Research directions
Cutaneous biology
The research in the laboratory of cutaneous biology is concentrated on the molecular pathogenesis of epidermal genodermatoses and cutaneous adnexal tumors. To deal with these projects, we are developing human models of genodermatoses and cutaneous tumors using viral gene transfer methods and keratinocyte grafts on scid mice. To analyze protein-protein interactions co-immunoprecipitations and the yeast-two hybrid system are employed. We are using gene transfer to express them in keratinocytes and cell lines. Novel assay systems are developed for molecular diagnostic of genodermatoses. Using bio informatics, new genes expressed during epidermal differentiation are isolated
Virulence factors of pathogenic fungi
Molecular genetic of Aspergillus fumigatus Candida albicans and Dermatophytes
Role of secreted aspartic proteases in virulence of Candida albicans
Research of specific inhibitors to be used as drugs in the treatment of candidiasis
Tissue engineering and transplantation
Skin regeneration in the acute burn with keratinocyte and fibroblast autografts
Therapy of hypopigmentation disorders with isolated melanocytes
Role of antioxidants in tissue regeneration
Melanoma
A study of melanoma metastasis and micrometastasis in sentinel nodes
Research of melanoma antigens and differentiation of melanocytes in melanomas and in relation to prognosis
Dermato-oncology
The research in dermato-oncology is focused on the molecular pathogenesis of tumor suppressor genes in cutaneous adnexal tumors. To carry out this research, modern methods in molecular and cellular biology are utilised such as analysis of protein-protein interaction, in vitro and in vivo transfer of genes and creation of animal models. Based on these new knowledge on the function of these genes, new ways of therapeutic interventions wil be designed and tested
Dermatology and Environment
Setting up of an European data network of dermatovigilance (Taskforce Eletronic Data of European Society of Contact Dermatitis)
Setting up of a directory for protection gloves used in a work sphere
Update et development of Swiss Derma, data base and help tool for the prescriptions on dermopharmacy, care and cutaneous Hygiene in Switzerland
Competences
Esthetic and corrective dermatology
Biologie moléculaire et cellulaire
Histopathologie de la peau
Dermato-oncologie
Dermatogénétique
Dermatomycologie
Génie tissulaire
