330. Peer-reviewed.
 
Quantification of the next-generation oral anti-tumor drugs dabrafenib, trametinib, vemurafenib, cobimetinib, pazopanib, regorafenib and two metabolites in human plasma by liquid chromatography-tandem mass spectrometry.
Cardoso E., Mercier T., Wagner A.D., Homicsko K., Michielin O., Ellefsen-Lavoie K., Cagnon L., Diezi M., Buclin T., Widmer N. et al., 2018/04/15. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1083 pp. 124-136. Peer-reviewed.
 
Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer.
Tanyi J.L., Bobisse S., Ophir E., Tuyaerts S., Roberti A., Genolet R., Baumgartner P., Stevenson B.J., Iseli C., Dangaj D. et al., 2018/04/11. Science translational medicine, 10 (436) pp. NA. Peer-reviewed.
 
T cell-induced CSF1 promotes melanoma resistance to PD1 blockade.
Neubert N.J., Schmittnaegel M., Bordry N., Nassiri S., Wald N., Martignier C., Tillé L., Homicsko K., Damsky W., Maby-El Hajjami H. et al., 2018/04/11. Science translational medicine, 10 (436) pp. NA. Peer-reviewed.
 
Immune-related adverse events of immune checkpoint inhibitors and the impact of sex-what we know and what we need to learn.
Özdemir B.C., Coukos G., Wagner A.D., 2018/04/01. Annals of oncology, 29 (4) p. 1067. Peer-reviewed.
Peptide-MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations.
Rius C., Attaf M., Tungatt K., Bianchi V., Legut M., Bovay A., Donia M., Thor Straten P., Peakman M., Svane I.M. et al., 2018/04/01. Journal of immunology, 200 (7) pp. 2263-2279. Peer-reviewed.
The DNA methylome of DDR genes and benefit from RT or TMZ in IDH mutant low-grade glioma treated in EORTC 22033.
Bady P., Kurscheid S., Delorenzi M., Gorlia T., van den Bent M.J., Hoang-Xuan K., Vauléon É., Gijtenbeek A., Enting R., Thiessen B. et al., 2018/04. Acta neuropathologica, 135 (4) pp. 601-615. Peer-reviewed.
 
Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8<sup>+</sup> T Cells.
Bantug G.R., Fischer M., Grählert J., Balmer M.L., Unterstab G., Develioglu L., Steiner R., Zhang L., Costa ASH, Gubser P.M. et al., 2018/03/20. Immunity, 48 (3) pp. 542-555.e6. Peer-reviewed.
Sensitive and frequent identification of high avidity neo-epitope specific CD8 + T cells in immunotherapy-naive ovarian cancer.
Bobisse S., Genolet R., Roberti A., Tanyi J.L., Racle J., Stevenson B.J., Iseli C., Michel A., Le Bitoux M.A., Guillaume P. et al., 2018/03/15. Nature communications, 9 (1) p. 1092. Peer-reviewed.
 
High-throughput and Sensitive Immunopeptidomics Platform Reveals Profound Interferonγ-Mediated Remodeling of the Human Leukocyte Antigen (HLA) Ligandome.
Chong C., Marino F., Pak H., Racle J., Daniel R.T., Müller M., Gfeller D., Coukos G., Bassani-Sternberg M., 2018/03. Molecular & cellular proteomics, 17 (3) pp. 533-548. Peer-reviewed.
 
Innate lymphoid cells in antitumor immunity.
Salomé B., Jandus C., 2018/03. Journal of leukocyte biology, 103 (3) pp. 479-483. Peer-reviewed.
Suppression of Tcf1 by Inflammatory Cytokines Facilitates Effector CD8 T Cell Differentiation.
Danilo M., Chennupati V., Silva J.G., Siegert S., Held W., 2018/02/20. Cell reports, 22 (8) pp. 2107-2117. Peer-reviewed.
 
Correction to: Characterization of the first fully human anti-TEM1 scFv in models of solid tumor imaging and immunotoxin-based therapy.
Yuan X., Yang M., Chen X., Zhang X., Sukhadia S., Musolino N., Bao H., Chen T., Xu C., Wang Q. et al., 2018/02. Cancer immunology, immunotherapy, 67 (2) pp. 329-339. Peer-reviewed.
Correlation study between osteoporosis and hematopoiesis in the context of adjuvant chemotherapy for breast cancer.
Schyrr F., Wolfer A., Pasquier J., Nicoulaz A.L., Lamy O., Naveiras O., 2018/02. Annals of hematology, 97 (2) pp. 309-317. Peer-reviewed.
 
Educational Tools to Introduce Computer-Aided Drug Design to Students and to the Public at Large.
Daina A., Blatter M.C., Gerritsen V.B., Zoete V., 2018/02/01. Chimia, 72 (1) pp. 55-61. Peer-reviewed.
 
Immunotherapy: a new standard of care in thoracic malignancies? A summary of the European Respiratory Society research seminar of the Thoracic Oncology Assembly.
Costantini A., Grynovska M., Lucibello F., Moisés J., Pagès F., Tsao M.S., Shepherd F.A., Bouchaab H., Garassino M., Aerts JGJV et al., 2018/02. The European respiratory journal, 51 (2) pp. NA. Peer-reviewed.
 
Metabolic adaptation of macrophages in chronic diseases.
Di Conza G., Ho P.C., 2018/02/01. Cancer letters, 414 pp. 250-256. Peer-reviewed.
 
Rationale for immunological approaches to breast cancer therapy.
Monnot G.C., Romero P., 2018/02. Breast, 37 pp. 187-195. Peer-reviewed.
T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus.
Bovay A., Zoete V., Dolton G., Bulek A.M., Cole D.K., Rizkallah P.J., Fuller A., Beck K., Michielin O., Speiser D.E. et al., 2018/02. European journal of immunology, 48 (2) pp. 258-272. Peer-reviewed.
 
Tumour endothelial marker 1/endosialin-mediated targeting of human sarcoma.
Guo Y., Hu J., Wang Y., Peng X., Min J., Wang J., Matthaiou E., Cheng Y., Sun K., Tong X. et al., 2018/02. European journal of cancer, 90 pp. 111-121. Peer-reviewed.
 
A Long-Distance Relay-tionship between Tumor and Bone.
Soukup K., Joyce J.A., 2018/01/16. Immunity, 48 (1) pp. 13-16. Peer-reviewed.
Organ-specific lymphatic vasculature: From development to pathophysiology.
Petrova T.V., Koh G.Y., 2018/01/02. The Journal of experimental medicine, 215 (1) pp. 35-49. Peer-reviewed.
 
Androgen receptor functions as transcriptional repressor of cancer-associated fibroblast activation.
Clocchiatti A., Ghosh S., Procopio M.G., Mazzeo L., Bordignon P., Ostano P., Goruppi S., Bottoni G., Katarkar A., Levesque M. et al., 2018. The Journal of Clinical Investigation, 128 (12) pp. 5531-5548. Peer-reviewed.
 
Characterization of Mouse Mesenteric Lymphatic Valve Structure and Function.
Sabine A., Davis M.J., Bovay E., Petrova T.V., 2018. Methods in molecular biology, 1846 pp. 97-129. Peer-reviewed.
Correction to: CART cells are prone to Fas- and DR5-mediated cell death.
Tschumi B.O., Dumauthioz N., Marti B., Zhang L., Lanitis E., Irving M., Schneider P., Mach J.P., Coukos G., Romero P. et al., 2018. Journal for Immunotherapy of Cancer, 6 (1) p. 92. Peer-reviewed.
Haematopoietic cell transplantation in Switzerland, changes and results over 20 years: a report from the Swiss Blood Stem Cell Transplantation Working Group for Blood and Marrow Transplantation registry 1997-2016.
Passweg J.R., Baldomero H., Ansari M., Baerlocher G.M., Bargetzi M., Chalandon Y., Duchosal M.A., Gerull S., Güngör T., Halter J.P. et al., 2018. Swiss medical weekly, 148 pp. w14589. Peer-reviewed.
 
Induction of Paracrine Signaling in Metastatic Melanoma Cells by PPARγ Agonist Rosiglitazone Activates Stromal Cells and Enhances Tumor Growth.
Pich C., Meylan P., Mastelic-Gavillet B., Nguyen T.N., Loyon R., Trang B.K., Moser H., Moret C., Goepfert C., Hafner J. et al., 2018. Cancer Research, 78 (22) pp. 6447-6461. Peer-reviewed.
Inhibition of Membrane-Bound BAFF by the Anti-BAFF Antibody Belimumab.
Kowalczyk-Quintas C., Chevalley D., Willen L., Jandus C., Vigolo M., Schneider P., 2018. Frontiers in Immunology, 9 p. 2698. Peer-reviewed.
Lack of Adipocytes Alters Hematopoiesis in Lipodystrophic Mice.
Wilson A., Fu H., Schiffrin M., Winkler C., Koufany M., Jouzeau J.Y., Bonnet N., Gilardi F., Renevey F., Luther S.A. et al., 2018. Frontiers in immunology, 9 p. 2573. Peer-reviewed.
Lymphatic vessel density is associated with CD8<sup>+</sup> T cell infiltration and immunosuppressive factors in human melanoma.
Bordry N., Broggi MAS, de Jonge K., Schaeuble K., Gannon P.O., Foukas P.G., Danenberg E., Romano E., Baumgaertner P., Fankhauser M. et al., 2018. Oncoimmunology, 7 (8) pp. e1462878. Peer-reviewed.
 
Mass Spectrometry Based Immunopeptidomics for the Discovery of Cancer Neoantigens.
Bassani-Sternberg M., 2018. Methods in molecular biology, 1719 pp. 209-221. Peer-reviewed.
 
Metabolic Control of CD8<sup>+</sup> T Cell Fate Decisions and Antitumor Immunity.
Zhang L., Romero P., 2018/01. Trends in molecular medicine, 24 (1) pp. 30-48. Peer-reviewed.
 
Modulation of the peripheral blood transcriptome by the ingestion of probiotic yoghurt and acidified milk in healthy, young men.
Burton K.J., Pimentel G., Zangger N., Vionnet N., Drai J., McTernan P.G., Pralong F.P., Delorenzi M., Vergères G., 2018. PloS one, 13 (2) pp. e0192947. Peer-reviewed.
Multiple roles of lymphatic vessels in peripheral lymph node development.
Bovay E., Sabine A., Prat-Luri B., Kim S., Son K., Willrodt A.H., Olsson C., Halin C., Kiefer F., Betsholtz C. et al., 2018. The Journal of Experimental Medicine, 215 (11) pp. 2760-2777. Peer-reviewed.
 
Predicting Antigen Presentation-What Could We Learn From a Million Peptides?
Gfeller D., Bassani-Sternberg M., 2018. Frontiers in immunology, 9 p. 1716. Peer-reviewed.
Prophylactic vs. Therapeutic Treatment With P2Et Polyphenol-Rich Extract Has Opposite Effects on Tumor Growth.
Lasso P., Gomez-Cadena A., Urueña C., Donda A., Martinez-Usatorre A., Barreto A., Romero P., Fiorentino S., 2018. Frontiers in oncology, 8 p. 356. Peer-reviewed.
 
Tumor infiltrating lymphocytes in lymph node metastases of stage III melanoma correspond to response and survival in nine patients treated with ipilimumab at the time of stage IV disease.
Diem S., Hasan Ali O., Ackermann C.J., Bomze D., Koelzer V.H., Jochum W., Speiser D.E., Mertz K.D., Flatz L., 2018/01. Cancer immunology, immunotherapy, 67 (1) pp. 39-45. Peer-reviewed.
Tumor Resident Memory T Cells: New Players in Immune Surveillance and Therapy.
Dumauthioz N., Labiano S., Romero P., 2018. Frontiers in immunology, 9 p. 2076. Peer-reviewed.
 
Feeling Exhausted? Tuning Irf4 Energizes Dysfunctional T Cells.
Chennupati V., Held W., 2017/12/19. Immunity, 47 (6) pp. 1009-1011. Peer-reviewed.
Natural antisense transcripts drive a regulatory cascade controlling c-MYC transcription.
Napoli S., Piccinelli V., Mapelli S.N., Pisignano G., Catapano C.V., 2017/12/02. RNA biology, 14 (12) pp. 1742-1755. Peer-reviewed.
 
Cancer immunotherapy full speed ahead.
Melero I., Navarro B., Teijeira A., Coukos G., 2017/12/01. Annals of oncology, 28 (suppl_12) pp. xii1-xii2. Peer-reviewed.
 
Mechanisms regulating T-cell infiltration and activity in solid tumors.
Lanitis E., Dangaj D., Irving M., Coukos G., 2017/12/01. Annals of oncology, 28 (suppl_12) pp. xii18-xii32. Peer-reviewed.
 
Obesity and the tumor microenvironment.
Olson O.C., Quail D.F., Joyce J.A., 2017/12/01. Science, 358 (6367) pp. 1130-1131. Peer-reviewed.
 
A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux.
Jena P.V., Roxbury D., Galassi T.V., Akkari L., Horoszko C.P., Iaea D.B., Budhathoki-Uprety J., Pipalia N., Haka A.S., Harvey J.D. et al., 2017/11/28. ACS nano, 11 (11) pp. 10689-10703. Peer-reviewed.
 
Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression.
Bakst R.L., Xiong H., Chen C.H., Deborde S., Lyubchik A., Zhou Y., He S., McNamara W., Lee S.Y., Olson O.C. et al., 2017/11/15. Cancer research, 77 (22) pp. 6400-6414. Peer-reviewed.
Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data.
Racle J., de Jonge K., Baumgaertner P., Speiser D.E., Gfeller D., 2017/11/13. eLife, 6 pp. 1-25. Peer-reviewed.
Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas.
Yan D., Kowal J., Akkari L., Schuhmacher A.J., Huse J.T., West B.L., Joyce J.A., 2017/10/26. Oncogene, 36 (43) pp. 6049-6058. Peer-reviewed.
 
Peripheral Deletion of CD8 T Cells Requires p38 MAPK in Cross-Presenting Dendritic Cells.
Smith T., Lin X., Mello M., Marquardt K., Cheung J., Lu B., Sherman L.A., Verdeil G., 2017/10/15. Journal of immunology, 199 (8) pp. 2713-2720. Peer-reviewed.
All TIEd up: mechanisms of Schlemm's canal maintenance.
Bernier-Latmani J., Petrova T.V., 2017/10/02. The Journal of clinical investigation, 127 (10) pp. 3594-3597. Peer-reviewed.
 
More T Cells versus Better T Cells in Patients with Breast Cancer.
Speiser D.E., Verdeil G., 2017/10. Cancer discovery, 7 (10) pp. 1062-1064. Peer-reviewed.
RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation.
Kopparam J., Chiffelle J., Angelino P., Piersigilli A., Zangger N., Delorenzi M., Meylan E., 2017/10. Cell death and differentiation, 24 (10) pp. 1761-1771. Peer-reviewed.
Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis.
Trabanelli S., Chevalier M.F., Martinez-Usatorre A., Gomez-Cadena A., Salomé B., Lecciso M., Salvestrini V., Verdeil G., Racle J., Papayannidis C. et al., 2017/09/19. Nature communications, 8 (1) p. 593. Peer-reviewed.
 
Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma.
Fankhauser M., Broggi MAS, Potin L., Bordry N., Jeanbart L., Lund A.W., Da Costa E., Hauert S., Rincon-Restrepo M., Tremblay C. et al., 2017/09/13. Science translational medicine, 9 (407) pp. 1-13. Peer-reviewed.
Curtailed T-cell activation curbs effector differentiation and generates CD8<sup>+</sup> T cells with a naturally-occurring memory stem cell phenotype.
Zanon V., Pilipow K., Scamardella E., De Paoli F., De Simone G., Price D.A., Martinez Usatorre A., Romero P., Mavilio D., Roberto A. et al., 2017/09. European journal of immunology, 47 (9) pp. 1468-1476. Peer-reviewed.
 
Intestinal lymphatic vasculature: structure, mechanisms and functions.
Bernier-Latmani J., Petrova T.V., 2017/09. Nature reviews. Gastroenterology & hepatology, 14 (9) pp. 510-526. Peer-reviewed.
 
Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.
Janouskova H., El Tekle G., Bellini E., Udeshi N.D., Rinaldi A., Ulbricht A., Bernasocchi T., Civenni G., Losa M., Svinkina T. et al., 2017/09. Nature medicine, 23 (9) pp. 1046-1054. Peer-reviewed.
 
α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming.
Liu P.S., Wang H., Li X., Chao T., Teav T., Christen S., Di Conza G., Cheng W.C., Chou C.H., Vavakova M. et al., 2017/09. Nature immunology, 18 (9) pp. 985-994. Peer-reviewed.
 
A Case for a Human Immuno-Peptidome Project Consortium.
Caron E., Aebersold R., Banaei-Esfahani A., Chong C., Bassani-Sternberg M., 2017/08/15. Immunity, 47 (2) pp. 203-208. Peer-reviewed.
 
Label-free identification of activated T lymphocytes through tridimensional microsensors on chip.
Rollo E., Tenaglia E., Genolet R., Bianchi E., Harari A., Coukos G., Guiducci C., 2017/08/15. Biosensors & bioelectronics, 94 pp. 193-199. Peer-reviewed.
 
Long-Term Engraftment of Primary Bone Marrow Stromal Cells Repairs Niche Damage and Improves Hematopoietic Stem Cell Transplantation.
Abbuehl J.P., Tatarova Z., Held W., Huelsken J., 2017/08/03. Cell stem cell, 21 (2) pp. 241-255.e6. Peer-reviewed.
 
Metabolic Regulation of Tregs in Cancer: Opportunities for Immunotherapy.
Wang H., Franco F., Ho P.C., 2017/08. Trends in cancer, 3 (8) pp. 583-592. Peer-reviewed.
 
Microenvironmental regulation of tumour angiogenesis.
De Palma M., Biziato D., Petrova T.V., 2017/08. Nature reviews. Cancer, 17 (8) pp. 457-474. Peer-reviewed.
 
Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF.
Quail D.F., Olson O.C., Bhardwaj P., Walsh L.A., Akkari L., Quick M.L., Chen I.C., Wendel N., Ben-Chetrit N., Walker J. et al., 2017/08. Nature cell biology, 19 (8) pp. 974-987. Peer-reviewed.
TCR-ligand dissociation rate is a robust and stable biomarker of CD8+ T cell potency.
Allard M., Couturaud B., Carretero-Iglesia L., Duong M.N., Schmidt J., Monnot G.C., Romero P., Speiser D.E., Hebeisen M., Rufer N., 2017/07/20. JCI insight, 2 (14) pp. e92570. Peer-reviewed.
The Transcription Factor Tcf1 Contributes to Normal NK Cell Development and Function by Limiting the Expression of Granzymes.
Jeevan-Raj B., Gehrig J., Charmoy M., Chennupati V., Grandclément C., Angelino P., Delorenzi M., Held W., 2017/07/18. Cell reports, 20 (3) pp. 613-626. Peer-reviewed.
 
In silico and cell-based analyses reveal strong divergence between prediction and observation of T-cell-recognized tumor antigen T-cell epitopes.
Schmidt J., Guillaume P., Dojcinovic D., Karbach J., Coukos G., Luescher I., 2017/07/14. The Journal of biological chemistry, 292 (28) pp. 11840-11849. Peer-reviewed.
 
Characterisation of multifocal breast cancer using the 70-gene signature in clinical low-risk patients enrolled in the EORTC 10041/BIG 03-04 MINDACT trial.
Aalders K.C., Kuijer A., Straver M.E., Slaets L., Litiere S., Viale G., Van't Veer L.J., Glas A.M., Delorenzi M., van Dalen T. et al., 2017/07. European journal of cancer, 79 pp. 98-105. Peer-reviewed.
 
Identification of innate lymphoid cells in single-cell RNA-Seq data.
Suffiotti M., Carmona S.J., Jandus C., Gfeller D., 2017/07. Immunogenetics, 69 (7) pp. 439-450. Peer-reviewed.
Rapid and Continued T-Cell Differentiation into Long-term Effector and Memory Stem Cells in Vaccinated Melanoma Patients.
Gannon P.O., Baumgaertner P., Huber A., Iancu E.M., Cagnon L., Abed Maillard S., Maby-El Hajjami H., Speiser D.E., Rufer N., 2017/07/01. Clinical cancer research, 23 (13) pp. 3285-3296. Peer-reviewed.
 
Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells.
Genini D., Brambilla L., Laurini E., Merulla J., Civenni G., Pandit S., D'Antuono R., Perez L., Levy D.E., Pricl S. et al., 2017/06/20. Proceedings of the National Academy of Sciences of the United States of America, 114 (25) pp. E4924-E4933. Peer-reviewed.
Characterization of perfluorocarbon relaxation times and their influence on the optimization of fluorine-19 MRI at 3 tesla.
Colotti R., Bastiaansen JAM, Wilson A., Flögel U., Gonzales C., Schwitter J., Stuber M., van Heeswijk R.B., 2017/06. Magnetic resonance in medicine, 77 (6) pp. 2263-2271. Peer-reviewed.
Immunoregulation of Dendritic Cell Subsets by Inhibitory Receptors in Urothelial Cancer.
Chevalier M.F., Bohner P., Pieraerts C., Lhermitte B., Gourmaud J., Nobile A., Rotman S., Cesson V., Martin V., Legris A.S. et al., 2017/06. European urology, 71 (6) pp. 854-857. Peer-reviewed.
 
Reenergizing T cell anti-tumor immunity by harnessing immunometabolic checkpoints and machineries.
Ho P.C., Kaech S.M., 2017/06. Current opinion in immunology, 46 pp. 38-44. Peer-reviewed.
A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers.
Pisignano G., Napoli S., Magistri M., Mapelli S.N., Pastori C., Di Marco S., Civenni G., Albino D., Enriquez C., Allegrini S. et al., 2017/05/30. Nature communications, 8 p. 15622. Peer-reviewed.
The ovarian cancer oncobiome.
Banerjee S., Tian T., Wei Z., Shih N., Feldman M.D., Alwine J.C., Coukos G., Robertson E.S., 2017/05/30. Oncotarget, 8 (22) pp. 36225-36245. Peer-reviewed.
 
The pathogen-related yeast protein Pry1, a member of the CAP protein superfamily, is a fatty acid-binding protein.
Darwiche R., Mène-Saffrané L., Gfeller D., Asojo O.A., Schneiter R., 2017/05/19. The Journal of biological chemistry, 292 (20) pp. 8304-8314. Peer-reviewed.
TCF1(+) hepatitis C virus-specific CD8(+) T cells are maintained after cessation of chronic antigen stimulation.
Wieland D., Kemming J., Schuch A., Emmerich F., Knolle P., Neumann-Haefelin C., Held W., Zehn D., Hofmann M., Thimme R., 2017/05/03. Nature communications, 8 p. 15050. Peer-reviewed.
Prediction of overall survival in stage II and III colon cancer beyond TNM system: a retrospective, pooled biomarker study.
Dienstmann R., Mason M.J., Sinicrope F.A., Phipps A.I., Tejpar S., Nesbakken A., Danielsen S.A., Sveen A., Buchanan D.D., Clendenning M. et al., 2017/05/01. Annals of oncology, 28 (5) pp. 1023-1031. Peer-reviewed.
Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents.
Olson O.C., Kim H., Quail D.F., Foley E.A., Joyce J.A., 2017/04/04. Cell reports, 19 (1) pp. 101-113. Peer-reviewed.
 
Broad and Conserved Immune Regulation by Genetically Heterogeneous Melanoma Cells.
Neubert N.J., Tillé L., Barras D., Soneson C., Baumgaertner P., Rimoldi D., Gfeller D., Delorenzi M., Fuertes Marraco S.A., Speiser D.E., 2017/04/01. Cancer research, 77 (7) pp. 1623-1636. Peer-reviewed.
Integrative clinicopathological and molecular analyses of angioimmunoblastic T-cell lymphoma and other nodal lymphomas of follicular helper T-cell origin.
Dobay M.P., Lemonnier F., Missiaglia E., Bastard C., Vallois D., Jais J.P., Scourzic L., Dupuy A., Fataccioli V., Pujals A. et al., 2017/04. Haematologica, 102 (4) pp. e148-e151. Peer-reviewed.
 
Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia.
Frismantas V., Dobay M.P., Rinaldi A., Tchinda J., Dunn S.H., Kunz J., Richter-Pechanska P., Marovca B., Pail O., Jenni S. et al., 2017/03/16. Blood, 129 (11) pp. e26-e37. Peer-reviewed.
Metabolic origins of spatial organization in the tumor microenvironment.
Carmona-Fontaine C., Deforet M., Akkari L., Thompson C.B., Joyce J.A., Xavier J.B., 2017/03/14. Proceedings of the National Academy of Sciences of the United States of America, 114 (11) pp. 2934-2939. Peer-reviewed.
Heterogeneity assessment of functional T cell avidity.
Ioannidou K., Baumgaertner P., Gannon P.O., Speiser M.F., Allard M., Hebeisen M., Rufer N., Speiser D.E., 2017/03/13. Scientific reports, 7 p. 44320. Peer-reviewed.
 
The Microenvironmental Landscape of Brain Tumors.
Quail D.F., Joyce J.A., 2017/03/13. Cancer cell, 31 (3) pp. 326-341. Peer-reviewed.
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules.
Daina A., Michielin O., Zoete V., 2017/03/03. Scientific reports, 7 p. 42717. Peer-reviewed.
 
Indoleamine 2,3-dioxygenase in psoriasis: a defective mechanism.
Trabanelli S., 2017/03. The British journal of dermatology, 176 (3) pp. 570-572. Peer-reviewed.
Single-cell transcriptome analysis of fish immune cells provides insight into the evolution of vertebrate immune cell types.
Carmona S.J., Teichmann S.A., Ferreira L., Macaulay I.C., Stubbington M.J., Cvejic A., Gfeller D., 2017/03. Genome research, 27 (3) pp. 451-461. Peer-reviewed.
 
Molecular Pathways: Deciphering Mechanisms of Resistance to Macrophage-Targeted Therapies.
Quail D.F., Joyce J.A., 2017/02/15. Clinical cancer research, 23 (4) pp. 876-884. Peer-reviewed.
Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens.
MacLachlan B.J., Greenshields-Watson A., Mason G.H., Schauenburg A.J., Bianchi V., Rizkallah P.J., Sewell A.K., Fuller A., Cole D.K., 2017/02/06. Journal of visualized experiments 120 p. 0. Peer-reviewed.
 
Intravesical Bacillus Calmette Guerin Combined with a Cancer Vaccine Increases Local T-Cell Responses in Non-muscle-Invasive Bladder Cancer Patients.
Derré L., Cesson V., Lucca I., Cerantola Y., Valerio M., Fritschi U., Vlamopoulos Y., Burruni R., Legris A.S., Dartiguenave F. et al., 2017/02/01. Clinical cancer research, 23 (3) pp. 717-725. Peer-reviewed.
 
T memory stem cells in health and disease.
Gattinoni L., Speiser D.E., Lichterfeld M., Bonini C., 2017/01/06. Nature medicine, 23 (1) pp. 18-27. Peer-reviewed.
'Hotspots' of Antigen Presentation Revealed by Human Leukocyte Antigen Ligandomics for Neoantigen Prioritization.
Müller M., Gfeller D., Coukos G., Bassani-Sternberg M., 2017. Frontiers in Immunology, 8 p. 1367. Peer-reviewed.
A BARF1-specific mAb as a new immunotherapeutic tool for the management of EBV-related tumors.
Turrini R., Merlo A., Martorelli D., Faè D.A., Sommaggio R., Montagner I.M., Barbieri V., Marin O., Zanovello P., Dolcetti R. et al., 2017. Oncoimmunology, 6 (4) pp. e1304338. Peer-reviewed.
Alpha-Galactosylceramide/CD1d-Antibody Fusion Proteins Redirect Invariant Natural Killer T Cell Immunity to Solid Tumors and Promote Prolonged Therapeutic Responses.
Zhang L., Donda A., 2017. Frontiers in immunology, 8 p. 1417. Peer-reviewed.
 
ATP Release from Chemotherapy-Treated Dying Leukemia Cells Elicits an Immune Suppressive Effect by Increasing Regulatory T Cells and Tolerogenic Dendritic Cells.
Lecciso M., Ocadlikova D., Sangaletti S., Trabanelli S., De Marchi E., Orioli E., Pegoraro A., Portararo P., Jandus C., Bontadini A. et al., 2017. Frontiers in immunology, 8 p. 1918. Peer-reviewed.
Caloric dose-responsive genes in blood cells differentiate the metabolic status of obese men.
Gille D., Zangger N., Soneson C., Bütikofer U., Delorenzi M., Schwander F., Kopf-Bolanz K.A., Chollet M., Walther B., Laederach K. et al., 2017. The Journal of Nutritional Biochemistry, 43 pp. 156-165. Peer-reviewed.
 
CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation.
Lopez-Mejia I.C., Lagarrigue S., Giralt A., Martinez-Carreres L., Zanou N., Denechaud P.D., Castillo-Armengol J., Chavey C., Orpinell M., Delacuisine B. et al., 2017. Molecular Cell, 68 (2) pp. 336-349.e6. Peer-reviewed.
 
Correlation between podoplanin expression and extracapsular spread in squamous cell carcinoma of the oral cavity using subjective immunoreactivity scores and semiquantitative image analysis.
Mermod M., Bongiovanni M., Petrova T.V., Dubikovskaya E.A., Simon C., Tolstonog G., Monnier Y., 2017/01. Head & neck, 39 (1) pp. 98-108. Peer-reviewed.
 
Cx47 fine-tunes the handling of serum lipids but is dispensable for lymphatic vascular function.
Meens M.J., Kutkut I., Rochemont V., Dubrot J., Kaladji F.R., Sabine A., Lyons O., Hendrikx S., Bernier-Latmani J., Kiefer F. et al., 2017. PloS one, 12 (7) pp. e0181476. Peer-reviewed.
 
Cyclophosphamide treatment regulates the balance of functional/exhausted tumor-specific CD8(+) T cells.
Hanoteau A., Henin C., Svec D., Bisilliat Donnet C., Denanglaire S., Colau D., Romero P., Leo O., Van den Eynde B., Moser M., 2017. Oncoimmunology, 6 (8) pp. e1318234. Peer-reviewed.
Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity.
Bassani-Sternberg M., Chong C., Guillaume P., Solleder M., Pak H., Gannon P.O., Kandalaft L.E., Coukos G., Gfeller D., 2017. PLoS Computational Biology, 13 (8) pp. e1005725. Peer-reviewed.
Design of short peptides to block BTLA/HVEM interactions for promoting anticancer T-cell responses.
Spodzieja M., Lach S., Iwaszkiewicz J., Cesson V., Kalejta K., Olive D., Michielin O., Speiser D.E., Zoete V., Derré L. et al., 2017. PloS one, 12 (6) pp. e0179201.
 
Differential role of Interleukin-1 and Interleukin-6 in K-Ras-driven pancreatic carcinoma undergoing mesenchymal transition.
Siddiqui I., Erreni M., Kamal M.A., Porta C., Marchesi F., Pesce S., Pasqualini F., Schiarea S., Chiabrando C., Mantovani A. et al., 2017. Oncoimmunology, 7 (2) pp. e1388485. Peer-reviewed.
 
Dysregulated Innate Lymphocytes in Patients With Primary Antibody Deficiency Treated With Intravenous Immunoglobulin.
Vigano S., Trabanelli S., Indulsi F., Salomé B., Harari A., Romero P., Helbling A., Jandus C., Jandus P., 2017. Journal of investigational allergology & clinical immunology, 27 (6) pp. 394-396. Peer-reviewed.
Editorial: Immunometabolic Regulations in Adaptive and Innate Immune Cells Shapes and Re-Directs Host Immunity.
Ho P.C., Hess C., 2017. Frontiers in immunology, 8 p. 852. Peer-reviewed.
Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel.
Irving M., Vuillefroy de Silly R., Scholten K., Dilek N., Coukos G., 2017. Frontiers in immunology, 8 p. 267. Peer-reviewed.
Fine-Tuning of Optimal TCR Signaling in Tumor-Redirected CD8 T Cells by Distinct TCR Affinity-Mediated Mechanisms
Presotto D., Erdes E., Duong M.N., Allard M., Regamey P.O., Quadroni M., Doucey M.A., Rufer N., Hebeisen M., 2017. Frontiers in Immunology, 8 p. 1564. Peer-reviewed.
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