Département d'immunobiologie

Equipe principale
Publications | Mémoires et thèses

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2186 publications

... | 2017 | 2016 | 2015 | 2014 | ...
OM-85 is an immunomodulator of interferon-β production and inflammasome activity.
Dang A.T., Pasquali C., Ludigs K., Guarda G., 2017/03/06. Scientific reports, 7 p. 43844. Peer-reviewed.
CXCL-8/IL8 Produced by Diffuse Large B-cell Lymphomas Recruits Neutrophils Expressing a Proliferation-Inducing Ligand APRIL.
Manfroi B., McKee T., Mayol J.F., Tabruyn S., Moret S., Villiers C., Righini C., Dyer M., Callanan M., Schneider P. et al., 2017/03/01. Cancer research, 77 (5) pp. 1097-1107. Peer-reviewed.
N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death.
Dufour F., Rattier T., Shirley S., Picarda G., Constantinescu A.A., Morlé A., Zakaria A.B., Marcion G., Causse S., Szegezdi E. et al., 2017/03. Cell death and differentiation, 24 (3) pp. 500-510. Peer-reviewed.
 
Racial Differences in Cancer Susceptibility and Survival: More Than the Color of the Skin?
Özdemir B.C., Dotto G.P., 2017/03. Trends in cancer, 3 (3) pp. 181-197. Peer-reviewed.
 
Reticular Perineurioma of the Hand: Diagnosis and Treatment of a Rare Case of Hand Mass.
Zaugg P., Maeder B., Nobile A., Raffoul W., Bollmann C., di Summa P.G., 2017/03. The Journal of hand surgery, 42 (3) pp. e199-e203. Peer-reviewed.
BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases Regulates the Survival of B Cells.
Smulski C.R., Kury P., Seidel L.M., Staiger H.S., Edinger A.K., Willen L., Seidl M., Hess H., Salzer U., Rolink A.G. et al., 2017/02/28. Cell reports, 18 (9) pp. 2189-2202. Peer-reviewed.
Translating the anticancer properties of eEF2K.
De Gassart A., Martinon F., 2017/02/16. Cell cycle, 16 (4) pp. 299-300. Peer-reviewed.
Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling.
Smulski C.R., Decossas M., Chekkat N., Beyrath J., Willen L., Guichard G., Lorenzetti R., Rizzi M., Eibel H., Schneider P. et al., 2017/02/09. Cell death & disease, 8 (2) pp. e2601. Peer-reviewed.
 
Antiviral screening identifies adenosine analogs targeting the endogenous dsRNA Leishmania RNA virus 1 (LRV1) pathogenicity factor.
Kuhlmann F.M., Robinson J.I., Bluemling G.R., Ronet C., Fasel N., Beverley S.M., 2017/01/31. Proceedings of the National Academy of Sciences of the United States of America, 114 (5) pp. E811-E819. Peer-reviewed.
B-cell receptor-driven MALT1 activity regulates MYC signaling in mantle cell lymphoma.
Dai B., Grau M., Juilland M., Klener P., Höring E., Molinsky J., Schimmack G., Aukema S.M., Hoster E., Vogt N. et al., 2017/01/19. Blood, 129 (3) pp. 333-346. Peer-reviewed.
 
[Recombinant Monoclonal Antibodies, from Tumor Targeting to Cancer Immunotherapy: A Critical Overview].
Mach J.P., 2017. Molekuliarnaia biologiia, 51 (6) pp. 1024-1038. Peer-reviewed.
 
A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.
Boege Y., Malehmir M., Healy M.E., Bettermann K., Lorentzen A., Vucur M., Ahuja A.K., Böhm F., Mertens J.C., Shimizu Y. et al., 2017. Cancer Cell, 32 (3) pp. 342-359.e10. Peer-reviewed.
A mouse model of systemic lupus erythematosus responds better to soluble TACI than to soluble BAFFR, correlating with depletion of plasma cells.
Haselmayer P., Vigolo M., Nys J., Schneider P., Hess H., 2017. European Journal of Immunology, 47 (6) pp. 1075-1085. Peer-reviewed.
A role for MALT1 activity in Kaposi's sarcoma-associated herpes virus latency and growth of primary effusion lymphoma.
Bonsignore L., Passelli K., Pelzer C., Perroud M., Konrad A., Thurau M., Stürzl M., Dai L., Trillo-Tinoco J., Del Valle L. et al., 2017. Leukemia, 31 (3) pp. 614-624. Peer-reviewed.
 
A Sir2 family protein Rv1151c deacetylates HU to alter its DNA binding mode in Mycobacterium tuberculosis.
Anand C., Garg R., Ghosh S., Nagaraja V., 2017. Biochemical and Biophysical Research Communications, 493 (3) pp. 1204-1209. Peer-reviewed.
 
Accounting for adjuvant-induced artifacts in the characterization of vaccine formulations by polyacrylamide gel electrophoresis.
Jakob V., Brunner L., Barnier-Quer C., Blust M., Collin N., Carter L., Carter D., Rausch K.M., Fox C.B., 2017. Therapeutic Advances in Vaccines, 5 (2) pp. 31-38. Peer-reviewed.
Anti-EDAR Agonist Antibody Therapy Resolves Palate Defects in Pax9(-/-) Mice.
Jia S., Zhou J., Wee Y., Mikkola M.L., Schneider P., D'Souza R.N., 2017. Journal of Dental Research, 96 (11) pp. 1282-1289. Peer-reviewed.
Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway.
Maldonado H., Calderon C., Burgos-Bravo F., Kobler O., Zuschratter W., Ramirez O., Härtel S., Schneider P., Quest A.F., Herrera-Molina R. et al., 2017. Biochimica et Biophysica Acta. Molecular Cell Research, 1864 (2) pp. 243-254. Peer-reviewed.
Characterization of hair-follicle side population cells in mouse epidermis and skin tumors.
Kim S.H., Sistrunk C., Miliani de Marval P.L., Rodriguez-Puebla M.L., 2017. Oncology Letters, 14 (6) pp. 6497-6504. Peer-reviewed.
Convergent roles of ATF3 and CSL in chromatin control of cancer-associated fibroblast activation.
Kim D.E., Procopio M.G., Ghosh S., Jo S.H., Goruppi S., Magliozzi F., Bordignon P., Neel V., Angelino P., Dotto G.P., 2017. The Journal of Experimental Medicine, 214 (8) pp. 2349-2368. Peer-reviewed.
CYFIP1 is directly controlled by NOTCH1 and down-regulated in cutaneous squamous cell carcinoma.
Dziunycz P.J., Neu J., Lefort K., Djerbi N., Freiberger S.N., Iotzova-Weiss G., French L.E., Dotto G.P., Hofbauer G.F., 2017. PLoS One, 12 (4) pp. e0173000. Peer-reviewed.
 
Detection of ASC Oligomerization by Western Blotting.
Lugrin J., Martinon F., 2017. Bio-Protocol, 7 (10) pp. NA. Peer-reviewed.
Ectodysplasin A in Biological Fluids and Diagnosis of Ectodermal Dysplasia.
Podzus J., Kowalczyk-Quintas C., Schuepbach-Mallepell S., Willen L., Staehlin G., Vigolo M., Tardivel A., Headon D., Kirby N., Mikkola M.L. et al., 2017. Journal of Dental Research, 96 (2) pp. 217-224. Peer-reviewed.
 
Emerging Major Histocompatibility Complex Class I-Related Functions of NLRC5.
Chelbi S.T., Dang A.T., Guarda G., 2017. Advances in Immunology, 133 pp. 89-119. Peer-reviewed.
Essential role of CCL21 in establishment of central self-tolerance in T cells.
Kozai M., Kubo Y., Katakai T., Kondo H., Kiyonari H., Schaeuble K., Luther S.A., Ishimaru N., Ohigashi I., Takahama Y., 2017. Journal of Experimental Medicine, 214 (7) pp. 1925-1935. Peer-reviewed.
Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid.
Castiglioni P., Hartley M.A., Rossi M., Prevel F., Desponds C., Utzschneider D.T., Eren R.O., Zangger H., Brunner L., Collin N. et al., 2017. PLoS Neglected Tropical Diseases, 11 (1) pp. e0005240. Peer-reviewed.
Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands.
Chung J., Ebens C.L., Perkey E., Radojcic V., Koch U., Scarpellino L., Tong A., Allen F., Wood S., Feng J. et al., 2017. Journal of Clinical Investigation, 127 (4) pp. 1574-1588. Peer-reviewed.
 
Frontline Science: Leishmania mexicana amastigotes can replicate within neutrophils.
Hurrell B.P., Beaumann M., Heyde S., Regli I.B., Müller A.J., Tacchini-Cottier F., 2017. Journal of Leukocyte Biology, 102 (5) pp. 1187-1198. Peer-reviewed.
IL-4Rα Signaling in Keratinocytes and Early IL-4 Production Are Dispensable for Generating a Curative T Helper 1 Response in Leishmania major-Infected C57BL/6 Mice.
Descatoire M., Hurrell B.P., Govender M., Passelli K., Martinez-Salazar B., Hurdayal R., Brombacher F., Guler R., Tacchini-Cottier F., 2017. Frontiers in Immunology, 8 p. 1265. Peer-reviewed.
 
In-silico prediction of dual function of DksA like hypothetical protein in V. cholerae O395 genome.
Dutta A., Katarkar A., Chaudhuri K., 2017. Microbiological Research, 195 pp. 60-70. Peer-reviewed.
Inflammation in gout: mechanisms and therapeutic targets.
So A.K., Martinon F., 2017. Nature Reviews. Rheumatology, 13 (11) pp. 639-647. Peer-reviewed.
Interleukin-35-Producing CD8α(+) Dendritic Cells Acquire a Tolerogenic State and Regulate T Cell Function.
Haller S., Duval A., Migliorini R., Stevanin M., Mack V., Acha-Orbea H., 2017. Frontiers in Immunology, 8 p. 98. Peer-reviewed.
Macrophage Survival Assay Using High Content Microscopy
Eren R.O., Fasel N., 2017. Bio-protocol, 7 (16) pp. e2509. Peer-reviewed.
 
Membrane scission driven by the PROPPIN Atg18.
Gopaldass N., Fauvet B., Lashuel H., Roux A., Mayer A., 2017. The EMBO Journal, 36 (22) pp. 3274-3291. Peer-reviewed.
miR-181a decelerates proliferation in cutaneous squamous cell carcinoma by targeting the proto-oncogene KRAS.
Neu J., Dziunycz P.J., Dzung A., Lefort K., Falke M., Denzler R., Freiberger S.N., Iotzova-Weiss G., Kuzmanov A., Levesque M.P. et al., 2017. PLoS One, 12 (9) pp. e0185028. Peer-reviewed.
Multi-layered control of Galectin-8 mediated autophagy during adenovirus cell entry through a conserved PPxY motif in the viral capsid.
Montespan C., Marvin S.A., Austin S., Burrage A.M., Roger B., Rayne F., Faure M., Campell E.M., Schneider C., Reimer R. et al., 2017. PLoS Pathogens, 13 (2) pp. e1006217. Peer-reviewed.
Natural immune response to Plasmodium vivax alpha-helical coiled coil protein motifs and its association with the risk of P. vivax malaria.
Céspedes N., Li Wai Suen CSN, Koepfli C., França C.T., Felger I., Nebie I., Arévalo-Herrera M., Mueller I., Corradin G., Herrera S., 2017. PLoS One, 12 (6) pp. e0179863. Peer-reviewed.
 
Periodic Fever with Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome Is Associated with a CARD8 Variant Unable To Bind the NLRP3 Inflammasome.
Cheung M.S., Theodoropoulou K., Lugrin J., Martinon F., Busso N., Hofer M., 2017. Journal of Immunology, 198 (5) pp. 2063-2069. Peer-reviewed.
QS-21 Adjuvant: Laboratory-Scale Purification Method and Formulation Into Liposomes.
Brunner L., Barnier-Quer C., Collin N., 2017. Methods in molecular biology, 1494 pp. 73-86. Peer-reviewed.
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.
Ciarlo E., Heinonen T., Théroude C., Herderschee J., Mombelli M., Lugrin J., Pfefferlé M., Tyrrell B., Lensch S., Acha-Orbea H. et al., 2017. Frontiers in immunology, 8 p. 1037. Peer-reviewed.
Small-molecule Wnt agonists correct cleft palates in Pax9 mutant mice in utero.
Jia S., Zhou J., Fanelli C., Wee Y., Bonds J., Schneider P., Mues G., D'Souza R.N., 2017. Development, 144 (20) pp. 3819-3828. Peer-reviewed.
Systems Approach Reveals Nuclear Factor Erythroid 2-Related Factor 2/Protein Kinase R Crosstalk in Human Cutaneous Leishmaniasis
Vivarini Á.C., Calegari-Silva T.C., Saliba A.M., Boaventura V.S., França-Costa J., Khouri R., Dierckx T., Dias-Teixeira K. L., Fasel N., Barral Aldina M.P. et al., 2017. Frontiers in Immunology, 8 p. 1127. Peer-reviewed.
Targeting BAFF and APRIL in systemic lupus erythematosus and other antibody-associated diseases.
Samy E., Wax S., Huard B., Hess H., Schneider P., 2017. International Reviews of Immunology, 36 (1) pp. 3-19. Peer-reviewed.
TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development.
Kaufmann SHE, Dockrell H.M., Drager N., Ho M.M., McShane H., Neyrolles O., Ottenhoff THM, Patel B., Roordink D., Spertini F. et al., 2017. Frontiers in immunology, 8 p. 1203. Peer-reviewed.
The use of a P. falciparum specific coiled-coil domain to construct a self-assembling protein nanoparticle vaccine to prevent malaria.
Karch C.P., Doll TAPF, Paulillo S.M., Nebie I., Lanar D.E., Corradin G., Burkhard P., 2017. Journal of Nanobiotechnology, 15 (1) p. 62. Peer-reviewed.
Notch regulates Th17 differentiation and controls trafficking of IL-17 and metabolic regulators within Th17 cells in a context-dependent manner.
Coutaz M., Hurrell B.P., Auderset F., Wang H., Siegert S., Eberl G., Ho P.C., Radtke F., Tacchini-Cottier F., 2016/12/15. Scientific reports, 6 p. 39117. Peer-reviewed.
 
A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation.
Arroyo J.D., Jourdain A.A., Calvo S.E., Ballarano C.A., Doench J.G., Root D.E., Mootha V.K., 2016/12/13. Cell metabolism, 24 (6) pp. 875-885. Peer-reviewed.
 
Role of FAST Kinase Domains 3 (FASTKD3) in Post-transcriptional Regulation of Mitochondrial Gene Expression.
Boehm E., Zornoza M., Jourdain A.A., Delmiro Magdalena A., García-Consuegra I., Torres Merino R., Orduña A., Martín M.A., Martinou J.C., De la Fuente M.A. et al., 2016/12/09. The Journal of biological chemistry, 291 (50) pp. 25877-25887. Peer-reviewed.
Tilting the balance between RNA interference and replication eradicates Leishmania RNA virus 1 and mitigates the inflammatory response.
Brettmann E.A., Shaik J.S., Zangger H., Lye L.F., Kuhlmann F.M., Akopyants N.S., Oschwald D.M., Owens K.L., Hickerson S.M., Ronet C. et al., 2016/10/25. Proceedings of the National Academy of Sciences of the United States of America, 113 (43) pp. 11998-12005. Peer-reviewed.
Vtc5, a Novel Subunit of the Vacuolar Transporter Chaperone Complex, Regulates Polyphosphate Synthesis and Phosphate Homeostasis in Yeast.
Desfougères Y., Gerasimaitė R.U., Jessen H.J., Mayer A., 2016/10/14. The Journal of biological chemistry, 291 (42) pp. 22262-22275. Peer-reviewed.
Pharmacological eEF2K activation promotes cell death and inhibits cancer progression.
De Gassart A., Demaria O., Panes R., Zaffalon L., Ryazanov A.G., Gilliet M., Martinon F., 2016/10. EMBO reports, 17 (10) pp. 1471-1484. Peer-reviewed.
Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.
Kowalczyk-Quintas C., Schuepbach-Mallepell S., Vigolo M., Willen L., Tardivel A., Smulski C.R., Zheng T.S., Gommerman J., Hess H., Gottenberg J.E. et al., 2016/09/16. The Journal of biological chemistry, 291 (38) pp. 19826-19834. Peer-reviewed.
Topical Simvastatin as Host-Directed Therapy against Severity of Cutaneous Leishmaniasis in Mice.
Parihar S.P., Hartley M.A., Hurdayal R., Guler R., Brombacher F., 2016/09/16. Scientific reports, 6 p. 33458. Peer-reviewed.
Mammalian Innate Immune Response to a Leishmania-Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence.
Eren R.O., Reverte M., Rossi M., Hartley M.A., Castiglioni P., Prevel F., Martin R., Desponds C., Lye L.F., Drexler S.K. et al., 2016/09/14. Cell host & microbe, 20 (3) pp. 318-328. Peer-reviewed.
PDCD4 is a CSL associated protein with a transcription repressive function in cancer associated fibroblast activation.
Jo S.H., Kim D.E., Clocchiatti A., Dotto G.P., 2016/09/13. Oncotarget, 7 (37) pp. 58717-58727. Peer-reviewed.
Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2 in Newly Formed Tertiary Lymphoid Structures.
Nayar S., Campos J., Chung M.M., Navarro-Núñez L., Chachlani M., Steinthal N., Gardner D.H., Rankin P., Cloake T., Caamaño J.H. et al., 2016/09/01. Journal of immunology, 197 (5) pp. 1957-1967. Peer-reviewed.
AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity.
Di Micco A., Frera G., Lugrin J., Jamilloux Y., Hsu E.T., Tardivel A., De Gassart A., Zaffalon L., Bujisic B., Siegert S. et al., 2016/08/09. Proceedings of the National Academy of Sciences of the United States of America, 113 (32) pp. E4671-80. Peer-reviewed.
The aged lymphoid tissue environment fails to support naïve T cell homeostasis.
Becklund B.R., Purton J.F., Ramsey C., Favre S., Vogt T.K., Martin C.E., Spasova D.S., Sarkisyan G., LeRoy E., Tan J.T. et al., 2016/08/02. Scientific reports, 6 p. 30842. Peer-reviewed.
 
Notch Signaling Regulates the Homeostasis of Tissue-Restricted Innate-like T Cells.
Chennupati V., Koch U., Coutaz M., Scarpellino L., Tacchini-Cottier F., Luther S.A., Radtke F., Zehn D., MacDonald H.R., 2016/08/01. Journal of immunology, 197 (3) pp. 771-782. Peer-reviewed.
Dual tumor suppressing and promoting function of Notch1 signaling in human prostate cancer.
Lefort K., Ostano P., Mello-Grand M., Calpini V., Scatolini M., Farsetti A., Dotto G.P., Chiorino G., 2016/07/26. Oncotarget, 7 (30) pp. 48011-48026. Peer-reviewed.
Organelle acidification negatively regulates vacuole membrane fusion in vivo.
Desfougères Y., Vavassori S., Rompf M., Gerasimaite R., Mayer A., 2016/07/01. Scientific reports, 6 p. 29045. Peer-reviewed.
Raptor hunted by caspases.
Martin R., Thome M., Martinon F., Fasel N., 2016/06/02. Cell death & disease, 7 (6) pp. e2242. Peer-reviewed.
Brefeldin A-Inhibited Guanine Nucleotide-Exchange Factor 1 (BIG1) Governs the Recruitment of Tumor Necrosis Factor Receptor-Associated Factor 2 (TRAF2) to Tumor Necrosis Factor Receptor 1 (TNFR1) Signaling Complexes.
Noguchi T., Tsuchida M., Kogue Y., Spadini C., Hirata Y., Matsuzawa A., 2016/04/09. International journal of molecular sciences, 17 (11) p. 1869. Peer-reviewed.
Squamous Cell Cancers: A Unified Perspective on Biology and Genetics.
Dotto G.P., Rustgi A.K., 2016/04/09. Cancer cell, 29 (5) pp. 622-637. Peer-reviewed.
Mitochondrial RNA granules: Compartmentalizing mitochondrial gene expression.
Jourdain A.A., Boehm E., Maundrell K., Martinou J.C., 2016/03/14. The Journal of cell biology, 212 (6) pp. 611-614. Peer-reviewed.
A functional BH3 domain in an aquaporin from Leishmania infantum.
Genes C.M., de Lucio H., González V.M., Sánchez-Murcia P.A., Rico E., Gago F., Fasel N., Jiménez-Ruiz A., 2016. Cell Death Discovery, 2 p. 16043. Peer-reviewed.
 
Absence of nonhematopoietic MHC class II expression protects mice from experimental autoimmune myocarditis.
Thelemann C., Haller S., Blyszczuk P., Kania G., Rosa M., Eriksson U., Rotman S., Reith W., Acha-Orbea H., 2016. European Journal of Immunology, 46 (3) pp. 656-664. Peer-reviewed.
Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas.
Vallois D., Dobay M.P., Morin R.D., Lemonnier F., Missiaglia E., Juilland M., Iwaszkiewicz J., Fataccioli V., Bisig B., Roberti A. et al., 2016. Blood, 128 (11) pp. 1490-1502. Peer-reviewed.
Ag85A DNA Vaccine Delivery by Nanoparticles: Influence of the Formulation Characteristics on Immune Responses.
Poecheim J., Barnier-Quer C., Collin N., Borchard G., 2016. Vaccines, 4 (3) pp. xx. Peer-reviewed.
An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response.
De Gassart A., Bujisic B., Zaffalon L., Decosterd L.A., Di Micco A., Frera G., Tallant R., Martinon F., 2016. Proceedings of the National Academy of Sciences of the United States of America, 113 (2) pp. E117-E126.
Antibody levels against GLURP R2, MSP1 block 2 hybrid and AS202.11 and the risk of malaria in children living in hyperendemic (Burkina Faso) and hypo-endemic (Ghana) areas.
Adu B., Cherif M.K., Bosomprah S., Diarra A., Arthur F.K., Dickson E.K., Corradin G., Cavanagh D.R., Theisen M., Sirima S.B. et al., 2016. Malaria Journal, 15 p. 123. Peer-reviewed.
Boosting Adaptive Immunity: A New Role for PAFR Antagonists.
Koga M.M., Bizzarro B., Sá-Nunes A., Rios F.J., Jancar S., 2016. Scientific Reports, 6 p. 39146.
CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas.
Juilland M., Gonzalez M., Erdmann T., Banz Y., Jevnikar Z., Hailfinger S., Tzankov A., Grau M., Lenz G., Novak U. et al., 2016. Blood, 127 (14) pp. 1780-1789. Peer-reviewed.
Caspase-mediated cleavage of raptor participates in the inactivation of mTORC1 during cell death.
Martin R., Desponds C., Eren R.O., Quadroni M., Thome M., Fasel N., 2016. Cell Death Discovery, 2 p. 16024. Peer-reviewed.
 
CCL19-CCR7-dependent reverse transendothelial migration of myeloid cells clears Chlamydia muridarum from the arterial intima.
Roufaiel M., Gracey E., Siu A., Zhu S.N., Lau A., Ibrahim H., Althagafi M., Tai K., Hyduk S.J., Cybulsky K.O. et al., 2016. Nature immunology, 17 (11) pp. 1263-1272. Peer-reviewed.
 
CD8 engineered cytotoxic T cells reprogram melanoma tumor environment.
Leignadier J., Favre S., Luther S.A., Luescher I.F., 2016. Oncoimmunology, 5 (3) pp. e1086861.
 
Cell-Free Assay for Inflammasome Activation.
Jamilloux Y., Martinon F., 2016. Methods in molecular biology, 1417 pp. 207-215. Peer-reviewed.
Characterization and application of two RANK-specific antibodies with different biological activities.
Chypre M., Seaman J., Cordeiro O.G., Willen L., Knoop K.A., Buchanan A., Sainson R.C., Williams I.R., Yagita H., Schneider P. et al., 2016. Immunology Letters, 171 pp. 5-14. Peer-reviewed.
Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains.
Wild R., Gerasimaite R., Jung J.Y., Truffault V., Pavlovic I., Schmidt A., Saiardi A., Jessen H.J., Poirier Y., Hothorn M. et al., 2016. Science, 352 (6288) pp. 986-990. Peer-reviewed.
CSL-p53: From senescence to CAF activation.
Procopio M.G., Laszlo C., Dotto G.P., 2016. Cell Cycle, 15 (4) pp. 485-486. Peer-reviewed.
Data for the crystal structure of APRIL-BAFF-BAFF heterotrimer.
Maskos K., Lammens A., Tan S.L., Hess H., Palinsky W., Schneider P., Jiang X., 2016. Data in Brief, 6 pp. 438-444. Peer-reviewed.
 
Derivation and Utilization of Functional CD8(+) Dendritic Cell Lines.
Pigni M., Ashok D., Acha-Orbea H., 2016. Methods in Molecular Biology, 1423 pp. 39-49. Peer-reviewed.
 
Design and Validation of a Novel Generic Platform for the Production of Tetravalent IgG1-like Bispecific Antibodies.
Golay J., Choblet S., Iwaszkiewicz J., Cérutti P., Ozil A., Loisel S., Pugnière M., Ubiali G., Zoete V., Michielin O. et al., 2016. Journal of Immunology, 196 (7) pp. 3199-3211. Peer-reviewed.
Dictyostelium EHD associates with Dynamin and participates in phagosome maturation.
Gueho A., Bosmani C., Gopaldass N., Molle V., Soldati T., Letourneur F., 2016. Journal of Cell Science, 129 (12) pp. 2354-2367. Peer-reviewed.
 
Different Leishmania Species Drive Distinct Neutrophil Functions.
Hurrell B.P., Regli I.B., Tacchini-Cottier F., 2016. Trends in Parasitology, 32 (5) pp. 392-401. Peer-reviewed.
 
Differential phosphorylation-based regulation of αB-crystallin chaperone activity for multipass transmembrane proteins.
Ciano M., Allocca S., Ciardulli M.C., Della Volpe L., Bonatti S., D'Agostino M., 2016. Biochemical and Biophysical Research Communications, 479 (2) pp. 325-330. Peer-reviewed.
Ectodysplasin a pathway contributes to human and murine skin repair.
Garcin C.L., Huttner K.M., Kirby N., Schneider P., Hardman M.J., 2016. Journal of Investigative Dermatology, 136 (5) pp. 1022-1030.
 
Enhancing actions of peptides derived from the γ-chain of fetal human hemoglobin on the immunostimulant activities of monophosphoryl lipid A.
Ulmer A.J., Kaconis Y., Heinbockel L., Correa W., Alexander C., Rietschel E.T., Mach J.P., Gorczynski R.M., Heini A., Rössle M. et al., 2016. Innate Immunity, 22 (3) pp. 168-180.
Enzymes of yeast polyphosphate metabolism: structure, enzymology and biological roles.
Gerasimaitė R., Mayer A., 2016. Biochemical Society Transactions, 44 (1) pp. 234-239.
Genomic and transcriptomic analysis of the streptomycin-dependent Mycobacterium tuberculosis strain 18b.
Benjak A., Uplekar S., Zhang M., Piton J., Cole S.T., Sala C., 2016. BMC Genomics, 17 p. 190. Peer-reviewed.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky D.J., Abdelmohsen K., Abe A., Abedin M.J., Abeliovich H., Acevedo Arozena A., Adachi H., Adams C.M., Adams P.D., Adeli K. et al., 2016/01. Autophagy, 12 (1) pp. 1-222.
Identification of <i>Salvia haenkei</i> as gerosuppressant agent by using an integrated senescence-screening assay.
Matic I., Revandkar A., Chen J., Bisio A., Dall'Acqua S., Cocetta V., Brun P., Mancino G., Milanese M., Mattei M. et al., 2016. Aging, 8 (12) pp. 3223-3240. Peer-reviewed.
 
Immunogenicity of dimorphic and C-terminal fragments of Plasmodium falciparum MSP2 formulated with different adjuvants in mice.
Balam S., Jafarshad A., Servis C., Frank G., Reed S., Pink R., Druilhe P., Spertini F., Corradin G., 2016. Vaccine, 34 (13) pp. 1566-1574. Peer-reviewed.
Immunotherapeutic targeting of LIGHT/LTβR/HVEM pathway fully recapitulates the reduced cytotoxic phenotype of LIGHT-deficient T cells.
Del Rio M.L., Fernandez-Renedo C., Chaloin O., Scheu S., Pfeffer K., Shintani Y., Perez-Simon J.A., Schneider P., Rodriguez-Barbosa J.I., 2016. mAbs, 8 (3) pp. 478-490. Peer-reviewed.
Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration.
Alvarez A., Lagos-Cabré R., Kong M., Cárdenas A., Burgos-Bravo F., Schneider P., Quest A.F., Leyton L., 2016. Biochimica et Biophysica Acta. Molecular Cell Research, 1863 (9) pp. 2175-2188. Peer-reviewed.
Leishmaniavirus-Dependent Metastatic Leishmaniasis Is Prevented by Blocking IL-17A.
Hartley M.A., Bourreau E., Rossi M., Castiglioni P., Eren R.O., Prevel F., Couppié P., Hickerson S.M., Launois P., Beverley S.M. et al., 2016. PLoS Pathogens, 12 (9) pp. e1005852. Peer-reviewed.
Lymphotoxin-dependent B cell-FRC crosstalk promotes de novo follicle formation and antibody production following intestinal helminth infection.
Dubey L.K., Lebon L., Mosconi I., Yang C.Y., Scandella E., Ludewig B., Luther S.A., Harris N.L., 2016. Cell Reports, 15 (7) pp. 1527-1541. Peer-reviewed.
Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner.
Zhang L., Tschumi B.O., Lopez-Mejia I.C., Oberle S.G., Meyer M., Samson G., Rüegg M.A., Hall M.N., Fajas L., Zehn D. et al., 2016. Cell Reports, 14 (5) pp. 1206-1217. Peer-reviewed.
Negative control of CSL gene transcription by stress/DNA damage response and p53.
Menietti E., Xu X., Ostano P., Joseph J.M., Lefort K., Dotto G.P., 2016. Cell Cycle, 15 (13) pp. 1767-1778. Peer-reviewed.
NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions.
Ludigs K., Jandus C., Utzschneider D.T., Staehli F., Bessoles S., Dang A.T., Rota G., Castro W., Zehn D., Vivier E. et al., 2016. Nature Communications, 7 p. 10554. Peer-reviewed.
NLRC5, a promising new entry in tumor immunology.
Chelbi S.T., Guarda G., 2016. Journal For Immunotherapy of Cancer, 4 (1) p. 39. Peer-reviewed.
 
NLRP12 is a neutrophil-specific, negative regulator of in vitro cell migration but does not modulate LPS- or infection-induced NF-κB or ERK signalling.
Zamoshnikova A., Groß C.J., Schuster S., Chen K.W., Wilson A., Tacchini-Cottier F., Schroder K., 2016. Immunobiology, 221 (2) pp. 341-346.
Organelle size control - increasing vacuole content activates SNAREs to augment organelle volume through homotypic fusion.
Desfougères Y., Neumann H., Mayer A., 2016. Journal of Cell Science, 129 (14) pp. 2817-2828.
 
Presence of Leishmania RNA Virus 1 in Leishmania guyanensis Increases the Risk of First-Line Treatment Failure and Symptomatic Relapse.
Bourreau E., Ginouves M., Prévot G., Hartley M.A., Gangneux J.P., Robert-Gangneux F., Dufour J., Sainte-Marie D., Bertolotti A., Pratlong F. et al., 2016. Journal of Infectious Diseases, 213 (1) pp. 105-111. Peer-reviewed.
 
Prevalence and Distribution of Leishmania RNA Virus 1 in Leishmania Parasites from French Guiana.
Ginouvès M., Simon S., Bourreau E., Lacoste V., Ronet C., Couppié P., Nacher M., Demar M., Prévot G., 2016. American Journal of Tropical Medicine and Hygiene, 94 (1) pp. 102-106.
Promoter methylation and downregulated expression of the TBX15 gene in ovarian carcinoma.
Gozzi G., Chelbi S.T., Manni P., Alberti L., Fonda S., Saponaro S., Fabbiani L., Rivasi F., Benhattar J., Losi L., 2016. Oncology Letters, 12 (4) pp. 2811-2819. Peer-reviewed.
 
Role of proapoptotic BH3-only proteins in Listeria monocytogenes infection.
Margaroli C., Oberle S., Lavanchy C., Scherer S., Rosa M., Strasser A., Pellegrini M., Zehn D., Acha-Orbea H., Ehirchiou D., 2016. European Journal of Immunology, 46 (6) pp. 1427-1437. Peer-reviewed.
Role of the CARMA1/BCL10/MALT1 complex in lymphoid malignancies.
Juilland M., Thome M., 2016. Current Opinion in Hematology, 23 (4) pp. 402-409.
SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis.
Ferreira V.P., Fazito Vale V., Pangburn M.K., Abdeladhim M., Ferreira Mendes-Sousa A., Coutinho-Abreu I.V., Rasouli M., Brandt E.A., Meneses C., Lima K.F. et al., 2016. Scientific Reports, 6 p. 19300. Peer-reviewed.
Severe Cutaneous Leishmaniasis in a Human Immunodeficiency Virus Patient Coinfected with Leishmania braziliensis and Its Endosymbiotic Virus.
Parmentier L., Cusini A., Müller N., Zangger H., Hartley M.A., Desponds C., Castiglioni P., Dubach P., Ronet C., Beverley S.M. et al., 2016. American Journal of Tropical Medicine and Hygiene, 94 (4) pp. 840-843. Peer-reviewed.
Sexual dimorphism in cancer.
Clocchiatti A., Cora E., Zhang Y., Dotto G.P., 2016. Nature Reviews. Cancer, 16 (5) pp. 330-339. Peer-reviewed.
Silencing of ASC in Cutaneous Squamous Cell Carcinoma.
Meier K., Drexler S.K., Eberle F.C., Lefort K., Yazdi A.S., 2016. PLoS One, 11 (10) pp. e0164742. Peer-reviewed.
Steric hindrance of SNARE transmembrane domain organization impairs the hemifusion‐to‐fusion transition
D'Agostino Massimo, Risselada Herre Jelger, Mayer Andreas, 2016. EMBO Reports, 17 (11) pp. 1590-1608. Peer-reviewed.
Stromal Fibroblasts in Tertiary Lymphoid Structures: A Novel Target in Chronic Inflammation.
Barone F., Gardner D.H., Nayar S., Steinthal N., Buckley C.D., Luther S.A., 2016. Frontiers in Immunology, 7 p. 477. Peer-reviewed.
 
Synthetic long peptide-based vaccine formulations for induction of cell mediated immunity: A comparative study of cationic liposomes and PLGA nanoparticles.
Varypataki E.M., Silva A.L., Barnier-Quer C., Collin N., Ossendorp F., Jiskoot W., 2016. Journal of Controlled Release, 226 pp. 98-106. Peer-reviewed.
T Cell Priming by Activated Nlrc5-Deficient Dendritic Cells Is Unaffected despite Partially Reduced MHC Class I Levels.
Rota G., Ludigs K., Siegert S., Tardivel A., Morgado L., Reith W., De Gassart A., Guarda G., 2016. Journal of Immunology, 196 (7) pp. 2939-2946.
 
The Nlrp3 inflammasome, IL-1β, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL/6 mice.
Charmoy M., Hurrell B.P., Romano A., Lee S.H., Ribeiro-Gomes F., Riteau N., Mayer-Barber K., Tacchini-Cottier F., Sacks D.L., 2016. European Journal of Immunology, 46 (4) pp. 897-911.
The paracaspase MALT1: biological function and potential for therapeutic inhibition.
Jaworski M., Thome M., 2016. Cellular and Molecular Life Sciences, 73 (3) pp. 459-473.
Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells.
Korniotis S., Gras C., Letscher H., Montandon R., Mégret J., Siegert S., Ezine S., Fallon P.G., Luther S.A., Fillatreau S. et al., 2016. Nature Communications, 7 p. 12134.
Unveiling the Role of the Integrated Endoplasmic Reticulum Stress Response in Leishmania Infection - Future Perspectives.
Dias-Teixeira K.L., Pereira R.M., Silva J.S., Fasel N., Aktas B.H., Lopes U.G., 2016. Frontiers In Immunology, 7 p. 283. Peer-reviewed.
 
WASH drives early recycling from macropinosomes and phagosomes to maintain surface phagocytic receptors.
Buckley C.M., Gopaldass N., Bosmani C., Johnston S.A., Soldati T., Insall R.H., King J.S., 2016. Proceedings of the National Academy of Sciences of the United States of America, 113 (40) pp. E5906-E5915.
 
Diabetogenic milieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets.
Brun T., Li N., Jourdain A.A., Gaudet P., Duhamel D., Meyer J., Bosco D., Maechler P., 2015/09/15. Human molecular genetics, 24 (18) pp. 5270-5284. Peer-reviewed.
 
A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function.
Jourdain A.A., Koppen M., Rodley C.D., Maundrell K., Gueguen N., Reynier P., Guaras A.M., Enriquez J.A., Anderson P., Simarro M. et al., 2015/02/24. Cell reports, 10 (7) pp. 1110-1121. Peer-reviewed.
A modular tethering complex for endosomal recycling.
Desfougères Y., D'Agostino M., Mayer A., 2015. Nature Cell Biology, 17 (5) pp. 540-541.
B cell activating factor is central to bleomycin- and IL-17-mediated experimental pulmonary fibrosis.
François A., Gombault A., Villeret B., Alsaleh G., Fanny M., Gasse P., Adam S.M., Crestani B., Sibilia J., Schneider P. et al., 2015. Journal of Autoimmunity, 56 pp. 1-11.
 
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation.
Procopio M.G., Laszlo C., Al Labban D., Kim D.E., Bordignon P., Jo S.H., Goruppi S., Menietti E., Ostano P., Ala U. et al., 2015. Nature Cell Biology, 17 (9) pp. 1193-1204. Peer-reviewed.
Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic mice.
Woess C., Tuzlak S., Labi V., Drach M., Bertele D., Schneider P., Villunger A., 2015. Cell Death and Differentiation, 22 (9) pp. 1477-1488.
Cutting edge: IL-1α is a crucial danger signal triggering acute myocardial inflammation during myocardial infarction.
Lugrin J., Parapanov R., Rosenblatt-Velin N., Rignault-Clerc S., Feihl F., Waeber B., Müller O., Vergely C., Zeller M., Tardivel A. et al., 2015. Journal of Immunology, 194 (2) pp. 499-503. Peer-reviewed.
Dendritic Cells Cause Bone Lesions in a New Mouse Model of Histiocytosis.
Grosjean F., Nasi S., Schneider P., Chobaz V., Liu A., Mordasini V., Moullec K., Vezzoni P., Lavanchy C., Busso N. et al., 2015. Plos One, 10 (8) pp. e0133917. Peer-reviewed.
DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport.
Bernier-Latmani J., Cisarovsky C., Demir C.S., Bruand M., Jaquet M., Davanture S., Ragusa S., Siegert S., Dormond O., Benedito R. et al., 2015. Journal of Clinical Investigation, 2015 pp. 4572-4586. Peer-reviewed.
 
Données actualisées sur la physiopathologie, les phénotypes et les traitements de la maladie de Still de l'adulte [Pathophysiology, subtypes, and treatments of adult-onset Still's disease: An update].
Gerfaud-Valentin M., Sève P., Hot A., Broussolle C., Jamilloux Y., 2015. La Revue de Médecine Interne, 36 (5) pp. 319-327.
Ectodysplasin/NF-κB Promotes Mammary Cell Fate via Wnt/β-catenin Pathway.
Voutilainen M., Lindfors P.H., Trela E., Lönnblad D., Shirokova V., Elo T., Rysti E., Schmidt-Ullrich R., Schneider P., Mikkola M.L., 2015. Plos Genetics, 11 (11) pp. e1005676. Peer-reviewed.
Epithelial NAIPs protect against colonic tumorigenesis.
Allam R., Maillard M.H., Tardivel A., Chennupati V., Bega H., Yu C.W., Velin D., Schneider P., Maslowski K.M., 2015. Journal of Experimental Medicine, 212 (3) pp. 369-383.
Exposure to Leishmania braziliensis triggers neutrophil activation and apoptosis.
Falcão S.A., Weinkopff T., Hurrell B.P., Celes F.S., Curvelo R.P., Prates D.B., Barral A., Borges V.M., Tacchini-Cottier F., de Oliveira C.I., 2015. PLoS Neglected Tropical Diseases, 9 (3) pp. e0003601.
Fruit and vegetables and cancer risk : a review of southern European studies
Turati F., Rossi M., Pelucchi C., Levi F., La Vecchia C., 2015. British Journal of Nutrition, 113 Suppl 2 pp. S102-S110.
GATA2 is required for lymphatic vessel valve development and maintenance.
Kazenwadel J., Betterman K.L., Chong C.E., Stokes P.H., Lee Y.K., Secker G.A., Agalarov Y., Demir C.S., Lawrence D.M., Sutton D.L. et al., 2015. Journal of Clinical Investigation, 125 (8) pp. 2979-2994. Peer-reviewed.
 
IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs.
Barone F., Nayar S., Campos J., Cloake T., Withers D.R., Toellner K.M., Zhang Y., Fouser L., Fisher B., Bowman S. et al., 2015. Proceedings of the National Academy of Sciences of the United States of America, 112 (35) pp. 11024-11029. Peer-reviewed.
Implication of different domains of the Leishmania major metacaspase in cell death and autophagy.
Casanova M., Gonzalez I.J., Sprissler C., Zalila H., Dacher M., Basmaciyan L., Späth G.F., Azas N., Fasel N., 2015. Cell Death and Disease, 6 pp. e1933. Peer-reviewed.
 
Maintaining dendritic cell viability in culture.
Vremec D., Hansen J., Strasser A., Acha-Orbea H., Zhan Y., O'Keeffe M., Shortman K., 2015. Molecular Immunology, 63 (2) pp. 264-267.
Metabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signaling.
Zeis T., Allaman I., Gentner M., Schroder K., Tschopp J., Magistretti P.J., Schaeren-Wiemers N., 2015. Brain, Behavior, and Immunity, 48 pp. 313-325.
Nanocarriers for DNA Vaccines: Co-Delivery of TLR-9 and NLR-2 Ligands Leads to Synergistic Enhancement of Proinflammatory Cytokine Release
Poecheim J., Heuking S., Brunner L., Barnier-Quer C., Collin N., Borchard G., 2015. Nanomaterials, 5 (4) pp. 2317-1334. Peer-reviewed.
Neuropathic Pain Phenotype Does Not Involve the NLRP3 Inflammasome and Its End Product Interleukin-1β in the Mice Spared Nerve Injury Model.
Curto-Reyes V., Kirschmann G., Pertin M., Drexler S.K., Decosterd I., Suter M.R., 2015. Plos One, 10 (7) pp. e0133707. Peer-reviewed.
Neutralization of (NK-cell-derived) B-cell activating factor by Belimumab restores sensitivity of chronic lymphoid leukemia cells to direct and Rituximab-induced NK lysis.
Wild J., Schmiedel B.J., Maurer A., Raab S., Prokop L., Stevanović S., Dörfel D., Schneider P., Salih H.R., 2015. Leukemia, 29 (8) pp. 1676-1683. Peer-reviewed.
 
New players driving inflammation in monogenic autoinflammatory diseases.
Martinon F., Aksentijevich I., 2015. Nature Reviews. Rheumatology, 11 (1) pp. 11-20. Peer-reviewed.
NLRC5 exclusively transactivates MHC class I and related genes through a distinctive SXY module.
Ludigs K., Seguín-Estévez Q., Lemeille S., Ferrero I., Rota G., Chelbi S., Mattmann C., MacDonald H.R., Reith W., Guarda G., 2015. PLoS Genetics, 11 (3) pp. e1005088. Peer-reviewed.
NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes.
Gustin A., Kirchmeyer M., Koncina E., Felten P., Losciuto S., Heurtaux T., Tardivel A., Heuschling P., Dostert C., 2015. Plos One, 10 (6) pp. e0130624. Peer-reviewed.
 
Pathogenesis of adult-onset Still's disease: new insights from the juvenile counterpart.
Jamilloux Y., Gerfaud-Valentin M., Martinon F., Belot A., Henry T., Sève P., 2015. Immunologic Research, 61 (1-2) pp. 53-62.
Pharmacological stimulation of edar signaling in the adult enhances sebaceous gland size and function.
Kowalczyk-Quintas C., Schuepbach-Mallepell S., Willen L., Smith T.K., Huttner K., Kirby N., Headon D.J., Schneider P., 2015. Journal of Investigative Dermatology, 135 (2) pp. 359-368.
 
Pyroptosis: Caspase-11 Unlocks the Gates of Death.
de Gassart A., Martinon F., 2015. Immunity, 43 (5) pp. 835-837.
Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion.
Hurrell B.P., Schuster S., Grün E., Coutaz M., Williams R.A., Held W., Malissen B., Malissen M., Yousefi S., Simon H.U. et al., 2015. PLoS Pathogens, 11 (5) pp. e1004929.
 
RNA interference screening identifies a novel role for PCTK1/CDK16 in medulloblastoma with c-Myc amplification.
Ćwiek P., Leni Z., Salm F., Dimitrova V., Styp-Rekowska B., Chiriano G., Carroll M., Höland K., Djonov V., Scapozza L. et al., 2015. Oncotarget, 6 (1) pp. 116-129. Peer-reviewed.
Sequencing and characterizing the genome of Estrella lausannensis as an undergraduate project: training students and biological insights.
Bertelli C., Aeby S., Chassot B., Clulow J., Hilfiker O., Rappo S., Ritzmann S., Schumacher P., Terrettaz C., Benaglio P. et al., 2015. Frontiers in Microbiology, 6 (101) p. 101. Peer-reviewed.
Severe pneumonia due to Parachlamydia acanthamoebae following intranasal inoculation: a mice model.
Pilloux L., Casson N., Sommer K., Klos A., Stehle J.C., Pusztaszeri M., Greub G., 2015. Microbes and Infection, 17 (11-12) pp. 755-760. Peer-reviewed.
STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity.
Demaria O., De Gassart A., Coso S., Gestermann N., Di Domizio J., Flatz L., Gaide O., Michielin O., Hwu P., Petrova T.V. et al., 2015. Proceedings of the National Academy of Sciences of the United States of America, 112 (50) pp. 15408-15413.
Stoichiometry of heteromeric BAFF and APRIL cytokines dictates their receptor binding and signaling properties.
Schuepbach-Mallepell S., Das D., Willen L., Vigolo M., Tardivel A., Lebon L., Kowalczyk-Quintas C., Nys J., Smulski C., Zheng T.S. et al., 2015. Journal of Biological Chemistry, 290 (26) pp. 16330-16342. Peer-reviewed.
Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival.
Johnston A.J., Murphy K.T., Jenkinson L., Laine D., Emmrich K., Faou P., Weston R., Jayatilleke K.M., Schloegel J., Talbo G. et al., 2015. Cell, 162 (6) pp. 1365-1378.
 
TLR3-Mediated CD8+ Dendritic Cell Activation Is Coupled with Establishment of a Cell-Intrinsic Antiviral State.
Széles L., Meissner F., Dunand-Sauthier I., Thelemann C., Hersch M., Singovski S., Haller S., Gobet F., Fuertes Marraco S.A., Mann M. et al., 2015. Journal of Immunology, 195 (3) pp. 1025-1033. Peer-reviewed.
 
TRANSVAC research infrastructure - Results and lessons learned from the European network of vaccine research and development
Geels M.J., Thøgersen R.L., Guzman C.A., Ho M.M., Verreck F., Collin N., Robertson J.S., McConkey S.J., Kaufmann S.H., Leroy O., 2015. Vaccine, 33 (41) pp. 5481-5487. Peer-reviewed.
Treatment of adult-onset Still's disease: a review
Jamilloux Y., Gerfaud-Valentin M., Henry T., Seve P., 2015. Therapeutics and Clinical Risk Management, 110 pp. 33-43.
Vacuolar SNARE Protein Transmembrane Domains Serve as Nonspecific Membrane Anchors with Unequal Roles in Lipid Mixing.
Pieren M., Desfougères Y., Michaillat L., Schmidt A., Mayer A., 2015. Journal of Biological Chemistry, 290 (20) pp. 12821-12832. Peer-reviewed.
Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation.
Ives A., Nomura J., Martinon F., Roger T., LeRoy D., Miner J.N., Simon G., Busso N., So A., 2015. Nature Communications, 6 p. 6555.
β-Catenin Signaling Drives Differentiation and Proinflammatory Function of IRF8-Dependent Dendritic Cells.
Cohen S.B., Smith N.L., McDougal C., Pepper M., Shah S., Yap G.S., Acha-Orbea H., Jiang A., Clausen B.E., Rudd B.D. et al., 2015. Journal of Immunology, 194 (1) pp. 210-222. Peer-reviewed.
A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression.
Wilson W.C., Hornig-Do H.T., Bruni F., Chang J.H., Jourdain A.A., Martinou J.C., Falkenberg M., Spåhr H., Larsson N.G., Lewis R.J. et al., 2014/12/01. Human molecular genetics, 23 (23) pp. 6345-6355. Peer-reviewed.
 
Expression and role of the embryonic protein SOX2 in head and neck squamous cell carcinoma.
Schröck A., Bode M., Göke F.J., Bareiss P.M., Schairer R., Wang H., Weichert W., Franzen A., Kirsten R., van Bremen T. et al., 2014/07. Carcinogenesis, 35 (7) pp. 1636-1642. Peer-reviewed.
A common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency.
Pieper K., Rizzi M., Speletas M., Smulski C.R., Sic H., Kraus H., Salzer U., Fiala G.J., Schamel W.W., Lougaris V. et al., 2014. Journal of Allergy and Clinical Immunology, 133 (4) pp. 1222-1225.e10. Peer-reviewed.
A new life for an old pump: V-ATPase and neurotransmitter release.
Vavassori S., Mayer A., 2014. Journal of Cell Biology, 205 (1) pp. 7-9.
 
A novel Nrf2-miR-29-desmocollin-2 axis regulates desmosome function in keratinocytes.
Kurinna S., Schäfer M., Ostano P., Karouzakis E., Chiorino G., Bloch W., Bachmann A., Gay S., Garrod D., Lefort K. et al., 2014. Nature Communications, 5 p. 5099.
A scoring method to standardize lesion monitoring following intra-dermal infection of Leishmania parasites in the murine ear
Schuster S., Hartley M.A., Tacchini-Cottier F., Ronet C., 2014. Frontiers in Cellular and Infection Microbiology, 4 p. 67.
 
Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses.
von Burg N., Chappaz S., Baerenwaldt A., Horvath E., Bose Dasgupta S., Ashok D., Pieters J., Tacchini-Cottier F., Rolink A., Acha-Orbea H. et al., 2014. Proceedings of the National Academy of Sciences of the United States of America, 111 (35) pp. 12835-12840.
 
Antigenicity and immunogenicity of a novel Plasmodium vivax circumsporozoite derived synthetic vaccine construct.
Céspedes N., Jiménez E., Lopez-Perez M., Rubiano K., Felger I., Alonso P., Arévalo-Herrera M., Corradin G., Herrera S., 2014. Vaccine, 32 (26) pp. 3179-3186.
Blocking Junctional Adhesion Molecule C Enhances Dendritic Cell Migration and Boosts the Immune Responses against Leishmania major.
Ballet R., Emre Y., Jemelin S., Charmoy M., Tacchini-Cottier F., Imhof B.A., 2014. PLoS Pathogens, 10 (12) pp. e1004550.
 
Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function.
Guey B., Bodnar M., Manié S.N., Tardivel A., Petrilli V., 2014. Proceedings of the National Academy of Sciences of the United States of America, 111 (48) pp. 17254-17259.
Classification of current anticancer immunotherapies.
Galluzzi L., Vacchelli E., Bravo-San Pedro J.M., Buqué A., Senovilla L., Baracco E.E., Bloy N., Castoldi F., Abastado J.P., Agostinis P. et al., 2014. Oncotarget, 5 (24) pp. 12472-12508.
Conditional deletion of ferritin h in mice reduces B and T lymphocyte populations.
Vanoaica L., Richman L., Jaworski M., Darshan D., Luther S.A., Kühn L.C., 2014. PLoS One, 9 (2) pp. e89270.
 
Connexins in lymphatic vessel physiology and disease.
Meens M.J., Sabine A., Petrova T.V., Kwak B.R., 2014. FEBS Letters, 588 (8) pp. 1271-1277.
Coupled synthesis and translocation restrains polyphosphate to acidocalcisome-like vacuoles and prevents its toxicity.
Gerasimaitė R., Sharma S., Desfougères Y., Schmidt A., Mayer A., 2014. Journal of Cell Science, 127 (23) pp. 5093-5104.
 
Cross-presenting dendritic cells are required for control of Leishmania major infection.
Ashok D., Schuster S., Ronet C., Rosa M., Mack V., Lavanchy C., Marraco S.F., Fasel N., Murphy K.M., Tacchini-Cottier F. et al., 2014. European Journal of Immunology, 44 (5) pp. 1422-1432.
Detection and measurement of paracaspase MALT1 activity.
Hailfinger S., Pelzer C., Thome M., 2014. Methods in Molecular Biology, 1133 pp. 177-188.
Ectodysplasin A (EDA) - EDA receptor signalling and its pharmacological modulation.
Kowalczyk-Quintas C., Schneider P., 2014. Cytokine and Growth Factor Reviews, 25 (2) pp. 195-203.
 
Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa.
Sellin M.E., Müller A.A., Felmy B., Dolowschiak T., Diard M., Tardivel A., Maslowski K.M., Hardt W.D., 2014. Cell Host and Microbe, 16 (2) pp. 237-248.
Extensive remodeling of DC function by rapid maturation-induced transcriptional silencing.
Seguín-Estévez Q., Dunand-Sauthier I., Lemeille S., Iseli C., Ibberson M., Ioannidis V., Schmid C.D., Rousseau P., Barras E., Geinoz A. et al., 2014. Nucleic Acids Research, 42 (15) pp. 9641-9655.
 
Extracellular histones in tissue injury and inflammation.
Allam R., Kumar S.V., Darisipudi M.N., Anders H.J., 2014. Journal of Molecular Medicine, 92 (5) pp. 465-472.
Generation and characterization of function-blocking anti-ectodysplasin A (EDA) monoclonal antibodies that induce ectodermal dysplasia.
Kowalczyk-Quintas C., Willen L., Dang A.T., Sarrasin H., Tardivel A., Hermes K., Schneider H., Gaide O., Donzé O., Kirby N. et al., 2014. Journal of Biological Chemistry, 289 (7) pp. 4273-4285. Peer-reviewed.
 
In memory of Garry Abelev 1928-2013.
Engelhardt N., Mach J.P., 2014. Tumour Biology, 35 (7) pp. 6169-6173.
iNKT/CD1d-antitumor immunotherapy significantly increases the efficacy of therapeutic CpG/peptide-based cancer vaccine.
Corgnac S., Perret R., Zhang L., Mach J.P., Romero P., Donda A., 2014. Journal for Immunotherapy of Cancer, 2 (1) p. 39. Peer-reviewed.
Interferon-γ Induces Expression of MHC Class II on Intestinal Epithelial Cells and Protects Mice from Colitis
Thelemann C., Eren R.O., Coutaz M., Brasseit J., Bouzourene H., Rosa M., Duval A., Lavanchy C., Mack V., Mueller C. et al., 2014. PLoS One, 9 (1) pp. e86844.
 
Interplay of mechanotransduction, FOXC2, connexins, and calcineurin signaling in lymphatic valve formation.
Sabine A., Petrova T.V., 2014. Advances in Anatomy, Embryology, and Cell Biology, 214 pp. 67-80.
Isolation and antimicrobial susceptibility pattern of Staphylococcus aureus in patients with surgical site infection at Debre Markos Referral Hospital, Amhara Region, Ethiopia
Kahsay A., Mihret A., Abebe T., Andualem T., 2014. Archives of Public Health, 72 (1) pp. 16-16. Peer-reviewed.
 
L'inflammation
Martinon F., 2014. pp. 175-181 dans Cramer P. (eds.) Le défi des maladies infectieuses, Docis.
Large T Antigen-Specific Cytotoxic T Cells Protect Against Dendritic Cell Tumors through Perforin-Mediated Mechanisms Independent of CD4 T Cell Help.
Duval A., Fuertes Marraco S.A., Schwitter D., Leuenberger L., Acha-Orbea H., 2014. Frontiers in Immunology, 5 p. 338.
Leishmania aethiopica field isolates bearing an endosymbiontic dsRNA virus induce pro-inflammatory cytokine response.
Zangger H., Hailu A., Desponds C., Lye L.F., Akopyants N.S., Dobson D.E., Ronet C., Ghalib H., Beverley S.M., Fasel N., 2014. PLoS Neglected Tropical Diseases, 8 (4) pp. e2836.
Leishmania metacaspase: an arginine-specific peptidase.
Martin R., Gonzalez I., Fasel N., 2014. Methods in Molecular Biology, 1133 pp. 189-202. Peer-reviewed.
 
Les inflammasomes et les maladies humaines
Jamilloux Y., Sève P., Henry T., 2014. Revue de Médecine Interne, 35 (11) pp. 730-741.
Malaria Vaccines: Progressing on a Bumpy Road
Corradin G., Nebie I., 2014. Ebiomedicine, 1 (1) pp. 6-7. Peer-reviewed.
MALT1 auto-proteolysis is essential for NF-κB-dependent gene transcription in activated lymphocytes.
Baens M., Bonsignore L., Somers R., Vanderheydt C., Weeks S.D., Gunnarsson J., Nilsson E., Roth R.G., Thome M., Marynen P., 2014. PLoS One, 9 (8) pp. e103774.
Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.
Jaworski M., Marsland B.J., Gehrig J., Held W., Favre S., Luther S.A., Perroud M., Golshayan D., Gaide O., Thome M., 2014. EMBO Journal, 33 (23) pp. 2765-2781.
 
Mammalian target of rapamycin complex 1 orchestrates invariant NKT cell differentiation and effector function.
Zhang L., Tschumi B.O., Corgnac S., Rüegg M.A., Hall M.N., Mach J.P., Romero P., Donda A., 2014. Journal of Immunology, 193 (4) pp. 1759-1765.
 
MHC Class II Transactivator Is an In Vivo Regulator of Osteoclast Differentiation and Bone Homeostasis Co-opted From Adaptive Immunity.
Benasciutti E., Mariani E., Oliva L., Scolari M., Perilli E., Barras E., Milan E., Orfanelli U., Fazzalari N.L., Campana L. et al., 2014. Journal of Bone and Mineral Research, 29 (2) pp. 290-303.
miR-34a/SIRT6 in squamous differentiation and cancer.
Dotto G.P., Karine L., 2014. Cell cycle, 13 (7) pp. 1055-1056. Peer-reviewed.
 
Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming.
Allam R., Lawlor K.E., Yu E.C., Mildenhall A.L., Moujalled D.M., Lewis R.S., Ke F., Mason K.D., White M.J., Stacey K.J. et al., 2014. EMBO Reports, 15 (9) pp. 982-990.
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