Centre intégratif de génomique

Equipe principale | CIG Services communs | Groupe Benton | Groupe Fajas | Groupe Fankhauser | Groupe Franken | Groupe Gambetta | Groupe Gatfield | Groupe Larsch | Groupe Michalik | Groupe Reymond | Groupe Roignant | Groupe van Leeuwen | Groupe Vastenhouw | Groupe Vjestica | Plateforme de biostatistique | Plateforme Genomics Technologies Facility (GTF) | Plateforme Protein Analysis Facility (PAF)
Publications | Mémoires et thèses

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1731 publications

 
CDK4 deletion in mice prevents fat accumulation and increases endurance capacity through activation of estrogen-related receptor (ERR)-driven oxidative metabolism in skeletal muscle
Barquissau Valentin, Zanou Nadège, Geller Sarah, Castillo-Armengol Judit, Marzetta Flavia, Huber Katharina, Ziegler Dorian, Lopez-Mejia Isabel, Fernandez Joan Blanco, Roger Catherine et al..
 
The role of gene expression on human sexual dimorphism: too early to call
Porcu Eleonora, Claringbould Annique, Lepik Kaido, Richardson Tom G., Santoni Federico A., Franke Lude, Reymond Alexandre, Kutalik Zoltán.
 
PD1 inhibits PKCθ-dependent phosphorylation of cytoskeleton-related proteins and immune synapse formation.
Chmiest D., Podavini S., Ioannidou K., Vallois D., Décaillet C., Gonzalez M., Quadroni M., Blackney K., Schairer R., de Leval L.L. et al. Blood advances. Peer-reviewed.
 
E2F transcription factor-1 modulates expression of glutamine metabolic genes in mouse embryonic fibroblasts and uterine sarcoma cells.
Huber K., Giralt A., Dreos R., Michenthaler H., Geller S., Barquissau V., Ziegler D.V., Tavernari D., Gallart-Ayala H., Krajina K. et al. Biochimica et biophysica acta. Molecular cell research. Peer-reviewed.
Environmental Control of Hypocotyl Elongation.
Krahmer J., Fankhauser C. Annual review of plant biology. Peer-reviewed.
Enhancer-promoter interactions become more instructive in the transition from cell-fate specification to tissue differentiation.
Pollex T., Rabinowitz A., Gambetta M.C., Marco-Ferreres R., Viales R.R., Jankowski A., Schaub C., Furlong EEM Nature genetics. Peer-reviewed.
 
Quantitative T2 Mapping of Acute Pancreatitis.
Porões F., Vietti Violi N., Piazza G., Uldry E., Lázaro-Fontanet E., Gaspar-Figueiredo S., Hilbert T., Ledoux J.B., Denys A., Schütz F. et al. Journal of magnetic resonance imaging. Peer-reviewed.
 
Comprehensive map of ribosomal 2'-O-methylation and C/D box snoRNAs in Drosophila melanogaster.
Sklias A., Cruciani S., Marchand V., Spagnuolo M., Lavergne G., Bourguignon V., Brambilla A., Dreos R., Marygold S.J., Novoa E.M. et al. Nucleic acids research. Peer-reviewed.
 
Transcription bodies regulate gene expression by sequestering CDK9.
Ugolini M., Kerlin M.A., Kuznetsova K., Oda H., Kimura H., Vastenhouw N.L. Nature cell biology. Peer-reviewed.
SMYD3: a new regulator of adipocyte precursor proliferation at the early steps of differentiation.
Sajic T., Ferreira Gomes C.K., Gasser M., Caputo T., Bararpour N., Landaluce-Iturriria E., Augsburger M., Walter N., Hainard A., Lopez-Mejia I.C. et al., 2024/04. International journal of obesity, 48 (4) pp. 557-566. Peer-reviewed.
 
Closing the scissor-shaped curve: Strategies to promote gender equality in academia.
Joyce J.A., Masina S., Michalik L., Pot C., Sempoux C., Amati F., 2024/03/14. Cell, 187 (6) pp. 1335-1342. Peer-reviewed.
GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis in the liver by attenuating the TGF-β1/SMAD3 pathway.
Jurado-Aguilar J., Barroso E., Bernard M., Zhang M., Peyman M., Rada P., Valverde Á.M., Wahli W., Palomer X., Vázquez-Carrera M., 2024/03. Metabolism, 152 p. 155772. Peer-reviewed.
 
GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion.
Gandasi N.R., Gao R., Kothegala L., Pearce A., Santos C., Acreman S., Basco D., Benrick A., Chibalina M.V., Clark A. et al., 2024/03. Diabetologia, 67 (3) pp. 528-546. Peer-reviewed.
Sensory neuron population expansion enhances odor tracking without sensitizing projection neurons
Takagi S., Sancer G., Abuin L., Stupski S.D., Arguello J.R., Prieto-Godino L.L., Stern D.L., Cruchet S., Álvarez-Ocaña R., Wienecke C.F.R. et al., 2024/02/07..
 
Orchestrating chromosome conformation capture analysis with Bioconductor.
Serizay J., Matthey-Doret C., Bignaud A., Baudry L., Koszul R., 2024/02/05. Nature communications, 15 (1) p. 1072. Peer-reviewed.
 
Correction to: Disrupted hypothalamic transcriptomics and proteomics in a mouse model of type 2 diabetes exposed to recurrent hypoglycaemia.
Castillo-Armengol J., Marzetta F., Sanchez-Archidona A.R., Fledelius C., Evans M., McNeilly A., McCrimmon R.J., Ibberson M., Thorens B., 2024/02. Diabetologia, 67 (2) p. 403. Peer-reviewed.
 
Disrupted hypothalamic transcriptomics and proteomics in a mouse model of type 2 diabetes exposed to recurrent hypoglycaemia.
Castillo-Armengol J., Marzetta F., Rodriguez Sanchez-Archidona A., Fledelius C., Evans M., McNeilly A., McCrimmon R.J., Ibberson M., Thorens B., 2024/02. Diabetologia, 67 (2) pp. 371-391. Peer-reviewed.
 
The Opioid Receptor Influences Circadian Rhythms in Human Keratinocytes through the β-Arrestin Pathway.
Bigliardi P., Junnarkar S., Markale C., Lo S., Bigliardi E., Kalyuzhny A., Ong S., Dunn R., Wahli W., Bigliardi-Qi M., 2024/01/25. Cells, 13 (3). Peer-reviewed.
 
Reindeer in the Arctic reduce sleep need during rumination.
Furrer M., Meier S.A., Jan M., Franken P., Sundset M.A., Brown S.A., Wagner G.C., Huber R., 2024/01/22. Current biology, 34 (2) pp. 427-433.e5. Peer-reviewed.
CIC-DUX4 Chromatin Profiling Reveals New Epigenetic Dependencies and Actionable Therapeutic Targets in CIC-Rearranged Sarcomas.
Bakaric A., Cironi L., Praz V., Sanalkumar R., Broye L.C., Favre-Bulle K., Letovanec I., Digklia A., Renella R., Stamenkovic I. et al., 2024/01/21. Cancers, 16 (2) p. 457. Peer-reviewed.
Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner.
Kompotis K., Mang G.M., Hubbard J., Jimenez S., Emmenegger Y., Polysopoulos C., Hor C.N., Wigger L., Hébert S.S., Mongrain V. et al., 2024/01/16. Proceedings of the National Academy of Sciences of the United States of America, 121 (3) pp. e2220532121. Peer-reviewed.
 
Rare copy-number variants as modulators of common disease susceptibility.
Auwerx C., Jõeloo M., Sadler M.C., Tesio N., Ojavee S., Clark C.J., Mägi R., Estonian Biobank Research Team, Reymond A., Kutalik Z., 2024/01/08. Genome medicine, 16 (1) p. 5. Peer-reviewed.
Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth.
Bodac A., Mayet A., Rana S., Pascual J., Bowler A.D., Roh V., Fournier N., Craciun L., Demetter P., Radtke F. et al., 2024/01. EMBO molecular medicine, 16 (1) pp. 158-184. Peer-reviewed.
Beyond cell cycle regulation: The pleiotropic function of CDK4 in cancer.
Ziegler D.V., Parashar K., Fajas L., 2024/01. Seminars in cancer biology, 98 pp. 51-63. Peer-reviewed.
Meta-analysis of dispensable essential genes and their interactions with bypass suppressors.
Pons C., van Leeuwen J., 2024/01. Life science alliance, 7 (1) pp. e202302192. Peer-reviewed.
 
Sleep and circadian rhythmicity as entangled processes serving homeostasis.
Franken P., Dijk D.J., 2024/01. Nature reviews. Neuroscience, 25 (1) pp. 43-59. Peer-reviewed.
 
smFISH for Plants.
Hani S., Mercier C., David P., Desnos T., Escudier J.M., Bertrand E., Nussaume L., 2024. pp. 87-100 dans Fluorescence In Situ Hybridization (FISH), Springer.
 
Targeted treatment of injured nestmates with antimicrobial compounds in an ant society.
Frank E.T., Kesner L., Liberti J., Helleu Q., LeBoeuf A.C., Dascalu A., Sponsler D.B., Azuma F., Economo E.P., Waridel P. et al., 2023/12/29. Nature communications, 14 (1) p. 8446. Peer-reviewed.
 
Experience with German Research Consortia in the Field of Chemical Biology of Native Nucleic Acid Modifications.
Helm M., Bohnsack M.T., Carell T., Dalpke A., Entian K.D., Ehrenhofer-Murray A., Ficner R., Hammann C., Höbartner C., Jäschke A. et al., 2023/12/15. ACS chemical biology, 18 (12) pp. 2441-2449. Peer-reviewed.
 
ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging.
Snieckute G., Ryder L., Vind A.C., Wu Z., Arendrup F.S., Stoneley M., Chamois S., Martinez-Val A., Leleu M., Dreos R. et al., 2023/12/08. Science, 382 (6675) pp. eadf3208. Peer-reviewed.
Light and temperature regulation of leaf morphogenesis in Arabidopsis.
Legris M., 2023/12. The New phytologist, 240 (6) pp. 2191-2196. Peer-reviewed.
Ryanodine receptor type 1 content decrease-induced endoplasmic reticulum stress is a hallmark of myopathies.
Vidal J., Fernandez E.A., Wohlwend M., Laurila P.P., Lopez-Mejia A., Ochala J., Lobrinus A.J., Kayser B., Lopez-Mejia I.C., Place N. et al., 2023/12. Journal of cachexia, sarcopenia and muscle, 14 (6) pp. 2882-2897. Peer-reviewed.
 
DNA methylation by CcrM contributes to genome maintenance in the Agrobacterium tumefaciens plant pathogen
Martin Sandra, Fournes Florian, Ambrosini Giovanna, Iseli Christian, BOJKOWSKA Karolina, Marquis Julien, Guex Nicolas, Collier Justine, 2023/11/28..
 
Air channels create a directional light signal to regulate hypocotyl phototropism.
Nawkar G.M., Legris M., Goyal A., Schmid-Siegert E., Fleury J., Mucciolo A., De Bellis D., Trevisan M., Schueler A., Fankhauser C., 2023/11/24. Science, 382 (6673) pp. 935-940. Peer-reviewed.
Comparative single-cell transcriptomic atlases reveal conserved and divergent features of drosophilid central brains
Lee D., Benton R., 2023/11/23..
 
Remote homolog detection places insect chemoreceptors in a cryptic protein superfamily spanning the tree of life.
Himmel N.J., Moi D., Benton R., 2023/11/20. Current biology, 33 (22) pp. 5023-5033.e4. Peer-reviewed.
 
Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein.
Kretz P.F., Wagner C., Mikhaleva A., Montillot C., Hugel S., Morella I., Kannan M., Fischer M.C., Milhau M., Yalcin I. et al., 2023/11/15. Genome biology, 24 (1) p. 261. Peer-reviewed.
 
AlphaFold Blindness to Topological Barriers Affects Its Ability to Correctly Predict Proteins' Topology.
Dabrowski-Tumanski P., Stasiak A., 2023/11/07. Molecules, 28 (22) p. 7462. Peer-reviewed.
 
Elafibranor upregulates the EMT-inducer S100A4 via PPARβ/δ.
Zhang M., Barroso E., Ruart M., Peña L., Peyman M., Aguilar-Recarte D., Montori-Grau M., Rada P., Cugat C., Montironi C. et al., 2023/11. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 167 p. 115623. Peer-reviewed.
 
The glucose transporter 2 regulates CD8<sup>+</sup> T cell function via environment sensing.
Fu H., Vuononvirta J., Fanti S., Bonacina F., D'Amati A., Wang G., Poobalasingam T., Fankhaenel M., Lucchesi D., Coleby R. et al., 2023/11. Nature metabolism, 5 (11) pp. 1969-1985. Peer-reviewed.
 
Diurnal control of iron responsive element (IRE)-containing mRNAs through iron regular proteins IRP1 and IRP2 is mediated by feeding rhythms
Nadimpalli Hima Priyanka, Katsioudi Georgia, Arpa Enes S., Chikhaoui Lies, Bulak Arpat A., Liechti Angelica, Palais Gaël, Tessmer Claudia, Hofmann Ilse, Galy Bruno et al., 2023/10/23..
ER-trafficking triggers NRF1 ubiquitination to promote its proteolytic activation.
Chavarria C., Zaffalon L., Ribeiro S.T., Op M., Quadroni M., Iatrou M.S., Chapuis C., Martinon F., 2023/10/20. iScience, 26 (10) p. 107777. Peer-reviewed.
 
FastSkin® Concept: A Novel Treatment for Complex Acute and Chronic Wound Management.
di Summa P.G., Di Marzio N., Jafari P., Jaconi M.E., Nesic D., 2023/10/16. Journal of clinical medicine, 12 (20) p. 6564. Peer-reviewed.
Global analysis of suppressor mutations that rescue human genetic defects.
Ünlü B., Pons C., Ho U.L., Batté A., Aloy P., van Leeuwen J., 2023/10/12. Genome medicine, 15 (1) p. 78. Peer-reviewed.
 
Matrix-Mediated Delivery of Silver Nanoparticles for Prevention of Staphylococcus aureus and Pseudomonas aeruginosa Biofilm Formation in Chronic Rhinosinusitis.
Yathavan B., Chhibber T., Steinhauff D., Pulsipher A., Alt J.A., Ghandehari H., Jafari P., 2023/10/05. Pharmaceutics, 15 (10) p. 2426. Peer-reviewed.
 
25 Years of thermomorphogenesis research: milestones and perspectives.
Quint M., Delker C., Balasubramanian S., Balcerowicz M., Casal J.J., Castroverde CDM, Chen M., Chen X., De Smet I., Fankhauser C. et al., 2023/10. Trends in plant science, 28 (10) pp. 1098-1100. Peer-reviewed.
 
Exploring the brain epitranscriptome: perspectives from the NSAS summit.
Lee S.M., Koo B., Carré C., Fischer A., He C., Kumar A., Liu K., Meyer K.D., Ming G.L., Peng J. et al., 2023/10. Frontiers in neuroscience, 17 p. 1291446. Peer-reviewed.
Chemogenetic activation of target neurons expressing insect Ionotropic Receptors in the mammalian central nervous system by systemic administration of ligand precursors
Iguchi Y., Fukabori R., Kato S., Takahashi K., Eifuku S., Maejima Y., Shimomura K., Mizuma H., Mawatari A., Doi H. et al., 2023/09/13..
Biallelic variants in NSUN6 cause an autosomal recessive neurodevelopmental disorder.
Mattioli F., Worpenberg L., Li C.T., Ibrahim N., Naz S., Sharif S., Firouzabadi S.G., Vosoogh S., Saraeva-Lamri R., Raymond L. et al., 2023/09. Genetics in medicine, 25 (9) p. 100900. Peer-reviewed.
Genome-wide Association Studies of Retinal Vessel Tortuosity Identify Numerous Novel Loci Revealing Genes and Pathways Associated With Ocular and Cardiometabolic Diseases.
Tomasoni M., Beyeler M.J., Vela S.O., Mounier N., Porcu E., Corre T., Krefl D., Button A.L., Abouzeid H., Konstantinidis Lazaros et al., 2023/09. Ophthalmology science, 3 (3) p. 100288. Peer-reviewed.
 
Hyperglycemia increases SCO-spondin and Wnt5a secretion into the cerebrospinal fluid to regulate ependymal cell beating and glucose sensing.
Nualart F., Cifuentes M., Ramírez E., Martínez F., Barahona M.J., Ferrada L., Saldivia N., Bongarzone E.R., Thorens B., Salazar K., 2023/09. PLoS biology, 21 (9) pp. e3002308. Peer-reviewed.
 
Chromosome-level organization of the regulatory genome in the Drosophila nervous system.
Mohana G., Dorier J., Li X., Mouginot M., Smith R.C., Malek H., Leleu M., Rodriguez D., Khadka J., Rosa P. et al., 2023/08/31. Cell, 186 (18) pp. 3826-3844.e26. Peer-reviewed.
Chromosomal deletions on 16p11.2 encompassing SH2B1 are associated with accelerated metabolic disease.
Hanssen R., Auwerx C., Jõeloo M., Sadler M.C., Estonian Biobank Research Team, Henning E., Keogh J., Bounds R., Smith M., Firth H.V. et al., 2023/08/15. Cell reports. Medicine, 4 (8) p. 101155. Peer-reviewed.
 
daf-42 is an evolutionarily young gene essential for dauer development in Caenorhabditis elegans.
Lim D.S., Kim J., Kim W., Kim N., Lee S.H., Lee D., Lee J., 2023/08/09. Genetics, 224 (4). Peer-reviewed.
 
Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia.
Gaspari S., Labouèbe G., Picard A., Berney X., Rodriguez Sanchez-Archidona A., Thorens B., 2023/08/03. EMBO reports, 24 (8) pp. e57344. Peer-reviewed.
 
From the archive: colour constancy, and an atomic romance.
Wu Edlyn, Vastenhouw Nadine L., 2023/08. Nature, 620 (7976) p. 957. Peer-reviewed.
 
Highlights from the 1st European cancer dependency map symposium and workshop
Trastulla Lucia, Savino Aurora, Beltrao Pedro, Ciriano Isidro Cortés, Fenici Peter, Garnett Mathew J., Guerini Ilaria, Bigas Nuria Lòpez, Mattaj Iain, Petsalaki Evangelia et al., 2023/08. FEBS Letters, 597 (15) pp. 1921-1927.
 
Sleeping embryonic genomes are awoken by OBOX proteins.
Wu E., Vastenhouw N.L., 2023/08. Nature, 620 (7976) pp. 956-957. Peer-reviewed.
 
β-Cell-Specific E2f1 Deficiency Impairs Glucose Homeostasis, β-Cell Identity, and Insulin Secretion.
Oger F., Bourouh C., Friano M.E., Courty E., Rolland L., Gromada X., Moreno M., Carney C., Rabhi N., Durand E. et al., 2023/08/01. Diabetes, 72 (8) pp. 1112-1126. Peer-reviewed.
 
MAGI1 Prevents Senescence and Promotes the DNA Damage Response in ER+ Breast Cancer.
Wörthmüller J., Disler S., Pradervand S., Richard F., Haerri L., Ruiz Buendía G.A., Fournier N., Desmedt C., Rüegg C., 2023/07/25. Cells, 12 (15) p. 1929. Peer-reviewed.
Multi-layered genetic approaches to identify approved drug targets.
Sadler M.C., Auwerx C., Deelen P., Kutalik Z., 2023/07/12. Cell genomics, 3 (7) p. 100341. Peer-reviewed.
Evolution of circadian behavioral plasticity through cis-regulatory divergence of a neuropeptide gene
Shahandeh M.P., Abuin L., Lescuyer De Decker L., Cergneux J., Koch R., Nagoshi E., Benton R., 2023/07/06..
 
Chronic hyperglycaemia increases the vulnerability of the hippocampus to oxidative damage induced during post-hypoglycaemic hyperglycaemia in a mouse model of chemically induced type 1 diabetes.
McNeilly A.D., Gallagher J.R., Evans M.L., de Galan B.E., Pedersen-Bjergaard U., Thorens B., Dinkova-Kostova A.T., Huang J.T., Ashford MLJ, McCrimmon R.J. et al., 2023/07. Diabetologia, 66 (7) pp. 1340-1352. Peer-reviewed.
 
Striking a gut-liver balance for the antidiabetic effects of metformin.
Barroso E., Montori-Grau M., Wahli W., Palomer X., Vázquez-Carrera M., 2023/07. Trends in pharmacological sciences, 44 (7) pp. 457-473. Peer-reviewed.
YWHAE loss of function causes a rare neurodevelopmental disease with brain abnormalities in human and mouse.
Denommé-Pichon A.S., Collins S.C., Bruel A.L., Mikhaleva A., Wagner C., Vancollie V.E., Thomas Q., Chevarin M., Weber M., Prada C.E. et al., 2023/07. Genetics in medicine, 25 (7) p. 100835. Peer-reviewed.
 
Protein S-acylation controls the subcellular localization and biological activity of PHYTOCHROME KINASE SUBSTRATE.
Lopez Vazquez A., Allenbach Petrolati L., Legris M., Dessimoz C., Lampugnani E.R., Glover N., Fankhauser C., 2023/06/26. The Plant cell, 35 (7) pp. 2635-2653. Peer-reviewed.
 
Do all norepinephrine surges disrupt sleep?
Lüthi A., Franken P., Fulda S., Siclari F., Van Someren EJW, 2023/06. Nature neuroscience, 26 (6) pp. 955-956. Peer-reviewed.
Odor-regulated oviposition behavior in an ecological specialist.
Álvarez-Ocaña R., Shahandeh M.P., Ray V., Auer T.O., Gompel N., Benton R., 2023/05/26. Nature communications, 14 (1) p. 3041. Peer-reviewed.
 
Author Correction: Possible association of 16p11.2 copy number variation with altered lymphocyte and neutrophil counts.
Giannuzzi G., Chatron N., Mannik K., Auwerx C., Pradervand S., Willemin G., Hoekzema K., Nuttle X., Chrast J., Sadler M.C. et al., 2023/05/24. NPJ genomic medicine, 8 (1) p. 9. Peer-reviewed.
 
Premature ovarian insufficiency is associated with global alterations in the regulatory landscape and gene expression in balanced X-autosome translocations.
Di-Battista A., Favilla B.P., Zamariolli M., Nunes N., Defelicibus A., Armelin-Correa L., da Silva I.T., Reymond A., Moyses-Oliveira M., Melaragno M.I., 2023/05/19. Epigenetics & chromatin, 16 (1) p. 19. Peer-reviewed.
 
Actin filaments accumulated in the nucleus remain in the vicinity of condensing chromosomes in the zebrafish early embryo.
Oda H., Sato Y., Kawashima S.A., Fujiwara Y., Pálfy M., Wu E., Vastenhouw N.L., Kanai M., Kimura H., 2023/05/15. Biology open, 12 (5) pp. bio059783. Peer-reviewed.
 
Secondary structure of the human mitochondrial genome affects formation of deletions.
Shamanskiy V., Mikhailova A.A., Tretiakov E.O., Ushakova K., Mikhailova A.G., Oreshkov S., Knorre D.A., Ree N., Overdevest J.B., Lukowski S.W. et al., 2023/05/08. BMC biology, 21 (1) p. 103. Peer-reviewed.
 
Molecular basis of translation termination at noncanonical stop codons in human mitochondria.
Saurer M., Leibundgut M., Nadimpalli H.P., Scaiola A., Schönhut T., Lee R.G., Siira S.J., Rackham O., Dreos R., Lenarčič T. et al., 2023/05/05. Science, 380 (6644) pp. 531-536. Peer-reviewed.
 
Identification of biomarkers for glycaemic deterioration in type 2 diabetes.
Slieker R.C., Donnelly L.A., Akalestou E., Lopez-Noriega L., Melhem R., Güneş A., Abou Azar F., Efanov A., Georgiadou E., Muniangi-Muhitu H. et al., 2023/05/03. Nature communications, 14 (1) p. 2533. Peer-reviewed.
The immunopeptidome landscape associated with T cell infiltration, inflammation and immune editing in lung cancer.
Kraemer A.I., Chong C., Huber F., Pak H., Stevenson B.J., Müller M., Michaux J., Altimiras E.R., Rusakiewicz S., Simó-Riudalbas L. et al., 2023/05. Nature cancer, 4 (5) pp. 608-628. Peer-reviewed.
Oral metformin transiently lowers post-prandial glucose response by reducing the apical expression of sodium-glucose co-transporter 1 in enterocytes.
Zubiaga L., Briand O., Auger F., Touche V., Hubert T., Thevenet J., Marciniak C., Quenon A., Bonner C., Peschard S. et al., 2023/04/21. iScience, 26 (4) p. 106057. Peer-reviewed.
Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock.
Bignon Y., Wigger L., Ansermet C., Weger B.D., Lagarrigue S., Centeno G., Durussel F., Götz L., Ibberson M., Pradervand S. et al., 2023/04/17. The Journal of clinical investigation, 133 (8) pp. e167133. Peer-reviewed.
 
Chemosensory Coding in Drosophila Single Sensilla.
Benton R., Dahanukar A., 2023/04/03. Cold Spring Harbor protocols, 2023 (4) pp. pdb.top107803. Peer-reviewed.
 
Recording from Fly Olfactory Sensilla.
Benton R., Dahanukar A., 2023/04/03. Cold Spring Harbor protocols, 2023 (4) pp. pdb.prot108063. Peer-reviewed.
 
Recording from Fly Taste Sensilla.
Dahanukar A., Benton R., 2023/04/03. Cold Spring Harbor protocols, 2023 (4) pp. pdb.prot108064. Peer-reviewed.
 
A caveolin-1 dependent glucose-6-phosphatase trafficking contributes to hepatic glucose production.
Gautier-Stein A., Chilloux J., Soty M., Thorens B., Place C., Zitoun C., Duchampt A., Da Costa L., Rajas F., Lamaze C. et al., 2023/04. Molecular metabolism, 70 p. 101700. Peer-reviewed.
The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance.
Brazane M., Dimitrova D.G., Pigeon J., Paolantoni C., Ye T., Marchand V., Da Silva B., Schaefer E., Angelova M.T., Stark Z. et al., 2023/04. Life science alliance, 6 (4) pp. e202201877. Peer-reviewed.
 
Shade avoidance in the context of climate change.
Casal J.J., Fankhauser C., 2023/03/17. Plant physiology, 191 (3) pp. 1475-1491. Peer-reviewed.
A Biallelic Truncating Variant in the TPR Domain of GEMIN5 Associated with Intellectual Disability and Cerebral Atrophy.
Ibrahim N., Naz S., Mattioli F., Guex N., Sharif S., Iqbal A., Ansar M., Reymond A., 2023/03/13. Genes, 14 (3) p. 707. Peer-reviewed.
Exploiting the mediating role of the metabolome to unravel transcript-to-phenotype associations.
Auwerx C., Sadler M.C., Woh T., Reymond A., Kutalik Z., Porcu E., 2023/03/09. eLife, 12 pp. e81097. Peer-reviewed.
 
Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs.
Yildiz E., El Alam G., Perino A., Jalil A., Denechaud P.D., Huber K., Fajas L., Auwerx J., Sorrentino G., Schoonjans K., 2023/03/06. eLife, 12 pp. e81926. Peer-reviewed.
 
Correction to: Reply to Letter by Tellier et al., 'Scientific refutation of ESHG statement on embryo selection'.
Forzano F., Antonova O., Clarke A., de Wert G., Hentze S., Jamshidi Y., Moreau Y., Perola M., Prokopenko I., Read A. et al., 2023/03. European journal of human genetics, 31 (3) p. 368. Peer-reviewed.
 
Reply to Letter by Tellier et al., 'Scientific refutation of ESHG statement on embryo selection'.
Forzano F., Antonova O., Clarke A., de Wert G., Hentze S., Jamshidi Y., Moreau Y., Perola M., Prokopenko I., Read A. et al., 2023/03. European journal of human genetics, 31 (3) pp. 279-281. Peer-reviewed.
A Database of Accurate Electrophoretic Migration Patterns for Human Proteins.
Mylonas R., Potts A., Waridel P., Barblan J., Conde Rubio MDC, Widmann C., Quadroni M., 2023/02/28. Journal of molecular biology, 435 (4) p. 167933. Peer-reviewed.
Structural screens identify candidate human homologs of insect chemoreceptors and cryptic Drosophila gustatory receptor-like proteins.
Benton R., Himmel N.J., 2023/02/20. eLife, 12 pp. e85537. Peer-reviewed.
Evolution of connectivity architecture in the Drosophila mushroom body
Ellis K.E., Smihula H., Ganguli I., Vigato E., Bervoets S., Auer T.O., Benton R., Kumar A.L., Caron S.J.C., 2023/02/12..
Targeting chemoresistant senescent pancreatic cancer cells improves conventional treatment efficacy.
Jaber S., Warnier M., Leers C., Vernier M., Goehrig D., Médard J.J., Vindrieux D., Ziegler D.V., Bernard D., 2023/02/05. Molecular biomedicine, 4 (1) p. 4. Peer-reviewed.
 
Deleterious, protein-altering variants in the transcriptional coregulator ZMYM3 in 27 individuals with a neurodevelopmental delay phenotype.
Hiatt S.M., Trajkova S., Sebastiano M.R., Partridge E.C., Abidi F.E., Anderson A., Ansar M., Antonarakis S.E., Azadi A., Bachmann-Gagescu R. et al., 2023/02/02. American journal of human genetics, 110 (2) pp. 215-227. Peer-reviewed.
 
The impact of 22q11.2 copy-number variants on human traits in the general population.
Zamariolli M., Auwerx C., Sadler M.C., van der Graaf A., Lepik K., Schoeler T., Moysés-Oliveira M., Dantas A.G., Melaragno M.I., Kutalik Z., 2023/02/02. American journal of human genetics, 110 (2) pp. 300-313. Peer-reviewed.
Tanycytes and hypothalamic FGF21: New players in the metabolic game.
Geller S., Pellerin L., 2023/01/31. Cell reports, 42 (1) p. 111954. Peer-reviewed.
Germline homozygous missense DEPDC5 variants cause severe refractory early-onset epilepsy, macrocephaly and bilateral polymicrogyria.
Ververi A., Zagaglia S., Menzies L., Baptista J., Caswell R., Baulac S., Ellard S., Lynch S., Genomics England Research Consortium, Jacques T.S. et al., 2023/01/27. Human molecular genetics, 32 (4) pp. 580-594. Peer-reviewed.
A conditional Smg6 mutant mouse model reveals circadian clock regulation through the nonsense-mediated mRNA decay pathway.
Katsioudi G., Dreos R., Arpa E.S., Gaspari S., Liechti A., Sato M., Gabriel C.H., Kramer A., Brown S.A., Gatfield D., 2023/01/13. Science advances, 9 (2) pp. eade2828. Peer-reviewed.
 
Nanog organizes transcription bodies.
Kuznetsova K., Chabot N.M., Ugolini M., Wu E., Lalit M., Oda H., Sato Y., Kimura H., Jug F., Vastenhouw N.L., 2023/01/09. Current biology, 33 (1) pp. 164-173.e5. Peer-reviewed.
 
Abscisic acid modulates neighbor proximity-induced leaf hyponasty in Arabidopsis.
Michaud O., Krahmer J., Galbier F., Lagier M., Galvão V.C., Ince Y.Ç., Trevisan M., Knerova J., Dickinson P., Hibberd J.M. et al., 2023/01/02. Plant physiology, 191 (1) pp. 542-557. Peer-reviewed.
A positive feedback loop between AMPK and GDF15 promotes metformin antidiabetic effects.
Aguilar-Recarte D., Barroso E., Zhang M., Rada P., Pizarro-Delgado J., Peña L., Palomer X., Valverde Á.M., Wahli W., Vázquez-Carrera M., 2023/01. Pharmacological research, 187 p. 106578. Peer-reviewed.
 
Contrasting effects of whole-body and hepatocyte-specific deletion of the RNA polymerase III repressor Maf1 in the mouse.
Willemin G., Mange F., Praz V., Lorrain S., Cousin P., Roger C., Willis I.M., Hernandez N., 2023. Frontiers in molecular biosciences, 10 p. 1297800. Peer-reviewed.
 
Heterologous investigation of metabotropic and ionotropic odorant receptors in ab3A neurons of Drosophila melanogaster.
Pettersson J.H., Cattaneo A.M., 2023. Frontiers in molecular biosciences, 10 p. 1275901. Peer-reviewed.
Oxidative stress-induced FAK activation contributes to uterine serous carcinoma aggressiveness.
Lopez-Mejia I.C., Pijuan J., Navaridas R., Santacana M., Gatius S., Velasco A., Castellà G., Panosa A., Cabiscol E., Pinyol M. et al., 2023/01. Molecular oncology, 17 (1) pp. 98-118. Peer-reviewed.
You can be an editor too!
Herr W., 2023/01/01. Genes & development, 37 (1-2) pp. 11-12. Peer-reviewed.
Drosophila olfaction: past, present and future.
Benton R., 2022/12/21. Proceedings. Biological sciences, 289 (1989) p. 20222054. Peer-reviewed.
Automated assembly scaffolding using RagTag elevates a new tomato system for high-throughput genome editing.
Alonge M., Lebeigle L., Kirsche M., Jenike K., Ou S., Aganezov S., Wang X., Lippman Z.B., Schatz M.C., Soyk S., 2022/12/15. Genome biology, 23 (1) p. 258. Peer-reviewed.
eLife's new model and its impact on science communication.
Urban L., De Niz M., Fernández-Chiappe F., Ebrahimi H., Han LKM, Mehta D., Mencia R., Mittal D., Ochola E., Paz Quezada C. et al., 2022/12/08. eLife, 11 pp. e84816. Peer-reviewed.
 
Quantifying the role of transcript levels in mediating DNA methylation effects on complex traits and diseases.
Sadler M.C., Auwerx C., Lepik K., Porcu E., Kutalik Z., 2022/12/07. Nature communications, 13 (1) p. 7559. Peer-reviewed.
Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response.
Snieckute G., Genzor A.V., Vind A.C., Ryder L., Stoneley M., Chamois S., Dreos R., Nordgaard C., Sass F., Blasius M. et al., 2022/12/06. Cell metabolism, 34 (12) pp. 2036-2046.e8. Peer-reviewed.
Cognitive and behavioral involvement in ALS has been known for more than a century.
Zago S., Lorusso L., Aiello E.N., Ugolini M., Poletti B., Ticozzi N., Silani V., 2022/12. Neurological sciences, 43 (12) pp. 6741-6760. Peer-reviewed.
Repeat Detector: versatile sizing of expanded tandem repeats and identification of interrupted alleles from targeted DNA sequencing.
Taylor A.S., Barros D., Gobet N., Schuepbach T., McAllister B., Aeschbach L., Randall E.L., Trofimenko E., Heuchan E.R., Barszcz P. et al., 2022/12. NAR genomics and bioinformatics, 4 (4) pp. lqac089. Peer-reviewed.
 
Susumu Seino, MD, DMSci (1948–2021): A Pioneer in the Biology of Insulin Secretion
Accili D., Bell GL, Thorens B., 2022/12/01. Diabetes, 71 (12) pp. 2490-2495.
 
Correction: The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice.
Forzano F., Antonova O., Clarke A., de Wert G., Hentze S., Jamshidi Y., Moreau Y., Perola M., Prokopenko I., Read A. et al., 2022/11..
In vivo and in vitro characterization of GL0034, a novel long-acting glucagon-like peptide-1 receptor agonist.
Jones B., Burade V., Akalestou E., Manchanda Y., Ramchunder Z., Carrat G., Nguyen-Tu M.S., Marchetti P., Piemonti L., Leclerc I. et al., 2022/11. Diabetes, obesity & metabolism, 24 (11) pp. 2090-2101. Peer-reviewed.
 
Knocking on GDF15's door for the treatment of type 2 diabetes mellitus.
Aguilar-Recarte D., Barroso E., Palomer X., Wahli W., Vázquez-Carrera M., 2022/11. Trends in endocrinology and metabolism, 33 (11) pp. 741-754. Peer-reviewed.
The great migration: How glial cells could regulate GnRH neuron development and shape adult reproductive life.
Duittoz A.H., Tillet Y., Geller S., 2022/11. Journal of chemical neuroanatomy, 125 p. 102149. Peer-reviewed.
GLUT2 expression by glial fibrillary acidic protein-positive tanycytes is required for promoting feeding-response to fasting.
Barahona M.J., Langlet F., Labouèbe G., Croizier S., Picard A., Thorens B., García-Robles M.A., 2022/10/21. Scientific reports, 12 (1) p. 17717. Peer-reviewed.
Translational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life.
Bhattacharya K., Maiti S., Zahoran S., Weidenauer L., Hany D., Wider D., Bernasconi L., Quadroni M., Collart M., Picard D., 2022/10/21. Nature communications, 13 (1) p. 6271. Peer-reviewed.
A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand.
Mikhailova A.G., Mikhailova A.A., Ushakova K., Tretiakov E.O., Iliushchenko D., Shamansky V., Lobanova V., Kozenkov I., Efimenko B., Yurchenko A.A. et al., 2022/10/14. Nucleic acids research, 50 (18) pp. 10264-10277. Peer-reviewed.
Omics-informed CNV calls reduce false-positive rates and improve power for CNV-trait associations.
Lepamets M., Auwerx C., Nõukas M., Claringbould A., Porcu E., Kals M., Jürgenson T., Estonian Biobank Research Team, Morris A.P., Võsa U. et al., 2022/10/13. HGG advances, 3 (4) p. 100133. Peer-reviewed.
Pheromone sensing in Drosophila requires support cell-expressed Osiris 8.
Scalzotto M., Ng R., Cruchet S., Saina M., Armida J., Su C.Y., Benton R., 2022/10/11. BMC biology, 20 (1) p. 230. Peer-reviewed.
A combination of plasma membrane sterol biosynthesis and autophagy is required for shade-induced hypocotyl elongation.
Ince Y.Ç., Krahmer J., Fiorucci A.S., Trevisan M., Galvão V.C., Wigger L., Pradervand S., Fouillen L., Van Delft P., Genva M. et al., 2022/10/10. Nature communications, 13 (1) p. 5659. Peer-reviewed.
 
Endothelial-immune crosstalk contributes to vasculopathy in nonalcoholic fatty liver disease.
Ng C.Y., Lee K.L., Muthiah M.D., Wu K.X., Chioh FWJ, Tan K., Soon GST, Shabbir A., Loo W.M., Low Z.S. et al., 2022/10/06. EMBO reports, 23 (10) pp. e55871. Peer-reviewed.
Contribution of schizophrenia polygenic burden to longitudinal phenotypic variance in 22q11.2 deletion syndrome.
Alver M., Mancini V., Läll K., Schneider M., Romano L., Estonian Biobank Research Team, Mägi R., Dermitzakis E.T., Eliez S., Reymond A., 2022/10. Molecular psychiatry, 27 (10) pp. 4191-4200. Peer-reviewed.
Cracking the encoding of human scent in the mosquito brain.
Prieto-Godino L.L., Auer T.O., 2022/10. Trends in neurosciences, 45 (10) pp. 713-715. Peer-reviewed.
Exploring conditional gene essentiality through systems genetics approaches in yeast.
Bosch-Guiteras N., van Leeuwen J., 2022/10. Current opinion in genetics & development, 76 p. 101963. Peer-reviewed.
 
Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion.
Strembitska A., Labouèbe G., Picard A., Berney X.P., Tarussio D., Jan M., Thorens B., 2022/09/30. Nature communications, 13 (1) p. 5761. Peer-reviewed.
Characterization of Two Mouse Chd7 Heterozygous Loss-of-Function Models Shows Dysgenesis of the Corpus Callosum and Previously Unreported Features of CHARGE Syndrome.
Collins S.C., Vancollie V.E., Mikhaleva A., Wagner C., Balz R., Lelliott C.J., Yalcin B., 2022/09/29. International journal of molecular sciences, 23 (19) p. 11509. Peer-reviewed.
 
Focus on circadian rhythms.
Harmer S.L., Fankhauser C., Webb AAR, 2022/09/28. Plant physiology, 190 (2) pp. 921-923. Peer-reviewed.
Global and precise identification of functional miRNA targets in mESCs by integrative analysis.
Schaefer M., Nabih A., Spies D., Hermes V., Bodak M., Wischnewski H., Stalder P., Ngondo R.P., Liechti L.A., Sajic T. et al., 2022/09/05. EMBO reports, 23 (9) pp. e54762. Peer-reviewed.
 
Copy number changes in co-expressed odorant receptor genes enable selection for sensory differences in drosophilid species.
Auer T.O., Álvarez-Ocaña R., Cruchet S., Benton R., Arguello J.R., 2022/09. Nature ecology & evolution, 6 (9) pp. 1343-1353. Peer-reviewed.
 
Molecular control of the development of hypothalamic neurons involved in metabolic regulation.
Croizier S., Bouret S.G., 2022/09. Journal of chemical neuroanatomy, 123 p. 102117. Peer-reviewed.
Towards mouse genetic-specific RNA-sequencing read mapping.
Gobet N., Jan M., Franken P., Xenarios I., 2022/09. PLoS computational biology, 18 (9) pp. e1010552. Peer-reviewed.
Limited evidence for blood eQTLs in human sexual dimorphism.
Porcu E., Claringbould A., Weihs A., Lepik K., BIOS Consortium, Richardson T.G., Völker U., Santoni F.A., Teumer A., Franke L. et al., 2022/08/11. Genome medicine, 14 (1) p. 89. Peer-reviewed.
 
A cross-disorder dosage sensitivity map of the human genome.
Collins R.L., Glessner J.T., Porcu E., Lepamets M., Brandon R., Lauricella C., Han L., Morley T., Niestroj L.M., Ulirsch J. et al., 2022/08/04. Cell, 185 (16) pp. 3041-3055.e25. Peer-reviewed.
 
Maternally loaded RNAs: no time to die.
Ugolini M., Vastenhouw N.L., 2022/08. Cell research, 32 (8) pp. 707-708. Peer-reviewed.
Structural and molecular characterization of paraventricular thalamic glucokinase-expressing neuronal circuits in the mouse.
Gaspari S., Quenneville S., Rodriguez Sanchez-Archidona A., Thorens B., Croizier S., 2022/08. The Journal of comparative neurology, 530 (11) pp. 1773-1949. Peer-reviewed.
 
Light regulates xylem cell differentiation via PIF in Arabidopsis.
Ghosh S., Nelson J.F., Cobb GMC, Etchells J.P., de Lucas M., 2022/07/19. Cell reports, 40 (3) p. 111075. Peer-reviewed.
Peroxisomal Proliferator-Activated Receptor β/δ Deficiency Induces Cognitive Alterations.
Espinosa-Jiménez T., Busquets O., Cano A., Sánchez-López E., Verdaguer E., Parcerisas A., Olloquequi J., Auladell C., Folch J., Wahli W. et al., 2022/07/11. Frontiers in pharmacology, 13 p. 902047. Peer-reviewed.
A novel Smg6 mouse model reveals regulation of circadian period and daily CRY2 accumulation through the nonsense-mediated mRNA decay pathway
Katsioudi G., Dreos R., Arpa E.S., Gaspari S., Liechti A., Sato M., Gabriel C.H., Kramer A., Brown S.A., Gatfield D., 2022/07/03..
Genome doubling enabled the expansion of yeast vesicle traffic pathways.
Purkanti R., Thattai M., 2022/07/02. Scientific reports, 12 (1) p. 11213. Peer-reviewed.
Hypothalamic Irak4 is a genetically controlled regulator of hypoglycemia-induced glucagon secretion.
Picard A., Berney X., Castillo-Armengol J., Tarussio D., Jan M., Sanchez-Archidona A.R., Croizier S., Thorens B., 2022/07. Molecular metabolism, 61 p. 101479. Peer-reviewed.
Pivotal role of O-antigenic polysaccharide display in the sensitivity against phage tail-like particles in environmental Pseudomonas kin competition.
Heiman C.M., Maurhofer M., Calderon S., Dupasquier M., Marquis J., Keel C., Vacheron J., 2022/07. The ISME journal, 16 (7) pp. 1683-1693. Peer-reviewed.
Regenerating islet-derived protein 3α: A promising therapy for diabetes. Preliminary data in rodents and in humans.
Le Lay A., Philippe E., Roth F., Sanchez-Archidona A.R., Mehl F., Denom J., Prasad R., Asplund O., Hansson O., Ibberson M. et al., 2022/07. Heliyon, 8 (7) pp. e09944. Peer-reviewed.
Sweet sensors support stressed cell survival.
Himmel N.J., Benton R., 2022/07. PLoS biology, 20 (7) pp. e3001705. Peer-reviewed.
Possible association of 16p11.2 copy number variation with altered lymphocyte and neutrophil counts.
Giannuzzi G., Chatron N., Mannik K., Auwerx C., Pradervand S., Willemin G., Hoekzema K., Nuttle X., Chrast J., Sadler M.C. et al., 2022/06/17. NPJ genomic medicine, 7 (1) p. 38. Peer-reviewed.
ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity.
Fougerat A., Schoiswohl G., Polizzi A., Régnier M., Wagner C., Smati S., Fougeray T., Lippi Y., Lasserre F., Raho I. et al., 2022/06/07. Cell reports, 39 (10) p. 110910. Peer-reviewed.
 
Poly(m6A) tails stabilize transcripts.
Lavergne G., Roignant J.Y., 2022/06/02. Molecular cell, 82 (11) pp. 1979-1980. Peer-reviewed.
Adipocyte-specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction.
Chen Y., Fernandez E.A., Roger C., Lopez-Mejia I.C., Fajas Coll L., Ji H., 2022/06. FEBS letters, 596 (11) pp. 1434-1444. Peer-reviewed.
Taste and Smell: A Unifying Chemosensory Theory
Mollo Ernesto, Boero Ferdinando, Peñuelas Josep, Fontana Angelo, Garson Mary J., Roussis Vassilios, Cerrano Carlo, Polese Gianluca, Cattaneo Alberto Maria, Mudianta I Wayan et al., 2022/06/01. The Quarterly Review of Biology, 97 (2) pp. 69-94.
Homocysteine Metabolism Pathway Is Involved in the Control of Glucose Homeostasis: A Cystathionine Beta Synthase Deficiency Study in Mouse.
Cruciani-Guglielmacci C., Meneyrol K., Denom J., Kassis N., Rachdi L., Makaci F., Migrenne-Li S., Daubigney F., Georgiadou E., Denis R.G. et al., 2022/05/25. Cells, 11 (11) p. 1737. Peer-reviewed.
Essential role of Cp190 in physical and regulatory boundary formation.
Kaushal A., Dorier J., Wang B., Mohana G., Taschner M., Cousin P., Waridel P., Iseli C., Semenova A., Restrepo S. et al., 2022/05/13. Science advances, 8 (19) pp. eabl8834. Peer-reviewed.
Astrocyte-targeting RNA interference against mutated superoxide dismutase 1 induces motoneuron plasticity and protects fast-fatigable motor units in a mouse model of amyotrophic lateral sclerosis.
Rochat C., Bernard-Marissal N., Källstig E., Pradervand S., Perrin F.E., Aebischer P., Raoul C., Schneider B.L., 2022/05. Glia, 70 (5) pp. 842-857. Peer-reviewed.
 
Correction: The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice.
Forzano F., Antonova O., Clarke A., de Wert G., Hentze S., Jamshidi Y., Moreau Y., Perola M., Prokopenko I., Read A. et al., 2022/05. European journal of human genetics, 30 (5) p. 628. Peer-reviewed.
Shade suppresses wound-induced leaf repositioning through a mechanism involving PHYTOCHROME KINASE SUBSTRATE (PKS) genes.
Fiorucci A.S., Michaud O., Schmid-Siegert E., Trevisan M., Allenbach Petrolati L., Çaka Ince Y., Fankhauser C., 2022/05. PLoS genetics, 18 (5) pp. e1010213. Peer-reviewed.
The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice.
Forzano F., Antonova O., Clarke A., de Wert G., Hentze S., Jamshidi Y., Moreau Y., Perola M., Prokopenko I., Read A. et al., 2022/05. European journal of human genetics, 30 (5) pp. 493-495. Peer-reviewed.
PPARs as Key Mediators in the Regulation of Metabolism and Inflammation.
Vázquez-Carrera M., Wahli W., 2022/04/30. International journal of molecular sciences, 23 (9) p. 5025. Peer-reviewed.
Glucose Starvation or Pyruvate Dehydrogenase Activation Induce a Broad, ERK5-Mediated, Metabolic Remodeling Leading to Fatty Acid Oxidation.
Khan AUH, Salehi H., Alexia C., Valdivielso J.M., Bozic M., Lopez-Mejia I.C., Fajas L., Gerbal-Chaloin S., Daujat-Chavanieu M., Gitenay D. et al., 2022/04/20. Cells, 11 (9) p. 1392. Peer-reviewed.
 
From pharmacogenetics to pharmaco-omics: Milestones and future directions.
Auwerx C., Sadler M.C., Reymond A., Kutalik Z., 2022/04/14. HGG advances, 3 (2) p. 100100. Peer-reviewed.
The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression.
Fougeray T., Polizzi A., Régnier M., Fougerat A., Ellero-Simatos S., Lippi Y., Smati S., Lasserre F., Tramunt B., Huillet M. et al., 2022/04/12. Cell reports, 39 (2) p. 110674. Peer-reviewed.
Predicting base editing outcomes using position-specific sequence determinants.
Pallaseni A., Peets E.M., Koeppel J., Weller J., Vanderstichele T., Ho U.L., Crepaldi L., van Leeuwen J., Allen F., Parts L., 2022/04/08. Nucleic acids research, 50 (6) pp. 3551-3564. Peer-reviewed.
 
The individual and global impact of copy-number variants on complex human traits.
Auwerx C., Lepamets M., Sadler M.C., Patxot M., Stojanov M., Baud D., Mägi R., Estonian Biobank Research Team, Porcu E., Reymond A. et al., 2022/04/07. American journal of human genetics, 109 (4) pp. 647-668. Peer-reviewed.
Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function.
Hinden L., Ahmad M., Hamad S., Nemirovski A., Szanda G., Glasmacher S., Kogot-Levin A., Abramovitch R., Thorens B., Gertsch J. et al., 2022/04/04. Nature communications, 13 (1) p. 1783. Peer-reviewed.
Chl1 helicase controls replication fork progression by regulating dNTP pools.
Batté A., van der Horst S.C., Tittel-Elmer M., Sun S.M., Sharma S., van Leeuwen J., Chabes A., van Attikum H., 2022/04. Life science alliance, 5 (4) pp. e202101153. Peer-reviewed.
Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target.
Smati S., Polizzi A., Fougerat A., Ellero-Simatos S., Blum Y., Lippi Y., Régnier M., Laroyenne A., Huillet M., Arif M. et al., 2022/04. Gut, 71 (4) pp. 807-821. Peer-reviewed.
Neuronal regulation of glucagon secretion and gluconeogenesis.
Thorens B., 2022/04. Journal of diabetes investigation, 13 (4) pp. 599-607. Peer-reviewed.
 
PIGN encephalopathy: Characterizing the epileptology.
Bayat A., de Valles-Ibáñez G., Pendziwiat M., Knaus A., Alt K., Biamino E., Bley A., Calvert S., Carney P., Caro-Llopis A. et al., 2022/04. Epilepsia, 63 (4) pp. 974-991. Peer-reviewed.
 
The distribution of Dlx1-2 and glutamic acid decarboxylase in the embryonic and adult hypothalamus reveals three differentiated LHA subdivisions in rodents.
Barbier M., Croizier S., Alvarez-Bolado G., Risold P.Y., 2022/04. Journal of chemical neuroanatomy, 121 p. 102089. Peer-reviewed.
Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor.
Personnaz J., Piccolo E., Dortignac A., Iacovoni J.S., Mariette J., Rocher V., Polizzi A., Batut A., Deleruyelle S., Bourdens L. et al., 2022/03/25. Science advances, 8 (12) pp. eabg9055. Peer-reviewed.
 
Author Correction: EMPReSS: standardized phenotype screens for functional annotation of the mouse genome
Janier Marc, Almadjub Mohammed, Beuf Olivier, Billotey Claire, Bolbos Radu, Canaple Laurence, Chereul Emmanuel, Grenier Denis, Hiba Bassem, Odet Christophe et al., 2022/03. Nature Genetics, 54 (3) pp. 358-360.
Representations of personalised medicine in family medicine: a qualitative analysis.
Boyer M.S., Widmer D., Cohidon C., Desvergne B., Cornuz J., Guessous I., Cerqui D., 2022/03/01. BMC primary care, 23 (1) p. 37. Peer-reviewed.
Reviewing findings on the polypeptide sequence of the SARS-CoV-2 S-protein to discuss the origins of the virus.
Cattaneo A.M., 2022/03. Future virology, 0 (0). Peer-reviewed.
 
Role of Dietary Supplements and Probiotics in Modulating Microbiota and Bone Health: The Gut-Bone Axis.
de Sire A., de Sire R., Curci C., Castiglione F., Wahli W., 2022/02/21. Cells, 11 (4) p. 743. Peer-reviewed.
Depriving Mice of Sleep also Deprives of Food.
Đukanović N., La Spada F., Emmenegger Y., Niederhäuser G., Preitner F., Franken P., 2022/02/11. Clocks & sleep, 4 (1) pp. 37-51. Peer-reviewed.
Analysis of Eukaryotic lincRNA Sequences Indicates Signatures of Hindered Translation Linked to Selection Pressure.
Brümmer A., Dreos R., Marques A.C., Bergmann S., 2022/02/03. Molecular biology and evolution, 39 (2) pp. msab356. Peer-reviewed.
Chemosensory Receptors in the Larval Maxilla of Papilio hospiton
Crava Cristina M., Bobkov Yuriy V., Sollai Giorgia, Anfora Gianfranco, Crnjar Roberto, Cattaneo Alberto Maria, 2022/02/03. Frontiers in Ecology and Evolution, 9.
Citrullination Was Introduced into Animals by Horizontal Gene Transfer from Cyanobacteria.
Cummings TFM, Gori K., Sanchez-Pulido L., Gavriilidis G., Moi D., Wilson A.R., Murchison E., Dessimoz C., Ponting C.P., Christophorou M.A., 2022/02/03. Molecular biology and evolution, 39 (2) pp. msab317. Peer-reviewed.
Expanded CAG/CTG repeats resist gene silencing mediated by targeted epigenome editing.
Yang B., Borgeaud A.C., Buřičová M., Aeschbach L., Rodríguez-Lima O., Ruiz Buendía G.A., Cinesi C., Taylor A.S., Baubec T., Dion V., 2022/02/03. Human molecular genetics, 31 (3) pp. 386-398. Peer-reviewed.
 
Functional interplay within the epitranscriptome: Reality or fiction?
Worpenberg L., Paolantoni C., Roignant J.Y., 2022/02. BioEssays, 44 (2) pp. e2100174. Peer-reviewed.
Parallel evolution of a splicing program controlling neuronal excitability in flies and mammals.
Torres-Méndez A., Pop S., Bonnal S., Almudi I., Avola A., Roberts RJV, Paolantoni C., Alcaina-Caro A., Martín-Anduaga A., Haussmann I.U. et al., 2022/01/28. Science advances, 8 (4) pp. eabk0445. Peer-reviewed.
 
An exon junction complex-independent function of Barentsz in neuromuscular synapse growth.
Ho C.H., Paolantoni C., Bawankar P., Tang Z., Brown S., Roignant J.Y., Treisman J.E., 2022/01/05. EMBO reports, 23 (1) pp. e53231. Peer-reviewed.
 
Sir3 heterochromatin protein promotes non-homologous end joining by direct inhibition of Sae2.
Bordelet H., Costa R., Brocas C., Dépagne J., Veaute X., Busso D., Batté A., Guérois R., Marcand S., Dubrana K., 2022/01/04. The EMBO journal, 41 (1) pp. e108813. Peer-reviewed.
Adipose-Specific PPARα Knockout Mice Have Increased Lipogenesis by PASK-SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue.
Hinds T.D., Kipp Z.A., Xu M., Yiannikouris F.B., Morris A.J., Stec D.F., Wahli W., Stec D.E., 2022. Cells, 11 (1) p. 4. Peer-reviewed.
Dissection of the macrophage response towards infection by the Leishmania-viral endosymbiont duo and dynamics of the type I interferon response.
Bekkar A., Isorce N., Snäkä T., Claudinot S., Desponds C., Kopelyanskiy D., Prével F., Reverte M., Xenarios I., Fasel N. et al., 2022. Frontiers in cellular and infection microbiology, 12 p. 941888. Peer-reviewed.
Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs.
Sønderby I.E., Ching CRK, Thomopoulos S.I., van der Meer D., Sun D., Villalon-Reina J.E., Agartz I., Amunts K., Arango C., Armstrong N.J. et al., 2022/01. Human brain mapping, 43 (1) pp. 300-328. Peer-reviewed.
From pairwise to multiple spliced alignment.
Jammali S., Djossou A., Ouédraogo WDD, Nevers Y., Chegrane I., Ouangraoua A., 2022. Bioinformatics advances, 2 (1) pp. vbab044. Peer-reviewed.
Ontogeny of ependymoglial cells lining the third ventricle in mice.
Lopez-Rodriguez D., Rohrbach A., Lanzillo M., Gervais M., Croizier S., Langlet F., 2022. Frontiers in endocrinology, 13 p. 1073759. Peer-reviewed.
 
Recording of Diurnal Gene Expression in Peripheral Organs of Mice Using the RT-Biolumicorder
Katsioudi G., Osorio-Forero A., Sinturel F., Hagedorn C., Kreppel F., Schibler U., Gatfield D., 2022. pp. 217-242 dans Circadian Regulation, Springer US.
Sex-Biased Control of Inflammation and Metabolism by a Mitochondrial Nod-Like Receptor.
Snäkä T., Bekkar A., Desponds C., Prével F., Claudinot S., Isorce N., Teixeira F., Grasset C., Xenarios I., Lopez-Mejia I.C. et al., 2022. Frontiers in immunology, 13 p. 882867. Peer-reviewed.
 
The Intricate Interplay between Cell Cycle Regulators and Autophagy in Cancer.
Ziegler D.V., Huber K., Fajas L., 2021/12/29. Cancers, 14 (1) p. 153. Peer-reviewed.
The sleep-wake distribution contributes to the peripheral rhythms in PERIOD-2.
Hoekstra M.M., Jan M., Katsioudi G., Emmenegger Y., Franken P., 2021/12/13. eLife, 10 pp. e69773. Peer-reviewed.
Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity.
Zanou N., Dridi H., Reiken S., Imamura de Lima T., Donnelly C., De Marchi U., Ferrini M., Vidal J., Sittenfeld L., Feige J.N. et al., 2021/12/10. Nature communications, 12 (1) p. 7219. Peer-reviewed.
Alpha Satellite Insertion Close to an Ancestral Centromeric Region.
Giannuzzi G., Logsdon G.A., Chatron N., Miller D.E., Reversat J., Munson K.M., Hoekzema K., Bonnet-Dupeyron M.N., Rollat-Farnier P.A., Baker C.A. et al., 2021/12/09. Molecular biology and evolution, 38 (12) pp. 5576-5587. Peer-reviewed.
 
The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes.
Lacroix M., Linares L.K., Rueda-Rincon N., Bloch K., Di Michele M., De Blasio C., Fau C., Gayte L., Blanchet E., Mairal A. et al., 2021/12/02. Nature communications, 12 (1) p. 7037. Peer-reviewed.
Blood virosphere in febrile Tanzanian children.
Cordey S., Laubscher F., Hartley M.A., Junier T., Keitel K., Docquier M., Guex N., Iseli C., Vieille G., Le Mercier P. et al., 2021/12. Emerging microbes & infections, 10 (1) pp. 982-993. Peer-reviewed.
 
GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation.
Pellegrino G., Martin M., Allet C., Lhomme T., Geller S., Franssen D., Mansuy V., Manfredi-Lozano M., Coutteau-Robles A., Delli V. et al., 2021/12. Nature neuroscience, 24 (12) pp. 1660-1672. Peer-reviewed.
Inhibition of G-protein signalling in cardiac dysfunction of intellectual developmental disorder with cardiac arrhythmia (IDDCA) syndrome.
De Nittis P., Efthymiou S., Sarre A., Guex N., Chrast J., Putoux A., Sultan T., Raza Alvi J., Ur Rahman Z., Zafar F. et al., 2021/12. Journal of medical genetics, 58 (12) pp. 815-831. Peer-reviewed.
Plasma triacylglycerols are biomarkers of β-cell function in mice and humans.
Sánchez-Archidona A.R., Cruciani-Guglielmacci C., Roujeau C., Wigger L., Lallement J., Denom J., Barovic M., Kassis N., Mehl F., Weitz J. et al., 2021/12. Molecular metabolism, 54 p. 101355. Peer-reviewed.
 
Prognostic impact of extranodal extension in resected head and neck squamous cell carcinomas in the era of postoperative chemoradiation: A retrospective monocentric study.
Gau M., Fonseca A., Ozsahin M., Fayette J., Poupart M., Roux P.E., Schütz F., Zrounba P., Grégoire V., 2021/12. Oral oncology, 123 p. 105605. Peer-reviewed.
 
Cellular senescence links mitochondria-ER contacts and aging.
Ziegler D.V., Martin N., Bernard D., 2021/11/24. Communications biology, 4 (1) p. 1323. Peer-reviewed.
 
Drosophila sechellia: A Genetic Model for Behavioral Evolution and Neuroecology.
Auer T.O., Shahandeh M.P., Benton R., 2021/11/23. Annual review of genetics, 55 pp. 527-554. Peer-reviewed.
Noradrenergic circuit control of non-REM sleep substates.
Osorio-Forero A., Cardis R., Vantomme G., Guillaume-Gentil A., Katsioudi G., Devenoges C., Fernandez LMJ, Lüthi A., 2021/11/22. Current biology, 31 (22) pp. 5009-5023.e7. Peer-reviewed.
 
Live-imaging of Mitochondrial System in Cultured Astrocytes.
Espourteille J., Zufferey V., Laurent J.H., Richetin K., 2021/11/16. Journal of visualized experiments p. 177. Peer-reviewed.
Biallelic truncation variants in ATP9A are associated with a novel autosomal recessive neurodevelopmental disorder.
Mattioli F., Darvish H., Paracha S.A., Tafakhori A., Firouzabadi S.G., Chapi M., Baig HMA, Reymond A., Antonarakis S.E., Ansar M., 2021/11/11. NPJ genomic medicine, 6 (1) p. 94. Peer-reviewed.
Médecine personnalisée et prévention des maladies chroniques - Besoins, perceptions et attentes des patients et des médecins généralistes [Personalized medicine and chronic disease prevention: Needs, attitudes and expectations regarding in general practice]
Cohidon C., Desvergne B., Widmer D., Cerqui D., Guessous I., Cornuz J., 2021/11/10. Revue medicale suisse, 17 (758) pp. 1939-1942. Peer-reviewed.
Architecture and plasticity: optimizing plant performance in dynamic environments.
Pierik R., Fankhauser C., Strader L.C., Sinha N., 2021/11/03. Plant physiology, 187 (3) pp. 1029-1032. Peer-reviewed.
Meristem transitions and plant architecture-learning from domestication for crop breeding.
Gaarslev N., Swinnen G., Soyk S., 2021/11/03. Plant physiology, 187 (3) pp. 1045-1056. Peer-reviewed.
Phototropin-mediated perception of light direction in leaves regulates blade flattening.
Legris M., Szarzynska-Erden B.M., Trevisan M., Allenbach Petrolati L., Fankhauser C., 2021/11/03. Plant physiology, 187 (3) pp. 1235-1249. Peer-reviewed.
 
Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice.
Rohrbach A., Caron E., Dali R., Brunner M., Pasquettaz R., Kolotuev I., Santoni F., Thorens B., Langlet F., 2021/11. Molecular metabolism, 53 p. 101311. Peer-reviewed.
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