Département de biochimie

Equipe principale
Publications | Mémoires et thèses

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1947 publications

Sous presse | 2020 | 2019 | 2018 | 2017 | ...
Out of Africa: the origins of the protozoan blood parasites of the Trypanosoma cruzi clade found in bats from Africa
Clément Laura, Dietrich Muriel, Markotter Wanda, Fasel Nicolas Jean, Monadjem Ara, López-Baucells Adria, Scaravelli Dino, Théou Philippe, Pigeault Romain, Ruedi manuel et al. Molecular Phylogeny and Evolution.
Inflammasomes contributing to inflammation in arthritis.
Spel L., Martinon F. Immunological reviews. Peer-reviewed.
Allosteric activation of MALT1 by its ubiquitin-binding Ig3 domain.
Schairer R., Hall G., Zhang M., Cowan R., Baravalle R., Muskett F.W., Coombs P.J., Mpamhanga C., Hale L.R., Saxty B. et al., 2020/02/11. Proceedings of the National Academy of Sciences of the United States of America, 117 (6) pp. 3093-3102. Peer-reviewed.
GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein.
Cheng J., Klei L.R., Hubel N.E., Zhang M., Schairer R., Maurer L.M., Klei H.B., Kang H., Concel V.J., Delekta P.C. et al., 2020/02/03. The Journal of clinical investigation, 130 (2) pp. 1036-1051. Peer-reviewed.
Pannexin-1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation.
Chen K.W., Demarco B., Broz P., 2020/02. European journal of immunology, 50 (2) pp. 170-177. Peer-reviewed.
'Break the Chains 2015' community-based HIV prevention campaign for men who have sex with men in Switzerland: non-randomised evaluation and cost analysis.
Frey K., Lociciro S., Blank P., Schwenkglenks M., Dubois-Arber F., Rosenbrock R., Lehner A., Staub R., Derendinger S., Schmidt A.J. et al., 2020/01/21. BMJ open, 10 (1) pp. e032459. Peer-reviewed.
Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis.
Chen K.W., Demarco B., Broz P., 2020/01/15. The EMBO journal, 39 (2) pp. e103397. Peer-reviewed.
Gender medicine and oncology: report and consensus of an ESMO workshop.
Wagner A.D., Oertelt-Prigione S., Adjei A., Buclin T., Cristina V., Csajka C., Coukos G., Dafni U., Dotto G.P., Ducreux M. et al., 2019/12/01. Annals of oncology, 30 (12) pp. 1914-1924. Peer-reviewed.
The gasdermins, a protein family executing cell death and inflammation.
Broz P., Pelegrín P., Shao F., 2019/11/05. Nature reviews. Immunology. Peer-reviewed.
No interactions between heparin and atacicept, an antagonist of B cell survival cytokines.
Kowalczyk-Quintas C., Willen D., Willen L., Golob M., Schuepbach-Mallepell S., Peter B., Eslami M., Vigolo M., Broly H., Samy E. et al., 2019/10. British journal of pharmacology, 176 (20) pp. 4019-4033. Peer-reviewed.
ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis.
Scambler T., Jarosz-Griffiths H.H., Lara-Reyna S., Pathak S., Wong C., Holbrook J., Martinon F., Savic S., Peckham D., McDermott M.F., 2019/09/18. eLife, 8. Peer-reviewed.
Magnetic Resonance Imaging-targeted Biopsy Versus Systematic Biopsy in the Detection of Prostate Cancer: A Systematic Review and Meta-analysis.
Kasivisvanathan V., Stabile A., Neves J.B., Giganti F., Valerio M., Shanmugabavan Y., Clement K.D., Sarkar D., Philippou Y., Thurtle D. et al., 2019/09. European urology, 76 (3) pp. 284-303. Peer-reviewed.
Prenatal Treatment of X-Linked Hypohidrotic Ectodermal Dysplasia using Recombinant Ectodysplasin in a Canine Model.
Margolis C.A., Schneider P., Huttner K., Kirby N., Houser T.P., Wildman L., Grove G.L., Schneider H., Casal M.L., 2019/09. The Journal of pharmacology and experimental therapeutics, 370 (3) pp. 806-813. Peer-reviewed.
The regulatory network behind MHC class I expression.
Jongsma MLM, Guarda G., Spaapen R.M., 2019/09. Molecular immunology, 113 pp. 16-21. Peer-reviewed.
CSL controls telomere maintenance and genome stability in human dermal fibroblasts.
Bottoni G., Katarkar A., Tassone B., Ghosh S., Clocchiatti A., Goruppi S., Bordignon P., Jafari P., Tordini F., Lunardi T. et al., 2019/08/29. Nature communications, 10 (1) p. 3884. Peer-reviewed.
Immunogenicity of a recombinant fusion construct composed of intrinsically unstructured, low polymorphic segments derived from merozoite surface protein 2 and trophozoite exported protein 1.
Tiendrebeogo R.W., Spallek R., Oehlmann W., Singh M., Theisen M., Nebie I., Moret R., Roussilhon C., Corradin G., 2019/08/23. Vaccine, 37 (36) pp. 5332-5340. Peer-reviewed.
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.
Collins S.C., Mikhaleva A., Vrcelj K., Vancollie V.E., Wagner C., Demeure N., Whitley H., Kannan M., Balz R., Anthony LFE et al., 2019/08/01. Nature communications, 10 (1) p. 3465. Peer-reviewed.
Sex Hormones and Anticancer Immunity.
Özdemir B.C., Dotto G.P., 2019/08/01. Clinical cancer research, 25 (15) pp. 4603-4610. Peer-reviewed.
NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death.
Radulovic K., Ayata C.K., Mak'Anyengo R., Lechner K., Wuggenig P., Kaya B., Hruz P., Gomez de Agüero M., Broz P., Weigmann B. et al., 2019/07/15. Journal of immunology, 203 (2) pp. 544-556. Peer-reviewed.
Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology.
Nayar S., Campos J., Smith C.G., Iannizzotto V., Gardner D.H., Mourcin F., Roulois D., Turner J., Sylvestre M., Asam S. et al., 2019/07/02. Proceedings of the National Academy of Sciences of the United States of America, 116 (27) pp. 13490-13497. Peer-reviewed.
Attenuation of chronic antiviral T-cell responses through constitutive COX2-dependent prostanoid synthesis by lymph node fibroblasts.
Schaeuble K., Cannelle H., Favre S., Huang H.Y., Oberle S.G., Speiser D.E., Zehn D., Luther S.A., 2019/07. PLoS biology, 17 (7) pp. e3000072. Peer-reviewed.
HVEM, a cosignaling molecular switch, and its interactions with BTLA, CD160 and LIGHT.
Rodriguez-Barbosa J.I., Schneider P., Weigert A., Lee K.M., Kim T.J., Perez-Simon J.A., Del Rio M.L., 2019/07. Cellular & molecular immunology, 16 (7) pp. 679-682. Peer-reviewed.
Electroporation of a nanoparticle-associated DNA vaccine induces higher inflammation and immunity compared to its delivery with microneedle patches in pigs.
Bernelin-Cottet C., Urien C., McCaffrey J., Collins D., Donadei A., McDaid D., Jakob V., Barnier-Quer C., Collin N., Bouguyon E. et al., 2019/06/29. Journal of controlled release, 308 pp. 14-28. Peer-reviewed.
A DNA-Modified Live Vaccine Prime-Boost Strategy Broadens the T-Cell Response and Enhances the Antibody Response against the Porcine Reproductive and Respiratory Syndrome Virus.
Bernelin-Cottet C., Urien C., Stubsrud E., Jakob V., Bouguyon E., Bordet E., Barc C., Boulesteix O., Contreras V., Barnier-Quer C. et al., 2019/06/14. Viruses, 11 (6). Peer-reviewed.
Amazonian Phlebovirus (Bunyaviridae) potentiates the infection of Leishmania (Leishmania) amazonensis: Role of the PKR/IFN1/IL-10 axis.
Rath C.T., Schnellrath L.C., Damaso C.R., de Arruda L.B., Vasconcelos PFDC, Gomes C., Laurenti M.D., Calegari Silva T.C., Vivarini Á.C., Fasel N. et al., 2019/06. PLoS neglected tropical diseases, 13 (6) pp. e0007500. Peer-reviewed.
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition.
Coll R.C., Hill J.R., Day C.J., Zamoshnikova A., Boucher D., Massey N.L., Chitty J.L., Fraser J.A., Jennings M.P., Robertson AAB et al., 2019/06. Nature chemical biology, 15 (6) pp. 556-559. Peer-reviewed.
TLR2 Signaling in Skin Nonhematopoietic Cells Induces Early Neutrophil Recruitment in Response to Leishmania major Infection.
Ronet C., Passelli K., Charmoy M., Scarpellino L., Myburgh E., Hauyon La Torre Y., Turco S., Mottram J.C., Fasel N., Luther S.A. et al., 2019/06. The Journal of Investigative Dermatology, 139 (6) pp. 1318-1328. Peer-reviewed.
IL-4Rα-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells.
Dubey L.K., Ludewig B., Luther S.A., Harris N.L., 2019/05/21. Cell Reports, 27 (8) pp. 2442-2458.e5. Peer-reviewed.
Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly.
Chen K.W., Demarco B., Heilig R., Shkarina K., Boettcher A., Farady C.J., Pelczar P., Broz P., 2019/05/15. The EMBO journal, 38 (10). Peer-reviewed.
Detection of antisense protein (ASP) RNA transcripts in individuals infected with human immunodeficiency virus type 1 (HIV-1).
Mancarella A., Procopio F.A., Achsel T., De Crignis E., Foley B.T., Corradin G., Bagni C., Pantaleo G., Graziosi C., 2019/05. The Journal of general virology, 100 (5) pp. 863-876. Peer-reviewed.
Gender and sex-time to bridge the gap.
Dotto G.P., 2019/05. EMBO Molecular Medicine, 11 (5). Peer-reviewed.
Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection.
Mello-Grand M., Gregnanin I., Sacchetto L., Ostano P., Zitella A., Bottoni G., Oderda M., Marra G., Munegato S., Pardini B. et al., 2019/04/29. Carcinogenesis, 40 (2) pp. 246-253. Peer-reviewed.
Role of ectodysplasin signalling in middle ear and nasal pathology in rat and mouse models of hypohidrotic ectodermal dysplasia.
Del-Pozo J., MacIntyre N., Azar A., Headon D., Schneider P., Cheeseman M., 2019/04/25. Disease models & mechanisms, 12 (4). Peer-reviewed.
γ-Catenin-Dependent Signals Maintain BCR-ABL1<sup>+</sup> B Cell Acute Lymphoblastic Leukemia.
Luong-Gardiol N., Siddiqui I., Pizzitola I., Jeevan-Raj B., Charmoy M., Huang Y., Irmisch A., Curtet S., Angelov G.S., Danilo M. et al., 2019/04/15. Cancer cell, 35 (4) pp. 649-663.e10. Peer-reviewed.
A role for stromal autophagy in cancer-associated fibroblast activation.
Goruppi S., Clocchiatti A., Dotto G.P., 2019/04. Autophagy, 15 (4) pp. 738-739. Peer-reviewed.
Trends of incidence and survival of patients with chronic myelomonocytic leukemia between 1999 and 2014: A comparison between Swiss and American population-based cancer registries.
Benzarti S., Daskalakis M., Feller A., Bacher V.U., Schnegg-Kaufmann A., Rüfer A., Holbro A., Schmidt A., Benz R., Solenthaler M. et al., 2019/04. Cancer epidemiology, 59 pp. 51-57. Peer-reviewed.
Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.
Niogret C., Miah SMS, Rota G., Fonta N.P., Wang H., Held W., Birchmeier W., Sexl V., Yang W., Vivier E. et al., 2019/03/29. Nature communications, 10 (1) p. 1444. Peer-reviewed.
Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus.
Marcandalli J., Fiala B., Ols S., Perotti M., de van der Schueren W., Snijder J., Hodge E., Benhaim M., Ravichandran R., Carter L. et al., 2019/03/07. Cell, 176 (6) pp. 1420-1431.e17. Peer-reviewed.
A proliferation-inducing ligand-mediated anti-inflammatory response of astrocytes in multiple sclerosis.
Baert L., Benkhoucha M., Popa N., Ahmed M.C., Manfroi B., Boutonnat J., Sturm N., Raguenez G., Tessier M., Casez O. et al., 2019/03. Annals of neurology, 85 (3) pp. 406-420. Peer-reviewed.
Divide to conquer: NLRP3 is activated on dispersed trans-Golgi network.
Chen K.W., Boucher D., Broz P., 2019/03. Cell research, 29 (3) pp. 181-182. Peer-reviewed.
First person – Christin Bissig
Bissig C., 2019/03/01. Journal of Cell Science, 132 (5) pp. jcs230466. Peer-reviewed.
Prevalence of oncogenic Human papillomavirus and genetic diversity in the L1 gene of HPV16 HPV 18 HPV31 and HPV33 found in women from Vojvodina Province Serbia.
Kovacevic G., Milosevic V., Knezevic P., Knezevic A., Knezevic I., Radovanov J., Nikolic N., Patic A., Petrovic V., Hrnjakovic Cvjetkovic I. et al., 2019/03. Biologicals, 58 pp. 57-63. Peer-reviewed.
Recognition of Intracellular Bacteria by Inflammasomes.
Broz P., 2019/03. Microbiology spectrum, 7 (2). Peer-reviewed.
Inhibition of NK Reactivity Against Solid Tumors by Platelet-Derived RANKL.
Clar K.L., Hinterleitner C., Schneider P., Salih H.R., Maurer S., 2019/02/26. Cancers, 11 (3). Peer-reviewed.
Intratumoral Tcf1<sup>+</sup>PD-1<sup>+</sup>CD8<sup>+</sup> T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy.
Siddiqui I., Schaeuble K., Chennupati V., Fuertes Marraco S.A., Calderon-Copete S., Pais Ferreira D., Carmona S.J., Scarpellino L., Gfeller D., Pradervand S. et al., 2019/01/15. Immunity, 50 (1) pp. 195-211.e10. Peer-reviewed.
A Surface-Induced Asymmetric Program Promotes Tissue Colonization by Pseudomonas aeruginosa.
Laventie B.J., Sangermani M., Estermann F., Manfredi P., Planes R., Hug I., Jaeger T., Meunier E., Broz P., Jenal U., 2019/01/09. Cell host & microbe, 25 (1) pp. 140-152.e6. Peer-reviewed.
A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion.
Valoskova K., Biebl J., Roblek M., Emtenani S., Gyoergy A., Misova M., Ratheesh A., Reis-Rodrigues P., Shkarina K., Larsen ISB et al., 2019. eLife, 8 pp. e41801. Peer-reviewed.
Assay of Lipid Mixing and Fusion Pore Formation in the Fusion of Yeast Vacuoles.
D'Agostino M., Mayer A., 2019. Methods in molecular biology, 1860 pp. 253-262. Peer-reviewed.
Development of Sample-Adaptable Holders for Lightsheet Microscopy.
Laroche T., Burri O., Dubey L.K., Seitz A., 2019. Frontiers in Neuroanatomy, 13 p. 26. Peer-reviewed.
Erratum: Author Correction: System immunology-based identification of blood transcriptional modules correlating to antibody responses in sheep.
Braun R.O., Brunner L., Wyler K., Auray G., García-Nicolás O., Python S., Zumkehr B., Gaschen V., Stoffel M.H., Collin N. et al., 2019. NPJ vaccines, 4 p. 10. Peer-reviewed.
Expression of Plet1 controls interstitial migration of murine small intestinal dendritic cells.
Karrich J.J., Romera-Hernández M., Papazian N., Veenbergen S., Cornelissen F., Aparicio-Domingo P., Stenhouse F.H., Peddie C.D., Hoogenboezem R.M., den Hollander CWJ et al., 2019. European Journal of Immunology, 49 (2) pp. 290-301. Peer-reviewed.
Feather arrays are patterned by interacting signalling and cell density waves.
Ho WKW, Freem L., Zhao D., Painter K.J., Woolley T.E., Gaffney E.A., McGrew M.J., Tzika A., Milinkovitch M.C., Schneider P. et al., 2019. PLoS Biology, 17 (2) pp. e3000132. Peer-reviewed.
Large-Scale 3-5 Hz Oscillation Constrains the Expression of Neocortical Fast Ripples in a Mouse Model of Mesial Temporal Lobe Epilepsy.
Sheybani L., van Mierlo P., Birot G., Michel C.M., Quairiaux C., 2019. eNeuro, 6 (1). Peer-reviewed.
Leishmania Parasite Quantification by Bioluminescence in Murine Models
Reverte Marta, Fasel Nicolas, 2019. BIO-PROTOCOL, 9 (22).
Leukotriene B<sub>4</sub> modulation of murine dendritic cells affects adaptive immunity.
Pires-Lapa M.A., Koga M.M., da Silva I.A., Filgueiras L.R., Jancar S., 2019. Prostaglandins & other Lipid Mediators, 141 pp. 34-39. Peer-reviewed.
Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation.
Lara-Reyna S., Scambler T., Holbrook J., Wong C., Jarosz-Griffiths H.H., Martinon F., Savic S., Peckham D., McDermott M.F., 2019. Frontiers in immunology, 10 p. 1789. Peer-reviewed.
Modeling Edar expression reveals the hidden dynamics of tooth signaling center patterning.
Sadier A., Twarogowska M., Steklikova K., Hayden L., Lambert A., Schneider P., Laudet V., Hovorakova M., Calvez V., Pantalacci S., 2019. PLoS Biology, 17 (2) pp. e3000064. Peer-reviewed.
Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation.
Demarco B., Chen K.W., Broz P., 2019. Molecular & cellular oncology, 6 (4) p. 1610324. Peer-reviewed.
RNA-Seq Revealed Expression of Many Novel Genes Associated With Leishmania donovani Persistence and Clearance in the Host Macrophage
Shadab M., Das S., Banerjee A., Sinha R., Asad M., Kamran M., Maji M., Jha B., Deepthi M., Kumar M. et al., 2019. Frontiers in Cellular and Infection Microbiology, 9 p. 17. Peer-reviewed.
Systems Immunology Characterization of Novel Vaccine Formulations for Mycoplasma hyopneumoniae Bacterins.
Matthijs AMF, Auray G., Jakob V., García-Nicolás O., Braun R.O., Keller I., Bruggman R., Devriendt B., Boyen F., Guzman C.A. et al., 2019. Frontiers in immunology, 10 p. 1087. Peer-reviewed.
The mKate fluorescent protein expressed by Leishmania mexicana modifies the parasite immunopathogenicity in BALB/c mice.
Diupotex M., Martínez-Salazar M.B., Escalona-Montaño A.R., Zamora-Chimal J., Salaiza-Suazo N., Ruiz-Remigio A., Roldán-Salgado A., Aguirre-García M.M., Martínez-Calvillo S., Gaytán P. et al., 2019. Parasite Immunology, 41 (2) pp. e12608. Peer-reviewed.
TRAIL-R1 and TRAIL-R2 Mediate TRAIL-Dependent Apoptosis in Activated Primary Human B Lymphocytes.
Staniek J., Lorenzetti R., Heller B., Janowska I., Schneider P., Unger S., Warnatz K., Seidl M., Venhoff N., Thiel J. et al., 2019. Frontiers in immunology, 10 p. 951. Peer-reviewed.
Androgen receptor functions as transcriptional repressor of cancer-associated fibroblast activation.
Clocchiatti A., Ghosh S., Procopio M.G., Mazzeo L., Bordignon P., Ostano P., Goruppi S., Bottoni G., Katarkar A., Levesque M. et al., 2018/12/03. The Journal of clinical investigation, 128 (12) pp. 5531-5548. Peer-reviewed.
Deletion of Interleukin-4 Receptor Alpha-Responsive Keratinocytes in BALB/c Mice Does Not Alter Susceptibility to Cutaneous Leishmaniasis.
Govender M., Hurdayal R., Martinez-Salazar B., Gqada K., Pillay S., Gcanga L., Passelli K., Nieuwenhuizen N.E., Tacchini-Cottier F., Guler R. et al., 2018/12. Infection and immunity, 86 (12) pp. e00710-18. Peer-reviewed.
Gasdermin D opens the way for NETs.
Spel L., Martinon F., 2018/12. Nature reviews. Rheumatology, 14 (12) pp. 690-692. Peer-reviewed.
Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection.
Cerqueira D.M., Gomes MTR, Silva ALN, Rungue M., Assis NRG, Guimarães E.S., Morais S.B., Broz P., Zamboni D.S., Oliveira S.C., 2018/12. PLoS pathogens, 14 (12) pp. e1007519. Peer-reviewed.
The criminal association of Leishmania parasites and viruses.
Rossi M., Fasel N., 2018/12. Current opinion in microbiology, 46 pp. 65-72. Peer-reviewed.
BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages.
Chauhan D., Bartok E., Gaidt M.M., Bock F.J., Herrmann J., Seeger J.M., Broz P., Beckmann R., Kashkar H., Tait SWG et al., 2018/11/27. Cell reports, 25 (9) pp. 2354-2368.e5. Peer-reviewed.
ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation.
Rühl S., Shkarina K., Demarco B., Heilig R., Santos J.C., Broz P., 2018/11/23. Science, 362 (6417) pp. 956-960. Peer-reviewed.
B Cell-Activating Factor Neutralization Aggravates Atherosclerosis.
Tsiantoulas D., Sage A.P., Göderle L., Ozsvar-Kozma M., Murphy D., Porsch F., Pasterkamp G., Menche J., Schneider P., Mallat Z. et al., 2018/11/13. Circulation, 138 (20) pp. 2263-2273. Peer-reviewed.
Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium.
Cagnet S., Ataca D., Sflomos G., Aouad P., Schuepbach-Mallepell S., Hugues H., Krust A., Ayyanan A., Scabia V., Brisken C., 2018/11/09. Nature communications, 9 (1) p. 4723. Peer-reviewed.
Sensing of invading pathogens by GBPs: At the crossroads between cell-autonomous and innate immunity.
Santos J.C., Broz P., 2018/10. Journal of leukocyte biology, 104 (4) pp. 729-735. Peer-reviewed.
SNARE-mediated membrane fusion arrests at pore expansion to regulate the volume of an organelle.
D'Agostino M., Risselada H.J., Endter L.J., Comte-Miserez V., Mayer A., 2018/10/01. The EMBO journal, 37 (19). Peer-reviewed.
Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation.
Rodriguez-Barbosa J.I., Ferreras M.C., Buhler L., Jones N.D., Schneider P., Perez-Simon J.A., Del Rio M.L., 2018/10. mAbs, 10 (7) pp. 1030-1044. Peer-reviewed.
Autophagy Controls CSL/RBPJκ Stability through a p62/SQSTM1-Dependent Mechanism.
Goruppi S., Jo S.H., Laszlo C., Clocchiatti A., Neel V., Dotto G.P., 2018/09/18. Cell reports, 24 (12) pp. 3108-3114.e4. Peer-reviewed.
Attenuation of Mammary Gland Dysplasia and Feeding Difficulties in Tabby Mice by Fetal Therapy.
Wahlbuhl M., Schuepbach-Mallepell S., Kowalczyk-Quintas C., Dick A., Fahlbusch F.B., Schneider P., Schneider H., 2018/09. Journal of mammary gland biology and neoplasia, 23 (3) pp. 125-138. Peer-reviewed.
CARD14 Gain-of-Function Mutation Alone Is Sufficient to Drive IL-23/IL-17-Mediated Psoriasiform Skin Inflammation In Vivo.
Mellett M., Meier B., Mohanan D., Schairer R., Cheng P., Satoh T.K., Kiefer B., Ospelt C., Nobbe S., Thome M. et al., 2018/09. The Journal of investigative dermatology, 138 (9) pp. 2010-2023. Peer-reviewed.
Noncanonical inflammasome signaling elicits gasdermin D-dependent neutrophil extracellular traps.
Chen K.W., Monteleone M., Boucher D., Sollberger G., Ramnath D., Condon N.D., von Pein J.B., Broz P., Sweet M.J., Schroder K., 2018/08/24. Science immunology, 3 (26) pp. eaar6676. Peer-reviewed.
B2-Lymphocyte responses to oxidative stress-derived antigens contribute to the evolution of nonalcoholic fatty liver disease (NAFLD).
Bruzzì S., Sutti S., Giudici G., Burlone M.E., Ramavath N.N., Toscani A., Bozzola C., Schneider P., Morello E., Parola M. et al., 2018/08/20. Free radical biology & medicine, 124 pp. 249-259. Peer-reviewed.
A proximity-dependent biotinylation (BioID) approach flags the p62/sequestosome-1 protein as a caspase-1 substrate.
Jamilloux Y., Lagrange B., Di Micco A., Bourdonnay E., Provost A., Tallant R., Henry T., Martinon F., 2018/08/10. The Journal of biological chemistry, 293 (32) pp. 12563-12575. Peer-reviewed.
Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.
Robak O.H., Heimesaat M.M., Kruglov A.A., Prepens S., Ninnemann J., Gutbier B., Reppe K., Hochrein H., Suter M., Kirschning C.J. et al., 2018/08/01. The Journal of clinical investigation, 128 (8) pp. 3535-3545. Peer-reviewed.
RNA fusions involving CD28 are rare in peripheral T-cell lymphomas and concentrate mainly in those derived from follicular helper T cells.
Vallois D., Dupuy A., Lemonnier F., Allen G., Missiaglia E., Fataccioli V., Ortonne N., Clavert A., Delarue R., Rousselet M.C. et al., 2018/08. Haematologica, 103 (8) pp. e360-e363. Peer-reviewed.
The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity.
Castro W., Chelbi S.T., Niogret C., Ramon-Barros C., Welten SPM, Osterheld K., Wang H., Rota G., Morgado L., Vivier E. et al., 2018/08. Nature immunology, 19 (8) pp. 809-820. Peer-reviewed.
Formation of the Intrathymic Dendritic Cell Pool Requires CCL21-Mediated Recruitment of CCR7<sup>+</sup> Progenitors to the Thymus.
Cosway E.J., Ohigashi I., Schauble K., Parnell S.M., Jenkinson W.E., Luther S., Takahama Y., Anderson G., 2018/07/15. Journal of immunology, 201 (2) pp. 516-523. Peer-reviewed.
CART cells are prone to Fas- and DR5-mediated cell death.
Tschumi B.O., Dumauthioz N., Marti B., Zhang L., Lanitis E., Irving M., Schneider P., Mach J.P., Coukos George, Romero P. et al., 2018/07/13. Journal for immunotherapy of cancer, 6 (1) p. 71. Peer-reviewed.
Analysis of cytokine immune response profile in response to inflammatory stimuli in mice with genetic defects in fetal and adult hemoglobin chain expression.
Khatri I., Alexander C., Brandenburg K., Chen Z., Heini A., Heumann D., Mach J.P., Mazzoli V., Rietschel E., Terskikh A. et al., 2018/07. The pharmacogenomics journal, 18 (4) pp. 546-555. Peer-reviewed.
Inflammation initiated by stressed organelles.
Martinon F., 2018/07. Joint, bone, spine, 85 (4) pp. 423-428. Peer-reviewed.
Leishmania amazonensis downregulates macrophage iNOS expression via Histone Deacetylase 1 (HDAC1): a novel parasite evasion mechanism.
Calegari-Silva T.C., Vivarini Á.C., Pereira RMS, Dias-Teixeira K.L., Rath C.T., Pacheco ASS, Silva GBL, Pinto CAS, Dos Santos J.V., Saliba A.M. et al., 2018/07. European journal of immunology, 48 (7) pp. 1188-1198. Peer-reviewed.
Corrigendum to "An altered REDOX environment, assisted by over-expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression" [Int. Immunopharmacol. 50 (2017) 69-76].
Gorczynski R.M., Alexander C., Brandenburg K., Chen Z., Heini A., Neumann D., Mach J.P., Rietschel E.T., Terskikh A., Ulmer A.J. et al., 2018/06. International immunopharmacology, 59 p. 414. Peer-reviewed.
Corrigendum to "Regulation of fetal hemoglobin expression during hematopoietic stem cell development and its importance in bone metabolism and osteoporosis" [Int. Immunopharmacol. 57 (2018) 112-120].
Kos O., Alexander C., Brandenburg K., Chen Z., Heini A., Heumann D., Khatri I., Mach J.P., Rietschel E.T., Terskikh A. et al., 2018/06. International immunopharmacology, 59 p. 413. Peer-reviewed.
Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B.
Al Labban D., Jo S.H., Ostano P., Saglietti C., Bongiovanni M., Panizzon R., Dotto G.P., 2018/06/01. The Journal of clinical investigation, 128 (6) pp. 2581-2599. Peer-reviewed.
Pan-SRC kinase inhibition blocks B-cell receptor oncogenic signaling in non-Hodgkin lymphoma.
Battistello E., Katanayeva N., Dheilly E., Tavernari D., Donaldson M.C., Bonsignore L., Thome M., Christie A.L., Murakami M.A., Michielin O. et al., 2018/05/24. Blood, 131 (21) pp. 2345-2356. Peer-reviewed.
Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity.
Rodda L.B., Lu E., Bennett M.L., Sokol C.L., Wang X., Luther S.A., Barres B.A., Luster A.D., Ye C.J., Cyster J.G., 2018/05/15. Immunity, 48 (5) pp. 1014-1028.e6. Peer-reviewed.
Manifold Roles of CCR7 and Its Ligands in the Induction and Maintenance of Bronchus-Associated Lymphoid Tissue.
Fleige H., Bosnjak B., Permanyer M., Ristenpart J., Bubke A., Willenzon S., Sutter G., Luther S.A., Förster R., 2018/04/17. Cell reports, 23 (3) pp. 783-795. Peer-reviewed.
Assay for high-throughput screening of inhibitors of the ASC-PYD inflammasome core filament
Sborgi Lorenzo, Ude Johanna, Dick Mathias S., Vesin Jonathan, Chambon Marc, Turcatti Gerardo, Broz Petr, Hiller Sebastian, 2018/04/09. Cell Stress, 2 (4) pp. 82-90.
A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors.
Vigolo M., Chambers M.G., Willen L., Chevalley D., Maskos K., Lammens A., Tardivel A., Das D., Kowalczyk-Quintas C., Schuepbach-Mallepell S. et al., 2018/03/23. Nature communications, 9 (1) p. 1199. Peer-reviewed.
LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.
Santos J.C., Dick M.S., Lagrange B., Degrandi D., Pfeffer K., Yamamoto M., Meunier E., Pelczar P., Henry T., Broz P., 2018/03/15. The EMBO journal, 37 (6) pp. 1-19. Peer-reviewed.
How to master the host immune system? Leishmania parasites have the solutions!
Rossi M., Fasel N., 2018/03/10. International immunology, 30 (3) pp. 103-111. Peer-reviewed.
Hydrogen sulfide inhibits NLRP3 inflammasome activation and reduces cytokine production both in vitro and in a mouse model of inflammation.
Castelblanco M., Lugrin J., Ehirchiou D., Nasi S., Ishii I., So A., Martinon F., Busso N., 2018/02/16. The Journal of biological chemistry, 293 (7) pp. 2546-2557. Peer-reviewed.
Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer.
Chen J., Guccini I., Di Mitri D., Brina D., Revandkar A., Sarti M., Pasquini E., Alajati A., Pinton S., Losa M. et al., 2018/02. Nature genetics, 50 (2) pp. 219-228. Peer-reviewed.
Function and mechanism of the pyrin inflammasome.
Heilig R., Broz P., 2018/02. European journal of immunology, 48 (2) pp. 230-238. Peer-reviewed.
Down selecting adjuvanted vaccine formulations: a comparative method for harmonized evaluation.
Younis S.Y., Barnier-Quer C., Heuking S., Sommandas V., Brunner L., Vd Werff N., Dubois P., Friede M., Kocken C., Collin N. et al., 2018/01/31. BMC immunology, 19 (1) p. 6. Peer-reviewed.
Mechanisms and Consequences of Inflammasome Activation.
Schroder K., Kanneganti T.D., Shao F., Broz P., 2018/01/19. Journal of molecular biology, 430 (2) pp. 131-132. Peer-reviewed.
Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite <i>Leishmania</i>.
Grybchuk D., Akopyants N.S., Kostygov A.Y., Konovalovas A., Lye L.F., Dobson D.E., Zangger H., Fasel N., Butenko A., Frolov A.O. et al., 2018/01/16. Proceedings of the National Academy of Sciences of the United States of America, 115 (3) pp. E506-E515. Peer-reviewed.
A Combination of Approved Antibodies Overcomes Resistance of Lung Cancer to Osimertinib by Blocking Bypass Pathways.
Romaniello D., Mazzeo L., Mancini M., Marrocco I., Noronha A., Kreitman M., Srivastava S., Ghosh S., Lindzen M., Salame T.M. et al., 2018. Clinical Cancer Research, 24 (22) pp. 5610-5621. Peer-reviewed.
A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein.
Tan J., Sack B.K., Oyen D., Zenklusen I., Piccoli L., Barbieri S., Foglierini M., Fregni C.S., Marcandalli J., Jongo S. et al., 2018. Nature Medicine, 24 (4) pp. 401-407. Peer-reviewed.
A rhodamine hydrazide–4-nitroindole-3-carboxaldehyde based turn on Hg2+ chemosensor: cytoplasmic live cell imaging, logic gate and memory device applications and computational studies
Bhowmick R., Musha Islam A.S., Sasmal M., Katarkar A., Ali M., 2018. Journal of Coordination Chemistry, 71 (11-13) pp. 2065-2081.
A simian-adenovirus-vectored rabies vaccine suitable for thermostabilisation and clinical development for low-cost single-dose pre-exposure prophylaxis.
Wang C., Dulal P., Zhou X., Xiang Z., Goharriz H., Banyard A., Green N., Brunner L., Ventura R., Collin N. et al., 2018. PLoS Neglected Tropical Diseases, 12 (10) pp. e0006870. Peer-reviewed.
Absence of MHC-II expression by lymph node stromal cells results in autoimmunity.
Dubrot J., Duraes F.V., Harlé G., Schlaeppi A., Brighouse D., Madelon N., Göpfert C., Stokar-Regenscheit N., Acha-Orbea H., Reith W. et al., 2018. Life Science Alliance, 1 (6) pp. e201800164. Peer-reviewed.
Correction to: CART cells are prone to Fas- and DR5-mediated cell death.
Tschumi B.O., Dumauthioz N., Marti B., Zhang L., Lanitis E., Irving M., Schneider P., Mach J.P., Coukos G., Romero P. et al., 2018. Journal for Immunotherapy of Cancer, 6 (1) p. 92. Peer-reviewed.
Development of a semi-automated image-based high-throughput drug screening system.
Eren R.O., Kopelyanskiy D., Moreau D., Chapalay J.B., Chambon M., Turcatti G., Lye L.F., Beverley S.M., Fasel N., 2018/01/01. Frontiers in bioscience, 10 pp. 242-253. Peer-reviewed.
Establishment and Characterization of a Functionally Competent Type 2 Conventional Dendritic Cell Line.
Pigni M., Ashok D., Stevanin M., Acha-Orbea H., 2018. Frontiers in immunology, 9 p. 1912. Peer-reviewed.
Functions of the <i>Dictyostelium</i> LIMP-2 and CD36 homologues in bacteria uptake, phagolysosome biogenesis and host cell defence.
Sattler N., Bosmani C., Barisch C., Guého A., Gopaldass N., Dias M., Leuba F., Bruckert F., Cosson P., Soldati T., 2018. Journal of Cell Science, 131 (17). Peer-reviewed.
Global Ion Suppression Limits the Potential of Mass Spectrometry Based Phosphoproteomics.
Dreier R.F., Ahrné E., Broz P., Schmidt A., 2018. Journal of Proteome Research, 18 (1) pp. 493-507. Peer-reviewed.
Guidelines and recommendations on yeast cell death nomenclature
Carmona-Gutierez D, Fasel N, 2018. Microbial Cell, 5 (1) pp. 4-31. Peer-reviewed.
Holding All the CARDs: How MALT1 Controls CARMA/CARD-Dependent Signaling.
Juilland M., Thome M., 2018. Frontiers in immunology, 9 p. 1927. Peer-reviewed.
Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis.
Huang H.Y., Rivas-Caicedo A., Renevey F., Cannelle H., Peranzoni E., Scarpellino L., Hardie D.L., Pommier A., Schaeuble K., Favre S. et al., 2018. Proceedings of the National Academy of Sciences of the United States of America, 115 (29) pp. E6826-E6835. Peer-reviewed.
Importance of EMT Factor ZEB1 in cDC1 "MutuDC Line" Mediated Induction of Th1 Immune Response.
Smita S., Ahad A., Ghosh A., Biswas V.K., Koga M.M., Gupta B., Acha-Orbea H., Raghav S.K., 2018. Frontiers in immunology, 9 p. 2604. Peer-reviewed.
Importance of polyphosphate in the <i>Leishmania</i> life cycle.
Kohl K., Zangger H., Rossi M., Isorce N., Lye L.F., Owens K.L., Beverley S.M., Mayer A., Fasel N., 2018. Microbial Cell, 5 (8) pp. 371-384. Peer-reviewed.
Inhibition of Membrane-Bound BAFF by the Anti-BAFF Antibody Belimumab.
Kowalczyk-Quintas C., Chevalley D., Willen L., Jandus C., Vigolo M., Schneider P., 2018. Frontiers in immunology, 9 p. 2698. Peer-reviewed.
Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion.
Monteleone M., Stanley A.C., Chen K.W., Brown D.L., Bezbradica J.S., von Pein J.B., Holley C.L., Boucher D., Shakespear M.R., Kapetanovic R. et al., 2018. Cell Reports, 24 (6) pp. 1425-1433. Peer-reviewed.
Lack of Adipocytes Alters Hematopoiesis in Lipodystrophic Mice.
Wilson A., Fu H., Schiffrin M., Winkler C., Koufany M., Jouzeau J.Y., Bonnet N., Gilardi F., Renevey F., Luther S.A. et al., 2018. Frontiers in immunology, 9 p. 2573. Peer-reviewed.
Leishmania guyanensis parasites block the activation of the inflammasome by inhibiting maturation of IL-1β.
Hartley M.A., Eren R.O., Rossi M., Prevel F., Castiglioni P., Isorce N., Desponds C., Lye L.F., Beverley S.M., Drexler S.K. et al., 2018. Microbial Cell, 5 (3) pp. 137-149. Peer-reviewed.
MALT1 protease activity in primary effusion lymphoma.
Juilland M., Bonsignore L., Thome M., 2018. Oncotarget, 9 (16) pp. 12542-12543. Peer-reviewed.
Mobilizable Plasmids for Tunable Gene Expression in Francisella novicida.
Brodmann M., Heilig R., Broz P., Basler M., 2018. Frontiers in cellular and infection microbiology, 8 p. 284. Peer-reviewed.
Multiple roles of lymphatic vessels in peripheral lymph node development.
Bovay E., Sabine A., Prat-Luri B., Kim S., Son K., Willrodt A.H., Olsson C., Halin C., Kiefer F., Betsholtz C. et al., 2018. The Journal of Experimental Medicine, 215 (11) pp. 2760-2777. Peer-reviewed.
Neutrophils enhance early Trypanosoma brucei infection onset.
Caljon G., Mabille D., Stijlemans B., De Trez C., Mazzone M., Tacchini-Cottier F., Malissen M., A Van Ginderachter J., Magez S., De Baetselier P. et al., 2018. Scientific Reports, 8 (1) p. 11203. Peer-reviewed.
Nitric Oxide Sensing through 1,2,3,4-Oxatriazole Formation from Acylhydrazide: A Kinetic Study.
Islam ASM, Bhowmick R., Chandra Garain B., Katarkar A., Ali M., 2018. The Journal of Organic Chemistry, 83 (21) pp. 13287-13295. Peer-reviewed.
Prenatal Correction of X-Linked Hypohidrotic Ectodermal Dysplasia.
Schneider H., Faschingbauer F., Schuepbach-Mallepell S., Körber I., Wohlfart S., Dick A., Wahlbuhl M., Kowalczyk-Quintas C., Vigolo M., Kirby N. et al., 2018. The New England Journal of Medicine, 378 (17) pp. 1604-1610. Peer-reviewed.
Regulation of fetal hemoglobin expression during hematopoietic stem cell development and its importance in bone metabolism and osteoporosis.
Kos O., Alexander C., Brandenburg K., Chen Z., Heini A., Heumann D., Khatri I., Mach J.P., Rietschel E.T., Tersikh A. et al., 2018. International Immunopharmacology, 57 pp. 112-120. Peer-reviewed.
Resistance of Leishmania (Viannia) Panamensis to Meglumine Antimoniate or Miltefosine Modulates Neutrophil Effector Functions.
Regli I.B., Fernández O.L., Martínez-Salazar B., Gómez M.A., Saravia N.G., Tacchini-Cottier F., 2018. Frontiers in Immunology, 9 p. 3040. Peer-reviewed.
Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.
Chennupati V., Veiga D.F., Maslowski K.M., Andina N., Tardivel A., Yu E.C., Stilinovic M., Simillion C., Duchosal M.A., Quadroni M. et al., 2018. The Journal of Clinical Investigation, 128 (4) pp. 1597-1614. Peer-reviewed.
Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo.
Rota G., Niogret C., Dang A.T., Barros C.R., Fonta N.P., Alfei F., Morgado L., Zehn D., Birchmeier W., Vivier E. et al., 2018. Cell Reports, 23 (1) pp. 39-49. Peer-reviewed.
System immunology-based identification of blood transcriptional modules correlating to antibody responses in sheep.
Braun R.O., Brunner L., Wyler K., Auray G., García-Nicolás O., Python S., Zumkehr B., Gaschen V., Stoffel M.H., Collin N. et al., 2018. NPJ vaccines, 3 p. 41. Peer-reviewed.
The AIM2 inflammasome: Sensor of pathogens and cellular perturbations.
Lugrin J., Martinon F., 2018/01. Immunological reviews, 281 (1) pp. 99-114. Peer-reviewed.
The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice.
Heilig R., Dick M.S., Sborgi L., Meunier E., Hiller S., Broz P., 2018. European Journal of Immunology, 48 (4) pp. 584-592. Peer-reviewed.
The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity.
Schneider K.S., Groß C.J., Dreier R.F., Saller B.S., Mishra R., Gorka O., Heilig R., Meunier E., Dick M.S., Ćiković T. et al., 2017/12/26. Cell reports, 21 (13) pp. 3846-3859. Peer-reviewed.
Emerging Role for the PERK/eIF2α/ATF4 in Human Cutaneous Leishmaniasis.
Dias-Teixeira K.L., Calegari-Silva T.C., Medina J.M., Vivarini Á.C., Cavalcanti Á., Teteo N., Santana AKM, Real F., Gomes C.M., Pereira RMS et al., 2017/12/06. Scientific reports, 7 (1) p. 17074. Peer-reviewed.
Magnesium uptake by connecting fluid-phase endocytosis to an intracellular inorganic cation filter.
Klompmaker S.H., Kohl K., Fasel N., Mayer A., 2017/12/01. Nature communications, 8 (1) p. 1879. Peer-reviewed.
A tethering complex drives the terminal stage of SNARE-dependent membrane fusion.
D'Agostino M., Risselada H.J., Lürick A., Ungermann C., Mayer A., 2017/11/30. Nature, 551 (7682) pp. 634-638. Peer-reviewed.
Perivascular Fibroblasts of the Developing Spleen Act as LTα1β2-Dependent Precursors of Both T and B Zone Organizer Cells.
Schaeuble K., Britschgi M.R., Scarpellino L., Favre S., Xu Y., Koroleva E., Lissandrin TKA, Link A., Matloubian M., Ware C.F. et al., 2017/11/28. Cell reports, 21 (9) pp. 2500-2514. Peer-reviewed.
Survival Mechanisms Used by Some Leishmania Species to Escape Neutrophil Killing
Regli I.B., Passelli K., Hurrell B.P., Tacchini-Cottier F., 2017/11/16. Frontiers in Immunology, 8 p. 1558. Peer-reviewed.
Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.
Jain V., Yogavel M., Kikuchi H., Oshima Y., Hariguchi N., Matsumoto M., Goel P., Touquet B., Jumani R.S., Tacchini-Cottier F. et al., 2017/10/03. Structure, 25 (10) pp. 1495-1505.e6. Peer-reviewed.
α<sub>V</sub>β<sub>3</sub> Integrin regulates astrocyte reactivity.
Lagos-Cabré R., Alvarez A., Kong M., Burgos-Bravo F., Cárdenas A., Rojas-Mancilla E., Pérez-Nuñez R., Herrera-Molina R., Rojas F., Schneider P. et al., 2017/09/29. Journal of neuroinflammation, 14 (1) p. 194. Peer-reviewed.
The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI.
Goruppi S., Procopio M.G., Jo S., Clocchiatti A., Neel V., Dotto G.P., 2017/09/05. Cell reports, 20 (10) pp. 2468-2479. Peer-reviewed.
An altered REDOX environment, assisted by over-expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression.
Gorczynski R.M., Alexander C., Brandenburg K., Chen Z., Heini A., Neumann D., Mach J.P., Rietschel E.T., Tersikh A., Ulmer A.J. et al., 2017/09. International immunopharmacology, 50 pp. 69-76. Peer-reviewed.
Cyclin D3 deficiency inhibits skin tumor development, but does not affect normal keratinocyte proliferation.
Lee S.H., Wang X., Kim S.H., Kim Y., Rodriguez-Puebla M.L., 2017/09. Oncology letters, 14 (3) pp. 2723-2734. Peer-reviewed.
Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis.
Dubey L.K., Karempudi P., Luther S.A., Ludewig B., Harris N.L., 2017/08/28. Nature communications, 8 (1) p. 367. Peer-reviewed.
The anti-influenza M2e antibody response is promoted by XCR1 targeting in pig skin.
Deloizy C., Fossum E., Barnier-Quer C., Urien C., Chrun T., Duval A., Codjovi M., Bouguyon E., Maisonnasse P., Hervé P.L. et al., 2017/08/09. Scientific reports, 7 (1) p. 7639. Peer-reviewed.
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Ciarlo E., Heinonen T., Lugrin J., Acha-Orbea H., Le Roy D., Auwerx J., Roger T., 2017/06/20. Scientific reports, 7 (1) p. 3853. Peer-reviewed.
Distinct pathophysiological cytokine profiles for discrimination between autoimmune pancreatitis, chronic pancreatitis, and pancreatic ductal adenocarcinoma.
Ghassem-Zadeh S., Gaida M.M., Szanyi S., Acha-Orbea H., Frossard J.L., Hinz U., Hackert T., Strobel O., Felix K., 2017/06/02. Journal of translational medicine, 15 (1) p. 126. Peer-reviewed.
Replicating viral vector platform exploits alarmin signals for potent CD8<sup>+</sup> T cell-mediated tumour immunotherapy.
Kallert S.M., Darbre S., Bonilla W.V., Kreutzfeldt M., Page N., Müller P., Kreuzaler M., Lu M., Favre S., Kreppel F. et al., 2017/05/26. Nature communications, 8 p. 15327. Peer-reviewed.
Type I interferons induced by endogenous or exogenous viral infections promote metastasis and relapse of leishmaniasis.
Rossi M., Castiglioni P., Hartley M.A., Eren R.O., Prével F., Desponds C., Utzschneider D.T., Zehn D., Cusi M.G., Kuhlmann F.M. et al., 2017/05/09. Proceedings of the National Academy of Sciences of the United States of America, 114 (19) pp. 4987-4992. Peer-reviewed.
Ppn2, a novel Zn2+-dependent polyphosphatase in the acidocalcisome-like yeast vacuole.
Gerasimaitė R., Mayer A., 2017/05/01. Journal of cell science, 130 (9) pp. 1625-1636. Peer-reviewed.
TAT-RasGAP317-326 Enhances Radiosensitivity of Human Carcinoma Cell Lines In Vitro and In Vivo through Promotion of Delayed Mitotic Cell Death.
Tsoutsou P., Annibaldi A., Viertl D., Ollivier J., Buchegger F., Vozenin M.C., Bourhis J., Widmann C., Matzinger O., 2017/05. Radiation research, 187 (5) pp. 562-569. Peer-reviewed.
Impairment of both IRE1 expression and XBP1 activation is a hallmark of GCB DLBCL and contributes to tumor growth.
Bujisic B., De Gassart A., Tallant R., Demaria O., Zaffalon L., Chelbi S., Gilliet M., Bertoni F., Martinon F., 2017/04/27. Blood, 129 (17) pp. 2420-2428. Peer-reviewed.
IRE1 gives weight to obesity-associated inflammation.
Bujisic B., Martinon F., 2017/04/18. Nature immunology, 18 (5) pp. 479-480. Peer-reviewed.
CD11b regulates the Treg/Th17 balance in murine arthritis via IL-6.
Stevanin M., Busso N., Chobaz V., Pigni M., Ghassem-Zadeh S., Zhang L., Acha-Orbea H., Ehirchiou D., 2017/04. European journal of immunology, 47 (4) pp. 637-645. Peer-reviewed.
TACI-dependent APRIL signaling maintains autoreactive B cells in a mouse model of systemic lupus erythematosus.
Tran N.L., Schneider P., Santiago-Raber M.L., 2017/04. European journal of immunology, 47 (4) pp. 713-723. Peer-reviewed.
Inositol Pyrophosphate Specificity of the SPX-Dependent Polyphosphate Polymerase VTC.
Gerasimaite R., Pavlovic I., Capolicchio S., Hofer A., Schmidt A., Jessen H.J., Mayer A., 2017/03/17. ACS chemical biology, 12 (3) pp. 648-653. Peer-reviewed.
OM-85 is an immunomodulator of interferon-β production and inflammasome activity.
Dang A.T., Pasquali C., Ludigs K., Guarda G., 2017/03/06. Scientific reports, 7 p. 43844. Peer-reviewed.
CXCL-8/IL8 Produced by Diffuse Large B-cell Lymphomas Recruits Neutrophils Expressing a Proliferation-Inducing Ligand APRIL.
Manfroi B., McKee T., Mayol J.F., Tabruyn S., Moret S., Villiers C., Righini C., Dyer M., Callanan M., Schneider P. et al., 2017/03/01. Cancer research, 77 (5) pp. 1097-1107. Peer-reviewed.
N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death.
Dufour F., Rattier T., Shirley S., Picarda G., Constantinescu A.A., Morlé A., Zakaria A.B., Marcion G., Causse S., Szegezdi E. et al., 2017/03. Cell death and differentiation, 24 (3) pp. 500-510. Peer-reviewed.
Racial Differences in Cancer Susceptibility and Survival: More Than the Color of the Skin?
Özdemir B.C., Dotto G.P., 2017/03. Trends in cancer, 3 (3) pp. 181-197. Peer-reviewed.
Reticular Perineurioma of the Hand: Diagnosis and Treatment of a Rare Case of Hand Mass.
Zaugg P., Maeder B., Nobile A., Raffoul W., Bollmann C., di Summa P.G., 2017/03. The Journal of hand surgery, 42 (3) pp. e199-e203. Peer-reviewed.
BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases Regulates the Survival of B Cells.
Smulski C.R., Kury P., Seidel L.M., Staiger H.S., Edinger A.K., Willen L., Seidl M., Hess H., Salzer U., Rolink A.G. et al., 2017/02/28. Cell reports, 18 (9) pp. 2189-2202. Peer-reviewed.
Translating the anticancer properties of eEF2K.
De Gassart A., Martinon F., 2017/02/16. Cell cycle, 16 (4) pp. 299-300. Peer-reviewed.
Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling.
Smulski C.R., Decossas M., Chekkat N., Beyrath J., Willen L., Guichard G., Lorenzetti R., Rizzi M., Eibel H., Schneider P. et al., 2017/02/09. Cell death & disease, 8 (2) pp. e2601. Peer-reviewed.
Antiviral screening identifies adenosine analogs targeting the endogenous dsRNA Leishmania RNA virus 1 (LRV1) pathogenicity factor.
Kuhlmann F.M., Robinson J.I., Bluemling G.R., Ronet C., Fasel N., Beverley S.M., 2017/01/31. Proceedings of the National Academy of Sciences of the United States of America, 114 (5) pp. E811-E819. Peer-reviewed.
B-cell receptor-driven MALT1 activity regulates MYC signaling in mantle cell lymphoma.
Dai B., Grau M., Juilland M., Klener P., Höring E., Molinsky J., Schimmack G., Aukema S.M., Hoster E., Vogt N. et al., 2017/01/19. Blood, 129 (3) pp. 333-346. Peer-reviewed.
[Recombinant Monoclonal Antibodies, from Tumor Targeting to Cancer Immunotherapy: A Critical Overview].
Mach J.P., 2017. Molekuliarnaia biologiia, 51 (6) pp. 1024-1038. Peer-reviewed.
A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.
Boege Y., Malehmir M., Healy M.E., Bettermann K., Lorentzen A., Vucur M., Ahuja A.K., Böhm F., Mertens J.C., Shimizu Y. et al., 2017. Cancer Cell, 32 (3) pp. 342-359.e10. Peer-reviewed.
A mouse model of systemic lupus erythematosus responds better to soluble TACI than to soluble BAFFR, correlating with depletion of plasma cells.
Haselmayer P., Vigolo M., Nys J., Schneider P., Hess H., 2017. European Journal of Immunology, 47 (6) pp. 1075-1085. Peer-reviewed.
A role for MALT1 activity in Kaposi's sarcoma-associated herpes virus latency and growth of primary effusion lymphoma.
Bonsignore L., Passelli K., Pelzer C., Perroud M., Konrad A., Thurau M., Stürzl M., Dai L., Trillo-Tinoco J., Del Valle L. et al., 2017. Leukemia, 31 (3) pp. 614-624. Peer-reviewed.
A Sir2 family protein Rv1151c deacetylates HU to alter its DNA binding mode in Mycobacterium tuberculosis.
Anand C., Garg R., Ghosh S., Nagaraja V., 2017. Biochemical and Biophysical Research Communications, 493 (3) pp. 1204-1209. Peer-reviewed.
Accounting for adjuvant-induced artifacts in the characterization of vaccine formulations by polyacrylamide gel electrophoresis.
Jakob V., Brunner L., Barnier-Quer C., Blust M., Collin N., Carter L., Carter D., Rausch K.M., Fox C.B., 2017. Therapeutic Advances in Vaccines, 5 (2) pp. 31-38. Peer-reviewed.
Anti-EDAR Agonist Antibody Therapy Resolves Palate Defects in Pax9(-/-) Mice.
Jia S., Zhou J., Wee Y., Mikkola M.L., Schneider P., D'Souza R.N., 2017. Journal of Dental Research, 96 (11) pp. 1282-1289. Peer-reviewed.
Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway.
Maldonado H., Calderon C., Burgos-Bravo F., Kobler O., Zuschratter W., Ramirez O., Härtel S., Schneider P., Quest A.F., Herrera-Molina R. et al., 2017. Biochimica et Biophysica Acta. Molecular Cell Research, 1864 (2) pp. 243-254. Peer-reviewed.
Characterization of hair-follicle side population cells in mouse epidermis and skin tumors.
Kim S.H., Sistrunk C., Miliani de Marval P.L., Rodriguez-Puebla M.L., 2017. Oncology Letters, 14 (6) pp. 6497-6504. Peer-reviewed.
Convergent roles of ATF3 and CSL in chromatin control of cancer-associated fibroblast activation.
Kim D.E., Procopio M.G., Ghosh S., Jo S.H., Goruppi S., Magliozzi F., Bordignon P., Neel V., Angelino P., Dotto G.P., 2017. The Journal of Experimental Medicine, 214 (8) pp. 2349-2368. Peer-reviewed.
CYFIP1 is directly controlled by NOTCH1 and down-regulated in cutaneous squamous cell carcinoma.
Dziunycz P.J., Neu J., Lefort K., Djerbi N., Freiberger S.N., Iotzova-Weiss G., French L.E., Dotto G.P., Hofbauer G.F., 2017. PLoS One, 12 (4) pp. e0173000. Peer-reviewed.
Detection of ASC Oligomerization by Western Blotting.
Lugrin J., Martinon F., 2017. Bio-Protocol, 7 (10) pp. NA. Peer-reviewed.
Ectodysplasin A in Biological Fluids and Diagnosis of Ectodermal Dysplasia.
Podzus J., Kowalczyk-Quintas C., Schuepbach-Mallepell S., Willen L., Staehlin G., Vigolo M., Tardivel A., Headon D., Kirby N., Mikkola M.L. et al., 2017. Journal of Dental Research, 96 (2) pp. 217-224. Peer-reviewed.
Emerging Major Histocompatibility Complex Class I-Related Functions of NLRC5.
Chelbi S.T., Dang A.T., Guarda G., 2017. Advances in Immunology, 133 pp. 89-119. Peer-reviewed.
Essential role of CCL21 in establishment of central self-tolerance in T cells.
Kozai M., Kubo Y., Katakai T., Kondo H., Kiyonari H., Schaeuble K., Luther S.A., Ishimaru N., Ohigashi I., Takahama Y., 2017. Journal of Experimental Medicine, 214 (7) pp. 1925-1935. Peer-reviewed.
Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid.
Castiglioni P., Hartley M.A., Rossi M., Prevel F., Desponds C., Utzschneider D.T., Eren R.O., Zangger H., Brunner L., Collin N. et al., 2017. PLoS Neglected Tropical Diseases, 11 (1) pp. e0005240. Peer-reviewed.
Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands.
Chung J., Ebens C.L., Perkey E., Radojcic V., Koch U., Scarpellino L., Tong A., Allen F., Wood S., Feng J. et al., 2017. Journal of Clinical Investigation, 127 (4) pp. 1574-1588. Peer-reviewed.
Frontline Science: Leishmania mexicana amastigotes can replicate within neutrophils.
Hurrell B.P., Beaumann M., Heyde S., Regli I.B., Müller A.J., Tacchini-Cottier F., 2017. Journal of Leukocyte Biology, 102 (5) pp. 1187-1198. Peer-reviewed.
IL-4Rα Signaling in Keratinocytes and Early IL-4 Production Are Dispensable for Generating a Curative T Helper 1 Response in Leishmania major-Infected C57BL/6 Mice.
Descatoire M., Hurrell B.P., Govender M., Passelli K., Martinez-Salazar B., Hurdayal R., Brombacher F., Guler R., Tacchini-Cottier F., 2017. Frontiers in Immunology, 8 p. 1265. Peer-reviewed.
In-silico prediction of dual function of DksA like hypothetical protein in V. cholerae O395 genome.
Dutta A., Katarkar A., Chaudhuri K., 2017. Microbiological Research, 195 pp. 60-70. Peer-reviewed.
Inflammation in gout: mechanisms and therapeutic targets.
So A.K., Martinon F., 2017. Nature Reviews. Rheumatology, 13 (11) pp. 639-647. Peer-reviewed.
Interleukin-35-Producing CD8α(+) Dendritic Cells Acquire a Tolerogenic State and Regulate T Cell Function.
Haller S., Duval A., Migliorini R., Stevanin M., Mack V., Acha-Orbea H., 2017. Frontiers in Immunology, 8 p. 98. Peer-reviewed.
Macrophage Survival Assay Using High Content Microscopy
Eren R.O., Fasel N., 2017. Bio-protocol, 7 (16) pp. e2509. Peer-reviewed.
Membrane scission driven by the PROPPIN Atg18.
Gopaldass N., Fauvet B., Lashuel H., Roux A., Mayer A., 2017. The EMBO Journal, 36 (22) pp. 3274-3291. Peer-reviewed.
miR-181a decelerates proliferation in cutaneous squamous cell carcinoma by targeting the proto-oncogene KRAS.
Neu J., Dziunycz P.J., Dzung A., Lefort K., Falke M., Denzler R., Freiberger S.N., Iotzova-Weiss G., Kuzmanov A., Levesque M.P. et al., 2017. PLoS One, 12 (9) pp. e0185028. Peer-reviewed.
Multi-layered control of Galectin-8 mediated autophagy during adenovirus cell entry through a conserved PPxY motif in the viral capsid.
Montespan C., Marvin S.A., Austin S., Burrage A.M., Roger B., Rayne F., Faure M., Campell E.M., Schneider C., Reimer R. et al., 2017. PLoS Pathogens, 13 (2) pp. e1006217. Peer-reviewed.
Natural immune response to Plasmodium vivax alpha-helical coiled coil protein motifs and its association with the risk of P. vivax malaria.
Céspedes N., Li Wai Suen CSN, Koepfli C., França C.T., Felger I., Nebie I., Arévalo-Herrera M., Mueller I., Corradin G., Herrera S., 2017. PLoS One, 12 (6) pp. e0179863. Peer-reviewed.
Periodic Fever with Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome Is Associated with a CARD8 Variant Unable To Bind the NLRP3 Inflammasome.
Cheung M.S., Theodoropoulou K., Lugrin J., Martinon F., Busso N., Hofer M., 2017. Journal of Immunology, 198 (5) pp. 2063-2069. Peer-reviewed.
QS-21 Adjuvant: Laboratory-Scale Purification Method and Formulation Into Liposomes.
Brunner L., Barnier-Quer C., Collin N., 2017. Methods in molecular biology, 1494 pp. 73-86. Peer-reviewed.
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.
Ciarlo E., Heinonen T., Théroude C., Herderschee J., Mombelli M., Lugrin J., Pfefferlé M., Tyrrell B., Lensch S., Acha-Orbea H. et al., 2017. Frontiers in immunology, 8 p. 1037. Peer-reviewed.
Small-molecule Wnt agonists correct cleft palates in Pax9 mutant mice in utero.
Jia S., Zhou J., Fanelli C., Wee Y., Bonds J., Schneider P., Mues G., D'Souza R.N., 2017. Development, 144 (20) pp. 3819-3828. Peer-reviewed.
Systems Approach Reveals Nuclear Factor Erythroid 2-Related Factor 2/Protein Kinase R Crosstalk in Human Cutaneous Leishmaniasis
Vivarini Á.C., Calegari-Silva T.C., Saliba A.M., Boaventura V.S., França-Costa J., Khouri R., Dierckx T., Dias-Teixeira K. L., Fasel N., Barral Aldina M.P. et al., 2017. Frontiers in Immunology, 8 p. 1127. Peer-reviewed.
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