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Centre intégratif de génomique

Coordonnées Equipe Publications  
Equipe principale | CIG Services communs | Genomics Technologies Facility (GTF) | Group Benton | Group Desvergne | Group Dion | Group Fajas | Group Fankhauser | Group Franken | Group Gatfield | Group Hamaratoglu Dion | Group Hernandez | Group Herr | Group Michalik | Group Reymond | Group Stasiak | Group Thorens | Group Wahli | Mouse Metabolic Evaluation Facility (MEF) | Protein Analysis Facility (PAF) |

Publications | Mémoires et thèses

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65 publications

2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 |
Clock-dependent chromatin topology modulates circadian transcription and behavior.
Mermet J., Yeung J., Hurni C., Mauvoisin D., Gustafson K., Jouffe C., Nicolas D., Emmenegger Y., Gobet C., Franken P. et al., 2018. Genes & Development, 32 (5-6) pp. 347-358. Peer-reviewed.
Hypocretin (orexin) is critical in sustaining theta/gamma-rich waking behaviors that drive sleep need.
Vassalli A., Franken P., 2017/07/03. Proceedings of the National Academy of Sciences of the United States of America, 114 (27) pp. E5464-E5473. Peer-reviewed.
Cerebral mGluR5 availability contributes to elevated sleep need and behavioral adjustment after sleep deprivation.
Holst S.C., Sousek A., Hefti K., Saberi-Moghadam S., Buck A., Ametamey S.M., Scheidegger M., Franken P., Henning A., Seifritz E. et al., 2017. eLife, 6 pp. eLife.28751. Peer-reviewed.
Development of Circadian Sleep Regulation in the Rat: A Longitudinal Study Under Constant Conditions.
Frank M.G., Ruby N.F., Heller H.C., Franken P., 2017. Sleep, 40 (3) pp. PII zsw077. Peer-reviewed.
Genetics and Genomic basis of sleep in rodents
O'Hara Bruce F., Jiang Peng, Turek Fred W., Franken Paul, 2017/01/01. pp. 296-309 dans Principles and Practice of Sleep Medicine chap. 29, Elesevier-Saunders.
Rai1 frees mice from the repression of active wake behaviors by light.
Diessler S., Kostic C., Arsenijevic Y., Kawasaki A., Franken P., 2017. eLife, 6 pp. e23292. Peer-reviewed.
Alerting or Somnogenic Light: Pick Your Color.
Bourgin P., Hubbard J., 2016. PLoS Biology, 14 (8) pp. e2000111. Peer-reviewed.
Altered Sleep Homeostasis in Rev-erbα Knockout Mice.
Mang G.M., La Spada F., Emmenegger Y., Chappuis S., Ripperger J.A., Albrecht U., Franken P., 2016. Sleep, 39 (3) pp. 589-601. Peer-reviewed.
Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing.
Nicod J., Davies R.W., Cai N., Hassett C., Goodstadt L., Cosgrove C., Yee B.K., Lionikaite V., McIntyre R.E., Remme C.A. et al., 2016. Nature Genetics, 48 (8) pp. 912-918. Peer-reviewed.
Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons.
Oettinghaus B., Schulz J.M., Restelli L.M., Licci M., Savoia C., Schmidt A., Schmitt K., Grimm A., Morè L., Hench J. et al., 2016. Cell Death and Differentiation, 23 (1) pp. 18-28.
A neuron-specific deletion of the microRNA-processing enzyme DICER induces severe but transient obesity in mice.
Mang G.M., Pradervand S., Du N.H., Arpat A.B., Preitner F., Wigger L., Gatfield D., Franken P., 2015. PLoS One, 10 (1) pp. e0116760.
Clock-Talk: Interactions between Central and Peripheral Circadian Oscillators in Mammals.
Schibler U., Gotic I., Saini C., Gos P., Curie T., Emmenegger Y., Sinturel F., Gosselin P., Gerber A., Fleury-Olela F. et al., 2015. Cold Spring Harbor Symposia on Quantitative Biology, 80 pp. 223-232.
Genetic dissection of sleep homeostasis.
Mang G.M., Franken P., 2015. Current Topics in Behavioral Neurosciences, 25 pp. 25-63.
Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions.
Arble D.M., Bass J., Behn C.D., Butler M.P., Challet E., Czeisler C., Depner C.M., Elmquist J., Franken P., Grandner M.A. et al., 2015. Sleep, 38 (12) pp. 1849-1860. Peer-reviewed.
In vivo imaging of the central and peripheral effects of sleep deprivation and suprachiasmatic nuclei lesion on PERIOD-2 protein in mice.
Curie T., Maret S., Emmenegger Y., Franken P., 2015. Sleep, 38 (9) pp. 1381-1394.
The systemic control of circadian gene expression.
Gerber A., Saini C., Curie T., Emmenegger Y., Rando G., Gosselin P., Gotic I., Gos P., Franken P., Schibler U., 2015. Diabetes, Obesity and Metabolism, 17 Suppl 1 pp. 23-32. Peer-reviewed.
Twist1 Is a TNF-Inducible Inhibitor of Clock Mediated Activation of Period Genes.
Meier D., Lopez M., Franken P., Fontana A., 2015. Plos One, 10 (9) pp. e0137229. Peer-reviewed.
Evaluation of a piezoelectric system as an alternative to electroencephalogram/ electromyogram recordings in mouse sleep studies.
Mang G.M., Nicod J., Emmenegger Y., Donohue K.D., O'Hara B.F., Franken P., 2014. Sleep, 37 (8) pp. 1383-1392.
Tumor necrosis factor and transforming growth factor β regulate clock genes by controlling the expression of the cold inducible RNA-binding protein (CIRBP).
Lopez M., Meier D., Müller A., Franken P., Fujita J., Fontana A., 2014. Journal of Biological Chemistry, 289 (5) pp. 2736-2744.
A role for clock genes in sleep homeostasis.
Franken P., 2013. Current Opinion in Neurobiology, 23 (5) pp. 864-872.
CD40 activation induces NREM sleep and modulates genes associated with sleep homeostasis.
Gast H., Müller A., Lopez M., Meier D., Huber R., Dechent F., Prinz M., Emmenegger Y., Franken P., Birchler T. et al., 2013. Brain, Behavior, and Immunity, 27 (1) pp. 133-144. Peer-reviewed.
Controlling complexity: the clinical relevance of mouse complex genetics.
Schughart K., Libert C., SYSGENET consortium, Kas M.J., Kas M.J., 2013. European Journal of Human Genetics, 21 (11) pp. 1191-1196.
Electroencephalogram paroxysmal theta characterizes cataplexy in mice and children.
Vassalli A., Dellepiane J.M., Emmenegger Y., Jimenez S., Vandi S., Plazzi G., Franken P., Tafti M., 2013. Brain, 136 (Pt 5) pp. 1592-1608.
Genetic interaction between circadian and homeostatic regulation of sleep
Mongrain V., Franken P., 2013. pp. 147-161 dans Shaw P., Tafti M., Thorpy M.J. (eds.) The Genetic Basis of Sleep and Sleep Disorders chap. 15, Cambridge University Press.
Homeostatic and circadian contribution to EEG and molecular state variables of sleep regulation.
Curie T., Mongrain V., Dorsaz S., Mang G.M., Emmenegger Y., Franken P., 2013. Sleep, 36 (3) pp. 311-323.
Meeting report of the European mouse complex genetics network SYSGENET.
Delprato A., Aransay A.M., Kollmus H., Schughart K., Falcon-Perez J.M., SYSGENET consortium, 2013. Mammalian Genome, 24 (5-6) pp. 190-197.
Neuroligin-1 links neuronal activity to sleep-wake regulation.
El Helou J., Bélanger-Nelson E., Freyburger M., Dorsaz S., Curie T., La Spada F., Gaudreault P.O., Beaumont É., Pouliot P., Lesage F. et al., 2013. Proceedings of the National Academy of Sciences of the United States of America, 110 (24) pp. 9974-9979.
Planning sleep-related animal and translational research
Mang G.M., Franken P., 2013. pp. 139-150 dans Kushida C.A. (eds.) Encyclopedia of Sleep, Elsevier.
Real-time recording of circadian liver gene expression in freely moving mice reveals the phase-setting behavior of hepatocyte clocks.
Saini C., Liani A., Curie T., Gos P., Kreppel F., Emmenegger Y., Bonacina L., Wolf J.P., Poget Y.A., Franken P. et al., 2013. Genes and Development, 27 (13) pp. 1526-1536.
Age-related changes in sleep in inbred mice are genotype dependent.
Hasan S., Dauvilliers Y., Mongrain V., Franken P., Tafti M., 2012. Neurobiology of Aging, 33 (1) pp. 195.e13-195.e26.
Circadian clock genes and the regulation of sleep
Curie T., Franken P., 2012. pp. 1-12 dans Shiromani P.J., Horvath T., Redline S., Van Cauter E. (eds.) Sleep loss and obesity: intersecting epidemics chap. 1, Springer.
Differential effects of sodium oxybate and baclofen on EEG, sleep, neurobehavioral performance, and memory.
Vienne J., Lecciso G., Constantinescu I., Schwartz S., Franken P., Heinzer R., Tafti M., 2012. Sleep, 35 (8) pp. 1071-1083.
Genetic mechanisms underlying rhythmic EEG activity during sleep
Franken P., 2012. pp. 59-89 dans Frank M.G. (eds.) Sleep and brain activity chap. 4, Elsevier.
Human disease: Strength to strength for mouse models.
Schughart K., Libert C., Kas M.J., 2012. Nature, 492 (7427) p. 41.
Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures.
Hinard V., Mikhail C., Pradervand S., Curie T., Houtkooper R.H., Auwerx J., Franken P., Tafti M., 2012. Journal of Neuroscience, 32 (36) pp. 12506-12517.
Sleep and EEG Phenotyping in Mice.
Mang G.M., Franken P., 2012. Current Protocols in Mouse Biology, 2 (1) pp. 55-74. Peer-reviewed.
Sleep and genetics
Franken P., Tafti P., 2012. pp. 43-45 dans Bassetti C.L., Knobl B., Schulz H (eds.) European Sleep Research Society, 1972-2012, European Sleep Research Society.
Sustaining sleep spindles through enhanced SK2-channel activity consolidates sleep and elevates arousal threshold.
Wimmer R.D., Astori S., Bond C.T., Rovó Z., Chatton J.Y., Adelman J.P., Franken P., Lüthi A., 2012. Journal of Neuroscience, 32 (40) pp. 13917-13928. Peer-reviewed.
Genetic basis of sleep in rodents
O'Hara B.F., Turek F.W., Franken P., 2011. pp. 161-174 dans Kryger M.H., Roth T., Dement W.C. (eds.) Principles and practice of sleep medicine chap. 14, Elsevier Saunders.
Sleep loss reduces the DNA-binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral cortex.
Mongrain V., La Spada F., Curie T., Franken P., 2011. PLoS One, 6 (10) pp. e26622.
The Ca(V)3.3 calcium channel is the major sleep spindle pacemaker in thalamus.
Astori S., Wimmer R.D., Prosser H.M., Corti C., Corsi M., Liaudet N., Volterra A., Franken P., Adelman J.P., Lüthi A., 2011. Proceedings of the National Academy of Sciences of the United States of America, 108 (33) pp. 13823-13828.
Differential effects of GABAB receptor subtypes, {gamma}-hydroxybutyric Acid, and Baclofen on EEG activity and sleep regulation.
Vienne J., Bettler B., Franken P., Tafti M., 2010/10/20. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30 (42) pp. 14194-14204. Peer-reviewed.
Separating the contribution of glucocorticoids and wakefulness to the molecular and electrophysiological correlates of sleep homeostasis.
Mongrain V., Hernandez S.A., Pradervand S., Dorsaz S., Curie T., Hagiwara G., Gip P., Heller H.C., Franken P., 2010. Sleep, 33 (9) pp. 1147-1157.
SYSGENET: a meeting report from a new European network for systems genetics.
Schughart K., SYSGENET consortium, 2010. Mammalian Genome, 21 (7-8) pp. 331-336.
cGMP-dependent protein kinase type I is implicated in the regulation of the timing and quality of sleep and wakefulness.
Langmesser S., Franken P., Feil S., Emmenegger Y., Albrecht U., Feil R., 2009. PloS one, 4 (1) pp. e4238.
Circadian clock genes and sleep homeostasis.
Franken P., Dijk D.J., 2009. European Journal of Neuroscience, 29 (9) pp. 1820-1829. Peer-reviewed.
Genetic approaches to the problem of sleep
Gregory A.M., Franken P., 2009. pp. 41-61 dans Frank M.G. (eds.) Current Advances in Sleep Biology chap. 4, Nova Science Publishers.
How to keep the brain awake? The complex molecular pharmacogenetics of wake promotion.
Hasan S., Pradervand S., Ahnaou A., Drinkenburg W., Tafti M., Franken P., 2009. Neuropsychopharmacology, 34 (7) pp. 1625-1640. Peer-reviewed.
Melanopsin as a sleep modulator: circadian gating of the direct effects of light on sleep and altered sleep homeostasis in Opn4(-/-) mice.
Tsai J.W., Hannibal J., Hagiwara G., Colas D., Ruppert E., Ruby N.F., Heller H.C., Franken P., Bourgin P., 2009. PLoS biology, 7 (6) pp. e1000125.
Sleep homeostasis
Franken P., 2009. pp. 3721-3725 dans Binder M. D., Hirokawa N., Windhorst U. (eds.) Encyclopedia of neuroscience, Springer.
The functions of sleep.
Franken P., Kopp C., Landolt H.P., Lüthi A., 2009. European Journal of Neuroscience, 29 (9) pp. 1739-1740.
Genetics of sleep.
Andretic R., Franken P., Tafti M., 2008. Annual Review of Genetics, 42 pp. 361-388. Peer-reviewed.
Sleep deprivation effects on circadian clock gene expression in the cerebral cortex parallel electroencephalographic differences among mouse strains.
Wisor J.P., Pasumarthi R.K., Gerashchenko D., Thompson C.L., Pathak S., Sancar A., Franken P., Lein E.S., Kilduff T.S., 2008. Journal of Neuroscience, 28 (28) pp. 7193-7201. Peer-reviewed.
T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites.
Cueni L., Canepari M., Luján R., Emmenegger Y., Watanabe M., Bond C.T., Franken P., Adelman J.P., Lüthi A., 2008. Nature Neuroscience, 11 (6) pp. 683-692. Peer-reviewed.
A non-circadian role for clock-genes in sleep homeostasis: a strain comparison.
Franken P., Thomason R., Heller H.C., O'Hara B.F., 2007. BMC Neuroscience, 8 (1) p. 87. Peer-reviewed.
Genomic and proteomic approaches towards an understanding of sleep.
O'Hara B.F., Ding J., Bernat R.L., Franken P., 2007. CNS and Neurological Disorders Drug Targets, 6 (1) pp. 71-81. Peer-reviewed.
Homer1a is a core brain molecular correlate of sleep loss.
Maret S., Dorsaz S., Gurcel L., Pradervand S., Petit B., Pfister C., Hagenbuchle O., O'Hara B.F., Franken P., Tafti M., 2007. Proceedings of the National Academy of Sciences of the United States of America, 104 (50) pp. 20090-20095. Peer-reviewed.
Molecular analysis of sleep.
Tafti M., Franken P., 2007. Cold Spring Harbor Symposia on Quantitative Biology, 72 pp. 573-578. Peer-reviewed.
Pattern recognition of sleep in rodents using piezoelectric signals generated by gross body movements.
Flores A.E., Flores J.E., Deshpande H., Picazo J.A., Xie X.S., Franken P., Heller H.C., Grahn D.A., O'Hara B.F., 2007. IEEE Transactions on Bio-medical Engineering, 54 (2) pp. 225-233. Peer-reviewed.
The quality of waking and process S.
Franken P., 2007. Sleep, 30 (2) pp. 126-127.
Glycogen content in the cerebral cortex increases with sleep loss in C57BL/6J mice.
Franken P., Gip P., Hagiwara G., Ruby N.F., Heller H.C., 2006. Neuroscience Letters, 402 (1-2) pp. 176-179. Peer-reviewed.
NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: genotype and sex interactions.
Franken P., Dudley C.A., Estill S.J., Barakat M., Thomason R., O'Hara B.F., McKnight S.L., 2006. Proceedings of the National Academy of Sciences of the United States of America, 103 (18) pp. 7118-7123.
Interaction of sleep homeostasis and circadian rhythmicity : dependent or independent systems?
Dijk D.J., Franken P., 2005. pp. 418-434 dans Kryger M.H., Roth T, Dement W.C. (eds.) Interaction of Sleep Homeostasis and Circadian Rhythmicity: Dependent or Independent Systems? chap. 34, Saunders.
Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice.
Xie X., Dumas T., Tang L., Brennan T., Reeder T., Thomas W., Klein R.D., Flores J., O'Hara B.F., Heller H.C. et al., 2005. Brain Research, 1052 (2) pp. 212-221. Peer-reviewed.
Retinoic acid signaling affects cortical synchrony during sleep.
Maret S., Franken P., Dauvilliers Y., Ghyselinck N.B., Chambon P., Tafti M., 2005. Science, 310 (5745) pp. 111-113.
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