Département d'oncologie fondamentale

Equipe principale
Publications | Mémoires et thèses

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659 publications

En préparation
 
The human CD8 T stem cell-like memory phenotype appears in the acute phase in Yellow Fever virus vaccination
Marraco Silvia A. Fuertes, Bovay Amandine, Nassiri Sina, Maby-El Hajjami Hélène, Ouertatani-Sakouhi Hajer, Held Werner, Speiser Daniel E..
[DOI][serval:BIB_D644B7DF7CE4]
 
NFAT5 induction by the tumor microenvironment enforces CD8 T cell exhaustion
Tillé Laure, Cropp Daniela, Bodley Gabrielle, Andreatta Massimo, Charmoy Mélanie, Crespo Isaac, Nassiri Sina, Lourenco Joao, Leblond Marine, Lopez-Rodriguez Cristina et al..
[DOI][serval:BIB_3D15B154D604]
Sous presse
 
Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells.
Colucci M., Zumerle S., Bressan S., Gianfanti F., Troiani M., Valdata A., D'Ambrosio M., Pasquini E., Varesi A., Cogo F. et al. Cancer cell. Peer-reviewed.
[DOI][Pmid][serval:BIB_F2A7089B8C4C]
 
Acute hypoxia does not alter tumor sensitivity to FLASH radiotherapy.
Leavitt R.J., Almeida A., Grilj V., Montay-Gruel P., Godfroid C., Petit B., Bailat C., Limoli C.L., Vozenin M.C. International journal of radiation oncology, biology, physics. Peer-reviewed.
[DOI][Pmid][serval:BIB_44E104806F28]
2024
 
A tetravalent nanovaccine that inhibits growth of HPV-associated head and neck carcinoma via dendritic and T cell activation.
Josi R., Speiser D.E., de Brot S., Vogt A.C., Sevick-Muraca E.M., Tolstonog G.V., Bachmann M.F., Mohsen M.O., 2024/04/19. iScience, 27 (4) p. 109439. Peer-reviewed.
[DOI][Pmid][serval:BIB_958F1E78AC86]
Antitumor Effect by Either FLASH or Conventional Dose Rate Irradiation Involves Equivalent Immune Responses.
Almeida A., Godfroid C., Leavitt R.J., Montay-Gruel P., Petit B., Romero J., Ollivier J., Meziani L., Sprengers K., Paisley R. et al., 2024/03/15. International journal of radiation oncology, biology, physics, 118 (4) pp. 1110-1122. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_E2E833E715DF]
 
Immunopeptidomics-based identification of naturally presented non-canonical circRNA-derived peptides.
Ferreira H.J., Stevenson B.J., Pak H., Yu F., Almeida Oliveira J., Huber F., Taillandier-Coindard M., Michaux J., Ricart-Altimiras E., Kraemer A.I. et al., 2024/03/15. Nature communications, 15 (1) p. 2357. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_6C0EA9079104]
 
Metabolic interplay: tumor macrophages and regulatory T cells.
Vilbois S., Xu Y., Ho P.C., 2024/03. Trends in cancer, 10 (3) pp. 242-255. Peer-reviewed.
[DOI][Pmid][serval:BIB_0E0F7603EBDF]
Immunosurveillance encounters cancer metabolism.
Chuang Y.M., Tzeng S.F., Ho P.C., Tsai C.H., 2024/02. EMBO reports, 25 (2) pp. 471-488. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_A1C1A9A9C8FE]
The mixed effect of Endocrine-Disrupting chemicals on biological age Acceleration: Unveiling the mechanism and potential intervention target.
Huang W., Zhang Z., Colucci M., Deng L., Yang M., Huang X., Zhou X., Jin Y., Lazzarini E., Balbi C. et al., 2024/02. Environment international, 184 p. 108447. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_24D689BA2E25]
Immuno-Transcriptomic Profiling of Blood and Tumor Tissue Identifies Gene Signatures Associated with Immunotherapy Response in Metastatic Bladder Cancer.
Desponds E., Croci D., Wosika V., Hadadi N., Fonseca Costa S.S., Ciarloni L., Ongaro M., Zdimerova H., Leblond M.M., Hosseinian Ehrensberger S. et al., 2024/01/19. Cancers, 16 (2) p. 433. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_0B06832BCD28]
2023
 
Successful Allergen-Specific Immunotherapy: Induction of Unresponsiveness by 'Vaccination'.
Bachmann M.F., Vogel M., Speiser D.E., 2023/12/14. Vaccines, 11 (12) p. 1852. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_0FACE41FBAC4]
 
Combinatorial Treatment with PARP and MAPK Inhibitors Overcomes Phenotype Switch-Driven Drug Resistance in Advanced Melanoma.
Ferretti L.P., Böhi F., Leslie Pedrioli D.M., Cheng P.F., Ferrari E., Baumgaertner P., Alvarado-Diaz A., Sella F., Cereghetti A., Turko P. et al., 2023/12/01. Cancer research, 83 (23) pp. 3974-3988. Peer-reviewed.
[DOI][Pmid][serval:BIB_89C72729E6A6]
 
The potential role of the microbiota in prostate cancer pathogenesis and treatment.
Pernigoni N., Guo C., Gallagher L., Yuan W., Colucci M., Troiani M., Liu L., Maraccani L., Guccini I., Migliorini D. et al., 2023/12. Nature reviews. Urology, 20 (12) pp. 706-718. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_98A4542D9F6F]
Emergence and fate of stem cell-like Tcf7<sup>+</sup> CD8<sup>+</sup> T cells during a primary immune response to viral infection.
Silva J.G., Pais Ferreira D., Dumez A., Wyss T., Veber R., Danilo M., Pinschewer D.D., Charmoy M., Held W., 2023/11/17. Science immunology, 8 (89) pp. eadh3113. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_0FB9CCAB8627]
Clonal expansion of intra-epithelial T cells in breast cancer revealed by spatial transcriptomics.
Romanens L., Chaskar P., Marcone R., Ryser S., Tille J.C., Genolet R., Heimgartner-Hu K., Heimgartner K., Moore J.S., Liaudet N. et al., 2023/11/01. International journal of cancer, 153 (9) pp. 1568-1578. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_BA0A2EA97728]
 
A phase 1 trial of adoptive transfer of vaccine-primed autologous circulating T cells in ovarian cancer.
Bobisse S., Bianchi V., Tanyi J.L., Sarivalasis A., Missiaglia E., Pétremand R., Benedetti F., Torigian D.A., Genolet R., Barras D. et al., 2023/10. Nature cancer, 4 (10) pp. 1410-1417. Peer-reviewed.
[DOI][Pmid][serval:BIB_E6692BB52E6C]
Activation of the transcription factor NFAT5 in the tumor microenvironment enforces CD8+ T cell exhaustion.
Tillé L., Cropp D., Charmoy M., Reichenbach P., Andreatta M., Wyss T., Bodley G., Crespo I., Nassiri S., Lourenco J. et al., 2023/10. Nature immunology, 24 (10) pp. 1645-1653. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_9B944FAF7B77]
 
Regulatory circuits of mitophagy restrict distinct modes of cell death during memory CD8<sup>+</sup> T cell formation.
Franco F., Bevilacqua A., Wu R.M., Kao K.C., Lin C.P., Rousseau L., Peng F.T., Chuang Y.M., Peng J.J., Park J. et al., 2023/09/29. Science immunology, 8 (87) pp. eadf7579. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_22AAC08FD04B]
IL-18 and VEGF-A trigger type 2 innate lymphoid cell accumulation and pro-tumoral function in chronic myeloid leukemia.
Fiordi B., Salvestrini V., Gugliotta G., Castagnetti F., Curti A., Speiser D.E., Marcenaro E., Jandus C., Trabanelli S., 2023/09/01. Haematologica, 108 (9) pp. 2396-2409. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_D5F179D9065E]
Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems.
Girotra M., Chiang Y.H., Charmoy M., Ginefra P., Hope H.C., Bataclan C., Yu Y.R., Schyrr F., Franco F., Geiger H. et al., 2023/09. Nature aging, 3 (9) pp. 1057-1066. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_E2F47D89B9B9]
 
Reductive carboxylation epigenetically instructs T cell differentiation.
Jaccard A., Wyss T., Maldonado-Pérez N., Rath J.A., Bevilacqua A., Peng J.J., Lepez A., Von Gunten C., Franco F., Kao K.C. et al., 2023/09. Nature, 621 (7980) pp. 849-856. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D1AE6E79E2FB]
 
Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies FIXER, a Conserved Profibrogenic Long Noncoding RNA.
Aghagolzadeh P., Plaisance I., Bernasconi R., Treibel T.A., Pulido Quetglas C., Wyss T., Wigger L., Nemir M., Sarre A., Chouvardas P. et al., 2023/08/29. Circulation, 148 (9) pp. 778-797. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F232AC7CF36C]
Methionine oxidation selectively enhances T cell reactivity against a melanoma antigen.
Chiriţoiu G.N., Munteanu CVA, Şulea T.A., Spiridon L., Petrescu A.J., Jandus C., Romero P., Petrescu Ş.M., 2023/07/21. iScience, 26 (7) p. 107205. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_2C13DCF0D25D]
Obesity-associated changes in molecular biology of primary breast cancer.
Nguyen H.L., Geukens T., Maetens M., Aparicio S., Bassez A., Borg A., Brock J., Broeks A., Caldas C., Cardoso F. et al., 2023/07/21. Nature communications, 14 (1) p. 4418. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_937F9691B6B2]
 
Author Correction: Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer.
Troiani M., Colucci M., D'Ambrosio M., Guccini I., Pasquini E., Varesi A., Valdata A., Mosole S., Revandkar A., Attanasio G. et al., 2023/07/20. Nature communications, 14 (1) p. 4386. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_20FABFC4E382]
Phenotype and Reactivity of Lymphocytes Expanded from Benign Prostate Hyperplasic Tissues and Prostate Cancer.
Ahmed R., Lozano L.E., Anastasio A., Lofek S., Mastelic-Gavillet B., Navarro Rodrigo B., Nguyen S., Dartiguenave F., Rodrigues-Dias S.C., Cesson V. et al., 2023/06/08. Cancers, 15 (12) p. 3114. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4F3B91EA43E2]
Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors.
Schmidt J., Chiffelle J., Perez MAS, Magnin M., Bobisse S., Arnaud M., Genolet R., Cesbron J., Barras D., Navarro Rodrigo B. et al., 2023/06/06. Nature communications, 14 (1) p. 3188. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_2898FB2D9415]
Mechanosensitive mTORC1 signaling maintains lymphatic valves.
Saygili Demir C., Sabine A., Gong M., Dormond O., Petrova T.V., 2023/06/05. The Journal of cell biology, 222 (6) pp. e202207049. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_94B65F6FC376]
 
Hugh Robson MacDonald (1946-2023).
Wilson A., Ferrero I., Speiser D.E., Held W., Romero P., 2023/05/09. Immunity, 56 (5) pp. 893-894. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_BE6A0AFFEA73]
Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8+ T cells.
Corria-Osorio J., Carmona S.J., Stefanidis E., Andreatta M., Ortiz-Miranda Y., Muller T., Rota I.A., Crespo I., Seijo B., Castro W. et al., 2023/05. Nature immunology, 24 (5) pp. 869-883. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B6529135A8DD]
TCR sequencing and cloning methods for repertoire analysis and isolation of tumor-reactive TCRs.
Genolet R., Bobisse S., Chiffelle J., Arnaud M., Petremand R., Queiroz L., Michel A., Reichenbach P., Cesbron J., Auger A. et al., 2023/04/24. Cell reports methods, 3 (4) p. 100459. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_AC23FF064822]
The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection.
Marx A.F., Kallert S.M., Brunner T.M., Villegas J.A., Geier F., Fixemer J., Abreu-Mota T., Reuther P., Bonilla W.V., Fadejeva J. et al., 2023/04/11. Immunity, 56 (4) pp. 813-828.e10. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_796365D38E1A]
Endothelial cell-derived oxysterol ablation attenuates experimental autoimmune encephalomyelitis.
Ruiz F., Peter B., Rebeaud J., Vigne S., Bressoud V., Roumain M., Wyss T., Yersin Y., Wagner I., Kreutzfeldt M. et al., 2023/03/06. EMBO reports, 24 (3) pp. e55328. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_89C0C5C31546]
Assessing the Impact of Persistent HIV Infection on Innate Lymphoid Cells Using In Vitro Models.
Boulay A., Trabanelli S., Boireau S., Boyer-Clavel M., Nisole S., Romero P., Jandus C., Beignon A.S., Arhel N.J., 2023/03/01. ImmunoHorizons, 7 (3) pp. 243-255. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_032D423D930B]
 
CD4+ T cells in cancer.
Speiser D.E., Chijioke O., Schaeuble K., Münz C., 2023/03. Nature cancer, 4 (3) pp. 317-329. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_4DD9885D9151]
 
Neoantigen-targeted CD8+ T cell responses with PD-1 blockade therapy.
Puig-Saus C., Sennino B., Peng S., Wang C.L., Pan Z., Yuen B., Purandare B., An D., Quach B.B., Nguyen D. et al., 2023/03. Nature, 615 (7953) pp. 697-704. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_B490E5522790]
 
Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells.
Sacirbegovic F., Günther M., Greco A., Zhao D., Wang X., Zhou M., Rosenberger S., Oberbarnscheidt M.H., Held W., McNiff J. et al., 2023/02/14. Immunity, 56 (2) pp. 369-385.e6. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_84CE58F053D5]
Dendritic cells direct circadian anti-tumour immune responses.
Wang C., Barnoud C., Cenerenti M., Sun M., Caffa I., Kizil B., Bill R., Liu Y., Pick R., Garnier L. et al., 2023/02. Nature, 614 (7946) pp. 136-143. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_33489F389D05]
 
A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link between metastasis and NAD+ metabolism.
Maric T., Bazhin A., Khodakivskyi P., Mikhaylov G., Solodnikova E., Yevtodiyenko A., Giordano Attianese GMP, Coukos G., Irving M., Joffraud M. et al., 2023/01/15. Biosensors & bioelectronics, 220 p. 114826. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C15EADDDA9C7]
Longitudinal analysis of DC subsets in patients with ovarian cancer: Implications for immunotherapy.
Mastelic-Gavillet B., Sarivalasis A., Lozano L.E., Lofek S., Wyss T., Melero I., de Vries IJM, Harari A., Romero P., Kandalaft L.E. et al., 2023. Frontiers in immunology, 14 p. 1119371. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_93460C0AF320]
2022
 
Addendum: Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma.
Schaller J., Hajjami H.M., Rusakiewicz S., Ioannidou K., Piazzon N., Miles A., Golshayan D., Gaide O., Hohl D., Speiser D.E. et al., 2022/12/06..
[DOI][Pmid][serval:BIB_714CA1B23F87]
c-MAF coordinates enterocyte zonation and nutrient uptake transcriptional programs.
González-Loyola A., Bernier-Latmani J., Roci I., Wyss T., Langer J., Durot S., Munoz O., Prat-Luri B., Delorenzi M., Lutolf M.P. et al., 2022/12/05. The Journal of experimental medicine, 219 (12) pp. e20212418. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_0333000E22CD]
Structure-based optimization of type III indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.
Röhrig U.F., Majjigapu S.R., Vogel P., Reynaud A., Pojer F., Dilek N., Reichenbach P., Ascenção K., Irving M., Coukos G. et al., 2022/12. Journal of enzyme inhibition and medicinal chemistry, 37 (1) pp. 1773-1811. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_EF494F840FDA]
 
Peroxynitrite in the tumor microenvironment changes the profile of antigens allowing escape from cancer immunotherapy.
Tcyganov E.N., Sanseviero E., Marvel D., Beer T., Tang H.Y., Hembach P., Speicher D.W., Zhang Q., Donthireddy L.R., Mostafa A. et al., 2022/10/10. Cancer cell, 40 (10) pp. 1173-1189.e6. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_71E8BFD40E0A]
Update on the current opinion, status and future development of digital pathology in Switzerland in light of COVID-19.
Koelzer V.H., Grobholz R., Zlobec I., Janowczyk A., Swiss Digital Pathology Consortium (SDiPath), 2022/10. Journal of clinical pathology, 75 (10). Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_AD00692E0355]
 
NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer.
Salomé B., Sfakianos J.P., Ranti D., Daza J., Bieber C., Charap A., Hammer C., Banchereau R., Farkas A.M., Ruan D.F. et al., 2022/09/12. Cancer cell, 40 (9) pp. 1027-1043.e9. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_2CBE768B4B2D]
In situ delivery of nanoparticles formulated with micron-sized crystals protects from murine melanoma.
Mohsen M.O., Heath M., Kramer M.F., Velazquez T.C., Bullimore A., Skinner M.A., Speiser D.E., Bachmann M.F., 2022/09. Journal for immunotherapy of cancer, 10 (9) pp. e004643. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_8242D14982A0]
Structure of the human NK cell NKR-P1:LLT1 receptor:ligand complex reveals clustering in the immune synapse.
Bláha J., Skálová T., Kalousková B., Skořepa O., Cmunt D., Grobárová V., Pazicky S., Poláchová E., Abreu C., Stránský J. et al., 2022/08/26. Nature communications, 13 (1) p. 5022. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B743FD90D9CF]
CD8 T cell function and cross-reactivity explored by stepwise increased peptide-HLA versus TCR affinity.
Baumgaertner P., Schmidt J., Costa-Nunes C.M., Bordry N., Guillaume P., Luescher I., Speiser D.E., Rufer N., Hebeisen M., 2022/08/10. Frontiers in immunology, 13 p. 973986. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_16DFBAE86CE1]
 
Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization.
Ignacio A., Shah K., Bernier-Latmani J., Köller Y., Coakley G., Moyat M., Hamelin R., Armand F., Wong N.C., Ramay H. et al., 2022/07/12. Immunity, 55 (7) pp. 1250-1267.e12. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_70C1B74BEBAC]
ADAMTS18<sup>+</sup> villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels.
Bernier-Latmani J., Mauri C., Marcone R., Renevey F., Durot S., He L., Vanlandewijck M., Maclachlan C., Davanture S., Zamboni N. et al., 2022/07/09. Nature communications, 13 (1) p. 3983. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_AC4B62DD6AED]
 
c-Maf enforces cytokine production and promotes memory-like responses in mouse and human type 2 innate lymphoid cells.
Trabanelli S., Ercolano G., Wyss T., Gomez-Cadena A., Falquet M., Cropp D., Imbratta C., Leblond M.M., Salvestrini V., Curti A. et al., 2022/06/14. The EMBO journal, 41 (12) pp. e109300. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_36B22253747B]
 
The C5a-C5aR1 complement axis is essential for neutrophil recruitment to draining lymph nodes via high endothelial venules in cutaneous leishmaniasis.
Prat-Luri B., Neal C., Passelli K., Ganga E., Amore J., Firmino-Cruz L., Petrova T.V., Müller A.J., Tacchini-Cottier F., 2022/05/03. Cell reports, 39 (5) p. 110777. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_793AA043940A]
The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function.
Wenes M., Jaccard A., Wyss T., Maldonado-Pérez N., Teoh S.T., Lepez A., Renaud F., Franco F., Waridel P., Yacoub Maroun C. et al., 2022/05/03. Cell metabolism, 34 (5) pp. 731-746.e9. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_17EB92736564]
Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth.
Bernier-Latmani J., Cisarovsky C., Mahfoud S., Ragusa S., Dupanloup I., Barras D., Renevey F., Nassiri S., Anderle P., Squadrito M.L. et al., 2022/05. Nature cardiovascular research, 1 (5) pp. 476-490. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_998EFE1BCFC2]
 
Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer.
Troiani M., Colucci M., D'Ambrosio M., Guccini I., Pasquini E., Varesi A., Valdata A., Mosole S., Revandkar A., Attanasio G. et al., 2022/04/21. Nature communications, 13 (1) p. 2177. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_223F6D67B5C1]
Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures.
Fleig S., Kapanadze T., Bernier-Latmani J., Lill J.K., Wyss T., Gamrekelashvili J., Kijas D., Liu B., Hüsing A.M., Bovay E. et al., 2022/04/19. Nature communications, 13 (1) p. 2022. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_513AD0411BD1]
Stem-cell-like T cells have a specific entry gate to the tumor.
Held W., Luther S.A., Petrova T.V., 2022/03/14. Cancer cell, 40 (3) pp. 243-245. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_51451730613C]
 
Helicobacter pylori infection has a detrimental impact on the efficacy of cancer immunotherapies.
Oster P., Vaillant L., Riva E., McMillan B., Begka C., Truntzer C., Richard C., Leblond M.M., Messaoudene M., Machremi E. et al., 2022/03. Gut, 71 (3) pp. 457-466. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_142E8F1FCE05]
The tumor-targeted CD40 agonist CEA-CD40 promotes T cell priming via a dual mode of action by increasing antigen delivery to dendritic cells and enhancing their activation.
Sum E., Rapp M., Dürr H., Mazumdar A., Romero P.J., Trumpfheller C., Umaña P., 2022/03. Journal for immunotherapy of cancer, 10 (3) pp. e003264. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_5157B6387D0C]
 
Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics.
Friess M.C., Kritikos I., Schineis P., Medina-Sanchez J.D., Gkountidi A.O., Vallone A., Sigmund E.C., Schwitter C., Vranova M., Matti C. et al., 2022/02/01. Cell reports, 38 (5) p. 110334. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_A2343778C0A7]
 
Bedside formulation of a personalized multi-neoantigen vaccine against mammary carcinoma.
Mohsen M.O., Speiser D.E., Michaux J., Pak H., Stevenson B.J., Vogel M., Inchakalody V.P., de Brot S., Dermime S., Coukos G. et al., 2022/01. Journal for immunotherapy of cancer, 10 (1) pp. e002927. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C41D094CADC7]
Efficacy and safety of universal (TCRKO) ARI-0001 CAR-T cells for the treatment of B-cell lymphoma.
Maldonado-Pérez N., Tristán-Manzano M., Justicia-Lirio P., Martínez-Planes E., Muñoz P., Pavlovic K., Cortijo-Gutiérrez M., Blanco-Benítez C., Castella M., Juan M. et al., 2022. Frontiers in immunology, 13 p. 1011858. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_3B4788238098]
Shared acute phase traits in effector and memory human CD8 T cells.
Fuertes Marraco S.A., Alpern D., Lofek S., Lourenco J., Bovay A., Maby-El Hajjami H., Delorenzi M., Deplancke B., Speiser D.E., 2022. Current research in immunology, 3 pp. 1-12. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_9E024DBBC914]
 
The Era of Cytotoxic CD4 T Cells.
Cenerenti M., Saillard M., Romero P., Jandus C., 2022. Frontiers in immunology, 13 p. 867189. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_5284EC872B4E]
2021
 
Blood-brain barrier alterations in human brain tumors revealed by genome-wide transcriptomic profiling.
Schaffenrath J., Wyss T., He L., Rushing E.J., Delorenzi M., Vasella F., Regli L., Neidert M.C., Keller A., 2021/12/01. Neuro-oncology, 23 (12) pp. 2095-2106. Peer-reviewed.
[DOI][Pmid][serval:BIB_454219DF2E83]
Therapeutic cancer vaccines revamping: technology advancements and pitfalls.
Antonarelli G., Corti C., Tarantino P., Ascione L., Cortes J., Romero P., Mittendorf E.A., Disis M.L., Curigliano G., 2021/12. Annals of oncology, 32 (12) pp. 1537-1551. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_60856EC0D50D]
Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas.
Heino S., Fang S., Lähde M., Högström J., Nassiri S., Campbell A., Flanagan D., Raven A., Hodder M., Nasreddin N. et al., 2021/11/19. Science advances, 7 (47) pp. eabj0512. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4CC88CEB1BCE]
Palmdelphin Regulates Nuclear Resilience to Mechanical Stress in the Endothelium.
Sáinz-Jaspeado M., Smith R.O., Plunde O., Pawelzik S.C., Jin Y., Nordling S., Ding Y., Aspenström P., Hedlund M., Bastianello G. et al., 2021/11/16. Circulation, 144 (20) pp. 1629-1645. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_12F7FC5B8E4A]
Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity.
Di Conza G., Tsai C.H., Gallart-Ayala H., Yu Y.R., Franco F., Zaffalon L., Xie X., Li X., Xiao Z., Raines L.N. et al., 2021/11. Nature immunology, 22 (11) pp. 1403-1415. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_38FF542D6B24]
 
An integrated pipeline for comprehensive analysis of immune cells in human brain tumor clinical samples.
Maas R.R., Soukup K., Klemm F., Kornete M., Bowman R.L., Bedel R., Marie D.N., Álvarez-Prado Á.F., Labes D., Wilson A. et al., 2021/10. Nature protocols, 16 (10) pp. 4692-4721. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_56ABDAED12F3]
BET inhibitors repress expression of interferon-stimulated genes and synergize with HDAC inhibitors in glioblastoma.
Gusyatiner O., Bady P., Pham MDT, Lei Y., Park J., Daniel R.T., Delorenzi M., Hegi M.E., 2021/10/01. Neuro-oncology, 23 (10) pp. 1680-1692. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_925836B89EDF]
 
Glutamine gluttony of efferocytes.
Jaccard A., Li X., Ho P.C., 2021/10. Nature metabolism, 3 (10) pp. 1280-1281. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_0E25E488861C]
Endothelial Colony-Forming Cells Dysfunctions Are Associated with Arterial Hypertension in a Rat Model of Intrauterine Growth Restriction.
Simoncini S., Coppola H., Rocca A., Bachmann I., Guillot E., Zippo L., Dignat-George F., Sabatier F., Bedel R., Wilson A. et al., 2021/09/21. International journal of molecular sciences, 22 (18) p. 10159. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_76C775F89D99]
Tumor-Associated Macrophages in Bladder Cancer: Biological Role, Impact on Therapeutic Response and Perspectives for Immunotherapy.
Leblond M.M., Zdimerova H., Desponds E., Verdeil G., 2021/09/21. Cancers, 13 (18) p. 4712. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_8DF2976B356C]
Targeting OLFML3 in Colorectal Cancer Suppresses Tumor Growth and Angiogenesis, and Increases the Efficacy of Anti-PD1 Based Immunotherapy.
Stalin J., Imhof B.A., Coquoz O., Jeitziner R., Hammel P., McKee T.A., Jemelin S., Poittevin M., Pocard M., Matthes T. et al., 2021/09/15. Cancers, 13 (18) p. 4625. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_64B45ACEAD1A]
PD-1<sup>+</sup> Tcf1<sup>+</sup> CD8<sup>+</sup> T cells from established chronic infection can form memory while retaining a stableimprint of persistent antigen exposure.
Charmoy M., Wyss T., Delorenzi M., Held W., 2021/09/07. Cell reports, 36 (10) p. 109672. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_2783DEBAC783]
 
Inflammatory metabolic profile of South African patients with prostate cancer.
Cacciatore S., Wium M., Licari C., Ajayi-Smith A., Masieri L., Anderson C., Salukazana A.S., Kaestner L., Carini M., Carbone G.M. et al., 2021/08/03. Cancer & metabolism, 9 (1) p. 29. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_AE197D4C04FB]
Yellow fever virus vaccination: an emblematic model to elucidate robust human immune responses.
Bovay A., Fuertes Marraco S.A., Speiser D.E., 2021/08/03. Human vaccines & immunotherapeutics, 17 (8) pp. 2471-2481. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_448E1556B8F5]
DCision-making in tumors governs T cell anti-tumor immunity.
Alfei F., Ho P.C., Lo W.L., 2021/08. Oncogene, 40 (34) pp. 5253-5261. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_A205E6D27239]
Characterization of the blood-brain barrier in genetically diverse laboratory mouse strains.
Schaffenrath J., Huang S.F., Wyss T., Delorenzi M., Keller A., 2021/07/28. Fluids and barriers of the CNS, 18 (1) p. 34. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_99330E3BC31E]
 
CD40 Agonist Targeted to Fibroblast Activation Protein α Synergizes with Radiotherapy in Murine HPV-Positive Head and Neck Tumors.
Labiano S., Roh V., Godfroid C., Hiou-Feige A., Romero J., Sum E., Rapp M., Boivin G., Wyss T., Simon C. et al., 2021/07/15. Clinical cancer research, 27 (14) pp. 4054-4065. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_01B309C22867]
 
Fibroblast Activation Protein α-Targeted CD40 Agonism Abrogates Systemic Toxicity and Enables Administration of High Doses to Induce Effective Antitumor Immunity.
Sum E., Rapp M., Fröbel P., Le Clech M., Dürr H., Giusti A.M., Perro M., Speziale D., Kunz L., Menietti E. et al., 2021/07/15. Clinical cancer research, 27 (14) pp. 4036-4053. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C5DC576E690C]
CD73 expression in normal, hyperplastic, and neoplastic thyroid: a systematic evaluation revealing CD73 overexpression as a feature of papillary carcinomas.
Monteiro I., Missiaglia E., Sciarra A., Santos J.V., Bouilly J., Romero P., Sempoux C., de Leval L., 2021/07. Virchows Archiv, 479 (1) pp. 209-214. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_DCA4A5411D48]
Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity.
Dumauthioz N., Tschumi B., Wenes M., Marti B., Wang H., Franco F., Li W., Lopez-Mejia I.C., Fajas L., Ho P.C. et al., 2021/07. Cellular & molecular immunology, 18 (7) pp. 1761-1771. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_D554C59D6F3C]
FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure.
González-Loyola A., Bovay E., Kim J., Lozano T.W., Sabine A., Renevey F., Arroz-Madeira S., Rapin A., Wypych T.P., Rota G. et al., 2021/07. Science advances, 7 (29) pp. eabf4335. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_3852082D8787]
 
Macrophage depletion induces edema through release of matrix-degrading proteases and proteoglycan deposition.
Bissinger S., Hage C., Wagner V., Maser I.P., Brand V., Schmittnaegel M., Jegg A.M., Cannarile M., Watson C., Klaman I. et al., 2021/06/16. Science translational medicine, 13 (598) pp. eabd4550. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_7A2ECCA71331]
 
Melanoma dedifferentiation induced by IFN-γ epigenetic remodeling in response to anti-PD-1 therapy.
Kim Y.J., Sheu K.M., Tsoi J., Abril-Rodriguez G., Medina E., Grasso C.S., Torrejon D.Y., Champhekar A.S., Litchfield K., Swanton C. et al., 2021/06/15. The Journal of clinical investigation, 131 (12) pp. e145859. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_63ED9038D5A4]
 
Can tumor cells take it all away?
Kohl A., Kao K.C., Ho P.C., 2021/06/01. Cell metabolism, 33 (6) pp. 1071-1072. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C38ABD4E6369]
Constant regulation for stable CD8 T-cell functional avidity and its possible implications for cancer immunotherapy.
Gilfillan C.B., Hebeisen M., Rufer N., Speiser D.E., 2021/06. European journal of immunology, 51 (6) pp. 1348-1360. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_DE9645D7CF3A]
Metabolic reprogramming of terminally exhausted CD8<sup>+</sup> T cells by IL-10 enhances anti-tumor immunity.
Guo Y., Xie Y.Q., Gao M., Zhao Y., Franco F., Wenes M., Siddiqui I., Bevilacqua A., Wang H., Yang H. et al., 2021/06. Nature immunology, 22 (6) pp. 746-756. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_C5D0B4808515]
Rapid Noninvasive Skin Monitoring by Surface Mass Recording and Data Learning.
Zhu Y., Lesch A., Li X., Lin T.E., Gasilova N., Jović M., Pick H.M., Ho P.C., Girault H.H., 2021/05/24. JACS Au, 1 (5) pp. 598-611. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_2FC489BC0711]
PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions.
Ercolano G., Gomez-Cadena A., Dumauthioz N., Vanoni G., Kreutzfeldt M., Wyss T., Michalik L., Loyon R., Ianaro A., Ho P.C. et al., 2021/05/05. Nature communications, 12 (1) p. 2538. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_976017D4D887]
STACAS: Sub-Type Anchor Correction for Alignment in Seurat to integrate single-cell RNA-seq data.
Andreatta M., Carmona S.J., 2021/05/05. Bioinformatics, 37 (6) pp. 882-884. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_D3F01C447F08]
Impact of Immunotherapy on CD4 T Cell Phenotypes and Function in Cancer.
Saillard M., Cenerenti M., Romero P., Jandus C., 2021/05/04. Vaccines, 9 (5) p. 454. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_A19532FDD59E]
 
Immune cell infiltration in colonic cancer: correlation between biopsy and surgical specimens.
Bordry N., Germann M., Foukas P.G., Sempoux C., Yan P., Dormond O., Speiser D.E., Demartines N., Sauvain M.O., 2021/04/30. The British journal of surgery, 108 (4) pp. 346-350. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_319A12C734E8]
 
70-gene signature as an aid for treatment decisions in early breast cancer: updated results of the phase 3 randomised MINDACT trial with an exploratory analysis by age.
Piccart M., van 't Veer L.J., Poncet C., Lopes Cardozo JMN, Delaloge S., Pierga J.Y., Vuylsteke P., Brain E., Vrijaldenhoven S., Neijenhuis P.A. et al., 2021/04. The Lancet. Oncology, 22 (4) pp. 476-488. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_AF08B9212168]
 
Serial Stimulation of Invariant Natural Killer T Cells with Covalently Stabilized Bispecific T-cell Engagers Generates Antitumor Immunity While Avoiding Anergy.
Kharkwal S.S., Johndrow C.T., Veerapen N., Kharkwal H., Saavedra-Avila N.A., Carreño L.J., Rothberg S., Zhang J., Garforth S.J., Jervis P.J. et al., 2021/04/01. Cancer research, 81 (7) pp. 1788-1801. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_53B538F5C2B5]
 
Targeting PIM1-Mediated Metabolism in Myeloid Suppressor Cells to Treat Cancer.
Xin G., Chen Y., Topchyan P., Kasmani M.Y., Burns R., Volberding P.J., Wu X., Cohn A., Chen Y., Lin C.W. et al., 2021/04. Cancer immunology research, 9 (4) pp. 454-469. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_2606CDB8F028]
Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma.
Schaller J., Hajjami H.M., Rusakiewicz S., Ioannidou K., Piazzon N., Miles A., Golshayan D., Gaide O., Hohl D., Speiser D.E. et al., 2021/03/30. Oncotarget, 12 (7) pp. 638-648. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_BF678E4FB907]
 
Human primed ILCPs support endothelial activation through NF-κB signaling.
Vanoni G., Ercolano G., Candiani S., Rutigliani M., Lanata M., Derré L., Marcenaro E., Schneider P., Romero P., Jandus C. et al., 2021/02/08. eLife, 10 pp. e58838. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_1C654EDB478E]
Not All Tumor-Infiltrating CD8+ T Cells Are Created Equal.
Held W., Speiser D.E., 2021/02/08. Cancer cell, 39 (2) pp. 145-147. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_E8253423DFBD]
Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients.
de Jonge K., Tillé L., Lourenco J., Maby-El Hajjami H., Nassiri S., Racle J., Gfeller D., Delorenzi M., Verdeil G., Baumgaertner P. et al., 2021/02/02. Oncoimmunology, 10 (1) p. 1873585. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_A6249CF0D69F]
 
Gain of HIF1 Activity and Loss of miRNA let-7d Promote Breast Cancer Metastasis to the Brain via the PDGF/PDGFR Axis.
Wyss C.B., Duffey N., Peyvandi S., Barras D., Martinez Usatorre A., Coquoz O., Romero P., Delorenzi M., Lorusso G., Rüegg C., 2021/02/01. Cancer research, 81 (3) pp. 594-605. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_96CE02E1BF45]
Microglia control small vessel calcification via TREM2.
Zarb Y., Sridhar S., Nassiri S., Utz S.G., Schaffenrath J., Maheshwari U., Rushing E.J., Nilsson KPR, Delorenzi M., Colonna M. et al., 2021/02. Science advances, 7 (9) pp. 135-145. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_C64510F66413]
Neuregulin-1 alleviate oxidative stress and mitigate inflammation by suppressing NOX4 and NLRP3/caspase-1 in myocardial ischaemia-reperfusion injury.
Wang F., Wang H., Liu X., Yu H., Huang X., Huang W., Wang G., 2021/02. Journal of cellular and molecular medicine, 25 (3) pp. 1783-1795. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_85C88F4C85DE]
Optimized gene engineering of murine CAR-T cells reveals the beneficial effects of IL-15 coexpression.
Lanitis E., Rota G., Kosti P., Ronet C., Spill A., Seijo B., Romero P., Dangaj D., Coukos G., Irving M., 2021/02/01. The Journal of experimental medicine, 218 (2) pp. e20192203. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_75DE24FE756B]
Severe COVID-19 patients exhibit an ILC2 NKG2D<sup>+</sup> population in their impaired ILC compartment.
Gomez-Cadena A., Spehner L., Kroemer M., Khelil M.B., Bouiller K., Verdeil G., Trabanelli S., Borg C., Loyon R., Jandus C., 2021/02. Cellular & molecular immunology, 18 (2) pp. 484-486. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_C1457954C261]
Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer.
Cachot A., Bilous M., Liu Y.C., Li X., Saillard M., Cenerenti M., Rockinger G.A., Wyss T., Guillaume P., Schmidt J. et al., 2021/02. Science advances, 7 (9) pp. eabe3348. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_7FDE10B2A046]
Tailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells.
Kanev K., Roelli P., Wu M., Wurmser C., Delorenzi M., Pfaffl M.W., Zehn D., 2021/01/25. Nature communications, 12 (1) p. 569. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_C79F07ADC7C7]
 
Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis.
Guccini I., Revandkar A., D'Ambrosio M., Colucci M., Pasquini E., Mosole S., Troiani M., Brina D., Sheibani-Tezerji R., Elia A.R. et al., 2021/01/11. Cancer cell, 39 (1) pp. 68-82.e9. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_396F2AB131D7]
SARS-CoV-2 structural features may explain limited neutralizing-antibody responses.
Bachmann M.F., Mohsen M.O., Zha L., Vogel M., Speiser D.E., 2021/01/04. NPJ vaccines, 6 (1) p. 2. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B9969183CF9D]
 
Biological evaluation of new TEM1 targeting recombinant antibodies for radioimmunotherapy: In vitro, in vivo and in silico studies.
D'Onofrio A., Gano L., Melo R., Mendes F., Oliveira M.C., Denoël T., Schaefer N., Viertl D., Fierle J., Coukos G. et al., 2021/01. European journal of pharmaceutics and biopharmaceutics, 158 pp. 233-244. Peer-reviewed.
[DOI][Pmid][serval:BIB_95FD98ADDB6D]
Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival.
Berner F., Niederer R., Luimstra J.J., Pop O.T., Jochum A.K., Purde M.T., Hasan Ali O., Bomze D., Bauer J., Freudenmann L.K. et al., 2021. Oncoimmunology, 10 (1) p. 2006893. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_F7C830C8D442]
Lack of Adiponectin Drives Hyperosteoclastogenesis in Lipoatrophic Mice.
Madel M.B., Fu H., Pierroz D.D., Schiffrin M., Winkler C., Wilson A., Pochon C., Toffoli B., Taïeb M., Jouzeau J.Y. et al., 2021. Frontiers in cell and developmental biology, 9 p. 627153. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_CB73EF97C8A9]
Pericytes regulate vascular immune homeostasis in the CNS.
Török O., Schreiner B., Schaffenrath J., Tsai H.C., Maheshwari U., Stifter S.A., Welsh C., Amorim A., Sridhar S., Utz S.G. et al., 2021. Proceedings of the National Academy of Sciences of the United States of America, 118 (10) pp. e2016587118. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_2E291B9300F3]
 
Redirecting iNKT Cell Antitumor Immunity with α-GalCer/CD1d-scFv Fusion Proteins.
Zhang L., Donda A., 2021. pp. 175-180 dans Invariant Natural Killer T-Cells, Springer.
[DOI][Pmid][serval:BIB_F7F5177397E9]
Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients.
Bibert S., Guex N., Lourenco J., Brahier T., Papadimitriou-Olivgeris M., Damonti L., Manuel O., Liechti R., Götz L., Tschopp J. et al., 2021. Frontiers in immunology, 12 p. 666163. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_91CEC9119F7E]
UCell: Robust and scalable single-cell gene signature scoring.
Andreatta M., Carmona S.J., 2021. Computational and structural biotechnology journal, 19 pp. 3796-3798. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_ADC3FAC598DC]
2020
Early drop of circulating T cells negatively correlates with the protective immune response to Yellow Fever vaccination.
Bovay A., Speiser D.E., Fuertes Marraco S.A., 2020/12/01. Human vaccines & immunotherapeutics, 16 (12) pp. 3103-3110. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_CF63CEAB6BA5]
Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes
Chong Chloe, Müller Markus, Pak HuiSong, Harnett Dermot, Huber Florian, Grun Delphine, Leleu Marion, Auger Aymeric, Arnaud Marion, Stevenson Brian J. et al., 2020/12. Nature Communications, 11 (1). Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_03EA897A1141]
Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation.
Pais Ferreira D., Silva J.G., Wyss T., Fuertes Marraco S.A., Scarpellino L., Charmoy M., Maas R., Siddiqui I., Tang L., Joyce J.A. et al., 2020/11/17. Immunity, 53 (5) pp. 985-1000.e11. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_A0FD9237651F]
 
Metastatic Colonization: Escaping Immune Surveillance.
Schaller J., Agudo J., 2020/11/16. Cancers, 12 (11) pp. E3385. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_BDE3AB20D662]
Optimized low-dose combinatorial drug treatment boosts selectivity and efficacy of colorectal carcinoma treatment.
Zoetemelk M., Ramzy G.M., Rausch M., Koessler T., van Beijnum J.R., Weiss A., Mieville V., Piersma S.R., de Haas R.R., Delucinge-Vivier C. et al., 2020/11. Molecular oncology, 14 (11) pp. 2894-2919. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_6B1C1DF10DF7]
 
Structural dissimilarity from self drives neoepitope escape from immune tolerance.
Devlin J.R., Alonso J.A., Ayres C.M., Keller GLJ, Bobisse S., Vander Kooi C.W., Coukos G., Gfeller D., Harari A., Baker B.M., 2020/11. Nature chemical biology, 16 (11) pp. 1269-1276. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_186F0AD1C570]
 
Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction.
Wells D.K., van Buuren M.M., Dang K.K., Hubbard-Lucey V.M., Sheehan KCF, Campbell K.M., Lamb A., Ward J.P., Sidney J., Blazquez A.B. et al., 2020/10/29. Cell, 183 (3) pp. 818-834.e13. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F6095670EC38]
 
Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma.
Kalbasi A., Tariveranmoshabad M., Hakimi K., Kremer S., Campbell K.M., Funes J.M., Vega-Crespo A., Parisi G., Champekar A., Nguyen C. et al., 2020/10/14. Science translational medicine, 12 (565) pp. eabb0152. Peer-reviewed.
[DOI][Pmid][serval:BIB_CF3704461FDA]
 
Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma.
Grasso C.S., Tsoi J., Onyshchenko M., Abril-Rodriguez G., Ross-Macdonald P., Wind-Rotolo M., Champhekar A., Medina E., Torrejon D.Y., Shin D.S. et al., 2020/10/12. Cancer cell, 38 (4) pp. 500-515.e3. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_0C3D2E2E7DDD]
 
Editorial overview: Pharmaceutical biotechnology: new frontiers in cancer immunotherapy.
Kandalaft L.E., Graciotti M., 2020/10. Current opinion in biotechnology, 65 pp. iii-v. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_6F4B29364362]
High versus low dose irradiation for tumor immune reprogramming.
de Olza M.O., Bourhis J., Irving M., Coukos G., Herrera F.G., 2020/10. Current opinion in biotechnology, 65 pp. 268-283. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_330632946BBD]
 
Metabolic and epigenetic regulation of T-cell exhaustion.
Franco F., Jaccard A., Romero P., Yu Y.R., Ho P.C., 2020/10. Nature metabolism, 2 (10) pp. 1001-1012. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C6CC159592FD]
 
Organoid technology and applications in cancer immunotherapy and precision medicine.
Homicsko K., 2020/10. Current opinion in biotechnology, 65 pp. 242-247. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_BB24203665BA]
T-cell repertoire analysis and metrics of diversity and clonality.
Chiffelle J., Genolet R., Perez M.A., Coukos G., Zoete V., Harari A., 2020/10. Current opinion in biotechnology, 65 pp. 284-295. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_598F3EDCA20B]
 
Survival of the fetus: cervical cancer and pregnancy, a challenging combination.
Levy L., Meuwly J.Y., Sarivalasis A., Achtari C., Mathevet P., Herrera F.G., 2020/09/05. Lancet, 396 (10252) p. 725. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_16AC5A00A805]
pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology.
Pethő Z., Najder K., Carvalho T., McMorrow R., Todesca L.M., Rugi M., Bulk E., Chan A., Löwik CWGM, Reshkin S.J. et al., 2020/09/02. Cancers, 12 (9) pp. E2484. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_72DDC078615F]
 
CD40 Agonist Restores the Antitumor Efficacy of Anti-PD1 Therapy in Muscle-Invasive Bladder Cancer in an IFN I/II-Mediated Manner.
Leblond M.M., Tillé L., Nassiri S., Gilfillan C.B., Imbratta C., Schmittnaegel M., Ries C.H., Speiser D.E., Verdeil G., 2020/09. Cancer immunology research, 8 (9) pp. 1180-1192. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_03172EE2E8EA]
 
High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays.
Brandenberg N., Hoehnel S., Kuttler F., Homicsko K., Ceroni C., Ringel T., Gjorevski N., Schwank G., Coukos G., Turcatti G. et al., 2020/09. Nature biomedical engineering, 4 (9) pp. 863-874. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_71E34713FAA0]
Identification of a superagonist variant of the immunodominant Yellow fever virus epitope NS4b214-222 by combinatorial peptide library screening.
Bovay A., Zoete V., Rizkallah P.J., Beck K., Delbreil P., Speiser D.E., Cole D.K., Fuertes Marraco S.A., 2020/09. Molecular immunology, 125 pp. 43-50. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_46FDF2862443]
Objective assessment of stored blood quality by deep learning.
Doan M., Sebastian J.A., Caicedo J.C., Siegert S., Roch A., Turner T.R., Mykhailova O., Pinto R.N., McQuin C., Goodman A. et al., 2020/09/01. Proceedings of the National Academy of Sciences of the United States of America, 117 (35) pp. 21381-21390. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_1BEFB5E7D470]
 
The commensal skin microbiota triggers type I IFN-dependent innate repair responses in injured skin.
Di Domizio J., Belkhodja C., Chenuet P., Fries A., Murray T., Mondéjar P.M., Demaria O., Conrad C., Homey B., Werner S. et al., 2020/09. Nature immunology, 21 (9) pp. 1034-1045. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_6FD139272D6D]
 
The hidden side of PD-L1.
Jaccard A., Ho P.C., 2020/09. Nature cell biology, 22 (9) pp. 1031-1032. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_CDDD22AA09ED]
 
<sup>177</sup>Lu radiolabeling and preclinical theranostic study of 1C1m-Fc: an anti-TEM-1 scFv-Fc fusion protein in soft tissue sarcoma.
Delage J.A., Faivre-Chauvet A., Fierle J.K., Gnesin S., Schaefer N., Coukos G., Dunn S.M., Viertl D., Prior J.O., 2020/08/17. EJNMMI research, 10 (1) p. 98. Peer-reviewed.
[DOI][Pmid][serval:BIB_4E04534CDA56]
 
The Interleukin 22 Pathway Interacts with Mutant KRAS to Promote Poor Prognosis in Colon Cancer.
McCuaig S., Barras D., Mann E.H., Friedrich M., Bullers S.J., Janney A., Garner L.C., Domingo E., Koelzer V.H., Delorenzi M. et al., 2020/08/15. Clinical cancer research, 26 (16) pp. 4313-4325. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E0B299A0A2D6]
Adipocyte-conditioned medium induces resistance of breast cancer cells to lapatinib.
Geneste A., Duong M.N., Molina L., Conilh L., Beaumel S., Cleret A., Chettab K., Lachat M., Jordheim L.P., Matera E.L. et al., 2020/08/14. BMC pharmacology & toxicology, 21 (1) p. 61. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_5A5A38569592]
Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment.
Dumas A.A., Pomella N., Rosser G., Guglielmi L., Vinel C., Millner T.O., Rees J., Aley N., Sheer D., Wei J. et al., 2020/08/03. The EMBO journal, 39 (15) pp. e103790. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_FFF9B15DBC96]
 
Correction to: Preclinical Evaluation and Dosimetry of [111In] CHX-DTPA-scFv78-Fc Targeting Endosialin/Tumor Endothelial Marker 1 (TEM1)
Cicone Francesco, Denoël Thibaut, Gnesin Silvano, Riggi Nicolo, Irving Melita, Jakka Gopinadh, Schaefer Niklaus, Viertl David, Coukos George, Prior John O., 2020/08. 1.
[DOI][WoS][Pmid][serval:BIB_81A7D3CC3803]
 
Distinct and shared gene expression for human innate versus adaptive helper lymphoid cells.
Ercolano G., Wyss T., Salomé B., Romero P., Trabanelli S., Jandus C., 2020/08. Journal of leukocyte biology, 108 (2) pp. 723-737. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_4DA23DC9CF93]
Preclinical Evaluation and Dosimetry of [111In]CHX-DTPA-scFv78-Fc Targeting Endosialin/Tumor Endothelial Marker 1 (TEM1).
Cicone F., Denoël T., Gnesin S., Riggi N., Irving M., Jakka G., Schaefer N., Viertl D., Coukos G., Prior J.O., 2020/08. Molecular imaging and biology, 22 (4) pp. 979-991. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_813B48F40C5F]
 
Rapid tumor vaccine using Toll-like receptor-activated ovarian cancer ascites monocytes.
Adams S.F., Grimm A.J., Chiang C.L., Mookerjee A., Flies D., Jean S., McCann G.A., Michaux J., Pak H., Huber F. et al., 2020/08. Journal for immunotherapy of cancer, 8 (2) pp. e000875. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_7B7CF92C7BCB]
Stemming the Tide of Cancer
Speiser DE, Held W, 2020/07/31..
[URN][serval:BIB_A4F7C29DB6C8]
 
Controlling technical variation amongst 6693 patient microarrays of the randomized MINDACT trial.
Jacob L., Witteveen A., Beumer I., Delahaye L., Wehkamp D., van den Akker J., Snel M., Chan B., Floore A., Bakx N. et al., 2020/07/27. Communications biology, 3 (1) p. 397. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_675A859CA6A3]
 
COVID-19: Mechanisms of Vaccination and Immunity.
Speiser D.E., Bachmann M.F., 2020/07/22. Vaccines, 8 (3). Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_AC767F5BF725]
 
Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance.
Akkari L., Bowman R.L., Tessier J., Klemm F., Handgraaf S.M., de Groot M., Quail D.F., Tillard L., Gadiot J., Huse J.T. et al., 2020/07/15. Science translational medicine, 12 (552) pp. eaaw7843. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_1B0920FD434E]
A mouse SWATH-mass spectrometry reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts.
Krasny L., Bland P., Burns J., Lima N.C., Harrison P.T., Pacini L., Elms M.L., Ning J., Martinez V.G., Yu Y.R. et al., 2020/07/14. Disease models & mechanisms, 13 (7) pp. dmm044586. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_AECF31D38959]
 
Biological functions of lymphatic vessels.
Petrova T.V., Koh G.Y., 2020/07/10. Science, 369 (6500). Peer-reviewed.
[DOI][Pmid][serval:BIB_0975AC40A1DE]
 
Multielemental Analysis of Low-Volume Samples Reveals Cancer-Specific Profile in Serum and Sorted Immune Cells
Konz Tobias, Monnard Caroline, Restrepo Marcela Rincon, Laval Julie, Sizzano Federico, Girotra Mukul, Dammone Gabriele, Palini Alessio, Coukos George, Rezzi Serge et al., 2020/07/07. Analytical Chemistry, 92 (13) pp. 8750-8758.
[DOI][Pmid][serval:BIB_3A58DA889942]
Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4<sup>+</sup> T cells.
Rath J.A., Bajwa G., Carreres B., Hoyer E., Gruber I., Martínez-Paniagua M.A., Yu Y.R., Nouraee N., Sadeghi F., Wu M. et al., 2020/07. Science advances, 6 (27) pp. eaaz7809. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_D26F38B87AE4]
Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells
Klemm F., Maas R.R., Bowman R.L., Kornete M., Soukup K., Nassiri S., Brouland J.P., Iacobuzio-Donahue C.A., Brennan C., Tabar V. et al., 2020/06/25. Cell, 181 (7) pp. 1643-1660.e17. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B25384BE18E8]
 
Quantitative and qualitative impairments in dendritic cell subsets of patients with ovarian or prostate cancer.
Mastelic-Gavillet B., Sarivalasis A., Lozano L.E., Wyss T., Inoges S., de Vries IJM, Dartiguenave F., Jichlinski P., Derrè L., Coukos G. et al., 2020/06/23. European journal of cancer, 135 pp. 173-182. Peer-reviewed.
[DOI][Pmid][serval:BIB_2DED61B64BB4]
Innate Immune Cells and Their Contribution to T-Cell-Based Immunotherapy.
Ginefra P., Lorusso G., Vannini N., 2020/06/22. International journal of molecular sciences, 21 (12) p. 4441. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_0AC8DC8B4A8A]
Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation.
Norden P.R., Sabine A., Wang Y., Demir C.S., Liu T., Petrova T.V., Kume T., 2020/06/08. eLife, 9 pp. e53814. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_066C420F0AD8]
Deciphering the Mechanisms of Improved Immunogenicity of Hypochlorous Acid-Treated Antigens in Anti-Cancer Dendritic Cell-Based Vaccines.
Graciotti M., Marino F., Pak H., Baumgaertner P., Thierry A.C., Chiffelle J., Perez MAS, Zoete V., Harari A., Bassani-Sternberg M. et al., 2020/06/02. Vaccines, 8 (2). Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_0A84027C58CB]
 
An optimized antigen-protein fusion.
Romero P., Donda A., Hubbell J.A., 2020/06. Nature biomedical engineering, 4 (6) pp. 583-584. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D08755FBF911]
Bivalent therapeutic vaccine against HPV16/18 genotypes consisting of a fusion protein between the extra domain A from human fibronectin and HPV16/18 E7 viral antigens.
Arribillaga L., Echeverria I., Belsue V., Gomez T., Lozano T., Casares N., Villanueva L., Domingos-Pereira S., Romero P.J., Nardelli-Haefliger D. et al., 2020/06. Journal for immunotherapy of cancer, 8 (1) pp. e000704. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_8F1E679B0434]
Safety and immunogenicity of novel 5T4 viral vectored vaccination regimens in early stage prostate cancer: a phase I clinical trial.
Cappuccini F., Bryant R., Pollock E., Carter L., Verrill C., Hollidge J., Poulton I., Baker M., Mitton C., Baines A. et al., 2020/06. Journal for immunotherapy of cancer, 8 (1) pp. e000928. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4F3CEFF08C20]
Mélanome localement avancé et métastatique : nouveautés [Locally advanced and metastatic melanoma : novelties]
Huber A., Latifyan S., Nikolopoulou A., Homicsko K., Berthod G., Michielin O., Özdemir B.C., 2020/05/27. Revue medicale suisse, 16 (695) pp. 1092-1097. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_E5DDB348D97F]
 
Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma.
Dheilly E., Battistello E., Katanayeva N., Sungalee S., Michaux J., Duns G., Wehrle S., Sordet-Dessimoz J., Mina M., Racle J. et al., 2020/05/11. Cancer cell, 37 (5) pp. 674-689.e12. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C0FB07A8B571]
 
Biallelic variants in PSMB1 encoding the proteasome subunit β6 cause impairment of proteasome function, microcephaly, intellectual disability, developmental delay and short stature.
Ansar M., Ebstein F., Özkoç H., Paracha S.A., Iwaszkiewicz J., Gesemann M., Zoete V., Ranza E., Santoni F.A., Sarwar M.T. et al., 2020/05/08. Human molecular genetics, 29 (7) pp. 1132-1143. Peer-reviewed.
[DOI][Pmid][serval:BIB_7528AD86E93D]
Tcf1<sup>+</sup> cells are required to maintain the inflationary T cell pool upon MCMV infection.
Welten SPM, Yermanos A., Baumann N.S., Wagen F., Oetiker N., Sandu I., Pedrioli A., Oduro J.D., Reddy S.T., Cicin-Sain L. et al., 2020/05/08. Nature communications, 11 (1) p. 2295. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4C6B9A0F8CD8]
 
Immune Therapy Opportunities in Ovarian Cancer.
Kandalaft L.E., Odunsi K., Coukos G., 2020/05. American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, 40 pp. 1-13. Peer-reviewed.
[DOI][Pmid][serval:BIB_71D55C2B15BF]
 
Optimized combinatorial pMHC class II multimer labeling for precision immune monitoring of tumor-specific CD4 T cells in patients.
Rockinger G.A., Guillaume P., Cachot A., Saillard M., Speiser D.E., Coukos G., Harari A., Romero P.J., Schmidt J., Jandus C., 2020/05. Journal for immunotherapy of cancer, 8 (1) pp. e000435. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_EBA81BA22D33]
 
Intra-uterine growth restriction induced by maternal low-protein diet causes long-term alterations of thymic structure and function in adult male rat offspring.
Armengaud J.B., Dennebouy Z., Labes D., Fumey C., Wilson A., Candotti F., Yzydorczyk C., Simeoni U., 2020/04/28. The British journal of nutrition, 123 (8) pp. 892-900. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_CAF70B17A491]
Native/citrullinated LL37-specific T-cells help autoantibody production in Systemic Lupus Erythematosus.
Lande R., Palazzo R., Gestermann N., Jandus C., Falchi M., Spadaro F., Riccieri V., James E.A., Butera A., Boirivant M. et al., 2020/04/03. Scientific reports, 10 (1) p. 5851. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_BB3E78FC1719]
 
A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy.
Giordano-Attianese G., Gainza P., Gray-Gaillard E., Cribioli E., Shui S., Kim S., Kwak M.J., Vollers S., Corria Osorio A.J., Reichenbach P. et al., 2020/04. Nature biotechnology, 38 (4) pp. 426-432. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_EBAD72E3D84D]
 
Efficacy of chemotherapy and atezolizumab in patients with non-small-cell lung cancer receiving antibiotics and proton pump inhibitors: pooled post hoc analyses of the OAK and POPLAR trials.
Chalabi M., Cardona A., Nagarkar D.R., Dhawahir Scala A., Gandara D.R., Rittmeyer A., Albert M.L., Powles T., Kok M., Herrera F.G. et al., 2020/04. Annals of oncology, 31 (4) pp. 525-531. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_BC73060F5887]
 
Immunosuppressive Mediators Impair Proinflammatory Innate Lymphoid Cell Function in Human Malignant Melanoma.
Ercolano G., Garcia-Garijo A., Salomé B., Gomez-Cadena A., Vanoni G., Mastelic-Gavillet B., Ianaro A., Speiser D.E., Romero P., Trabanelli S. et al., 2020/04. Cancer immunology research, 8 (4) pp. 556-564. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_61DAEC10A322]
Insights from immuno-oncology: the Society for Immunotherapy of Cancer Statement on access to IL-6-targeting therapies for COVID-19.
Ascierto P.A., Fox B., Urba W., Anderson A.C., Atkins M.B., Borden E.C., Brahmer J., Butterfield L.H., Cesano A., Chen D. et al., 2020/04. Journal for immunotherapy of cancer, 8 (1). Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_819D81E8FA74]
Murine CD8 T-cell functional avidity is stable in vivo but not in vitro: Independence from homologous prime/boost time interval and antigen density.
Gilfillan C.B., Wang C., Mohsen M.O., Rufer N., Hebeisen M., Allard M., Verdeil G., Irvine D.J., Bachmann M.F., Speiser D.E., 2020/04. European journal of immunology, 50 (4) pp. 505-514. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_5686BF1354AC]
 
Neoadjuvant immune-checkpoint blockade in resectable colon cancer.
Coukos G., 2020/04. Nature medicine, 26 (4) pp. 473-474. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_EEF5ED613F7B]
miR-155 Overexpression in OT-1 CD8<sup>+</sup> T Cells Improves Anti-Tumor Activity against Low-Affinity Tumor Antigen.
Monnot G.C., Martinez-Usatorre A., Lanitis E., Lopes S.F., Cheng W.C., Ho P.C., Irving M., Coukos G., Donda A., Romero P., 2020/03/27. Molecular therapy oncolytics, 16 pp. 111-123. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_39DC24C5C585]
ER Stress Responses: An Emerging Modulator for Innate Immunity.
Di Conza G., Ho P.C., 2020/03/12. Cells, 9 (3) p. 695. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_A1E25DB37FD0]
 
Antiangiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice.
Ragusa S., Prat-Luri B., González-Loyola A., Nassiri S., Squadrito M.L., Guichard A., Cavin S., Gjorevski N., Barras D., Marra G. et al., 2020/03/02. The Journal of clinical investigation, 130 (3) pp. 1199-1216. Peer-reviewed.
[DOI][Pmid][serval:BIB_C704575BD9D9]
CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors.
Wang H., Franco F., Tsui Y.C., Xie X., Trefny M.P., Zappasodi R., Mohmood S.R., Fernández-García J., Tsai C.H., Schulze I. et al., 2020/03. Nature immunology, 21 (3) pp. 298-308. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B4EB98E7D705]
Consensus guidelines for the definition, detection and interpretation of immunogenic cell death.
Galluzzi L., Vitale I., Warren S., Adjemian S., Agostinis P., Martinez A.B., Chan T.A., Coukos G., Demaria S., Deutsch E. et al., 2020/03. Journal for immunotherapy of cancer, 8 (1) pp. e000337. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_56620B5927E2]
 
Minimal immune response to booster vaccination against Yellow Fever associated with pre-existing antibodies.
Bovay A., Nassiri S., Maby-El Hajjami H., Marcos Mondéjar P., Akondy R.S., Ahmed R., Lawson B., Speiser D.E., Fuertes Marraco S.A., 2020/02/24. Vaccine, 38 (9) pp. 2172-2182. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F8B9AD9600C1]
 
Mass Spectrometry Based Immunopeptidomics Leads to Robust Predictions of Phosphorylated HLA Class I Ligands.
Solleder M., Guillaume P., Racle J., Michaux J., Pak H.S., Müller M., Coukos G., Bassani-Sternberg M., Gfeller D., 2020/02. Molecular & cellular proteomics, 19 (2) pp. 390-404. Peer-reviewed.
[DOI][Pmid][serval:BIB_0EBACC6764B1]
Targeting mitochondria to stimulate hematopoiesis.
Girotra M., Naveiras O., Vannini N., 2020/01/28. Aging, 12 (2) pp. 1042-1043. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_928D9FEE87C4]
Disulfide-Linked Peptides for Blocking BTLA/HVEM Binding.
Spodzieja M., Kuncewicz K., Sieradzan A., Karczyńska A., Iwaszkiewicz J., Cesson V., Węgrzyn K., Zhukov I., Maszota-Zieleniak M., Michielin O. et al., 2020/01/18. International journal of molecular sciences, 21 (2). Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_A28A31EE871C]
Noninvasive rapid detection of metabolic adaptation in activated human T lymphocytes by hyperpolarized <sup>13</sup>C magnetic resonance.
Can E., Mishkovsky M., Yoshihara HAI, Kunz N., Couturier D.L., Petrausch U., Doucey M.A., Comment A., 2020/01/13. Scientific reports, 10 (1) p. 200. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_3D4D5F06B036]
Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation.
Hämälistö S., Stahl J.L., Favaro E., Yang Q., Liu B., Christoffersen L., Loos B., Guasch Boldú C., Joyce J.A., Reinheckel T. et al., 2020/01/13. Nature communications, 11 (1) p. 229. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_61F53FCBFD55]
Neutrophils suppress tumor-infiltrating T cells in colon cancer via matrix metalloproteinase-mediated activation of TGFβ.
Germann M., Zangger N., Sauvain M.O., Sempoux C., Bowler A.D., Wirapati P., Kandalaft L.E., Delorenzi M., Tejpar S., Coukos G. et al., 2020/01/09. EMBO molecular medicine, 12 (1) pp. e10681. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_F06A8D6CE8D2]
A community proposal to integrate structural bioinformatics activities in ELIXIR (3D-Bioinfo Community).
Orengo C., Velankar S., Wodak S., Zoete V., Bonvin AMJJ, Elofsson A., Feenstra K.A., Gerloff D.L., Hamelryck T., Hancock J.M. et al., 2020. F1000Research, 9. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_7E6BA5C7154A]
An Immunomodulatory Gallotanin-Rich Fraction From Caesalpinia spinosa Enhances the Therapeutic Effect of Anti-PD-L1 in Melanoma.
Lasso P., Gomez-Cadena A., Urueña C., Donda A., Martinez-Usatorre A., Romero P., Barreto A., Fiorentino S., 2020. Frontiers in immunology, 11 p. 584959. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_A80580548E5B]
 
Analysis of cancer cell-intrinsic immune regulation in response to CD8+ T cell attack.
Neubert N.J., Tillé L., Martignier C., Fuertes Marraco S.A., Speiser D.E., 2020. Methods in enzymology, 631 pp. 443-466. Peer-reviewed.
[DOI][Pmid][serval:BIB_775822DA0012]
 
Assessment of memory formation by metabolically engineered antigen-specific CD8 T cells.
Wenes M., Romero P., Zhang L., 2020. Methods in enzymology, 631 pp. 77-90. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_63A6DEA3E726]
BAFF 60-mer, and Differential BAFF 60-mer Dissociating Activities in Human Serum, Cord Blood and Cerebrospinal Fluid.
Eslami M., Meinl E., Eibel H., Willen L., Donzé O., Distl O., Schneider H., Speiser D.E., Tsiantoulas D., Yalkinoglu Ö. et al., 2020. Frontiers in cell and developmental biology, 8 p. 577662. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4C23317E84BA]
c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes.
Imbratta C., Hussein H., Andris F., Verdeil G., 2020. Frontiers in immunology, 11 p. 206. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_89FA771824D7]
Cancer and HIV-1 Infection: Patterns of Chronic Antigen Exposure.
Vigano S., Bobisse S., Coukos G., Perreau M., Harari A., 2020. Frontiers in immunology, 11 p. 1350. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_19C82F6CB34E]
Charting the immune landscape in brain cancers
Soukup Klara, Joyce Johanna, 2020. TheScienceBreaker.
[URN][DOI][serval:BIB_BAB9056856AB]
Deciphering the transcriptomic landscape of tumor-infiltrating CD8 lymphocytes in B16 melanoma tumors with single-cell RNA-Seq
Carmona Santiago J., Siddiqui Imran, Bilous Mariia, Held Werner, Gfeller David, 2020/01/01. OncoImmunology, 9 (1) p. 1737369. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_EDA6E7092CF7]
 
Detecting and analyzing murine innate lymphoid cells.
Gomez-Cadena A., Romero P., Trabanelli S., Jandus C., 2020. Methods in enzymology, 631 pp. 329-342. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_91629D320BEA]
Durable response to palbociclib and letrozole in ovarian cancer with CDKN2A loss.
Frisone D., Charrier M., Clement S., Christinat Y., Thouvenin L., Homicsko K., Michielin O., Bodmer A., Chappuis P.O., McKee T.A. et al., 2020. Cancer biology & therapy, 21 (3) pp. 197-202. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_DDF548EFECDC]
Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells.
Martinez-Usatorre A., Carmona S.J., Godfroid C., Yacoub Maroun C., Labiano S., Romero P., 2020. Frontiers in immunology, 11 p. 340. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_8D693EC9FE6D]
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