Centre intégratif de génomique

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Publications | Mémoires et thèses

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121 publications

2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2003 | 1994 |
Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes.
Khamis A., Canouil M., Siddiq A., Crouch H., Falchi M., Bulow M.V., Ehehalt F., Marselli L., Distler M., Richter D. et al., 2019/06. Molecular metabolism, 24 pp. 98-107. Peer-reviewed.
Targeting the Brain to Cure Type 2 Diabetes.
Thorens B., 2019/03. Diabetes, 68 (3) pp. 476-478. Peer-reviewed.
Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance.
van der Klaauw A.A., Croizier S., Mendes de Oliveira E., Stadler LKJ, Park S., Kong Y., Banton M.C., Tandon P., Hendricks A.E., Keogh J.M. et al., 2019/02/07. Cell, 176 (4) pp. 729-742.e18. Peer-reviewed.
Profound Perturbation of the Metabolome in Obesity Is Associated with Health Risk.
Cirulli E.T., Guo L., Leon Swisher C., Shah N., Huang L., Napier L.A., Kirkness E.F., Spector T.D., Caskey C.T., Thorens B. et al., 2019/02/05. Cell metabolism, 29 (2) pp. 488-500.e2. Peer-reviewed.
Tanycyte Gene Expression Dynamics in the Regulation of Energy Homeostasis.
Langlet F., 2019. Frontiers in endocrinology, 10 p. 286. Peer-reviewed.
SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney.
Auberson M., Stadelmann S., Stoudmann C., Seuwen K., Koesters R., Thorens B., Bonny O., 2018/12. Pflugers Archiv, 470 (12) pp. 1739-1751. Peer-reviewed.
Central Dicer-miR-103/107 controls developmental switch of POMC progenitors into NPY neurons and impacts glucose homeostasis.
Croizier S., Park S., Maillard J., Bouret S.G., 2018/10/12. eLife, 7. Peer-reviewed.
Sitagliptin and Roux-en-Y gastric bypass modulate insulin secretion via regulation of intra-islet PYY.
Guida C., McCulloch L.J., Godazgar M., Stephen S.D., Baker C., Basco D., Dong J., Chen D., Clark A., Ramracheya R.D., 2018/03. Diabetes, obesity & metabolism, 20 (3) pp. 571-581. Peer-reviewed.
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.
Solimena M., Schulte A.M., Marselli L., Ehehalt F., Richter D., Kleeberg M., Mziaut H., Knoch K.P., Parnis J., Bugliani M. et al., 2018/03. Diabetologia, 61 (3) pp. 641-657. Peer-reviewed.
α-cell glucokinase suppresses glucose-regulated glucagon secretion.
Basco D., Zhang Q., Salehi A., Tarasov A., Dolci W., Herrera P., Spiliotis I., Berney X., Tarussio D., Rorsman P. et al., 2018/02/07. Nature communications, 9 (1) p. 546. Peer-reviewed.
GLUT2-Expressing Neurons as Glucose Sensors in the Brain: Electrophysiological Analysis.
Labouèbe G., Thorens B., Lamy C., 2018. Methods in molecular biology, 1713 pp. 255-267. Peer-reviewed.
microRNA-205-5p is a modulator of insulin sensitivity that inhibits FOXO function.
Langlet F., Tarbier M., Haeusler R.A., Camastra S., Ferrannini E., Friedländer M.R., Accili D., 2018. Molecular Metabolism, 17 pp. 49-60. Peer-reviewed.
Carbohydrates and insulin resistance in clinical nutrition: Recommendations from the ESPEN expert group.
Barazzoni R., Deutz NEP, Biolo G., Bischoff S., Boirie Y., Cederholm T., Cuerda C., Delzenne N., Leon Sanz M., Ljungqvist O. et al., 2017/04. Clinical nutrition, 36 (2) pp. 355-363. Peer-reviewed.
Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for <i>Elovl2</i> in glucose-induced insulin secretion.
Cruciani-Guglielmacci C., Bellini L., Denom J., Oshima M., Fernandez N., Normandie-Levi P., Berney X.P., Kassis N., Rouch C., Dairou J. et al., 2017/04. Molecular metabolism, 6 (4) pp. 340-351. Peer-reviewed.
Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans.
Wigger L., Cruciani-Guglielmacci C., Nicolas A., Denom J., Fernandez N., Fumeron F., Marques-Vidal P., Ktorza A., Kramer W., Schulte A. et al., 2017/02/28. Cell reports, 18 (9) pp. 2269-2279. Peer-reviewed.
Alain Ktorza, PhD in Memoriam
Thorens B., Accili D., Ahrén B., Boitard C., Seino S., Cerasi E., 2017. Diabetes, Obesity & Metabolism, 19 (Suppl 1) p. 3. Peer-reviewed.
Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation.
Dror E., Dalmas E., Meier D.T., Wueest S., Thévenet J., Thienel C., Timper K., Nordmann T.M., Traub S., Schulze F. et al., 2017. Nature Immunology, 18 (3) pp. 283-292. Peer-reviewed.
Homeostasis Meets Motivation in the Battle to Control Food Intake.
Ferrario C.R., Labouèbe G., Liu S., Nieh E.H., Routh V.H., Xu S., O'Connor E.C., 2016/11/09. The Journal of neuroscience, 36 (45) pp. 11469-11481. Peer-reviewed.
A Genetic Screen Identifies Hypothalamic Fgf15 as a Regulator of Glucagon Secretion.
Picard A., Soyer J., Berney X., Tarussio D., Quenneville S., Jan M., Grouzmann E., Burdet F., Ibberson M., Thorens B., 2016/11/08. Cell reports, 17 (7) pp. 1795-1806. Peer-reviewed.
Sex-Specific Control of Fat Mass and Counterregulation by Hypothalamic Glucokinase.
Steinbusch L.K., Picard A., Bonnet M.S., Basco D., Labouèbe G., Thorens B., 2016/10. Diabetes, 65 (10) pp. 2920-2931. Peer-reviewed.
Revisiting the physiological roles of SGLTs and GLUTs using positron emission tomography in mice.
Sala-Rabanal M., Hirayama B.A., Ghezzi C., Liu J., Huang S.C., Kepe V., Koepsell H., Yu A., Powell D.R., Thorens B. et al., 2016/08/01. The Journal of physiology, 594 (15) pp. 4425-4438. Peer-reviewed.
The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response.
Agrawal N., Delanoue R., Mauri A., Basco D., Pasco M., Thorens B., Léopold P., 2016/04/12. Cell metabolism, 23 (4) pp. 675-684.
Biological Characterization of Gene Response to Insulin-Induced Hypoglycemia in Mouse Retina.
Emery M., Nanchen N., Preitner F., Ibberson M., Roduit R., 2016. Plos One, 11 (2) pp. e0150266. Peer-reviewed.
Glucose-responsive neurons of the paraventricular thalamus control sucrose-seeking behavior.
Labouèbe G., Boutrel B., Tarussio D., Thorens B., 2016. Nature Neuroscience, 19 (8) pp. 999-1002.
Glutamate Cysteine Ligase-Modulatory Subunit Knockout Mouse Shows Normal Insulin Sensitivity but Reduced Liver Glycogen Storage.
Lavoie S., Steullet P., Kulak A., Preitner F., Do K.Q., Magistretti P.J., 2016. Frontiers in Physiology, 7 p. 142. Peer-reviewed.
Intestinal PPARγ signalling is required for sympathetic nervous system activation in response to caloric restriction.
Duszka K., Picard A., Ellero-Simatos S., Chen J., Defernez M., Paramalingam E., Pigram A., Vanoaica L., Canlet C., Parini P. et al., 2016. Scientific Reports, 6 p. 36937. Peer-reviewed.
Novel de novo mutations in ZBTB20 in Primrose syndrome with congenital hypothyroidism.
Mattioli F., Piton A., Gérard B., Superti-Furga A., Mandel J.L., Unger S., 2016. American Journal of Medical Genetics. Part A, 170 (6) pp. 1626-1629. Peer-reviewed.
Sorcin links pancreatic β cell lipotoxicity to ER Ca2+ stores.
Marmugi A., Parnis J., Chen X., Carmichael L., Hardy J., Mannan N., Marchetti P., Piemonti L., Bosco D., Johnson P. et al., 2016. Diabetes, 65 (4) pp. 1009-1021.
Autocrine Action of IGF2 Regulates Adult β-Cell Mass and Function.
Modi H., Jacovetti C., Tarussio D., Metref S., Madsen O.D., Zhang F.P., Rantakari P., Poutanen M., Nef S., Gorman T. et al., 2015. Diabetes, 64 (12) pp. 4148-4157. Peer-reviewed.
Brain glucose sensing in homeostatic and hedonic regulation.
Steinbusch L., Labouèbe G., Thorens B., 2015. Trends In Endocrinology and Metabolism: Tem, 26 (9) pp. 455-466.
Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.
Marquard J., Otter S., Welters A., Stirban A., Fischer A., Eglinger J., Herebian D., Kletke O., Klemen M.S., Stožer A. et al., 2015. Nature Medicine, 21 (4) pp. 363-372.
Clic4, a novel protein that sensitizes β-cells to apoptosis.
Patel D., Ythier D., Brozzi F., Eizirik D.L., Thorens B., 2015. Molecular Metabolism, 4 (4) pp. 253-264.
Double incretin receptor knock-out (DIRKO) mice present with alterations of trabecular and cortical micromorphology and bone strength.
Mieczkowska A., Mansur S., Bouvard B., Flatt P.R., Thorens B., Irwin N., Chappard D., Mabilleau G., 2015. Osteoporosis International, 26 (1) pp. 209-218.
GLUT2, glucose sensing and glucose homeostasis.
Thorens B., 2015. Diabetologia, 58 (2) pp. 221-232.
Ins1 (Cre) knock-in mice for beta cell-specific gene recombination.
Thorens B., Tarussio D., Maestro M.A., Rovira M., Heikkilä E., Ferrer J., 2015. Diabetologia, 58 (3) pp. 558-565.
No development of hypertension in the hyperuricemic liver-Glut9 knockout mouse.
Preitner F., Pimentel A., Metref S., Berthonneche C., Sarre A., Moret C., Rotman S., Centeno G., Firsov D., Thorens B., 2015. Kidney International, 87 (5) pp. 940-947.
Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass.
Mitchell R.K., Mondragon A., Chen L., Mcginty J.A., French P.M., Ferrer J., Thorens B., Hodson D.J., Rutter G.A., Da Silva Xavier G., 2015. Human Molecular Genetics, 24 (5) pp. 1390-1399.
The Islet and Metabolism Keep Time.
Thorens B., Accili D., Ahrén B., Cerasi E., Seino S., Boitard C., 2015. Diabetes, Obesity and Metabolism, 17 Suppl 1 pp. 3-5. Peer-reviewed.
Type 2 Diabetes, SGLT2 Inhibitors, and Glucose Secretion.
Hattersley A.T., Thorens B., 2015. New England Journal of Medicine, 373 (10) pp. 974-976. Peer-reviewed.
A novel human aquaporin-4 splice variant exhibits a dominant-negative activity: a new mechanism to regulate water permeability.
De Bellis M., Pisani F., Mola M.G., Basco D., Catalano F., Nicchia G.P., Svelto M., Frigeri A., 2014. Molecular Biology of the Cell, 25 (4) pp. 470-480.
Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development.
Winnik S., Gaul D.S., Preitner F., Lohmann C., Weber J., Miranda M.X., Liu Y., van Tits L.J., Mateos J.M., Brokopp C.E. et al., 2014. Basic Research in Cardiology, 109 (1) p. 399.
Gluco-incretins regulate beta-cell glucose competence by epigenetic silencing of Fxyd3 expression.
Vallois D., Niederhäuser G., Ibberson M., Nagaray V., Marselli L., Marchetti P., Chatton J.Y., Thorens B., 2014. PLoS One, 9 (7) pp. e103277.
Glutamine Stimulates Biosynthesis and Secretion of Insulin-like Growth Factor 2 (IGF2), an Autocrine Regulator of Beta Cell Mass and Function.
Modi H., Cornu M., Thorens B., 2014. Journal of Biological Chemistry, 289 (46) pp. 31972-31982.
Hypoglycemia-activated GLUT2 neurons of the nucleus tractus solitarius stimulate vagal activity and glucagon secretion.
Lamy C.M., Sanno H., Labouèbe G., Picard A., Magnan C., Chatton J.Y., Thorens B., 2014. Cell Metabolism, 19 (3) pp. 527-538. Peer-reviewed.
Incretin receptor null mice reveal key role of GLP-1 but not GIP in pancreatic beta cell adaptation to pregnancy.
Moffett R.C., Vasu S., Thorens B., Drucker D.J., Flatt P.R., 2014. PLoS One, 9 (6) pp. e96863.
LKB1 and AMPK differentially regulate pancreatic β-cell identity.
Kone M., Pullen T.J., Sun G., Ibberson M., Martinez-Sanchez A., Sayers S., Nguyen-Tu M.S., Kantor C., Swisa A., Dor Y. et al., 2014. FASEB Journal, 28 (11) pp. 4972-4985.
Nervous glucose sensing regulates postnatal β cell proliferation and glucose homeostasis.
Tarussio D., Metref S., Seyer P., Mounien L., Vallois D., Magnan C., Foretz M., Thorens B., 2014. Journal of Clinical Investigation, 124 (1) pp. 413-424.
Neural regulation of pancreatic islet cell mass and function.
Thorens B., 2014. Diabetes, Obesity and Metabolism, 16 Suppl 1 pp. 87-95.
Role of Endogenous GLP-1 and GIP in Beta Cell Compensatory Responses to Insulin Resistance and Cellular Stress.
Vasu S., Moffett R.C., Thorens B., Flatt P.R., 2014. PLoS One, 9 (6) pp. e101005.
The mind and the belly: a glance at how the nervous system directs metabolism.
Accili D., Ahrén B., Boitard C., Seino S., Thorens B., Cerasi E., 2014. Diabetes, Obesity and Metabolism, 16 Suppl 1 pp. 1-3.
The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing.
Röder P.V., Geillinger K.E., Zietek T.S., Thorens B., Koepsell H., Daniel H., 2014. PLoS One, 9 (2) pp. e89977.
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains.
Simon M.M., Greenaway S., White J.K., Fuchs H., Gailus-Durner V., Wells S., Sorg T., Wong K., Bedu E., Cartwright E.J. et al., 2013. Genome Biology, 14 (7) pp. R82. Peer-reviewed.
Glucose-dependent insulinotropic polypeptide receptor deficiency leads to modifications of trabecular bone volume and quality in mice.
Gaudin-Audrain C., Irwin N., Mansur S., Flatt P.R., Thorens B., Baslé M., Chappard D., Mabilleau G., 2013. Bone, 53 (1) pp. 221-230.
Hepatic glucose sensing is required to preserve β cell glucose competence.
Seyer P., Vallois D., Poitry-Yamate C., Schütz F., Metref S., Tarussio D., Maechler P., Staels B., Lanz B., Grueter R. et al., 2013. Journal of Clinical Investigation, 123 (4) pp. 1662-1676.
Incretins: what is known, new and controversial in 2013?
Burcelin R., Thorens B., European Club for the study of GLP-1 (EuCSGLP-1), 2013. Diabetes and Metabolism, 39 (2) pp. 89-93.
Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice
Lengacher S., Nehiri-Sitayeb T., Steiner N., Carneiro L., Favrod C., Preitner F., Thorens B., Stehle J.C., Dix L., Pralong F. et al., 2013. PLoS One, 8 (12) pp. e82505.
Shifting the paradigm of islet inflammation-good guy or bad guy?
Ahrén B., Accili D., Boitard C., Cerasi E., Thorens B., Seino S., 2013. Diabetes, Obesity and Metabolism, 15 Suppl 3 pp. 4-9. Peer-reviewed.
Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in β-cells.
Deisl C., Simonin A., Anderegg M., Albano G., Kovacs G., Ackermann D., Moch H., Dolci W., Thorens B., A Hediger M. et al., 2013. Proceedings of the National Academy of Sciences of the United States of America, 110 (24) pp. 10004-10009. Peer-reviewed.
The Peroxisomal Enzyme L-PBE Is Required to Prevent the Dietary Toxicity of Medium-Chain Fatty Acids.
Ding J., Loizides-Mangold U., Rando G., Zoete V., Michielin O., Reddy J.K., Wahli W., Riezman H., Thorens B., 2013. Cell Reports, 5 (1) pp. 248-258.
The required beta cell research for improving treatment of type 2 diabetes.
Thorens B., 2013. Journal of Internal Medicine, 274 (3) pp. 203-214.
The SLC2 (GLUT) family of membrane transporters.
Mueckler M., Thorens B., 2013. Molecular Aspects of Medicine, 34 (2-3) pp. 121-138. Peer-reviewed.
Urate-induced acute renal failure and chronic inflammation in liver-specific Glut9 knockout mice.
Preitner F., Laverriere-Loss A., Metref S., Da Costa A., Moret C., Rotman S., Bazin D., Daudon M., Sandt C., Dessombz A. et al., 2013. American Journal of Physiology. Renal Physiology, 305 (5) pp. F786-F795.
Fanconi-Bickel syndrome and autosomal recessive proximal tubulopathy with hypercalciuria (ARPTH) are allelic variants caused by GLUT2 mutations.
Mannstadt M., Magen D., Segawa H., Stanley T., Sharma A., Sasaki S., Bergwitz C., Mounien L., Boepple P., Thorens B. et al., 2012. Journal of Clinical Endocrinology and Metabolism, 97 (10) pp. E1978-E1986.
MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity.
Jacovetti C., Abderrahmani A., Parnaud G., Jonas J.C., Peyot M.L., Cornu M., Laybutt R., Meugnier E., Rome S., Thorens B. et al., 2012. Journal of Clinical Investigation, 122 (10) pp. 3541-3551. Peer-reviewed.
Plac8 is required for white adipocyte differentiation in vitro and cell number control in vivo.
Jimenez-Preitner M., Berney X., Thorens B., 2012. PLoS One, 7 (11) pp. e48767.
PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice.
Iglesias J., Barg S., Vallois D., Lahiri S., Roger C., Yessoufou A., Pradevand S., McDonald A., Bonal C., Reimann F. et al., 2012. Journal of Clinical Investigation, 122 (11) pp. 4105-4117.
Sensing of glucose in the brain.
Thorens B., 2012. pp. 277-294 dans Joost H.G. (eds.) Appetite control, Springer-Verlag.
The hyperstimulated β-cell: prelude to diabetes?
Boitard C., Accili D., Ahrén B., Cerasi E., Seino S., Thorens B., 2012. Diabetes, Obesity and Metabolism, 14 Suppl 3 pp. iv-viii.
Bioinformatics-driven identification and examination of candidate genes for non-alcoholic fatty liver disease.
Banasik K., Justesen J.M., Hornbak M., Krarup N.T., Gjesing A.P., Sandholt C.H., Jensen T.S., Grarup N., Andersson A., Jørgensen T. et al., 2011. PLoS One, 6 (1) pp. e16542.
Brain glucose sensing and neural regulation of insulin and glucagon secretion.
Thorens B., 2011. Diabetes, Obesity and Metabolism, 13 (Suppl 1) pp. 82-88.
Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis.
Faivre E., Gault V.A., Thorens B., Hölscher C., 2011. Journal of Neurophysiology, 105 (4) pp. 1574-1580.
In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.
Hu He K.H., Lorenzo P.I., Brun T., Jimenez Moreno C.M., Aeberhard D., Vallejo Ortega J., Cornu M., Thorel F., Gjinovci A., Thorens B. et al., 2011. Diabetes, 60 (6) pp. 1705-1715.
Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice.
Thorel F., Damond N., Chera S., Wiederkehr A., Thorens B., Meda P., Wollheim C.B., Herrera P.L., 2011. Diabetes, 60 (11) pp. 2872-2882.
Of fat, β cells, and diabetes.
Thorens B., 2011. Cell Metabolism, 14 (4) pp. 439-440.
Oxidative phosphorylation flexibility in the liver of mice resistant to high-fat diet-induced hepatic steatosis.
Poussin C., Ibberson M., Hall D., Ding J., Soto J., Abel E.D., Thorens B., 2011. Diabetes, 60 (9) pp. 2216-2224.
PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance.
Becattini B., Marone R., Zani F., Arsenijevic D., Seydoux J., Montani J.P., Dulloo A.G., Thorens B., Preitner F., Wymann M.P. et al., 2011. Proceedings of the National Academy of Sciences of the United States of America, 108 (42) pp. E854-E863.
Plac8 is an inducer of C/EBPβ required for brown fat differentiation, thermoregulation, and control of body weight.
Jimenez-Preitner M., Berney X., Uldry M., Vitali A., Cinti S., Ledford J.G., Thorens B., 2011. Cell Metabolism, 14 (5) pp. 658-670.
Central control of glucose homeostasis: the brain--endocrine pancreas axis.
Thorens B., 2010. Diabetes and Metabolism, 36 (Suppl 3) pp. S45-S49.
Central glucose sensing and the control of energy homeostasis
Thorens B., 2010. pp. S222 dans 14th International Congress of Endocrinology, Endocrine Journal. Peer-reviewed.
EuroDia: a beta-cell gene expression resource.
Liechti R., Csárdi G., Bergmann S., Schütz F., Sengstag T., Boj S.F., Servitja J.M., Ferrer J., Van Lommel L., Schuit F. et al., 2010. Database, 2010 pp. baq024.
Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression.
Cornu M., Modi H., Kawamori D., Kulkarni R.N., Joffraud M., Thorens B., 2010. Journal of Biological Chemistry, 285 (14) pp. 10538-10545. Peer-reviewed.
Glucose transporters in the 21st Century.
Thorens B., Mueckler M.M., 2010. American Journal of Physiology. Endocrinology and Metabolism, 298 pp. 141-5.
Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons.
Mounien L., Marty N., Tarussio D., Metref S., Genoux D., Preitner F., Foretz M., Thorens B., 2010. FASEB Journal, 24 (6) pp. 1747-1758. Peer-reviewed.
Neurochemical profile of the mouse hypothalamus using in vivo 1H MRS at 14.1T.
Lei H., Poitry-Yamate C., Preitner F., Thorens B., Gruetter R., 2010. NMR in Biomedicine, 23 (6) pp. 578-583.
Peroxisomal and microsomal lipid pathways associated with resistance to hepatic steatosis and reduced pro-inflammatory state.
Hall D., Poussin C., Velagapudi V.R., Empsen C., Joffraud M., Beckmann J.S., Geerts A.E., Ravussin Y., Ibberson M., Oresic M. et al., 2010. Journal of Biological Chemistry, 285 (40) pp. 31011-31023.
Thioredoxin-interacting protein links oxidative stress to inflammasome activation.
Zhou R., Tardivel A., Thorens B., Choi I., Tschopp J., 2010. Nature Immunology, 11 (2) pp. 136-140. Peer-reviewed.
Uric acid transport and disease.
So A., Thorens B., 2010. Journal of Clinical Investigation, 120 (6) pp. 1791-1799.
Expression of the NH(2)-terminal fragment of RasGAP in pancreatic beta-cells increases their resistance to stresses and protects mice from diabetes.
Yang J.Y., Walicki J., Jaccard E., Dubuis G., Bulat N., Hornung J.P., Thorens B., Widmann C., 2009. Diabetes, 58 (11) pp. 2596-2606. Peer-reviewed.
GLP-1 protects beta-cells against apoptosis by enhancing the activity of an IGF-2/IGF-1 receptor autocrine loop
Cornu M, Thorens B, 2009. Islets, 1 (3) pp. 280-282. Peer-reviewed.
Glucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF-2/IGF-1 receptor autocrine loop.
Cornu M., Yang J.Y., Jaccard E., Poussin C., Widmann C., Thorens B., 2009. Diabetes, 58 (8) pp. 1816-1825. Peer-reviewed.
Glucose-dependent insulinotropic polypeptide (GIP) and its receptor (GIPR): cellular localization, lesion-affected expression, and impaired regenerative axonal growth.
Buhren B.A., Gasis M., Thorens B., Müller H.W., Bosse F., 2009. Journal of Neuroscience Research, 87 (8) pp. 1858-1870.
Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy.
Preitner F., Bonny O., Laverrière A., Rotman S., Firsov D., Da Costa A., Metref S., Thorens B., 2009. Proceedings of the National Academy of Sciences of the United States of America, 106 (36) pp. 15501-15506.
Involvement of 4E-BP1 in the protection induced by HDLs on pancreatic beta cells.
Pétremand J., Bulat N., Butty A.C., Poussin C., Rütti S., Au K., Ghosh S., Mooser V., Thorens B., Yang J.Y. et al., 2009. Molecular Endocrinology, 23 (10) pp. 1572-1586. Peer-reviewed.
Metabolic effects of diets differing in glycaemic index depend on age and endogenous glucose-dependent insulinotrophic polypeptide in mice.
Isken F., Weickert M.O., Tschöp M.H., Nogueiras R., Möhlig M., Abdelrahman A., Klaus S., Thorens B., Pfeiffer A.F., 2009. Diabetologia, 52 (10) pp. 2159-2168.
Mouse GLUT9: evidences for a urate uniporter.
Bibert S., Hess S.K., Firsov D., Thorens B., Geering K., Horisberger J.D., Bonny O., 2009. American Journal of Physiology. Renal Physiology, 297 (3) pp. F612-F619. Peer-reviewed.
Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.
Hill J.W., Xu Y., Preitner F., Fukuda M., Cho Y.R., Luo J., Balthasar N., Coppari R., Cantley L.C., Kahn B.B. et al., 2009. Endocrinology, 150 (11) pp. 4874-4882.
Regulation of adaptive behaviour during fasting by hypothalamic Foxa2.
Silva J.P., von Meyenn F., Howell J., Thorens B., Wolfrum C., Stoffel M., 2009. Nature, 462 (7273) pp. 646-650. Peer-reviewed.
Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice
Minehira K., Young S. G., Villanueva C. J., Yetukuri L., Oresic M., Hellerstein M. K., Farese, R. V., Jr. , Horton J. D., Preitner F., Thorens B. et al., 2008. Journal of Lipid Research, 49 (9) pp. 2038-2044. Peer-reviewed.
Deficiency of glucose-dependent insulinotropic polypeptide receptor prevents ovariectomy-induced obesity in mice.
Isken F., Pfeiffer A.F., Nogueiras R., Osterhoff M.A., Ristow M., Thorens B., Tschöp M.H., Weickert M.O., 2008. American journal of physiology. Endocrinology and metabolism, 295 (2) pp. E350-5. Peer-reviewed.
Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice.
Poussin C., Hall D., Minehira K., Galzin A.M., Tarussio D., Thorens B., 2008. PLoS ONE, 3 (10) pp. e3385. Peer-reviewed.
Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway.
Ferdaoussi M., Abdelli S., Yang J.Y., Cornu M., Niederhauser G., Favre D., Widmann C., Regazzi R., Thorens B., Waeber G. et al., 2008. Diabetes, 57 (5) pp. 1205-1215. Peer-reviewed.
Glucose sensing and the pathogenesis of obesity and type 2 diabetes.
Thorens B., 2008. International Journal of Obesity, 32 Suppl 6 pp. S62-S71.
Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14.
Klinger S., Poussin C., Debril M.B., Dolci W., Halban P.A., Thorens B., 2008. Diabetes, 57 (3) pp. 584-93. Peer-reviewed.
Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice.
Troy S., Soty M., Ribeiro L., Laval L., Migrenne S., Fioramonti X., Pillot B., Fauveau V., Aubert R., Viollet B. et al., 2008. Cell Metabolism, 8 (3) pp. 201-211. Peer-reviewed.
Molecular biology of gluco-incretin function
Klinger S., Thorens B., 2008. pp. 315-334 dans Seino S., Bell G. I. (eds.) Pancreatic Beta Cell in Health and Disease, Springer.
PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.
Zehetner J., Danzer C., Collins S., Eckhardt K., Gerber P.A., Ballschmieter P., Galvanovskis J., Shimomura K., Ashcroft F.M., Thorens B. et al., 2008. Genes and Development, 22 (22) pp. 3135-3146. Peer-reviewed.
Development and preclinical assessment of a bioartificial pancreas.
Thorens B., 2007/03/02. Swiss medical weekly, 137 (Suppl 155) pp. 68S-71S. Peer-reviewed.
Brain glucose sensing, counterregulation, and energy homeostasis.
Marty N., Dallaporta M., Thorens B., 2007. Physiology, 22 pp. 241-251.
Expression of the gene encoding the high-Km glucose transporter 2 by the early postimplantation mouse embryo is essential for neural tube defects associated with diabetic embryopathy.
Li R., Thorens B., Loeken M.R., 2007. Diabetologia, 50 (3) pp. 682-689. Peer-reviewed.
GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion.
Cani P.D., Holst J.J., Drucker D.J., Delzenne N.M., Thorens B., Burcelin R., Knauf C., 2007. Molecular and Cellular Endocrinology, 276 (1-2) pp. 18-23. Peer-reviewed.
A missing sugar prevents glucose entry: a new twist on insulin secretion.
Thorens B., 2006. Cell Metabolism, 3 (1) pp. 3-5. Peer-reviewed.
A toggle for type 2 diabetes?
Thorens B., 2006. New England Journal of Medicine, 354 (15) pp. 1636-1638.
Evidence from glut2-null mice that glucose is a critical physiological regulator of feeding.
Bady I., Marty N., Dallaporta M., Emery M., Gyger J., Tarussio D., Foretz M., Thorens B., 2006. Diabetes, 55 (4) pp. 988-995. Peer-reviewed.
GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function.
Membrez M., Hummler E., Beermann F., Haefliger J.A., Savioz R., Pedrazzini T., Thorens B., 2006. Molecular and Cellular Biology, 26 (11) pp. 4268-4276. Peer-reviewed.
L'axe entéro-insulaire: rôle de l'intestin et régulation glycémique
Thorens B., 2006. Journées annuelles de diabétologie de l'Hôtel-Dieu pp. 67-73.
Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta-cells.
Tweedie E., Artner I., Crawford L., Poffenberger G., Thorens B., Stein R., Powers A.C., Gannon M., 2006. Diabetes, 55 (12) pp. 3264-3270. Peer-reviewed.
Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain.
Knauf C., Rieusset J., Foretz M., Cani P.D., Uldry M., Hosokawa M., Martinez E., Bringart M., Waget A., Kersten S. et al., 2006. Endocrinology, 147 (9) pp. 4067-4078. Peer-reviewed.
Tetracycline-regulated expression of VEGF-A in beta cells induces angiogenesis: improvement of engraftment following transplantation.
Mathe Z., Dupraz P., Rinsch C., Thorens B., Bosco D., Zbinden M., Morel P., Berney T., Pepper M.S., 2006. Cell Transplantation, 15 (7) pp. 621-636. Peer-reviewed.
Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors.
Marty N., Dallaporta M., Foretz M., Emery M., Tarussio D., Bady I., Binnert C., Beermann F., Thorens B., 2005. Journal of Clinical Investigation, 115 (12) pp. 3545-3553. Peer-reviewed.
GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization.
Burcelin R., Crivelli V., Perrin C., Da Costa A., Mu J., Kahn B.B., Birnbaum M.J., Kahn C.R., Vollenweider P., Thorens B., 2003. Journal of Clinical Investigation, 111 (10) pp. 1555-1562. Peer-reviewed.
Regulated expression of GLUT2 in diabetes studied in transplanted pancreatic beta cells.
Thorens B., Roduit R., 1994/08. Biochemical Society Transactions, 22 (3) pp. 684-687.
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