Lee Laurent-Applegate - ARCHIVE

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138 publications

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Importance of Cell Therapy in Improving the Surgical Care of Severe Burn Patients: Evolution Between Two Similar Cases at 17-year Interval
Monnier Sandra, Abdel-Sayed Philippe, de Buys Roessingh Anthony S, Chemali Michèle, Hirt-Burri Nathalie, Applegate Lee Ann, Raffoul Wassim Cell Transplantation.
 
Bonnes Pratiques de Fabrication et thérapies cellulaires au chevet des grands brûlés romands
Laurent Alexis, Abdel-Sayed Philippe, Chemale Michèle, Hirt-Burri Nathalie, Raffoul Wassim, Applegate Lee Ann, de Buys Roesingh Anthony S PharmaJournal Suisse.
 
Progenitor Biological Bandages: An authentic Swiss tool for safe therapeutic management of burns, ulcers and donor site grafts
Laurent Alexis, Scaletta Corinne, Michetti Murielle, Hirt-Burri Nathalie, Flahaut Marjorie, Raffoul Wassim, de buys Roesingh Anthony S, Applegate Lee Ann dans Methods in Molecular Biology, Springer US.
 
Implications of chlorhexidine use in burn units for wound healing.
Abdel-Sayed P., Tornay D., Hirt-Burri N., de Buys Roessingh A., Raffoul W., Applegate L.A., 2020/08. Burns, 46 (5) pp. 1150-1156. Peer-reviewed.
 
Bringing Safe and Standardized Cell Therapies to Industrialized Processing for Burns and Wounds
Laurent Alexis, Lin Poyin, Scaletta Corinne, Hirt-Burri Nathalie, Michetti Murielle, de Buys Roessingh Anthony S., Raffoul Wassim, She Bin-Ru, Applegate Lee Ann, 2020/06/19. Frontiers in Bioengineering and Biotechnology, 8 p. 581.
 
Reply to the Letter to the Editor on "The use of antiseptics in burn wounds - our perspective".
Abdel-Sayed P., Tornay D., Hirt-Burri N., de Buys Roessingh A., Raffoul W., Applegate L.A., 2020/06. Burns, 46 (4) pp. 981-982. Peer-reviewed.
 
Banking Progenitor Cells for Hippiatric Regenerative Medicine: Optimized Establishment of Safe and Consistent Cell Sources for Standardized Veterinary Therapeutic Protocols
Laurent Alexis, Darwiche Salim, Hirt-Burri Nathalie, Scaletta Corinne, Michetti Murielle, Laurent Philippe, Raffoul Wassim, Buys Roessingh Anthony S de, Applegate Lee Ann, 2020/04/13. American Journal of Biomedical Science & Research, 8 (4).
Efficient decellularization of equine tendon with preserved biomechanical properties and cytocompatibility for human tendon surgery indications.
Aeberhard P.A., Grognuz A., Peneveyre C., McCallin S., Hirt-Burri N., Antons J., Pioletti D., Raffoul W., Applegate L.A., 2020/04. Artificial organs, 44 (4) pp. E161-E171. Peer-reviewed.
 
Primary Progenitor Muscle Cells for Regenerative Medicine: Standardization of Therapeutic Protocols and Optimized In Vivo Murine Model For Volumetric Muscle Loss
Laurent Alexis, Hirt-Burri Nathalie, Amiot Clotilde, Scaletta Corinne, Applegate Lee Ann, Buys Roessingh Anthony S de, 2020/03/19. American Journal of Biomedical Science & Research, 8 (2) pp. 143-153.
 
Microencapsulation improves chondrogenesis in vitro and cartilaginous matrix stability in vivo compared to bulk encapsulation.
Li F., Levinson C., Truong V.X., Laurent-Applegate L.A., Maniura-Weber K., Thissen H., Forsythe J.S., Zenobi-Wong M., Frith J.E., 2020/03/17. Biomaterials science, 8 (6) pp. 1711-1725. Peer-reviewed.
 
GMP Tiered Cell Banking of Non-enzymatically Isolated Dermal Progenitor Fibroblasts for Allogenic Regenerative Medicine
Laurent Alexis, Scaletta Corinne, Michetti Murielle, Hirt-Burri Nathalie, de Buys Roessingh Anthony S., Raffoul Wassim, Applegate Lee Ann, 2020. dans Methods in Molecular Biology, Springer US.
 
Swiss Fetal Transplantation Program and Non-enzymatically Isolated Primary Progenitor Cell Types for Regenerative Medicine
Laurent Alexis, Scaletta Corinne, Hirt-Burri Nathalie, Raffoul Wassim, de Buys Roessingh Anthony S., Applegate Lee Ann, 2020. dans Methods in Molecular Biology, Springer US.
 
An injectable heparin-conjugated hyaluronan scaffold for local delivery of transforming growth factor β1 promotes successful chondrogenesis.
Levinson C., Lee M., Applegate L.A., Zenobi-Wong M., 2019/11. Acta biomaterialia, 99 pp. 168-180. Peer-reviewed.
 
Potency and stability of liposomal Amphotericin B formulated for topical management of Aspergillus spp. infections in burn patients
Laurent Alexis, Pantet Olivier, Laurent Lydie, Hirt-Burri Nathalie, de Buys Roessingh Anthony, Raffoul Wassim, Laurent Philippe, Monod Michel, Ann Applegate Lee, 2019/09. Burns Open.
 
Foetal cell Therapy in Treatment of Burns and Wounds
Applegate Lee Ann, de Buys Roessingh Anthony, Raffoul Wassim, Hirt-Burri Nathalie, 2019/07/23. dans Comprehensive Biotechnology 3rd edition , Elsevier Science & Technology, 2019.
 
Polyelectrolyte nanocomplexes based on chitosan derivatives for wound healing application.
Patrulea V., Laurent-Applegate L.A., Ostafe V., Borchard G., Jordan O., 2019/07. European journal of pharmaceutics and biopharmaceutics, 140 pp. 100-108. Peer-reviewed.
Cell therapies for skin regeneration: an overview of 40 years of experience in burn units.
Abdel-Sayed P., Michetti M., Scaletta C., Flahaut M., Hirt-Burri N., de Buys Roessingh A., Raffoul W., Applegate L.A., 2019/05/06. Swiss medical weekly, 149 pp. w20079. Peer-reviewed.
Expression and Activity of TRPA1 and TRPV1 in the Intervertebral Disc: Association with Inflammation and Matrix Remodeling
Kameda Takuya, Zvick Joel, Vuk Miriam, Sadowska Aleksandra, Tam Wai Kit, Leung Victor Y., Bölcskei Kata, Helyes Zsuzsanna, Applegate Lee Ann, Hausmann Oliver N. et al., 2019/04/10. International Journal of Molecular Sciences, 20 (7) p. 1767.
 
Cell Therapies for Tendon: Treatments and Regenerative Medicine
Grognuz Anthony, Aeberhard Pierre-Arnaud, Michetti Murielle, Hirt-Burri Nathalie, Scaletta Corinne, de Buys Roessingh Anthony, Raffoul Wassim, Applegate Lee Ann, 2019. pp. 385-408 dans Regenerative Medicine and Plastic Surgery, Springer International Publishing.
Gait analysis following single-shot hyaluronic acid supplementation: a pilot randomized double-blinded controlled trial.
Pereira L.C., Schweizer C., Moufarrij S., Krähenbühl S.M., Favre J., Gremion G., Applegate L.A., Jolles B.M., 2019. Pilot and feasibility studies, 5 p. 56. Peer-reviewed.
Patient care for postamputation pain and the complexity of therapies: living experiences.
Flahaut M., Laurent N.L., Michetti M., Hirt-Burri N., Jensen W., Lontis R., Applegate L.A., Raffoul W., 2018/11/01. Pain management, 8 (6) pp. 441-453. Peer-reviewed.
Decellularised tissues obtained by a CO2-philic detergent and supercritical CO2
Antons J, Marascio MGM, Aeberhard P, Weissenberger G, Hirt-Burri N, Applegate LA, Bourban PE, Pioletti DP, 2018/09/04. European Cells and Materials, 36 pp. 81-95.
Effect of temporal onsets of mechanical loading on bone formation inside a tissue engineering scaffold combined with cell therapy.
Hausherr T.C., Nuss K., Thein E., Krähenbühl S., Applegate L.A., Pioletti D.P., 2018/06. Bone reports, 8 pp. 173-179. Peer-reviewed.
 
Trace element intakes should be revisited in burn nutrition protocols: A cohort study.
Jafari P., Thomas A., Haselbach D., Watfa W., Pantet O., Michetti M., Raffoul W., Applegate L.A., Augsburger M., Berger M.M., 2018/06. Clinical nutrition, 37 (3) pp. 958-964. Peer-reviewed.
 
Zone-dependent mechanical properties of human articular cartilage obtained by indentation measurements.
Antons J., Marascio MGM, Nohava J., Martin R., Applegate L.A., Bourban P.E., Pioletti D.P., 2018/05/04. Journal of materials science. Materials in medicine, 29 (5) p. 57. Peer-reviewed.
 
Transcriptome Analysis of Pseudomonas aeruginosa Cultured in Human Burn Wound Exudates.
Gonzalez M.R., Ducret V., Leoni S., Fleuchot B., Jafari P., Raffoul W., Applegate L.A., Que Y.A., Perron K., 2018. Frontiers in cellular and infection microbiology, 8 p. 39. Peer-reviewed.
 
Human chondroprogenitors in alginate-collagen hybrid scaffolds produce stable cartilage in vivo.
Studer D., Cavalli E., Formica F.A., Kuhn G.A., Salzmann G., Mumme M., Steinwachs M.R., Laurent-Applegate L.A., Maniura-Weber K., Zenobi-Wong M., 2017/11. Journal of tissue engineering and regenerative medicine, 11 (11) pp. 3014-3026. Peer-reviewed.
Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs.
Delacrétaz A., Zdralovic A., Vandenberghe F., Saigi-Morgui N., Glatard A., Quteineh L., Gholam-Rezaee M., Raffoul W., Applegate L.A., Jafari P. et al., 2017/09/10. Gene, 628 pp. 8-15. Peer-reviewed.
 
Tissue Engineering, Cell Therapy, and Regenerative Medicine: Concepts and Applications in Plastic Surgery
Jafari Paris, Murielle Michetti, lakshmana Yerneni, Raffoul Wassim, Applegate Lee ann, 2017/09/01. dans Principles and Advances in Plastic Surgery, Thieme.
 
Development of an Effective Cell Seeding Technique: Simulation, Implementation, and Analysis of Contributing Factors.
Nasrollahzadeh N., Applegate L.A., Pioletti D.P., 2017/08. Tissue engineering. Part C, Methods, 23 (8) pp. 485-496. Peer-reviewed.
Return of the cadaver: Key role of anatomic dissection for plastic surgery resident training.
Krähenbühl S.M., Čvančara P., Stieglitz T., Bonvin R., Michetti M., Flahaut M., Durand S., Deghayli L., Applegate L.A., Raffoul W., 2017/07. Medicine, 96 (29) pp. e7528. Peer-reviewed.
First Insights into Human Fingertip Regeneration by Echo-Doppler Imaging and Wound Microenvironment Assessment.
Jafari P., Muller C., Grognuz A., Applegate L.A., Raffoul W., di Summa P.G., Durand S., 2017/05/13. International journal of molecular sciences, 18 (5) p. 0. Peer-reviewed.
Human Bone Progenitor Cells for Clinical Application: What Kind of Immune Reaction Does Fetal Xenograft Tissue Trigger in Immunocompetent Rats?
Hausherr Tanja C., Nuss Katja, Thein Eric, Applegate Lee A., Pioletti Dominique P., 2017/05. Cell Transplantation, 26 (5) pp. 879-890.
 
Alternatives for Dermal Toxicity Testing
Appelgate Lee Ann, Jafari Paris, Scaletta Corinne, de Buys Roessingh Anthony, Raffoul Wassim, Hirt-Buri Nathalie, 2017. pp. 547-562 dans Ch. 40 "Progrenitor Skin Cell Therapy and Evolution of Medical Applications" chap. 40, Springer International Publishing.
 
Progenitor Skin Cell Therapy and Evolution of Medical Applications
Jafari Paris, Scaletta Corinne, De Buys Roessingh Anthony, Raffoul Wassim, Hirt-Burri Nathalie, 2017. dans Alternatives for Dermal Toxicity Testing , Springer International Publishing.
Factor XIII Cross-Linked Hyaluronan Hydrogels for Cartilage Tissue Engineering
Broguiere Nicolas, Cavalli Emma, Salzmann Gian M., Applegate Lee Ann, Zenobi-Wong Marcy, 2016/12/12. ACS Biomaterials Science & Engineering, 2 (12) pp. 2176-2184.
Stability Enhancement Using Hyaluronic Acid Gels for Delivery of Human Fetal Progenitor Tenocytes.
Grognuz A., Scaletta C., Farron A., Pioletti D.P., Raffoul W., Applegate L.A., 2016/12/03. Cell medicine, 8 (3) pp. 87-97. Peer-reviewed.
Topical Negative Pressure on Burns: An Innovative Method for Wound Exudate Collection.
Baudoin J., Jafari P., Meuli J., Applegate L.A., Raffoul W., 2016/11. Plastic and reconstructive surgery. Global open, 4 (11) pp. e1117. Peer-reviewed.
Burn patient care lost in good manufacturing practices?
Dimitropoulos G., Jafari P., de Buys Roessingh A., Hirt-Burri N., Raffoul W., Applegate L.A., 2016/06/30. Annals of burns and fire disasters, 29 (2) pp. 111-115.
Corrigendum: Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages.
Abdel-Sayed P., Kaeppeli A., Siriwardena T., Darbre T., Perron K., Jafari P., Reymond J.L., Pioletti D.P., Applegate L.A., 2016/04/07. Scientific reports, 6 p. 23872. Peer-reviewed.
Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages.
Abdel-Sayed P., Kaeppeli A., Siriwardena T., Darbre T., Perron K., Jafari P., Reymond J.L., Pioletti D.P., Applegate L.A., 2016/02/25. Scientific reports, 6 p. 22020. Peer-reviewed.
Effect of Human Burn Wound Exudate on Pseudomonas aeruginosa Virulence.
Gonzalez M.R., Fleuchot B., Lauciello L., Jafari P., Applegate L.A., Raffoul W., Que Y.A., Perron K., 2016. Msphere, 1 (2) pp. e00111-15. Peer-reviewed.
Human Fetal Progenitor Tenocytes for Regenerative Medicine.
Grognuz A., Scaletta C., Farron A., Raffoul W., Applegate L.A., 2016. Cell Transplantation, 25 (3) pp. 463-479. Peer-reviewed.
Osteogenesis imperfecta: from diagnosis and multidisciplinary treatment to future perspectives.
Bregou Bourgeois A., Aubry-Rozier B., Bonafé L., Laurent-Applegate L., Pioletti D.P., Zambelli P.Y., 2016. Swiss medical weekly, 146 pp. w14322. Peer-reviewed.
 
Peptide-decorated chitosan derivatives enhance fibroblast adhesion and proliferation in wound healing.
Patrulea V., Hirt-Burri N., Jeannerat A., Applegate L.A., Ostafe V., Jordan O., Borchard G., 2016. Carbohydrate Polymers, 142 pp. 114-123. Peer-reviewed.
 
Nouveautés dans l'ostéogenèse imparfaite: de la recherche à la prise en charge multidisciplinaire [News in osteogenesis imperfecta: from research to clinical management]
Aubry-Rozier B., Unger S., Bregou A., Freymond Morisod M., Vaswani A., Scheider P., Bonafé L., 2015/03/18. Revue medicale suisse, 11 (466) pp. 657-658,660-662.
 
Optimized synthesis of O-carboxymethyl-N,N,N-trimethyl chitosan.
Patrulea V., Applegate L.A., Ostafe V., Jordan O., Borchard G., 2015. Carbohydrate Polymers, 122 pp. 46-52. Peer-reviewed.
Sildenafil as a therapeutic option for digital ischemic ulceration: case report.
Krähenbühl S.M., Depairon M., Faure M., Vietti Violi N., Applegate L.A., Raffoul W., 2015. Journal of Hand Surgery, 40 (5) pp. 890-893. Peer-reviewed.
 
Biologie osseuse et cartilagineuse
Hirt-Burri N., Applegate L.A., 2014. pp. 71-78 dans Jolles-Haeberli B. (eds.) Manuel Pratique de Chirurgie Orthopédique chap. 3, Elsevier Masson.
Cell therapies for tendons: old cell choice for modern innovation.
Petrou I.G., Grognuz A., Hirt-Burri N., Raffoul W., Applegate L.A., 2014. Swiss Medical Weekly, 144 pp. w13989. Peer-reviewed.
 
Centre romand des brûlés commune enfant et adulte
de Buys Roessingh A., Jung C., Raffoul W., Applegate L.A., Jeanmonod J, Beger M, 2014. Bulletin des médecins Suisses, 95 pp. 22-23. Peer-reviewed.
 
How important is hydrotherapy? Effects of dynamic action of hot spring water as a rehabilitative treatment for burn patients in Switzerland
Moufarrij S., Deghayli L., Raffoul W., Hirt-Burri N., Michetti M., de Buys Roessingh A., Norberg M., Applegate L.A., 2014. Annals of Burns and Fire Disasters, 27 (4) pp. 184-191.
 
Insurance coverage of pediatric burns: Switzerland versus USA.
Deghayli L., Moufarrij S., Norberg M., Sheridan R., Raffoul W., de Buys Roessingh A., Hirt-Burri N., Applegate L.A., 2014. Burns, 40 (5) pp. 814-825.
 
Lessons from the womb
Zenobi-Wong , Laurent-Applegate , 2014. CAMMB University Zurich.
Autologous keratinocyte suspension in platelet concentrate accelerates and enhances wound healing - a prospective randomized clinical trial on skin graft donor sites: platelet concentrate and keratinocytes on donor sites.
Guerid S., Darwiche S.E., Berger M.M., Applegate L.A., Benathan M., Raffoul W., 2013. Fibrogenesis and Tissue Repair, 6 (8) pp. 1-8.
Cell Therapy Assistance in Reconstructive Surgery for Musculoskeletal Tissues Following Burn and Trauma: Swiss Cellular Transplantation Platform
De Buys Roessingh A., Guerid S, Que Y.A., Berger M., Hirt-Burri N., Scaletta C., Wassim R., Applegate L.A., 2013. Journal of Defense Management, 1 (S3) pp. 1-7.
 
Cellular Derivatives and Efficacy in Wound and Scar Management
Lapp A., Furrer P., Ramelet A.A., Aubort C., Aubort P., Laurent P., Applegate L.A., 2013. Journal of Cosmetics, Dermatological Sciences and Applications, 3 (1) pp. 36-45.
 
Fetal Cell Therapy and Tissue Engineering for Musculoskeletal Tissues
Hirt-Burri N., Applegate L.A., 2013. pp. 185-192 dans Bhattacharya N., Stubblefield P. (eds.) Human Fetal Tissue Transplantation chap. 14, Springer.
 
Organ Donation and Whole-Cell Bioprocessing in the Swiss Fetal Progenitor Cell Transplantation Platform
Applegate L.A., Weber D., Simon J.P., Hirt-Burri N., De Buys Roessingh A., Raffoul W., 2013. pp. 125-148 dans Saidi R.F. (eds.) Organ Donation and Organ Donors: Issues, Challenges and Perspectives, Nova Publications.
Development of a cost-effective method for platelet-rich plasma (PRP) preparation for topical wound healing.
Akhundov K., Pietramaggiori G., Waselle L., Darwiche S., Guerid S., Scaletta C., Hirt-Burri N., Applegate L.A., Raffoul W.V., 2012. Annals of Burns and Fire Disasters, 25 (4) pp. 207-213.
 
Functionalization of microstructured open-porous bioceramic scaffolds with human fetal bone cells.
Krauss Juillerat F., Borcard F., Staedler D., Scaletta C., Applegate L.A., Comas H., Gauckler L.J., Gerber-Lemaire S., Juillerat-Jeanneret L., Gonzenbach U.T., 2012. Bioconjugate Chemistry, 23 (11) pp. 2278-2290.
 
Covalent cell surface functionalization of human fetal osteoblasts for tissue engineering.
Borcard F., Godinat A., Staedler D., Comas H., Dumont A.L., Chapuis Bernasconi C., Scaletta C., Applegate L.A., Krauss Juillerat F., Gonzenbach U. et al., 2011/06. Bioconjugate Chemistry, 22 pp. 1422-1432. Peer-reviewed.
Biologicals and fetal cell therapy for wound and scar management.
Hirt-Burri N., Ramelet A.A., Raffoul W., de Buys Roessingh A., Scaletta C., Pioletti D., Applegate L.A., 2011. ISRN Dermatology, 2011 (549870) p. 549870.
Bone regeneration and stem cells.
Arvidson K., Abdallah B.M., Applegate L.A., Baldini N., Cenni E., Gomez-Barrena E., Granchi D., Kassem M., Konttinen Y.T., Mustafa K. et al., 2011. Journal of Cellular and Molecular Medicine, 15 (4) pp. 718-746. Peer-reviewed.
 
Human fetal bone cells in delivery systems for bone engineering.
Tenorio D.M., Scaletta C., Jaccoud S., Hirt-Burri N., Pioletti D.P., Jaques B., Applegate L.A., 2011. Journal of Tissue Engineering and Regenerative Medicine, 5 (10) pp. 806-14. Peer-reviewed.
 
Regulation of proliferation and differentiation of human fetal bone cells.
Krattinger N., Applegate L.A., Biver E., Pioletti D.P., Caverzasio J., 2011. European Cells and Materials, 21 pp. 46-58.
 
Viscoelastic assessment of skin quality for clinical applications
Darwiche S., Bouziad N.A., Raffoul W., Applegate L., Pioletti D., 2011. pp. 235-236 dans 36th Congress of the Society of Biomechanics, Computer Methods in Biomechanics and Biomedical Engineering. Peer-reviewed.
Plasticity of fetal cartilaginous cells.
Quintin A., Schizas C., Scaletta C., Jaccoud S., Applegate L.A., Pioletti D.P., 2010. Cell transplantation, 19 (10) pp. 1349-1357. Peer-reviewed.
 
Proliferative and Osteogenic Differentiation Potentials of Human Fetal Bone Cells
Krattinger Nathalie, Applegate Lee-Ann, Pioletti Dominique, Caverzasio Joseph, 2010. p. 51 dans IBMS Davos Workshop on Bone Biology and Therapeutics, Bone. Peer-reviewed.
 
Isolation and in vitro chondrogenic potential of human foetal spine cells.
Quintin A., Schizas C., Scaletta C., Jaccoud S., Gerber S., Osterheld M.C., Juillerat L., Applegate L.A., Pioletti D.P., 2009/08. Journal of cellular and molecular medicine, 13 (8B) pp. 2559-2569. Peer-reviewed.
 
Bioengineering of Human Fetal Tissues For Clinical Use
Applegate L.A., Hirt-Burri N., Scaletta C., Bauren J.-F., Pioletti D.P., 2009. pp. 133-152 dans Garcia Audric, Durand Ciel (eds.) Bioengineering: Principles, Methodologies and Applications chap. 4, Nova Science Publisher's.
 
Chronic wound healing by fetal cell therapy may be explained by differential gene profiling observed in fetal versus old skin cells.
Ramelet A.A., Hirt-Burri N., Raffoul W., Scaletta C., Pioletti D.P., Offord E., Mansourian R., Applegate L.A., 2009. Experimental Gerontology, 44 (3) pp. 208-18. Peer-reviewed.
 
In vitro characterization of immune-related properties of human fetal bone cells for potential tissue engineering applications.
Montjovent M.O., Bocelli-Tyndall C., Scaletta C., Scherberich A., Mark S., Martin I., Applegate L.A., Pioletti D.P., 2009. Tissue Engineering. Part A, 15 (7) pp. 1523-1532.
 
Whole-cell bioprocessing of human fetal cells for tissue engineering of skin.
Applegate L.A., Scaletta C., Hirt-Burri N., Raffoul W., Pioletti D., 2009. Skin Pharmacology and Physiology, 22 (2) pp. 63-73.
 
Human fetal bone cells associated with ceramic reinforced PLA scaffolds for tissue engineering.
Montjovent M.O., Mark S., Mathieu L., Scaletta C., Scherberich A., Delabarde C., Zambelli P.Y., Bourban P.E., Applegate L.A., Pioletti D.P., 2008. Bone, 42 (3) pp. 554-564. Peer-reviewed.
Human muscular fetal cells: a potential cell source for muscular therapies.
Hirt-Burri N., de Buys Roessingh A.S., Scaletta C., Gerber S., Pioletti D.P., Applegate L.A., Hohlfeld J., 2008. Pediatric Surgery International, 24 (1) pp. 37-47.
 
Laser-ultraviolet-A induced ultra weak photon emission in human skin cells: A biophotonic comparison between keratinocytes and fibroblasts.
Niggli H.J., Tudisco S., Lanzanò L., Applegate L.A., Scordino A., Musumeci F., 2008. Indian Journal of Experimental Biology, 46 (5) pp. 358-363.
 
Wound-healing gene family expression differences between fetal and foreskin cells used for bioengineered skin substitutes.
Hirt-Burri N., Scaletta C., Gerber S., Pioletti D.P., Applegate L.A., 2008. Artificial Organs, 32 (7) pp. 509-518. Peer-reviewed.
 
Repair of critical size defects in the rat cranium using ceramic-reinforced PLA scaffolds obtained by supercritical gas foaming
Montjovent M. O., Mathieu L., Schmoekel H., Mark S., Bourban P. E., Zambelli P. Y., Laurent-Applegate L. A., Pioletti D. P., 2007/10. Journal of Biomedical Materials Research. Part A, 83 (1) pp. 41-51.
Consistency and safety of cell banks for research and clinical use: preliminary analysis of fetal skin banks.
Quintin A., Hirt-Burri N., Scaletta C., Schizas C., Pioletti D.P., Applegate L.A., 2007. Cell Transplantation, 16 (7) pp. 675-684.
Water-filtered infrared-A radiation (wIRA) is not implicated in cellular degeneration of human skin.
Gebbers N., Hirt-Burri N., Scaletta C., Hoffmann G., Applegate L.A., 2007. German Medical Science : Gms E-journal, 5 pp. Doc08.
Bone tissue engineering using foetal cell therapy.
Pioletti D.P., Montjovent M.O., Zambelli P.Y., Applegate L., 2006/09/02. Swiss medical weekly, 136 (35-36) pp. 557-560. Peer-reviewed.
Development, characterization, and use of a fetal skin cell bank for tissue engineering in wound healing.
De Buys Roessingh A.S., Hohlfeld J., Scaletta C., Hirt-Burri N., Gerber S., Hohlfeld P., Gebbers J.O., Applegate L.A., 2006. Cell Transplantation, 15 (8-9) pp. 823-834.
 
Biocompatibility of bioresorbable poly(L-lactic acid) composite scaffolds obtained by supercritical gas foaming with human fetal bone cells
Montjovent M. O., Mathieu L., Hinz B., Applegate L. L., Bourban P. E., Zambelli P. Y., Manson J. A., Pioletti D. P., 2005/12. Tissue Engineering, 11 (11-12) pp. 1640-9.
 
Discrimination between normal and cancer cells by using spectral analysis of delayed luminescence
Musumeci F., Privitera G., Scordino A., Tudisco S., Lo Presti C., Applegate L. A., Niggli H. J., 2005. Applied Physics Letters, 86 (15). Peer-reviewed.
 
Laser-ultraviolet-A-induced ultraweak photon emission in mammalian cells.
Niggli H.J., Tudisco S., Privitera G., Applegate L.A., Scordino A., Musumeci F., 2005. Journal of Biomedical Optics, 10 (2) p. 024006. Peer-reviewed.
 
Spectral analysis of laser-induced ultraweak delayed luminescence in cultured normal and tumor human cells: temperature dependence.
Musumeci F., Applegate L.A., Privitera G., Scordino A., Tudisco S., Niggli H.J., 2005. Journal of Photochemistry and Photobiology. B, Biology, 79 (2) pp. 93-99. Peer-reviewed.
 
Tissue engineered fetal skin constructs for paediatric burns.
Hohlfeld J., de Buys Roessingh A., Hirt-Burri N., Chaubert P., Gerber S., Scaletta C., Hohlfeld P., Applegate L.A., 2005. Lancet, 366 (9488) pp. 840-842. Peer-reviewed.
 
Fetal bone cells for tissue engineering.
Montjovent M.O., Burri N., Mark S., Federici E., Scaletta C., Zambelli P.Y., Hohlfeld P., Leyvraz P.F., Applegate L.L., Pioletti D.P., 2004. Bone, 35 (6) pp. 1323-1333.
 
Plasticity of protein expression during culture of fetal skin cells.
Vuadens F., Crettaz D., Scelatta C., Servis C., Quadroni M., Bienvenut W.V., Schneider P., Hohlfeld P., Applegate L.A., Tissot J.D., 2003. Electrophoresis, 24 (7-8) pp. 1281-1291. Peer-reviewed.
 
A food-based formulation provides lycopene with the same bioavailability to humans as that from tomato paste
Richelle M., Bortlik K., Liardet S., Hager C., Lambelet P., Baur M., Applegate L. A., Offord E. A., 2002. Journal of Nutrition, 132 (3) pp. 404-408.
 
Photoprotective potential of lycopene, beta-carotene, vitamin E, vitamin C and carnosic acid in UVA-irradiated human skin fibroblasts
Offord E. A., Gautier J. C., Avanti O., Scaletta C., Runge F., Kramer K., Applegate L. A., 2002. Free Radical Biology and Medicine, 32 (12) pp. 1293-1303.
 
Use of sunscreens in families living in Switzerland
Berret J., Liardet S., Scaletta C., Panizzon R., Hohlfeld P., Applegate L. A., 2002. Dermatology, 204 (3) pp. 202-8.
 
Ultraweak photon emission in assessing bone growth factor efficiency using fibroblastic differentiation.
Niggli H.J., Scaletta C., Yu Y., Popp F.A., Applegate L.A., 2001. Journal of photochemistry and photobiology. B, Biology, 64 (1) pp. 62-8. Peer-reviewed.
 
Induction of the putative protective protein ferritin by infrared radiation: implications in skin repair
Applegate L. A., Scaletta C., Panizzon R., Frenk E., Hohlfeld P., Schwarzkopf S., 2000/03. International Journal of Molecular Medicine, 5 (3) pp. 247-51.
 
In vivo induction of pyrimidine dimers in human skin by UVA radiation: initiation of cell damage and/or intercellular communication?
Applegate L. A., Scaletta C., Panizzon R., Niggli H., Frenk E., 1999/05. International Journal of Molecular Medicine, 3 (5) pp. 467-72.
 
Exposure to various ultraviolet radiations in human skin in situ: Biomarkers for oxidative stress
Liardet S., Schwarzkopf S., Scaletta C., Frenk E., Panizzon R., Applegate L.A., 1999. p. 469 dans 29th Annual Meeting of the European Society for Dermatological Research, Journal of Investigative Dermatology. Peer-reviewed.
 
Evidence that ferritin is UV inducible in human skin: part of a putative defense mechanism
Applegate L. A., Scaletta C., Panizzon R., Frenk E., 1998/07. Journal of Investigative Dermatology, 111 (1) pp. 159-63.
 
Sunlight and carcinogenesis: expression of p53 and pyrimidine dimers in human skin following UVA I, UVA I + II and solar simulating radiations
Burren R., Scaletta C., Frenk E., Panizzon R. G., Applegate L. A., 1998/04. International Journal of Cancer, 76 (2) pp. 201-6.
 
Erythema induction by ultraviolet radiation points to a possible acquired defense mechanism in chronically sun-exposed human skin
Applegate L. A., Scaletta C., Treina G., Mascotto R. E., Fourtanier A., Frenk E., 1997. Dermatology, 194 (1) pp. 41-49.
 
Expression of DNA damage and stress proteins by UVA irradiation of human skin in vivo
Applegate L. A., Scaletta C., Fourtanier A., Mascotto R. E., Seite S., Frenk E., 1997. European Journal of Dermatology, 7 (3) pp. 215-219. Peer-reviewed.
 
Glutathione response after UVA irradiation in mitotic and postmitotic human skin fibroblasts and keratinocytes
Niggli H. J., Applegate L. A., 1997. Photochemistry and Photobiology, 65 (4) pp. 680-684.
 
Expression of intercellular adhesion molecule-1 in UVA-irradiated human skin cells in vitro and in vivo.
Treina G., Scaletta C., Fourtanier A., Seité S., Frenk E., Applegate L.A., 1996. The British journal of dermatology, 135 (2) pp. 241-7. Peer-reviewed.
 
Susceptibility of human melanoma cells to oxidative stress including UVA radiation
Applegate L. A., Scaletta C., Labidi F., Vile G. F., Frenk E., 1996. International Journal of Cancer, 67 (3) pp. 430-434.
 
Oxidative defense in cultured human skin fibroblasts and keratinocytes from sun-exposed and non-exposed skin
Applegate L. A., Frenk E., 1995/06. Photodermatology, Photoimmunology and Photomedicine, 11 (3) pp. 95-101. Peer-reviewed.
 
Cellular Defense-Mechanisms of the Skin Against Oxidant Stress and in Particular Uva Radiation
Applegate L. A., Frenk E., 1995. European Journal of Dermatology, 5 (2) pp. 97-103. Peer-reviewed.
 
Two genes contribute to different extents to the heme oxygenase enzyme activity measured in cultured human skin fibroblasts and keratinocytes: implications for protection against oxidant stress
Applegate L. A., Noel A., Vile G., Frenk E., Tyrrell R. M., 1995. Photochemistry and Photobiology, 61 (3) pp. 285-291.
 
Cellular sensitivity to oxidative stress in the photosensitivity dermatitis/actinic reticuloid syndrome
Applegate L. A., Frenk E., Gibbs N., Johnson B., Ferguson J., Tyrrell R. M., 1994/05. Journal of Investigative Dermatology, 102 (5) pp. 762-7. Peer-reviewed.
 
Ultraviolet A-induced cellular membrane damage in the photosensitivity dermatitis/actinic reticuloid syndrome
Luy H., Frenk E., Applegate L. A., 1994. Photodermatology, Photoimmunology and Photomedicine, 10 (3) pp. 126-133.
 
Expression of fibroblast growth factors in ultraviolet radiation-induced corneal tumors and corneal tumor cell lines from Monodelphis domestica
Sabourin C. L., Kusewitt D. F., Applegate L. A., Budge C. L., Ley R. D., 1993. Molecular Carcinogenesis, 7 (3) pp. 197-205.
 
The proximal promoter region of the human heme oxygenase gene contains elements involved in stimulation of transcriptional activity by a variety of agents including oxidants
Tyrrell R. M., Applegate L. A., Tromvoukis Y., 1993. Carcinogenesis, 14 (4) pp. 761-765.
 
Specific chromosomal defects associated with ultraviolet radiation-induced cutaneous tumors in Monodelphis domestica (Marsupialia, mammalia)
Pathak S., Gadhia M., Dhaliwal M. K., Applegate L. A., Ley R. D., 1992/12. Cancer Genetics and Cytogenetics, 64 (2) pp. 158-62. Peer-reviewed.
Endogenous glutathione levels modulate the frequency of both spontaneous and long wavelength ultraviolet induced mutations in human cells
Applegate L. A., Lautier D., Frenk E., Tyrrell R. M., 1992. Carcinogenesis, 13 (9) pp. 1557-1560.
 
DNA damage is involved in the induction of opacification and neovascularization of the cornea by ultraviolet radiation
Applegate L. A., Ley R. D., 1991. Experimental Eye Research, 52 (4) pp. 493-497.
 
Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells
Applegate L. A., Luscher P., Tyrrell R. M., 1991. Cancer Research, 51 (3) pp. 974-978.
 
Photoreactivation of ultraviolet radiation-induced release of arachidonic acid from marsupial cells
Kaleta E. W., Applegate L. A., Ley R. D., 1991. Photochemistry and Photobiology, 54 (5) pp. 747-752.
 
Photoreactivation of ultraviolet radiation-induced skin and eye tumors of Monodelphis domestica
Ley R. D., Applegate L. A., Fry R. J., Sanchez A. B., 1991. Cancer Research, 51 (24) pp. 6539-6542.
 
Ultraviolet radiation-induced skin tumors in a South American opossum (Monodelphis domestica)
Kusewitt D. F., Applegate L. A., Ley R. D., 1991. Veterinary Pathology, 28 (1) pp. 55-65.
 
Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured skin fibroblasts
Keyse S. M., Applegate L. A., Tromvoukis Y., Tyrrell R. M., 1990/09. Molecular and Cellular Biology, 10 (9) pp. 4967-9. Peer-reviewed.
 
Hypersensitivity of skin fibroblasts from basal cell nevus syndrome patients to killing by ultraviolet B but not by ultraviolet C radiation
Applegate L. A., Goldberg L. H., Ley R. D., Ananthaswamy H. N., 1990. Cancer Research, 50 (3) pp. 637-641.
 
Naturally occurring malignant melanoma in the South American opossum (Monodelphis domestica)
Kusewitt D. F., Applegate L. A., Bucana C. D., Ley R. D., 1990. Veterinary Pathology, 27 (1) pp. 66-68.
 
Photoreactivation of cyclobutane dimers and (6-4) photoproducts in the epidermis of the marsupial, Monodelphis domestica
Mitchell D. L., Applegate L. A., Nairn R. S., Ley R. D., 1990. Photochemistry and Photobiology, 51 (6) pp. 653-658.
 
Ultraviolet radiation--induced malignant melanoma in Monodelphis domestica
Ley R. D., Applegate L. A., Padilla R. S., Stuart T. D., 1989/07. Photochemistry and Photobiology, 50 (1) pp. 1-5. Peer-reviewed.
 
Deletion of the c-Ha-ras-1 allele in human skin cancers
Ananthaswamy H. N., Applegate L. A., Goldberg L. H., Bales E. S., 1989. Molecular Carcinogenesis, 2 (5) pp. 298-301.
 
Excision repair characteristics of denV-transformed xeroderma pigmentosum cells
Ley R. D., Applegate L. A., de Riel J. K., Henderson E. E., 1989. Mutation Research, 217 (2) pp. 101-107.
 
Identification of the molecular target for the suppression of contact hypersensitivity by ultraviolet radiation
Applegate L. A., Ley R. D., Alcalay J., Kripke M. L., 1989. Journal of Experimental Medicine, 170 (4) pp. 1117-1131.
 
Immunosuppression in phototherapy
Ullrich S. E., Alcalay J., Applegate L. A., Kripke M. L., 1989. Ciba Foundation Symposium, 146 pp. 131-139.
 
Ultraviolet radiation-induced lethality and repair of pyrimidine dimers in fish embryos
Applegate L. A., Ley R. D., 1988/03. Mutation Research, 198 (1) pp. 85-92. Peer-reviewed.
 
Excision repair of UVR-induced pyrimidine dimers in corneal DNA
Freeman S. E., Applegate L. A., Ley R. D., 1988. Photochemistry and Photobiology, 47 (1) pp. 159-163.
 
Photocarcinogenesis : DNA repair in marsupials.
Ley R.C. Applegate L.A., 1988. Journal of Cutaneous Aging and Cosmetic Dermatology 1 pp. 71-76.
 
Photorepair of ultraviolet radiation-induced pyrimidine dimers in corneal DNA
Ley R. D., Applegate L. A., Freeman S. E., 1988. Mutation Research, 194 (1) pp. 49-55.
 
Photoreversal of the ultraviolet radiation-induced disappearance of ATPase-positive Langerhans cells in the epidermis of Monodelphis domestica
LeVee G. J., Applegate L. A., Ley R. D., 1988. Journal of Leukocyte Biology, 44 (6) pp. 508-513.
 
Excision repair of pyrimidine dimers in marsupial cells
Applegate L. A., Ley R. D., 1987. Photochemistry and Photobiology, 45 (2) pp. 241-245.
 
Hair growth induction by ultraviolet radiation in the marsupial Monodelphis domestica
Ley R. D., Applegate L. A., 1987. Archives of Dermatology, 123 (8) pp. 1032-1035.
 
Loss of photoreversibility of sunburn cell induction in Monodelphis domestica
Ley R. D., Applegate L. A., 1987. Photochemistry and Photobiology, 46 (2) pp. 315-317.
 
UV radiation-induced skin tumors in Monodelphis domestica
Ley R. D., Applegate L. A., Stuart T. D., Fry R. J., 1987. Photo-Dermatology, 4 (3) pp. 144-147.
 
Ultraviolet radiation-induced histopathologic changes in the skin of the marsupial Monodelphis domestica. II. Quantitative studies of the photoreactivation of induced hyperplasia and sunburn cell formation
Ley R. D., Applegate L. A., 1985/10. Journal of Investigative Dermatology, 85 (4) pp. 365-7. Peer-reviewed.
 
Ultraviolet radiation-induced histopathological changes in the skin of the marsupial Monodelphis domestica. I. The effects of acute and chronic exposures and of photoreactivation treatment
Applegate L. A., Stuart T. D., Ley R. D., 1985. British Journal of Dermatology, 113 (2) pp. 219-227.
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